DE69839093T2 - System zur behandlung von blut und verfahren zur optischen bestimmung des volumens der im plasma enthaltenen blutplättchen - Google Patents

System zur behandlung von blut und verfahren zur optischen bestimmung des volumens der im plasma enthaltenen blutplättchen Download PDF

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Publication number
DE69839093T2
DE69839093T2 DE69839093T DE69839093T DE69839093T2 DE 69839093 T2 DE69839093 T2 DE 69839093T2 DE 69839093 T DE69839093 T DE 69839093T DE 69839093 T DE69839093 T DE 69839093T DE 69839093 T2 DE69839093 T2 DE 69839093T2
Authority
DE
Germany
Prior art keywords
platelet
volume
optical density
value
output
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69839093T
Other languages
German (de)
English (en)
Other versions
DE69839093D1 (de
Inventor
Richard I. Northbrook Brown
John T. Wheeling FOLEY
Kyungyoon Gurnee Min
Mark Hainesville SAHLIN
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Fenwal Inc
Original Assignee
Fenwal Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fenwal Inc filed Critical Fenwal Inc
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Publication of DE69839093D1 publication Critical patent/DE69839093D1/de
Publication of DE69839093T2 publication Critical patent/DE69839093T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D17/00—Separation of liquids, not provided for elsewhere, e.g. by thermal diffusion
    • B01D17/02—Separation of non-miscible liquids
    • B01D17/0217—Separation of non-miscible liquids by centrifugal force
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A61M1/3696—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D21/00—Separation of suspended solid particles from liquids by sedimentation
    • B01D21/003—Sedimentation tanks provided with a plurality of compartments separated by a partition wall
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D21/00—Separation of suspended solid particles from liquids by sedimentation
    • B01D21/24—Feed or discharge mechanisms for settling tanks
    • B01D21/2405—Feed mechanisms for settling tanks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D21/00—Separation of suspended solid particles from liquids by sedimentation
    • B01D21/24—Feed or discharge mechanisms for settling tanks
    • B01D21/245—Discharge mechanisms for the sediments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D21/00—Separation of suspended solid particles from liquids by sedimentation
    • B01D21/26—Separation of sediment aided by centrifugal force or centripetal force
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D21/00—Separation of suspended solid particles from liquids by sedimentation
    • B01D21/26—Separation of sediment aided by centrifugal force or centripetal force
    • B01D21/262—Separation of sediment aided by centrifugal force or centripetal force by using a centrifuge
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D21/00—Separation of suspended solid particles from liquids by sedimentation
    • B01D21/30—Control equipment
    • B01D21/32—Density control of clear liquid or sediment, e.g. optical control ; Control of physical properties
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B13/00—Control arrangements specially designed for centrifuges; Programme control of centrifuges
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0413—Blood
    • A61M2202/0427—Platelets; Thrombocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3306—Optical measuring means
    • A61M2205/331—Optical measuring means used as turbidity change detectors, e.g. for priming-blood or plasma-hemoglubine-interface detection
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2221/00—Applications of separation devices
    • B01D2221/10—Separation devices for use in medical, pharmaceutical or laboratory applications, e.g. separating amalgam from dental treatment residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Thermal Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • External Artificial Organs (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69839093T 1997-07-18 1998-06-22 System zur behandlung von blut und verfahren zur optischen bestimmung des volumens der im plasma enthaltenen blutplättchen Expired - Lifetime DE69839093T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/896,665 US5958250A (en) 1995-06-07 1997-07-18 Blood processing systems and methods which optically derive the volume of platelets contained in a plasma constituent
US896665 1997-07-18
PCT/US1998/012924 WO1999003557A1 (en) 1997-07-18 1998-06-22 Blood processing systems and methods which optically derive the volume of platelets contained in a plasma constituent

Publications (2)

Publication Number Publication Date
DE69839093D1 DE69839093D1 (de) 2008-03-20
DE69839093T2 true DE69839093T2 (de) 2009-02-05

Family

ID=25406599

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69839093T Expired - Lifetime DE69839093T2 (de) 1997-07-18 1998-06-22 System zur behandlung von blut und verfahren zur optischen bestimmung des volumens der im plasma enthaltenen blutplättchen

Country Status (8)

Country Link
US (2) US5958250A (enExample)
EP (1) EP1015089B1 (enExample)
JP (1) JP2001510171A (enExample)
CN (1) CN1140311C (enExample)
BR (1) BR9811513A (enExample)
CA (1) CA2296364C (enExample)
DE (1) DE69839093T2 (enExample)
WO (1) WO1999003557A1 (enExample)

Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5651766A (en) * 1995-06-07 1997-07-29 Transfusion Technologies Corporation Blood collection and separation system
US6312607B1 (en) 1995-06-07 2001-11-06 Baxter International Inc. Blood processing systems and methods which optically monitor incremental platelet volumes in a plasma constituent
US5958250A (en) * 1995-06-07 1999-09-28 Baxter International Inc. Blood processing systems and methods which optically derive the volume of platelets contained in a plasma constituent
US6254784B1 (en) * 1997-10-30 2001-07-03 Baxter International Inc. Optical interface detection system for centrifugal blood processing
US6334842B1 (en) * 1999-03-16 2002-01-01 Gambro, Inc. Centrifugal separation apparatus and method for separating fluid components
JP3817091B2 (ja) * 1999-07-02 2006-08-30 テルモ株式会社 細胞数測定装置
US6294094B1 (en) * 1999-09-03 2001-09-25 Baxter International Inc. Systems and methods for sensing red blood cell hematocrit
US7011761B2 (en) * 1999-09-03 2006-03-14 Baxter International Inc. Red blood cell processing systems and methods which control red blood cell hematocrit
US6284142B1 (en) * 1999-09-03 2001-09-04 Baxter International Inc. Sensing systems and methods for differentiating between different cellular blood species during extracorporeal blood separation or processing
US6348156B1 (en) 1999-09-03 2002-02-19 Baxter International Inc. Blood processing systems and methods with sensors to detect contamination due to presence of cellular components or dilution due to presence of plasma
US7142988B1 (en) 1999-09-07 2006-11-28 Monsanto Company Method and information system for non-random selection of uniform structural and functional features for tissue and plant product processing
US6730054B2 (en) * 1999-10-16 2004-05-04 Baxter International Inc. Blood collection systems and methods that derive estimated effects upon the donor's blood volume and hematocrit
US6884228B2 (en) 2001-03-06 2005-04-26 Baxter International Inc. Automated system adaptable for use with different fluid circuits
US6582386B2 (en) 2001-03-06 2003-06-24 Baxter International Inc. Multi-purpose, automated blood and fluid processing systems and methods
US6808503B2 (en) 2001-03-06 2004-10-26 Baxter International Inc. Automated system and method for pre-surgical blood donation and fluid replacement
US6706008B2 (en) 2001-03-06 2004-03-16 Baxter International Inc. Automated system and method for withdrawing compounds from blood
WO2002087662A1 (en) * 2001-04-27 2002-11-07 Nexell Therapeutics Inc. Cell processing and fluid transfer apparatus and method of use
US6878105B2 (en) * 2001-08-16 2005-04-12 Baxter International Inc. Red blood cell processing systems and methods with deliberate under spill of red blood cells
US7186230B2 (en) * 2002-03-04 2007-03-06 Therakos, Inc Method and apparatus for the continuous separation of biological fluids into components
US7479123B2 (en) 2002-03-04 2009-01-20 Therakos, Inc. Method for collecting a desired blood component and performing a photopheresis treatment
US7211037B2 (en) 2002-03-04 2007-05-01 Therakos, Inc. Apparatus for the continuous separation of biological fluids into components and method of using same
US20030205538A1 (en) 2002-05-03 2003-11-06 Randel Dorian Methods and apparatus for isolating platelets from blood
US7992725B2 (en) 2002-05-03 2011-08-09 Biomet Biologics, Llc Buoy suspension fractionation system
US6905612B2 (en) * 2003-03-21 2005-06-14 Hanuman Llc Plasma concentrate apparatus and method
US7374678B2 (en) 2002-05-24 2008-05-20 Biomet Biologics, Inc. Apparatus and method for separating and concentrating fluids containing multiple components
US7832566B2 (en) 2002-05-24 2010-11-16 Biomet Biologics, Llc Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles
US7845499B2 (en) 2002-05-24 2010-12-07 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
US20060278588A1 (en) 2002-05-24 2006-12-14 Woodell-May Jennifer E Apparatus and method for separating and concentrating fluids containing multiple components
WO2003099412A1 (en) 2002-05-24 2003-12-04 Biomet Manufacturing Corp. Apparatus and method for separating and concentrating fluids containing multiple components
US6982038B2 (en) 2002-06-14 2006-01-03 Medtronic, Inc. Centrifuge system utilizing disposable components and automated processing of blood to collect platelet rich plasma
US20050049539A1 (en) * 2003-09-03 2005-03-03 O'hara Gerald P. Control system for driving fluids through an extracorporeal blood circuit
ITMI20031715A1 (it) * 2003-09-05 2005-03-06 Dideco Spa Dispositivo di comando nella raccolta differenziata dei
US7060018B2 (en) * 2003-09-11 2006-06-13 Cobe Cardiovascular, Inc. Centrifuge apparatus for processing blood
JP2005094683A (ja) * 2003-09-19 2005-04-07 Funai Electric Co Ltd ゲートウェイ
US7476209B2 (en) 2004-12-21 2009-01-13 Therakos, Inc. Method and apparatus for collecting a blood component and performing a photopheresis treatment
DK1848473T3 (da) * 2005-02-07 2013-09-02 Hanuman Llc Plasmakoncentrationsanordning
US7694828B2 (en) 2005-04-27 2010-04-13 Biomet Manufacturing Corp. Method and apparatus for producing autologous clotting components
US8567609B2 (en) 2006-05-25 2013-10-29 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
WO2008127639A1 (en) 2007-04-12 2008-10-23 Biomet Biologics, Llc Buoy suspension fractionation system
US8328024B2 (en) 2007-04-12 2012-12-11 Hanuman, Llc Buoy suspension fractionation system
EP2620139B1 (en) 2008-02-27 2016-07-20 Biomet Biologics, LLC Interleukin-1 receptor antagonist rich solutions
US8075468B2 (en) * 2008-02-27 2011-12-13 Fenwal, Inc. Systems and methods for mid-processing calculation of blood composition
US8337711B2 (en) 2008-02-29 2012-12-25 Biomet Biologics, Llc System and process for separating a material
US8187475B2 (en) 2009-03-06 2012-05-29 Biomet Biologics, Llc Method and apparatus for producing autologous thrombin
US8313954B2 (en) 2009-04-03 2012-11-20 Biomet Biologics, Llc All-in-one means of separating blood components
US9011800B2 (en) 2009-07-16 2015-04-21 Biomet Biologics, Llc Method and apparatus for separating biological materials
JP6027720B2 (ja) * 2009-12-14 2016-11-16 日機装株式会社 血液浄化装置
US8591391B2 (en) 2010-04-12 2013-11-26 Biomet Biologics, Llc Method and apparatus for separating a material
US9164079B2 (en) 2011-03-17 2015-10-20 Greyledge Technologies Llc Systems for autologous biological therapeutics
US10413652B2 (en) * 2011-04-13 2019-09-17 Fenwal, Inc. Systems and methods for use and control of an automated separator with adsorption columns
US11386993B2 (en) 2011-05-18 2022-07-12 Fenwal, Inc. Plasma collection with remote programming
WO2013043316A1 (en) * 2011-09-22 2013-03-28 Fenwal, Inc. Drive system for centrifuge
WO2013043315A1 (en) * 2011-09-22 2013-03-28 Fenwal, Inc. Drive system for centrifuge
WO2014011499A1 (en) 2012-07-12 2014-01-16 Terumo Bct, Inc. Hybrid blood component storage bag and method of making such bag
JP6174144B2 (ja) * 2012-07-30 2017-08-02 フェンウォール、インコーポレイテッド 脂質の光学的検出
US9642956B2 (en) 2012-08-27 2017-05-09 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
US9594020B2 (en) 2012-09-04 2017-03-14 Fenwal, Inc. Interface detector for blood processing system
US20140271589A1 (en) 2013-03-15 2014-09-18 Biomet Biologics, Llc Treatment of collagen defects using protein solutions
US9950035B2 (en) 2013-03-15 2018-04-24 Biomet Biologics, Llc Methods and non-immunogenic compositions for treating inflammatory disorders
US9895418B2 (en) 2013-03-15 2018-02-20 Biomet Biologics, Llc Treatment of peripheral vascular disease using protein solutions
US10143725B2 (en) 2013-03-15 2018-12-04 Biomet Biologics, Llc Treatment of pain using protein solutions
US10208095B2 (en) 2013-03-15 2019-02-19 Biomet Manufacturing, Llc Methods for making cytokine compositions from tissues using non-centrifugal methods
JP6732727B2 (ja) * 2014-03-28 2020-07-29 テルモ ビーシーティー、インコーポレーテッド 制御ループを用いた分離プロセスにおけるゲイン
US9550028B2 (en) 2014-05-06 2017-01-24 Biomet Biologics, LLC. Single step desiccating bead-in-syringe concentrating device
US9833557B2 (en) 2014-12-19 2017-12-05 Fenwal, Inc. Systems and methods for determining free plasma hemoglobin
DE102015004409A1 (de) * 2015-04-02 2016-10-06 Laser- Und Medizin-Technologie Gmbh, Berlin Verfahren und Vorrichtung zur Separation und Analyse von Blutbestandteilen
EP3354300B1 (en) 2017-01-30 2020-08-05 Fenwal, Inc. Systems for collecting mononuclear cells having a suitable hematocrit for extracorporeal photopheresis
CN106890373A (zh) * 2017-02-10 2017-06-27 广州上诺生物技术有限公司 一种用于数字化管理血浆过滤白细胞的方法及系统
US10561784B2 (en) 2017-05-31 2020-02-18 Fenwal, Inc. Stationary optical monitoring system for blood processing system
US12033750B2 (en) 2018-05-21 2024-07-09 Fenwal, Inc. Plasma collection
US11412967B2 (en) 2018-05-21 2022-08-16 Fenwal, Inc. Systems and methods for plasma collection
EP3621674B1 (en) 2018-05-21 2021-09-15 Fenwal, Inc. Systems for optimization of plasma collection volumes
US11484891B2 (en) 2019-05-23 2022-11-01 Fenwal, Inc. Adjustment of target interface location between separated fluid components in a centrifuge
MX2022007119A (es) * 2019-12-12 2022-07-11 S D Sight Diagnostics Ltd Deteccion de plaquetas en una muestra de sangre.
EP4035700B1 (en) 2021-01-29 2025-03-05 Fenwal, Inc. Automated splitting of a fluid into uneven volumes
US11898967B2 (en) 2021-02-02 2024-02-13 Fenwal, Inc. Predicting malfunction and failure of centrifuge umbilicus
US20240024559A1 (en) * 2022-07-22 2024-01-25 Fenwal, Inc. Blood processing and treatment systems and methods with procedure estimator

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3727066A (en) * 1968-02-16 1973-04-10 Baxter Laboratories Inc Probe photometer with fluid sensing device
US3752995A (en) * 1972-04-07 1973-08-14 Coulter Electronics Blank value storing photometer
US3861800A (en) * 1972-07-27 1975-01-21 Becton Dickinson Co Particle counter independent of flow rate
US3861877A (en) * 1974-01-21 1975-01-21 Clinical Technology Inc Optical analysis of fluids
US4468219A (en) * 1983-12-20 1984-08-28 International Business Machines Corporation Pump flow rate compensation system
JPS62226057A (ja) * 1986-03-28 1987-10-05 Minoru Tomita 全血用赤血球の凝集率測定方法及びその装置
US5792372A (en) * 1987-01-30 1998-08-11 Baxter International, Inc. Enhanced yield collection systems and methods for obtaining concentrated platelets from platelet-rich plasma
US5573678A (en) * 1987-01-30 1996-11-12 Baxter International Inc. Blood processing systems and methods for collecting mono nuclear cells
US4834890A (en) * 1987-01-30 1989-05-30 Baxter International Inc. Centrifugation pheresis system
US5656163A (en) * 1987-01-30 1997-08-12 Baxter International Inc. Chamber for use in a rotating field to separate blood components
US5104526A (en) * 1987-01-30 1992-04-14 Baxter International Inc. Centrifugation system having an interface detection system
US4828716A (en) * 1987-04-03 1989-05-09 Andronic Devices, Ltd. Apparatus and method for separating phases of blood
US4810090A (en) * 1987-08-24 1989-03-07 Cobe Laboratories, Inc. Method and apparatus for monitoring blood components
FR2625320B1 (fr) * 1987-12-28 1990-05-18 Rgl Transfusion Sanguine Centr Appareil automatique de separation des composants du sang
US4927545A (en) * 1988-10-06 1990-05-22 Medical Automation Specialties, Inc. Method and apparatus for automatic processing and analyzing of blood serum
US5316667A (en) * 1989-05-26 1994-05-31 Baxter International Inc. Time based interface detection systems for blood processing apparatus
US5681273A (en) * 1991-12-23 1997-10-28 Baxter International Inc. Systems and methods for predicting blood processing parameters
US5730883A (en) * 1991-12-23 1998-03-24 Baxter International Inc. Blood processing systems and methods using apparent hematocrit as a process control parameter
US5639382A (en) * 1991-12-23 1997-06-17 Baxter International Inc. Systems and methods for deriving recommended storage parameters for collected blood components
US6319471B1 (en) * 1992-07-10 2001-11-20 Gambro, Inc. Apparatus for producing blood component products
US5658240A (en) * 1992-03-04 1997-08-19 Cobe Laboratories, Inc. Blood component collection system with optimizer
US5496265A (en) * 1992-03-04 1996-03-05 Cobe Laboratories, Inc. Blood component collection system with optimizer
EP0696211B1 (en) * 1993-04-27 2000-09-20 Haemonetics Corporation Apheresis apparatus
US5437598A (en) * 1994-01-21 1995-08-01 Cobe Laboratories, Inc. Automation of plasma sequestration
US5478479A (en) * 1994-05-20 1995-12-26 Haemonetics Corporation Two-stage cell wash process controlled by optical sensor
US5958250A (en) * 1995-06-07 1999-09-28 Baxter International Inc. Blood processing systems and methods which optically derive the volume of platelets contained in a plasma constituent
US5769811A (en) * 1995-10-31 1998-06-23 Haemonetics Corporation Blood-processing machine system
US5637082A (en) * 1996-02-22 1997-06-10 Haemonetics Corporation Adaptive apheresis apparatus
WO1998043720A1 (en) * 1997-04-03 1998-10-08 Baxter International Inc. Interface detection and control systems and methods
US5980760A (en) * 1997-07-01 1999-11-09 Baxter International Inc. System and methods for harvesting mononuclear cells by recirculation of packed red blood cells
US6027657A (en) * 1997-07-01 2000-02-22 Baxter International Inc. Systems and methods for collecting diluted mononuclear cells

Also Published As

Publication number Publication date
US6183651B1 (en) 2001-02-06
EP1015089A4 (en) 2000-12-20
CN1268067A (zh) 2000-09-27
DE69839093D1 (de) 2008-03-20
WO1999003557A1 (en) 1999-01-28
US5958250A (en) 1999-09-28
CA2296364A1 (en) 1999-01-28
CN1140311C (zh) 2004-03-03
BR9811513A (pt) 2000-09-26
JP2001510171A (ja) 2001-07-31
CA2296364C (en) 2008-05-06
EP1015089B1 (en) 2008-02-06
EP1015089A1 (en) 2000-07-05

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