DE69838669D1 - Mikropartikel, geeignet als kontrastmittel im ultraschall und zur wirkstoffgabe in den blutkreislauf - Google Patents

Mikropartikel, geeignet als kontrastmittel im ultraschall und zur wirkstoffgabe in den blutkreislauf

Info

Publication number
DE69838669D1
DE69838669D1 DE69838669T DE69838669T DE69838669D1 DE 69838669 D1 DE69838669 D1 DE 69838669D1 DE 69838669 T DE69838669 T DE 69838669T DE 69838669 T DE69838669 T DE 69838669T DE 69838669 D1 DE69838669 D1 DE 69838669D1
Authority
DE
Germany
Prior art keywords
microparticles
contrast
ultrasound
activity
blood circuit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69838669T
Other languages
English (en)
Other versions
DE69838669T2 (de
Inventor
Thomas B Ottoboni
Robert E Short
Ronald K Yamamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Point Biomedical Corp
Original Assignee
Point Biomedical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Point Biomedical Corp filed Critical Point Biomedical Corp
Application granted granted Critical
Publication of DE69838669D1 publication Critical patent/DE69838669D1/de
Publication of DE69838669T2 publication Critical patent/DE69838669T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6925—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a microcapsule, nanocapsule, microbubble or nanobubble
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/225—Microparticles, microcapsules

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acoustics & Sound (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nanotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
DE69838669T 1997-04-30 1998-04-30 Mikropartikel, geeignet als kontrastmittel im ultraschall und zur wirkstoffgabe in den blutkreislauf Expired - Lifetime DE69838669T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US84715397A 1997-04-30 1997-04-30
PCT/US1998/008827 WO1998048783A1 (en) 1997-04-30 1998-04-30 Microparticles useful as ultrasonic contrast agents and for delivery of drugs into the bloodstream
US847153 2004-05-17

Publications (2)

Publication Number Publication Date
DE69838669D1 true DE69838669D1 (de) 2007-12-20
DE69838669T2 DE69838669T2 (de) 2008-10-30

Family

ID=25299908

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19882362T Ceased DE19882362T1 (de) 1997-04-30 1998-04-30 Mikropartikel, geeignet als Ultraschallkontrastmittel und zum Transport von Arzneimitteln in den Blutstrom
DE69838669T Expired - Lifetime DE69838669T2 (de) 1997-04-30 1998-04-30 Mikropartikel, geeignet als kontrastmittel im ultraschall und zur wirkstoffgabe in den blutkreislauf

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE19882362T Ceased DE19882362T1 (de) 1997-04-30 1998-04-30 Mikropartikel, geeignet als Ultraschallkontrastmittel und zum Transport von Arzneimitteln in den Blutstrom

Country Status (11)

Country Link
US (4) US6193951B1 (de)
EP (1) EP0979071B1 (de)
JP (1) JP2001527547A (de)
AT (1) ATE377414T1 (de)
AU (1) AU739919B2 (de)
CA (1) CA2289088C (de)
DE (2) DE19882362T1 (de)
ES (1) ES2296332T3 (de)
GB (1) GB2340040B (de)
NO (1) NO995313L (de)
WO (1) WO1998048783A1 (de)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6143211A (en) * 1995-07-21 2000-11-07 Brown University Foundation Process for preparing microparticles through phase inversion phenomena
US6524802B1 (en) * 1996-03-29 2003-02-25 The Johns Hopkins University School Of Medicine Methods of detecting growth differentiation factor-14
ES2288760T3 (es) 1996-04-25 2008-01-16 Bioarray Solutions Ltd. Ensamblaje electrocinetico controlado por luz de particulas proximas a superficies.
US6193951B1 (en) * 1997-04-30 2001-02-27 Point Biomedical Corporation Microparticles useful as ultrasonic contrast agents
US20020159951A1 (en) * 1997-05-06 2002-10-31 Unger Evan C. Novel targeted compositions for diagnostic and therapeutic use
US6416740B1 (en) * 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
US6896659B2 (en) * 1998-02-06 2005-05-24 Point Biomedical Corporation Method for ultrasound triggered drug delivery using hollow microbubbles with controlled fragility
WO2000006124A2 (en) * 1998-07-30 2000-02-10 Point Biomedical Corporation A novel excipient for the lyophilization of aqueous suspensions of microparticles
AU6635900A (en) * 1999-08-13 2001-03-13 Point Biomedical Corporation Microparticles useful as ultrasonic contrast agents and for lymphatic system
AU6636000A (en) 1999-08-13 2001-03-13 Point Biomedical Corporation Hollow microspheres with controlled fragility for medical use
US6527718B1 (en) 1999-08-20 2003-03-04 Brian G Connor Ultrasound system for continuous imaging and delivery of an encapsulated agent
US6740039B1 (en) 1999-08-20 2004-05-25 Koninklijke Philips Electronics N.V. Methods and apparatus for displaying information relating to delivery and activation of a therapeutic agent using ultrasound energy
US6479145B1 (en) * 1999-09-09 2002-11-12 Regents Of The University Of Minnesota Biopolymers and biopolymer blends, and method for producing same
EP1311839B1 (de) * 2000-06-21 2006-03-01 Bioarray Solutions Ltd Multianalytische molekularanalyse durch verwendung anwendungsspezifischer zufallspartikelarrays
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
JP2004537401A (ja) * 2001-08-08 2004-12-16 ブラウン ユニバーシティ リサーチ ファウンデーション 疎水性薬物の微粉砕方法
KR20040068122A (ko) 2001-10-15 2004-07-30 바이오어레이 솔루션스 리미티드 공동 검색과 효소-매개된 탐지에 의한 다형성 좌위의 다중분석
US20030147965A1 (en) * 2001-12-10 2003-08-07 Spherics, Inc. Methods and products useful in the formation and isolation of microparticles
JP4290381B2 (ja) * 2002-04-11 2009-07-01 学校法人 聖マリアンナ医科大学 ピリドンカルボン酸化合物含有エマルション
US6919068B2 (en) * 2002-05-17 2005-07-19 Point Biomedical Corporation Method of preparing gas-filled polymer matrix microparticles useful for echographic imaging
US7101566B2 (en) * 2002-06-28 2006-09-05 Ethicon, Inc. Polymer coated microparticles for sustained release
EP1551459A4 (de) * 2002-07-11 2007-02-07 Targeson Llc Mikrobläschen-zusammensetzungen und verfahren zu ihrer herstellung und verwendung
FR2842737B1 (fr) * 2002-07-25 2006-01-27 Centre Nat Rech Scient Particules revetues en surface de hyaluronane ou d'un de ses derives et leur utilisation a titre de vecteurs biologiques pour des matieres actives
WO2004047007A1 (en) 2002-11-15 2004-06-03 Bioarray Solutions, Ltd. Analysis, secure access to, and transmission of array images
GB0228826D0 (en) * 2002-12-11 2003-01-15 Okpala Joseph Hair technology in creating particles with improved delivery capabilities
FR2850385B1 (fr) * 2003-01-29 2007-04-20 Inst Gustave Roussy Igr Microparticules echogenes, servant notamment comme agent de contraste pour l'exploration ultrasonique et/ou comme emboles pour le detections ultrasoniques
US7767219B2 (en) 2003-01-31 2010-08-03 Boston Scientific Scimed, Inc. Localized drug delivery using drug-loaded nanocapsules
US20040185108A1 (en) * 2003-03-18 2004-09-23 Short Robert E. Method of preparing gas-filled polymer matrix microparticles useful for delivering drug
US20040228800A1 (en) * 2003-05-15 2004-11-18 Scicotec Gmbh Non-invasive identification of patients at increased risk for myocardial infarction
GB0311664D0 (en) * 2003-05-21 2003-06-25 Univ Manchester Polymeric hollow nanospheres
US7537788B2 (en) * 2003-07-25 2009-05-26 Rubicor Medical, Inc. Post-biopsy cavity treatment implants and methods
US7744852B2 (en) 2003-07-25 2010-06-29 Rubicor Medical, Llc Methods and systems for marking post biopsy cavity sites
US20050020899A1 (en) * 2003-07-25 2005-01-27 Rubicor Medical, Inc. Post-biopsy cavity treatmetn implants and methods
EP1673108A4 (de) * 2003-09-09 2009-06-03 Point Biomedical Corp Verfahren und zusammensetzungen für die ultraschalldarstellung von apoptose
WO2005029705A2 (en) * 2003-09-18 2005-03-31 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
NZ546072A (en) * 2003-09-22 2009-08-28 Bioarray Solutions Ltd Surface immobilized polyelectrolyte with multiple functional groups capable of covalently bonding to biomolecules
US20050074406A1 (en) * 2003-10-03 2005-04-07 Scimed Life Systems, Inc. Ultrasound coating for enhancing visualization of medical device in ultrasound images
CA2544041C (en) * 2003-10-28 2015-12-08 Bioarray Solutions Ltd. Optimization of gene expression analysis using immobilized capture probes
CN1905806A (zh) * 2003-10-28 2007-01-31 佰尔瑞溶液有限公司 带有吸附的或结合的生物分子的胶－壳珠子
WO2005045059A2 (en) * 2003-10-28 2005-05-19 Bioarray Solutions Ltd. Allele assignment and probe selection in multiplexed assays of polymorphic targets
US7049077B2 (en) 2003-10-29 2006-05-23 Bioarray Solutions Ltd. Multiplexed nucleic acid analysis by fragmentation of double-stranded DNA
WO2005041897A2 (en) * 2003-10-31 2005-05-12 Point Biomedical Corporation Reconstitutable microsphere compositions useful as ultrasonic contrast agents
US20080019904A1 (en) * 2004-06-29 2008-01-24 Koninklijke Philips Electronics, N.V. System For Manufacturing Micro-Sheres
US7363170B2 (en) * 2004-07-09 2008-04-22 Bio Array Solutions Ltd. Transfusion registry network providing real-time interaction between users and providers of genetically characterized blood products
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
US8119153B2 (en) * 2004-08-26 2012-02-21 Boston Scientific Scimed, Inc. Stents with drug eluting coatings
WO2006044996A2 (en) * 2004-10-15 2006-04-27 The Trustees Of Columbia University In The City Of New York System and method for automated boundary detection of body structures
WO2006046200A1 (en) * 2004-10-29 2006-05-04 Koninklijke Philips Electronics N.V. Preparation of dispersions of particles for use as contrast agents in ultrasound imaging
EP2248578B1 (de) 2005-03-04 2012-06-06 President and Fellows of Harvard College Verfahren zur Bildung mehrerer Emulsionen
US10687785B2 (en) 2005-05-12 2020-06-23 The Trustees Of Columbia Univeristy In The City Of New York System and method for electromechanical activation of arrhythmias
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
US20090042284A1 (en) * 2005-07-04 2009-02-12 Shunro Tachibana Method for labeling/separation of cells and agent for labeling/separation of cells
WO2007035721A2 (en) * 2005-09-19 2007-03-29 The Trustees Of Columbia University In The City Of New York Ultrasound method to open blood brain barrier
EP1963805A4 (de) * 2005-12-09 2010-01-06 Univ Columbia Systeme und verfahren zur elastografie-bildgebung
WO2007085990A1 (en) * 2006-01-24 2007-08-02 Koninklijke Philips Electronics N.V. Method for producing a particle comprising a gas core and a shell and particles thus obtained
AU2007226258A1 (en) * 2006-03-10 2007-09-20 Mcgill University Ultrasound molecular sensors and uses thereof
US20080305175A1 (en) * 2006-11-30 2008-12-11 Agency For Science, Technology And Research Micro-Container
US8696353B2 (en) * 2007-12-18 2014-04-15 Koninklijke Philips N.V. Antimicrobial filled capsules in an ultrasound field for treatment of dental biofilm
EP2103313A1 (de) * 2008-03-19 2009-09-23 Koninklijke Philips Electronics N.V. Verfahren für die Synthese von Hohlkugeln
WO2011035312A1 (en) 2009-09-21 2011-03-24 The Trustees Of Culumbia University In The City Of New York Systems and methods for opening of a tissue barrier
WO2010014977A1 (en) 2008-08-01 2010-02-04 The Trustees Of Columbia University In The City Of New York Systems and methods for matching and imaging tissue characteristics
US8367427B2 (en) * 2008-08-20 2013-02-05 Baxter International Inc. Methods of processing compositions containing microparticles
US8323615B2 (en) * 2008-08-20 2012-12-04 Baxter International Inc. Methods of processing multi-phasic dispersions
US8323685B2 (en) * 2008-08-20 2012-12-04 Baxter International Inc. Methods of processing compositions containing microparticles
WO2010030819A1 (en) 2008-09-10 2010-03-18 The Trustees Of Columbia University In The City Of New York Systems and methods for opening a tissue
US8940277B2 (en) * 2008-11-06 2015-01-27 University of Pittsburgh—of the Commonwealth System of Higher Education Intracellular microbubble for imaging an anatomical site
US20120128776A1 (en) * 2009-07-31 2012-05-24 Koninklijke Philips Electronics N.V. Method for the preparation of microparticles with efficient bioactive molecule incorporation
EP2470287A4 (de) 2009-08-28 2015-01-21 Univ Columbia Systeme, verfahren und vorrichtungen zur herstellung gasgefüllter mikroblasen
US20120211084A1 (en) 2009-09-02 2012-08-23 President And Fellows Of Harvard College Multiple emulsions created using jetting and other techniques
EP2493458A2 (de) * 2009-10-30 2012-09-05 The Ohio State University Biologisch abbaubare multifunktionspartikel für selektive abzielung, bildgebung und therapeutische freisetzung sowie ihre verwendung zur behandlung von augenerkrankungen
WO2011116154A2 (en) * 2010-03-17 2011-09-22 President And Fellows Of Harvard College Melt emulsification
WO2011139927A1 (en) * 2010-05-01 2011-11-10 The Trustees Of Columbia University In The City Of New York Methods devices and systems of preparing targeted microbubble shells
GB201102148D0 (en) * 2011-02-08 2011-03-23 Ucl Business Plc Layered bodies, compositions containing them and processes for producing them
EP2701625A1 (de) 2011-04-26 2014-03-05 Encapson B.V. Beschichtung zur verbesserung der ultraschallsichtbarkeit
US9238206B2 (en) 2011-05-23 2016-01-19 President And Fellows Of Harvard College Control of emulsions, including multiple emulsions
WO2012162664A1 (en) 2011-05-26 2012-11-29 The Trustees Of Columbia University In The City Of New York Systems and methods for opening of a tissue barrier in primates
EP2729238A2 (de) 2011-07-06 2014-05-14 President and Fellows of Harvard College Multiple emulsionen und verfahren zur herstellung von multiplen emulsionen
US8927529B2 (en) 2012-01-30 2015-01-06 SpineThera Treatment of back pain by injection of microparticles of dexamethasone acetate and a polymer
WO2014059170A1 (en) 2012-10-10 2014-04-17 The Trustees Of Columbia University In The City Of New York Systems and methods for mechanical mapping of cardiac rhythm
JP6069516B2 (ja) 2012-10-31 2017-02-01 エンキャプソン・ベー・フェー エコー輝度の向上ための被膜を備えた医療機器
KR101446681B1 (ko) * 2012-11-21 2014-10-07 한국과학기술연구원 간 종양 표적화 초음파 조영제 및 그 제조방법
US9247921B2 (en) 2013-06-07 2016-02-02 The Trustees Of Columbia University In The City Of New York Systems and methods of high frame rate streaming for treatment monitoring
US10322178B2 (en) 2013-08-09 2019-06-18 The Trustees Of Columbia University In The City Of New York Systems and methods for targeted drug delivery
US10028723B2 (en) 2013-09-03 2018-07-24 The Trustees Of Columbia University In The City Of New York Systems and methods for real-time, transcranial monitoring of blood-brain barrier opening
US10052394B2 (en) 2014-11-21 2018-08-21 General Electric Company Microbubble tether for diagnostic and therapeutic applications
WO2016115133A1 (en) * 2015-01-12 2016-07-21 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Polymer microbubbles as x-ray dark field contrast agents
US20160361443A1 (en) * 2015-06-12 2016-12-15 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Ultrasound Molecular Imaging With Targeted Biocompatible Microbubbles
EP3515404B1 (de) 2016-10-28 2020-03-18 Spinethera Pharmazeutische zusammensetzungen und verwendungen davon
DE102022102770A1 (de) 2022-02-07 2023-08-10 Rheinisch-Westfälische Technische Hochschule Aachen, Körperschaft des öffentlichen Rechts Oberflächenmodifizierung von Mikrobläschen und Nanopartikeln auf Poly(alkylcyanacrylat)-Basis

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1900865A1 (de) 1969-01-09 1970-08-27 Bayer Ag Verfahren zur Herstellung von Mikrokapseln
DE3141641A1 (de) * 1981-10-16 1983-04-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen Ultraschall-kontrastmittel und dessen herstellung
US4718433A (en) 1983-01-27 1988-01-12 Feinstein Steven B Contrast agents for ultrasonic imaging
DE3421468A1 (de) * 1984-06-08 1985-12-19 Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim Lipidnanopellets als traegersystem fuer arzneimittel zur peroralen anwendung
US5425366A (en) * 1988-02-05 1995-06-20 Schering Aktiengesellschaft Ultrasonic contrast agents for color Doppler imaging
JP2907911B2 (ja) * 1988-02-05 1999-06-21 シエーリング アクチエンゲゼルシヤフト 超音波造影剤、その製造方法及び該超音波造影剤からなる診断又は治療用製剤
US5041292A (en) 1988-08-31 1991-08-20 Theratech, Inc. Biodegradable hydrogel matrices for the controlled release of pharmacologically active agents
US5271961A (en) 1989-11-06 1993-12-21 Alkermes Controlled Therapeutics, Inc. Method for producing protein microspheres
WO1991006287A1 (en) * 1989-11-06 1991-05-16 Enzytech, Inc. Protein microspheres and methods of using them
US5922304A (en) * 1989-12-22 1999-07-13 Imarx Pharmaceutical Corp. Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents
US5542935A (en) * 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US5580575A (en) * 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
DE4004430A1 (de) 1990-02-09 1991-08-14 Schering Ag Aus polyaldehyden aufgebaute kontrastmittel
GB2256183B (en) 1990-02-20 1994-03-09 Delta Biotechnology Ltd Double emulsion technique producing diagnostic aid microcapsules for pharmaceutical use
GB9003821D0 (en) * 1990-02-20 1990-04-18 Danbiosyst Uk Diagnostic aid
US6120805A (en) * 1990-04-06 2000-09-19 Rhone-Poulenc Rorer Sa Microspheres, process for their preparation and their use
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
US5948387A (en) * 1990-06-01 1999-09-07 Imarx Pharmaceutical Corp. Contrast media for ultrasonic imaging
US5310540A (en) 1990-10-05 1994-05-10 Sintetica Sa Method for the preparation of stable suspensions of hollow gas-filled microspheres suitable for ultrasonic echography
DK166600B1 (da) * 1991-01-17 1993-06-21 Therkel Bisgaard Vaerktoejssaet til brug ved suturering i dybe operationsaabninger eller legemshulrum
GB9107628D0 (en) 1991-04-10 1991-05-29 Moonbrook Limited Preparation of diagnostic agents
WO1994016739A1 (en) * 1993-01-25 1994-08-04 Sonus Pharmaceuticals, Inc. Phase shift colloids as ultrasound contrast agents
US5565215A (en) * 1993-07-23 1996-10-15 Massachusettes Institute Of Technology Biodegradable injectable particles for imaging
GB9318288D0 (en) * 1993-09-03 1993-10-20 Nycomed Imaging As Improvements in or relating to contrast agents
US6068857A (en) * 1993-09-09 2000-05-30 Schering Aktiengesellchaft Microparticles containing active ingredients, agents containing these microparticles, their use for ultrasound-controlled release of active ingredients, as well as a process for their production
US5569468A (en) * 1994-02-17 1996-10-29 Modi; Pankaj Vaccine delivery system for immunization, using biodegradable polymer microspheres
US5620883A (en) 1994-04-01 1997-04-15 The Johns Hopkins University Living cells microencapsulated in a polymeric membrane having two layers
US5730955A (en) * 1994-08-02 1998-03-24 Molecular Biosystems, Inc. Process for making gas-filled microspheres containing a liquid hydrophobic barrier
US5562893A (en) * 1994-08-02 1996-10-08 Molecular Biosystems, Inc. Gas-filled microspheres with fluorine-containing shells
US5509896A (en) * 1994-09-09 1996-04-23 Coraje, Inc. Enhancement of thrombolysis with external ultrasound
DE19510690A1 (de) * 1995-03-14 1996-09-19 Schering Ag Polymere Nano- und/oder Mikropartikel, Verfahren zu deren Herstellung, sowie Verwendung in medizinischen Diagnostik und Therapie
US5560364A (en) * 1995-05-12 1996-10-01 The Board Of Regents Of The University Of Nebraska Suspended ultra-sound induced microbubble cavitation imaging
US6139819A (en) * 1995-06-07 2000-10-31 Imarx Pharmaceutical Corp. Targeted contrast agents for diagnostic and therapeutic use
US5648098A (en) * 1995-10-17 1997-07-15 The Board Of Regents Of The University Of Nebraska Thrombolytic agents and methods of treatment for thrombosis
US5611344A (en) * 1996-03-05 1997-03-18 Acusphere, Inc. Microencapsulated fluorinated gases for use as imaging agents
US5837221A (en) * 1996-07-29 1998-11-17 Acusphere, Inc. Polymer-lipid microencapsulated gases for use as imaging agents
US5846517A (en) * 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
US6090800A (en) * 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
US6193951B1 (en) * 1997-04-30 2001-02-27 Point Biomedical Corporation Microparticles useful as ultrasonic contrast agents
US6045777A (en) * 1997-06-30 2000-04-04 Acusphere, Inc. Method for enhancing the echogenicity and decreasing the attenuation of microencapsulated gases
US6205352B1 (en) * 1997-11-19 2001-03-20 Oncology Innovations, Inc. Sentinel node identification using non-isotope means
US6444192B1 (en) * 1999-02-05 2002-09-03 The Regents Of The University Of California Diagnostic imaging of lymph structures
US6224554B1 (en) * 1999-03-31 2001-05-01 Point Biomedical Corporation Method to measure ambient fluid pressure
AU6635900A (en) * 1999-08-13 2001-03-13 Point Biomedical Corporation Microparticles useful as ultrasonic contrast agents and for lymphatic system
AU2002341959A1 (en) * 2001-10-04 2003-04-14 Case Western Reserve University Drug delivery devices and methods

Also Published As

Publication number Publication date
GB2340040A (en) 2000-02-16
CA2289088A1 (en) 1998-11-05
US20010012522A1 (en) 2001-08-09
DE19882362T1 (de) 2000-05-18
AU7173098A (en) 1998-11-24
NO995313L (no) 1999-12-29
GB9925661D0 (en) 1999-12-29
ES2296332T3 (es) 2008-04-16
DE69838669T2 (de) 2008-10-30
JP2001527547A (ja) 2001-12-25
ATE377414T1 (de) 2007-11-15
WO1998048783A1 (en) 1998-11-05
EP0979071A1 (de) 2000-02-16
CA2289088C (en) 2007-08-07
EP0979071B1 (de) 2007-11-07
US20090081130A1 (en) 2009-03-26
NO995313D0 (no) 1999-10-29
EP0979071A4 (de) 2004-03-10
US20040086459A1 (en) 2004-05-06
AU739919B2 (en) 2001-10-25
US6193951B1 (en) 2001-02-27
GB2340040B (en) 2001-11-28

Similar Documents

Publication Publication Date Title
DE69838669D1 (de) Mikropartikel, geeignet als kontrastmittel im ultraschall und zur wirkstoffgabe in den blutkreislauf
ATE285228T1 (de) Arzneistoffverabreichungsystem zur verzögerten, völlstandigen wirkstoffabgabe im verdauungstrakt
DK0906243T4 (da) Oplöselige oxider til biologiske anvendelser
ATE353615T1 (de) Gesteuertes freisetzungssystem zur abgabe von therapeutika in den innenohrkanal
ATE269709T1 (de) Tablette mit verzögerter freigabe enthaltend einen blutzuckersenkenden wirkstoff und einen antihyperglyzemischen wirkstoff
ES2118251T3 (es) Preparaciones de microparticulas a base de copolimeros biologicamente degradables.
CA2338605A1 (en) Pliable and moldable polymeric delivery system for bioactive agents
DE69823055D1 (de) Abgabe von polyethylene glycol-molekül- konjugaten aus abbaubarem hydrogel
NL300253I2 (nl) Contrastmiddel voor diagnostische beeldvorming metverlengde retentie in bloed.
HUP0002935A2 (hu) Gyomorban visszatartott, szabályozott hatóanyag kibocsátású mikrogömböcskék javított gyógyszeradagolás elősegítésére
TR200101302T2 (tr) BMT yada PBSC transplantı alan hastalarda in vitro ya da in vivo temizleyici madde olarak kimerik anti-CD20 antikorunun kullanımı.
BR0014652A (pt) Fabricação de conjugados de agente terapêutico-poliglutamato
CA2396152A1 (en) Osmotic device within an osmotic device
HUP0004945A2 (hu) Gyomor-bélrendszerben késleltetett teljes hatóanyag-kibocsátást biztosító hatóanyag-célbajuttató rendszer
EE05620B1 (et) Omeprasooli mikrograanulid, nende valmistamismeetod ja farmatseutilised preparaadid
ATE422879T1 (de) Beschichtete teilchen mit verzögerter freisetzung und diese enthaltende tabletten
ATE362522T1 (de) Wasserlösliches abgabeprodukt
IT1303242B1 (it) Procedimento e sistema per l'erogazione controllata di servizinumerici quali, ad esempio, servizi telematici multimediali.
WO2001008711A3 (en) Stable microbubbles for the use as an ultrasound contrast agent
FR2730411B1 (fr) Association medicamenteuse utile pour la transfection et l'expression in vivo d'exogenes
TR199900596T2 (xx) Otoim�n hastal�klara kar�� maddeler olarak proteinlerin kullan�m�.
IT1292798B1 (it) Sistema sterile e procedimento di filtraggio di liquidi biologici o medicali, in particolare di sangue o componenti del sangue.
ATE406908T1 (de) Oxidierte proteine und deren biologische und therapeutische aktivität sowie diagnostische verwendung über die hemmung der interaktion zwischen oxidierten proteinen und cd36
BR0202759A (pt) Composição farmacêutica de liberação modificada contendo bupropiona como substância ativa
Chamberlain Bonding technology makes implantsbiologically active'

Legal Events

Date Code Title Description
8364 No opposition during term of opposition