DE69839768D1 - Rekombinante lactoferrin, verfahren zu ihrer herstellung mittels pflanzen und ihre verwendung - Google Patents

Rekombinante lactoferrin, verfahren zu ihrer herstellung mittels pflanzen und ihre verwendung

Info

Publication number
DE69839768D1
DE69839768D1 DE69839768T DE69839768T DE69839768D1 DE 69839768 D1 DE69839768 D1 DE 69839768D1 DE 69839768 T DE69839768 T DE 69839768T DE 69839768 T DE69839768 T DE 69839768T DE 69839768 D1 DE69839768 D1 DE 69839768D1
Authority
DE
Germany
Prior art keywords
lactoferrin
derived proteins
plants
production
plant cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69839768T
Other languages
English (en)
Inventor
Dominique Legrand
Valerie Salmon
Genevieve Spik
Veronique Gruber
Philippe Bournat
Bertrand Merot
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meristem Therapeutics SA
Original Assignee
Meristem Therapeutics SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meristem Therapeutics SA filed Critical Meristem Therapeutics SA
Application granted granted Critical
Publication of DE69839768D1 publication Critical patent/DE69839768D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
    • C12N15/8281—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for bacterial resistance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
    • C12N15/8282—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for fungal resistance
DE69839768T 1997-05-02 1998-05-04 Rekombinante lactoferrin, verfahren zu ihrer herstellung mittels pflanzen und ihre verwendung Expired - Fee Related DE69839768D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9705699A FR2762850B1 (fr) 1997-05-02 1997-05-02 Lactoferrines recombinantes, leurs procedes de production par les plantes ainsi que leurs utilisations
PCT/FR1998/000895 WO1998050543A1 (fr) 1997-05-02 1998-05-04 Lactoferrines recombinantes, leurs procedes de production par les plantes ainsi que leurs utilisations

Publications (1)

Publication Number Publication Date
DE69839768D1 true DE69839768D1 (de) 2008-09-04

Family

ID=9506722

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69839768T Expired - Fee Related DE69839768D1 (de) 1997-05-02 1998-05-04 Rekombinante lactoferrin, verfahren zu ihrer herstellung mittels pflanzen und ihre verwendung

Country Status (9)

Country Link
US (3) US6569831B1 (de)
EP (1) EP0981617B1 (de)
JP (1) JP2001527406A (de)
AT (1) ATE402260T1 (de)
AU (1) AU7659298A (de)
CA (1) CA2288435A1 (de)
DE (1) DE69839768D1 (de)
FR (1) FR2762850B1 (de)
WO (1) WO1998050543A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2762850B1 (fr) * 1997-05-02 2000-02-11 Biocem Lactoferrines recombinantes, leurs procedes de production par les plantes ainsi que leurs utilisations
IT1299565B1 (it) * 1998-07-17 2000-03-16 Plantechno S R L Polinucleotide sintetico codificante per la lattoferrina umana, vettori, cellule e piante transgeniche che lo contengono.
US6399570B1 (en) * 1999-02-05 2002-06-04 Agennix, Inc. Antimicrobial/endotoxin neutralizing polypeptide
AU772964C (en) * 1999-03-17 2004-10-07 University Of Victoria Innovation And Development Corporation Transgenic plants that are resistant to a broad spectrum of pathogens
US6835868B1 (en) 1999-03-17 2004-12-28 University Of Victoria Innovation And Development Corporation Transgenic plants expressing dermaseptin peptides providing broad spectrum resistance to pathogens
US7138150B2 (en) * 2000-05-02 2006-11-21 Ventria Bioscience Method of making an anti-infective composition for treating oral infections
AU2001255797A1 (en) 2000-05-02 2001-11-12 Applied Phytologics, Inc. Enhanced gene expression in plants using transcription factors
US20080050503A1 (en) * 2000-05-02 2008-02-28 Ning Huang Expression of human milk proteins in transgenic plants
US7304208B2 (en) * 2000-05-02 2007-12-04 Ventria Bioscience Expression of human serum albumin (HSA) in monocot seeds
US7417178B2 (en) * 2000-05-02 2008-08-26 Ventria Bioscience Expression of human milk proteins in transgenic plants
US6991824B2 (en) * 2000-05-02 2006-01-31 Ventria Bioscience Expression of human milk proteins in transgenic plants
AU2012202697B2 (en) * 2001-02-14 2015-05-07 Ventria Bioscience Expression of human milk proteins in transgenic plants
WO2002064814A2 (en) * 2001-02-14 2002-08-22 Ventria Bioscience Expression of human milk proteins in transgenic plants
AU2002250126A1 (en) * 2001-02-14 2002-08-28 Ventria Bioscience Feed additive compositions and methods
ES2467155T3 (es) * 2001-02-14 2014-06-12 Ventria Bioscience Expresión de proteínas de leche humana en plantas transgénicas
SE0200598D0 (sv) * 2002-02-27 2002-02-27 A & Science Invest Ab Pharmaceutical composition and method for treatment or prevention of vascular disease or states of tissue hypoperfusion with hypoxic and/or ischemic consequences
AU2002360677A1 (en) * 2002-12-20 2004-07-29 Ventria Bioscience Lactoferrin protein with iron for treating iron deficiency and anemia
EP1691822A4 (de) * 2003-12-09 2008-01-02 Ventria Bioscience Hochexpression von fusionspolypeptiden in pflanzensamen mit samenaufbewahrungsproteinen als fusionsträger
WO2005067699A1 (en) * 2003-12-23 2005-07-28 Ventria Bioscience Methods of expressing heterologous protein in plant seeds using monocot non seed-storage protein promoters
KR20080039885A (ko) * 2005-06-28 2008-05-07 벤트리아 바이오사이언스 식물 세포로부터 생산된 세포 배양 배지의 성분
EP1904638A2 (de) 2005-07-18 2008-04-02 Metabogal Ltd. Mukosale oder enterale verabreichung biologisch aktiver makromoleküle
JP2009513572A (ja) * 2005-09-28 2009-04-02 ベントリア バイオサイエンス 腸管障害及び／又は下痢用の経口組成物
EP1808491A1 (de) * 2006-01-13 2007-07-18 Meristem Therapeutics S.A. Genetisch modifizierte Pflanze mit verändertem Gehalt an Reserveproteinen
NZ555163A (en) 2007-05-14 2010-05-28 Fonterra Co Operative Group Methods of immune or hematological enhancement, inhibiting tumour formation or growth, and treating or preventing cancer, cancer symptoms, or the symptoms of cancer treatments
EP2398896A4 (de) 2009-02-20 2013-02-20 Ventria Bioscience Zellkulturmedien mit kombinationen aus proteinen
IL301396A (en) 2020-09-30 2023-05-01 Nobell Foods Inc Recombinant milk proteins and food compositions containing them
US10947552B1 (en) 2020-09-30 2021-03-16 Alpine Roads, Inc. Recombinant fusion proteins for producing milk proteins in plants
US10894812B1 (en) 2020-09-30 2021-01-19 Alpine Roads, Inc. Recombinant milk proteins

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2436095A (en) * 1994-05-05 1995-11-29 Ferrodynamics, Inc. Cloning, expression, and uses of human lactoferrin
KR0154495B1 (ko) * 1995-05-22 1998-10-15 김은영 인체 락토페린 유전자로 형질전환된 항바이러스성 식물체의 제조방법
FR2736930B1 (fr) 1995-07-17 1997-09-19 Biocem Procede de production, par des cellules vegetales, de proteines heminiques, proteines ainsi obtenues et produits contenant ces proteines
CN1228123A (zh) * 1996-08-14 1999-09-08 诺瓦提斯公司 对植物病原真菌有抑制活性的肽
FR2762850B1 (fr) * 1997-05-02 2000-02-11 Biocem Lactoferrines recombinantes, leurs procedes de production par les plantes ainsi que leurs utilisations

Also Published As

Publication number Publication date
US7354902B2 (en) 2008-04-08
FR2762850A1 (fr) 1998-11-06
EP0981617B1 (de) 2008-07-23
AU7659298A (en) 1998-11-27
FR2762850B1 (fr) 2000-02-11
US20030229925A1 (en) 2003-12-11
US8334254B2 (en) 2012-12-18
ATE402260T1 (de) 2008-08-15
JP2001527406A (ja) 2001-12-25
US6569831B1 (en) 2003-05-27
US20110092411A1 (en) 2011-04-21
CA2288435A1 (fr) 1998-11-12
EP0981617A1 (de) 2000-03-01
WO1998050543A1 (fr) 1998-11-12

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee