JP2001510171A - 血漿成分中に含まれる血小板量を光学的に導出する血液処理システムおよび方法 - Google Patents
血漿成分中に含まれる血小板量を光学的に導出する血液処理システムおよび方法Info
- Publication number
- JP2001510171A JP2001510171A JP2000502846A JP2000502846A JP2001510171A JP 2001510171 A JP2001510171 A JP 2001510171A JP 2000502846 A JP2000502846 A JP 2000502846A JP 2000502846 A JP2000502846 A JP 2000502846A JP 2001510171 A JP2001510171 A JP 2001510171A
- Authority
- JP
- Japan
- Prior art keywords
- output
- plasma
- platelet
- plasma component
- amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- 210000004369 blood Anatomy 0.000 title claims abstract description 53
- 239000008280 blood Substances 0.000 title claims abstract description 53
- 238000000034 method Methods 0.000 title claims description 43
- 230000003287 optical effect Effects 0.000 claims abstract description 58
- 238000003860 storage Methods 0.000 claims description 51
- 238000000926 separation method Methods 0.000 claims description 16
- 150000002632 lipids Chemical class 0.000 claims description 12
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- 238000000149 argon plasma sintering Methods 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 210000004623 platelet-rich plasma Anatomy 0.000 description 106
- 210000001772 blood platelet Anatomy 0.000 description 97
- 210000002381 plasma Anatomy 0.000 description 73
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- 239000000306 component Substances 0.000 description 12
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- 238000009795 derivation Methods 0.000 description 8
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- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D17/00—Separation of liquids, not provided for elsewhere, e.g. by thermal diffusion
- B01D17/02—Separation of non-miscible liquids
- B01D17/0217—Separation of non-miscible liquids by centrifugal force
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
- A61M1/3696—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D21/00—Separation of suspended solid particles from liquids by sedimentation
- B01D21/003—Sedimentation tanks provided with a plurality of compartments separated by a partition wall
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D21/00—Separation of suspended solid particles from liquids by sedimentation
- B01D21/24—Feed or discharge mechanisms for settling tanks
- B01D21/2405—Feed mechanisms for settling tanks
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D21/00—Separation of suspended solid particles from liquids by sedimentation
- B01D21/24—Feed or discharge mechanisms for settling tanks
- B01D21/245—Discharge mechanisms for the sediments
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D21/00—Separation of suspended solid particles from liquids by sedimentation
- B01D21/26—Separation of sediment aided by centrifugal force or centripetal force
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D21/00—Separation of suspended solid particles from liquids by sedimentation
- B01D21/26—Separation of sediment aided by centrifugal force or centripetal force
- B01D21/262—Separation of sediment aided by centrifugal force or centripetal force by using a centrifuge
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D21/00—Separation of suspended solid particles from liquids by sedimentation
- B01D21/30—Control equipment
- B01D21/32—Density control of clear liquid or sediment, e.g. optical control ; Control of physical properties
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B13/00—Control arrangements specially designed for centrifuges; Programme control of centrifuges
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B5/00—Other centrifuges
- B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
- B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
- A61M2202/0427—Platelets; Thrombocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3306—Optical measuring means
- A61M2205/331—Optical measuring means used as turbidity change detectors, e.g. for priming-blood or plasma-hemoglubine-interface detection
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2221/00—Applications of separation devices
- B01D2221/10—Separation devices for use in medical, pharmaceutical or laboratory applications, e.g. separating amalgam from dental treatment residues
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Anesthesiology (AREA)
- Thermal Sciences (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- External Artificial Organs (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/896,665 US5958250A (en) | 1995-06-07 | 1997-07-18 | Blood processing systems and methods which optically derive the volume of platelets contained in a plasma constituent |
| US08/896,665 | 1997-07-18 | ||
| PCT/US1998/012924 WO1999003557A1 (en) | 1997-07-18 | 1998-06-22 | Blood processing systems and methods which optically derive the volume of platelets contained in a plasma constituent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001510171A true JP2001510171A (ja) | 2001-07-31 |
| JP2001510171A5 JP2001510171A5 (enExample) | 2006-01-05 |
Family
ID=25406599
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000502846A Pending JP2001510171A (ja) | 1997-07-18 | 1998-06-22 | 血漿成分中に含まれる血小板量を光学的に導出する血液処理システムおよび方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US5958250A (enExample) |
| EP (1) | EP1015089B1 (enExample) |
| JP (1) | JP2001510171A (enExample) |
| CN (1) | CN1140311C (enExample) |
| BR (1) | BR9811513A (enExample) |
| CA (1) | CA2296364C (enExample) |
| DE (1) | DE69839093T2 (enExample) |
| WO (1) | WO1999003557A1 (enExample) |
Families Citing this family (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5651766A (en) * | 1995-06-07 | 1997-07-29 | Transfusion Technologies Corporation | Blood collection and separation system |
| US6312607B1 (en) | 1995-06-07 | 2001-11-06 | Baxter International Inc. | Blood processing systems and methods which optically monitor incremental platelet volumes in a plasma constituent |
| US5958250A (en) * | 1995-06-07 | 1999-09-28 | Baxter International Inc. | Blood processing systems and methods which optically derive the volume of platelets contained in a plasma constituent |
| US6254784B1 (en) * | 1997-10-30 | 2001-07-03 | Baxter International Inc. | Optical interface detection system for centrifugal blood processing |
| US6334842B1 (en) * | 1999-03-16 | 2002-01-01 | Gambro, Inc. | Centrifugal separation apparatus and method for separating fluid components |
| JP3817091B2 (ja) * | 1999-07-02 | 2006-08-30 | テルモ株式会社 | 細胞数測定装置 |
| US6294094B1 (en) * | 1999-09-03 | 2001-09-25 | Baxter International Inc. | Systems and methods for sensing red blood cell hematocrit |
| US7011761B2 (en) * | 1999-09-03 | 2006-03-14 | Baxter International Inc. | Red blood cell processing systems and methods which control red blood cell hematocrit |
| US6284142B1 (en) * | 1999-09-03 | 2001-09-04 | Baxter International Inc. | Sensing systems and methods for differentiating between different cellular blood species during extracorporeal blood separation or processing |
| US6348156B1 (en) | 1999-09-03 | 2002-02-19 | Baxter International Inc. | Blood processing systems and methods with sensors to detect contamination due to presence of cellular components or dilution due to presence of plasma |
| US7142988B1 (en) | 1999-09-07 | 2006-11-28 | Monsanto Company | Method and information system for non-random selection of uniform structural and functional features for tissue and plant product processing |
| US6730054B2 (en) * | 1999-10-16 | 2004-05-04 | Baxter International Inc. | Blood collection systems and methods that derive estimated effects upon the donor's blood volume and hematocrit |
| US6884228B2 (en) | 2001-03-06 | 2005-04-26 | Baxter International Inc. | Automated system adaptable for use with different fluid circuits |
| US6582386B2 (en) | 2001-03-06 | 2003-06-24 | Baxter International Inc. | Multi-purpose, automated blood and fluid processing systems and methods |
| US6808503B2 (en) | 2001-03-06 | 2004-10-26 | Baxter International Inc. | Automated system and method for pre-surgical blood donation and fluid replacement |
| US6706008B2 (en) | 2001-03-06 | 2004-03-16 | Baxter International Inc. | Automated system and method for withdrawing compounds from blood |
| WO2002087662A1 (en) * | 2001-04-27 | 2002-11-07 | Nexell Therapeutics Inc. | Cell processing and fluid transfer apparatus and method of use |
| US6878105B2 (en) * | 2001-08-16 | 2005-04-12 | Baxter International Inc. | Red blood cell processing systems and methods with deliberate under spill of red blood cells |
| US7186230B2 (en) * | 2002-03-04 | 2007-03-06 | Therakos, Inc | Method and apparatus for the continuous separation of biological fluids into components |
| US7479123B2 (en) | 2002-03-04 | 2009-01-20 | Therakos, Inc. | Method for collecting a desired blood component and performing a photopheresis treatment |
| US7211037B2 (en) | 2002-03-04 | 2007-05-01 | Therakos, Inc. | Apparatus for the continuous separation of biological fluids into components and method of using same |
| US20030205538A1 (en) | 2002-05-03 | 2003-11-06 | Randel Dorian | Methods and apparatus for isolating platelets from blood |
| US7992725B2 (en) | 2002-05-03 | 2011-08-09 | Biomet Biologics, Llc | Buoy suspension fractionation system |
| US6905612B2 (en) * | 2003-03-21 | 2005-06-14 | Hanuman Llc | Plasma concentrate apparatus and method |
| US7374678B2 (en) | 2002-05-24 | 2008-05-20 | Biomet Biologics, Inc. | Apparatus and method for separating and concentrating fluids containing multiple components |
| US7832566B2 (en) | 2002-05-24 | 2010-11-16 | Biomet Biologics, Llc | Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles |
| US7845499B2 (en) | 2002-05-24 | 2010-12-07 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
| US20060278588A1 (en) | 2002-05-24 | 2006-12-14 | Woodell-May Jennifer E | Apparatus and method for separating and concentrating fluids containing multiple components |
| WO2003099412A1 (en) | 2002-05-24 | 2003-12-04 | Biomet Manufacturing Corp. | Apparatus and method for separating and concentrating fluids containing multiple components |
| US6982038B2 (en) | 2002-06-14 | 2006-01-03 | Medtronic, Inc. | Centrifuge system utilizing disposable components and automated processing of blood to collect platelet rich plasma |
| US20050049539A1 (en) * | 2003-09-03 | 2005-03-03 | O'hara Gerald P. | Control system for driving fluids through an extracorporeal blood circuit |
| ITMI20031715A1 (it) * | 2003-09-05 | 2005-03-06 | Dideco Spa | Dispositivo di comando nella raccolta differenziata dei |
| US7060018B2 (en) * | 2003-09-11 | 2006-06-13 | Cobe Cardiovascular, Inc. | Centrifuge apparatus for processing blood |
| JP2005094683A (ja) * | 2003-09-19 | 2005-04-07 | Funai Electric Co Ltd | ゲートウェイ |
| US7476209B2 (en) | 2004-12-21 | 2009-01-13 | Therakos, Inc. | Method and apparatus for collecting a blood component and performing a photopheresis treatment |
| DK1848473T3 (da) * | 2005-02-07 | 2013-09-02 | Hanuman Llc | Plasmakoncentrationsanordning |
| US7694828B2 (en) | 2005-04-27 | 2010-04-13 | Biomet Manufacturing Corp. | Method and apparatus for producing autologous clotting components |
| US8567609B2 (en) | 2006-05-25 | 2013-10-29 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
| WO2008127639A1 (en) | 2007-04-12 | 2008-10-23 | Biomet Biologics, Llc | Buoy suspension fractionation system |
| US8328024B2 (en) | 2007-04-12 | 2012-12-11 | Hanuman, Llc | Buoy suspension fractionation system |
| EP2620139B1 (en) | 2008-02-27 | 2016-07-20 | Biomet Biologics, LLC | Interleukin-1 receptor antagonist rich solutions |
| US8075468B2 (en) * | 2008-02-27 | 2011-12-13 | Fenwal, Inc. | Systems and methods for mid-processing calculation of blood composition |
| US8337711B2 (en) | 2008-02-29 | 2012-12-25 | Biomet Biologics, Llc | System and process for separating a material |
| US8187475B2 (en) | 2009-03-06 | 2012-05-29 | Biomet Biologics, Llc | Method and apparatus for producing autologous thrombin |
| US8313954B2 (en) | 2009-04-03 | 2012-11-20 | Biomet Biologics, Llc | All-in-one means of separating blood components |
| US9011800B2 (en) | 2009-07-16 | 2015-04-21 | Biomet Biologics, Llc | Method and apparatus for separating biological materials |
| JP6027720B2 (ja) * | 2009-12-14 | 2016-11-16 | 日機装株式会社 | 血液浄化装置 |
| US8591391B2 (en) | 2010-04-12 | 2013-11-26 | Biomet Biologics, Llc | Method and apparatus for separating a material |
| US9164079B2 (en) | 2011-03-17 | 2015-10-20 | Greyledge Technologies Llc | Systems for autologous biological therapeutics |
| US10413652B2 (en) * | 2011-04-13 | 2019-09-17 | Fenwal, Inc. | Systems and methods for use and control of an automated separator with adsorption columns |
| US11386993B2 (en) | 2011-05-18 | 2022-07-12 | Fenwal, Inc. | Plasma collection with remote programming |
| WO2013043316A1 (en) * | 2011-09-22 | 2013-03-28 | Fenwal, Inc. | Drive system for centrifuge |
| WO2013043315A1 (en) * | 2011-09-22 | 2013-03-28 | Fenwal, Inc. | Drive system for centrifuge |
| WO2014011499A1 (en) | 2012-07-12 | 2014-01-16 | Terumo Bct, Inc. | Hybrid blood component storage bag and method of making such bag |
| JP6174144B2 (ja) * | 2012-07-30 | 2017-08-02 | フェンウォール、インコーポレイテッド | 脂質の光学的検出 |
| US9642956B2 (en) | 2012-08-27 | 2017-05-09 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
| US9594020B2 (en) | 2012-09-04 | 2017-03-14 | Fenwal, Inc. | Interface detector for blood processing system |
| US20140271589A1 (en) | 2013-03-15 | 2014-09-18 | Biomet Biologics, Llc | Treatment of collagen defects using protein solutions |
| US9950035B2 (en) | 2013-03-15 | 2018-04-24 | Biomet Biologics, Llc | Methods and non-immunogenic compositions for treating inflammatory disorders |
| US9895418B2 (en) | 2013-03-15 | 2018-02-20 | Biomet Biologics, Llc | Treatment of peripheral vascular disease using protein solutions |
| US10143725B2 (en) | 2013-03-15 | 2018-12-04 | Biomet Biologics, Llc | Treatment of pain using protein solutions |
| US10208095B2 (en) | 2013-03-15 | 2019-02-19 | Biomet Manufacturing, Llc | Methods for making cytokine compositions from tissues using non-centrifugal methods |
| JP6732727B2 (ja) * | 2014-03-28 | 2020-07-29 | テルモ ビーシーティー、インコーポレーテッド | 制御ループを用いた分離プロセスにおけるゲイン |
| US9550028B2 (en) | 2014-05-06 | 2017-01-24 | Biomet Biologics, LLC. | Single step desiccating bead-in-syringe concentrating device |
| US9833557B2 (en) | 2014-12-19 | 2017-12-05 | Fenwal, Inc. | Systems and methods for determining free plasma hemoglobin |
| DE102015004409A1 (de) * | 2015-04-02 | 2016-10-06 | Laser- Und Medizin-Technologie Gmbh, Berlin | Verfahren und Vorrichtung zur Separation und Analyse von Blutbestandteilen |
| EP3354300B1 (en) | 2017-01-30 | 2020-08-05 | Fenwal, Inc. | Systems for collecting mononuclear cells having a suitable hematocrit for extracorporeal photopheresis |
| CN106890373A (zh) * | 2017-02-10 | 2017-06-27 | 广州上诺生物技术有限公司 | 一种用于数字化管理血浆过滤白细胞的方法及系统 |
| US10561784B2 (en) | 2017-05-31 | 2020-02-18 | Fenwal, Inc. | Stationary optical monitoring system for blood processing system |
| US12033750B2 (en) | 2018-05-21 | 2024-07-09 | Fenwal, Inc. | Plasma collection |
| US11412967B2 (en) | 2018-05-21 | 2022-08-16 | Fenwal, Inc. | Systems and methods for plasma collection |
| EP3621674B1 (en) | 2018-05-21 | 2021-09-15 | Fenwal, Inc. | Systems for optimization of plasma collection volumes |
| US11484891B2 (en) | 2019-05-23 | 2022-11-01 | Fenwal, Inc. | Adjustment of target interface location between separated fluid components in a centrifuge |
| MX2022007119A (es) * | 2019-12-12 | 2022-07-11 | S D Sight Diagnostics Ltd | Deteccion de plaquetas en una muestra de sangre. |
| EP4035700B1 (en) | 2021-01-29 | 2025-03-05 | Fenwal, Inc. | Automated splitting of a fluid into uneven volumes |
| US11898967B2 (en) | 2021-02-02 | 2024-02-13 | Fenwal, Inc. | Predicting malfunction and failure of centrifuge umbilicus |
| US20240024559A1 (en) * | 2022-07-22 | 2024-01-25 | Fenwal, Inc. | Blood processing and treatment systems and methods with procedure estimator |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3727066A (en) * | 1968-02-16 | 1973-04-10 | Baxter Laboratories Inc | Probe photometer with fluid sensing device |
| US3752995A (en) * | 1972-04-07 | 1973-08-14 | Coulter Electronics | Blank value storing photometer |
| US3861800A (en) * | 1972-07-27 | 1975-01-21 | Becton Dickinson Co | Particle counter independent of flow rate |
| US3861877A (en) * | 1974-01-21 | 1975-01-21 | Clinical Technology Inc | Optical analysis of fluids |
| US4468219A (en) * | 1983-12-20 | 1984-08-28 | International Business Machines Corporation | Pump flow rate compensation system |
| JPS62226057A (ja) * | 1986-03-28 | 1987-10-05 | Minoru Tomita | 全血用赤血球の凝集率測定方法及びその装置 |
| US5792372A (en) * | 1987-01-30 | 1998-08-11 | Baxter International, Inc. | Enhanced yield collection systems and methods for obtaining concentrated platelets from platelet-rich plasma |
| US5573678A (en) * | 1987-01-30 | 1996-11-12 | Baxter International Inc. | Blood processing systems and methods for collecting mono nuclear cells |
| US4834890A (en) * | 1987-01-30 | 1989-05-30 | Baxter International Inc. | Centrifugation pheresis system |
| US5656163A (en) * | 1987-01-30 | 1997-08-12 | Baxter International Inc. | Chamber for use in a rotating field to separate blood components |
| US5104526A (en) * | 1987-01-30 | 1992-04-14 | Baxter International Inc. | Centrifugation system having an interface detection system |
| US4828716A (en) * | 1987-04-03 | 1989-05-09 | Andronic Devices, Ltd. | Apparatus and method for separating phases of blood |
| US4810090A (en) * | 1987-08-24 | 1989-03-07 | Cobe Laboratories, Inc. | Method and apparatus for monitoring blood components |
| FR2625320B1 (fr) * | 1987-12-28 | 1990-05-18 | Rgl Transfusion Sanguine Centr | Appareil automatique de separation des composants du sang |
| US4927545A (en) * | 1988-10-06 | 1990-05-22 | Medical Automation Specialties, Inc. | Method and apparatus for automatic processing and analyzing of blood serum |
| US5316667A (en) * | 1989-05-26 | 1994-05-31 | Baxter International Inc. | Time based interface detection systems for blood processing apparatus |
| US5681273A (en) * | 1991-12-23 | 1997-10-28 | Baxter International Inc. | Systems and methods for predicting blood processing parameters |
| US5730883A (en) * | 1991-12-23 | 1998-03-24 | Baxter International Inc. | Blood processing systems and methods using apparent hematocrit as a process control parameter |
| US5639382A (en) * | 1991-12-23 | 1997-06-17 | Baxter International Inc. | Systems and methods for deriving recommended storage parameters for collected blood components |
| US6319471B1 (en) * | 1992-07-10 | 2001-11-20 | Gambro, Inc. | Apparatus for producing blood component products |
| US5658240A (en) * | 1992-03-04 | 1997-08-19 | Cobe Laboratories, Inc. | Blood component collection system with optimizer |
| US5496265A (en) * | 1992-03-04 | 1996-03-05 | Cobe Laboratories, Inc. | Blood component collection system with optimizer |
| EP0696211B1 (en) * | 1993-04-27 | 2000-09-20 | Haemonetics Corporation | Apheresis apparatus |
| US5437598A (en) * | 1994-01-21 | 1995-08-01 | Cobe Laboratories, Inc. | Automation of plasma sequestration |
| US5478479A (en) * | 1994-05-20 | 1995-12-26 | Haemonetics Corporation | Two-stage cell wash process controlled by optical sensor |
| US5958250A (en) * | 1995-06-07 | 1999-09-28 | Baxter International Inc. | Blood processing systems and methods which optically derive the volume of platelets contained in a plasma constituent |
| US5769811A (en) * | 1995-10-31 | 1998-06-23 | Haemonetics Corporation | Blood-processing machine system |
| US5637082A (en) * | 1996-02-22 | 1997-06-10 | Haemonetics Corporation | Adaptive apheresis apparatus |
| WO1998043720A1 (en) * | 1997-04-03 | 1998-10-08 | Baxter International Inc. | Interface detection and control systems and methods |
| US5980760A (en) * | 1997-07-01 | 1999-11-09 | Baxter International Inc. | System and methods for harvesting mononuclear cells by recirculation of packed red blood cells |
| US6027657A (en) * | 1997-07-01 | 2000-02-22 | Baxter International Inc. | Systems and methods for collecting diluted mononuclear cells |
-
1997
- 1997-07-18 US US08/896,665 patent/US5958250A/en not_active Expired - Lifetime
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- 1998-06-22 CA CA002296364A patent/CA2296364C/en not_active Expired - Lifetime
- 1998-06-22 DE DE69839093T patent/DE69839093T2/de not_active Expired - Lifetime
- 1998-06-22 JP JP2000502846A patent/JP2001510171A/ja active Pending
- 1998-06-22 BR BR9811513-8A patent/BR9811513A/pt not_active Application Discontinuation
- 1998-06-22 EP EP98930444A patent/EP1015089B1/en not_active Expired - Lifetime
- 1998-06-22 WO PCT/US1998/012924 patent/WO1999003557A1/en not_active Ceased
- 1998-06-22 CN CNB988073757A patent/CN1140311C/zh not_active Expired - Lifetime
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1999
- 1999-08-25 US US09/382,893 patent/US6183651B1/en not_active Expired - Lifetime
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| US6183651B1 (en) | 2001-02-06 |
| EP1015089A4 (en) | 2000-12-20 |
| CN1268067A (zh) | 2000-09-27 |
| DE69839093T2 (de) | 2009-02-05 |
| DE69839093D1 (de) | 2008-03-20 |
| WO1999003557A1 (en) | 1999-01-28 |
| US5958250A (en) | 1999-09-28 |
| CA2296364A1 (en) | 1999-01-28 |
| CN1140311C (zh) | 2004-03-03 |
| BR9811513A (pt) | 2000-09-26 |
| CA2296364C (en) | 2008-05-06 |
| EP1015089B1 (en) | 2008-02-06 |
| EP1015089A1 (en) | 2000-07-05 |
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