DE69838340D1 - Behandlung von neoplasmen mit interferon-empfindlichen, klonalen viren - Google Patents
Behandlung von neoplasmen mit interferon-empfindlichen, klonalen virenInfo
- Publication number
- DE69838340D1 DE69838340D1 DE69838340T DE69838340T DE69838340D1 DE 69838340 D1 DE69838340 D1 DE 69838340D1 DE 69838340 T DE69838340 T DE 69838340T DE 69838340 T DE69838340 T DE 69838340T DE 69838340 D1 DE69838340 D1 DE 69838340D1
- Authority
- DE
- Germany
- Prior art keywords
- viruses
- neoplasms
- interferon
- sensitive
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
- A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18111—Avulavirus, e.g. Newcastle disease virus
- C12N2760/18132—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18111—Avulavirus, e.g. Newcastle disease virus
- C12N2760/18151—Methods of production or purification of viral material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/70—Mechanisms involved in disease identification
- G01N2800/7023—(Hyper)proliferation
- G01N2800/7028—Cancer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Oncology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Gastroenterology & Hepatology (AREA)
- Analytical Chemistry (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Cell Biology (AREA)
- Communicable Diseases (AREA)
- General Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US94824497A | 1997-10-09 | 1997-10-09 | |
US948244 | 1997-10-09 | ||
PCT/US1998/021230 WO1999018799A1 (en) | 1997-10-09 | 1998-10-09 | Treatment of neoplasms with viruses |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69838340D1 true DE69838340D1 (de) | 2007-10-11 |
DE69838340T2 DE69838340T2 (de) | 2008-05-21 |
Family
ID=25487533
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69838340T Expired - Lifetime DE69838340T2 (de) | 1997-10-09 | 1998-10-09 | Behandlung von neoplasmen mit interferonempfindlichen, klonalen viren |
Country Status (13)
Country | Link |
---|---|
EP (2) | EP1032269B1 (de) |
JP (3) | JP2001519175A (de) |
CN (2) | CN1281336A (de) |
AT (1) | ATE371372T1 (de) |
AU (1) | AU9603898A (de) |
CA (1) | CA2305269C (de) |
DE (1) | DE69838340T2 (de) |
ES (1) | ES2292207T3 (de) |
HK (1) | HK1028935A1 (de) |
HU (1) | HUP0003911A3 (de) |
IL (1) | IL135507A0 (de) |
NZ (4) | NZ550147A (de) |
WO (1) | WO1999018799A1 (de) |
Families Citing this family (72)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6565831B1 (en) | 1999-02-24 | 2003-05-20 | Oncolytics Biotech Inc. | Methods for preventing reovirus recognition for the treatment of cellular proliferative disorders |
US6110461A (en) | 1997-08-13 | 2000-08-29 | Oncolytics Biotech Inc. | Reovirus for the treatment of neoplasia |
US6136307A (en) | 1997-08-13 | 2000-10-24 | Oncolytics Biotech Inc. | Reovirus for the treatment of cellular proliferative disorders |
ATE371372T1 (de) * | 1997-10-09 | 2007-09-15 | Wellstat Biologics Corp | Behandlung von neoplasmen mit interferon- empfindlichen, klonalen viren |
US7780962B2 (en) | 1997-10-09 | 2010-08-24 | Wellstat Biologics Corporation | Treatment of neoplasms with RNA viruses |
US7470426B1 (en) | 1997-10-09 | 2008-12-30 | Wellstat Biologics Corporation | Treatment of neoplasms with viruses |
US20030044384A1 (en) | 1997-10-09 | 2003-03-06 | Pro-Virus, Inc. | Treatment of neoplasms with viruses |
AU4246900A (en) * | 1999-04-15 | 2000-11-02 | Pro-Virus, Inc. | Treatment of neoplasms with viruses |
WO2000073479A1 (en) * | 1999-05-28 | 2000-12-07 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | A combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector |
US8147822B1 (en) | 1999-09-17 | 2012-04-03 | Wellstat Biologics Corporation | Oncolytic virus |
ES2260057T3 (es) * | 1999-09-17 | 2006-11-01 | Wellstat Biologics Corporation | Virus oncolitico. |
DE19951795A1 (de) * | 1999-10-27 | 2001-05-10 | Knebel Doeberitz Magnus Von | Verwendung von Parvoviren zur Verbesserung des Allgemeinzustandes bei Tumorpatienten oder Patienten mit chronischen oder konsumierenden Erkrankungen |
EP1227828A1 (de) * | 1999-11-12 | 2002-08-07 | Oncolytics Biotech, Inc. | Viren zur behandlung der zellulären proliferativen erkrankungen |
AUPQ425699A0 (en) | 1999-11-25 | 1999-12-23 | University Of Newcastle Research Associates Limited, The | A method of treating a malignancy in a subject and a pharmaceutical composition for use in same |
AR028039A1 (es) | 2000-05-03 | 2003-04-23 | Oncolytics Biotech Inc | Remocion de reovirus de celulas neoplasticas intermediadas por ras a partir de composiciones celulares mixtas |
US8491884B2 (en) | 2000-05-03 | 2013-07-23 | Oncolytics Biotech Inc. | Virus clearance of neoplastic cells from mixed cellular compositions |
US7306902B2 (en) * | 2002-06-28 | 2007-12-11 | Oncolyties Biotech Inc. | Oncolytic viruses as phenotyping agents for neoplasms |
CA2412493C (en) | 2000-06-26 | 2010-11-09 | Wellstat Biologics Corporation | Purging of cells using viruses |
AR035227A1 (es) * | 2001-02-20 | 2004-05-05 | Oncolytics Biotech Inc | Uso de un agente quimioterapeutico para la manufactura de un medicamento para la sensibilizacion de celulas neoplasicas resistentes a agentes quimioterapeuticos con reovirus |
CN1520303B (zh) * | 2001-03-27 | 2013-04-24 | 纽约大学 | 利用基于α病毒且靶向高亲和性层粘连蛋白受体的载体进行肿瘤治疗 |
ATE500808T1 (de) | 2001-05-11 | 2011-03-15 | Wellstat Biologics Corp | Onkolytische virustherapie |
US20140088177A1 (en) * | 2001-07-11 | 2014-03-27 | University Of Miami | Recombinant vsv for the treatment of tumor cells |
US20040005546A1 (en) | 2002-02-28 | 2004-01-08 | Oncolytics Biotech Inc. | Use of ribozymes in the detection of adventitious agents |
CA2374388C (en) | 2002-02-28 | 2005-07-12 | Matthew C. Coffey | The use of ribozymes in the detection of adventitious agents |
EP1944035A1 (de) * | 2002-05-09 | 2008-07-16 | Oncolytics Biotech Inc. | Verfahren zur Schmerzlinderung durch onkolytische Viren |
TR200501460T3 (tr) * | 2002-05-09 | 2005-06-21 | Oncolytics Biotech, Inc. | Onkolitik virüsler kullanarak ağrı azaltma yöntemi |
CN1655827B (zh) | 2002-05-27 | 2010-06-23 | 佩尔·松内·霍尔姆 | 腺病毒和编码其的核酸的新应用 |
AU2003243307B2 (en) * | 2002-06-21 | 2010-04-01 | Wellstat Biologics Corporation | Administration of therapeutic viruses |
EP1578396A4 (de) | 2002-08-12 | 2007-01-17 | David Kirn | Verfahren und zusammensetzungen gegen pockenviren und krebs |
AU2002953436A0 (en) | 2002-12-18 | 2003-01-09 | The University Of Newcastle Research Associates Limited | A method of treating a malignancy in a subject via direct picornaviral-mediated oncolysis |
MXPA05009526A (es) | 2003-03-07 | 2005-12-15 | Robarts Res Inst | Uso de virus de mixoma para el tratamiento terapeutico de cancer e infeccion viral cronica. |
US7731974B2 (en) | 2003-03-27 | 2010-06-08 | Ottawa Hospital Research Institute | Mutant vesicular stomatitis viruses and uses thereof |
AU2004289953B2 (en) | 2003-06-18 | 2008-09-25 | Genelux Corporation | Modified recombinant vaccina viruses and other microorganisms, uses thereof |
CA2503774C (en) | 2003-06-20 | 2007-09-25 | Microbix Biosystems Inc. | Improvements in virus production |
WO2005014017A1 (ja) | 2003-08-08 | 2005-02-17 | Yuji Shino | 癌治療用医薬組成物 |
US20070110719A1 (en) | 2003-11-14 | 2007-05-17 | Holm Per S | Novel use of adenoviruses and nucleic acids that code for said viruses |
WO2005111200A1 (en) * | 2004-05-17 | 2005-11-24 | Universite De Montreal | Novel strains of reoviruses and methods of uses thereof |
FI20040704A0 (fi) * | 2004-05-21 | 2004-05-21 | Ari Hinkkanen | Replikatiivisen viruksen tai sen rekombinantin käyttö terapiassa |
EP1863906A4 (de) | 2005-03-07 | 2009-06-03 | Robarts Res Inst | Verwendung einer kombination aus myxoma-virus und rapamycin zur therapeutischen behandlung |
US7303898B2 (en) | 2005-03-29 | 2007-12-04 | New York University | Defective sindbis viral vectors |
EP1917351A4 (de) | 2005-08-01 | 2009-12-16 | Univ Technologies Int | Abgeschwächtes reovirus |
US10668119B2 (en) | 2005-08-01 | 2020-06-02 | Virocure, Inc. | Attenuated reovirus |
CA2621982C (en) | 2005-09-07 | 2017-11-28 | Jennerex Biotherapeutics Ulc | Systemic treatment of metastatic and/or systemically-disseminated cancers using gm-csf-expressing poxviruses |
US8980246B2 (en) | 2005-09-07 | 2015-03-17 | Sillajen Biotherapeutics, Inc. | Oncolytic vaccinia virus cancer therapy |
PT2529747T (pt) | 2005-12-02 | 2018-05-09 | Icahn School Med Mount Sinai | Vírus da doença de newcastle quiméricos que apresentam proteínas de superfície não nativas e suas utilizações |
EP2007883B1 (de) * | 2006-04-20 | 2011-12-28 | Wyeth LLC | Reinigungsverfahren zur isolierung von gereinigtem vesikulärem stomatitisvirus aus zellkultur |
NZ572893A (en) | 2006-06-01 | 2011-06-30 | Robarts Res Inst | Myxoma virus mutants for cancer treatment |
JP5606067B2 (ja) * | 2006-09-15 | 2014-10-15 | オタワ ホスピタル リサーチ インスティテュート | 腫瘍崩壊性ラブドウイルス |
US20090098529A1 (en) | 2006-10-16 | 2009-04-16 | Nanhai Chen | Methods for attenuating virus strains for diagnostic and therapeutic uses |
US10369171B2 (en) | 2007-03-13 | 2019-08-06 | Virocure, Inc. | Attenuated reoviruses for selection of cell populations |
EP2202297B1 (de) * | 2007-07-18 | 2014-05-14 | Genelux Corporation | Verwendung eines chemotherapeutischen Wirkstoffs zur Vorbereitung eines Arzneimittels zur Behandlung oder Milderung der mit oncolytischen Virentherapie verbundenen Nebenwirkungen |
CA2699805A1 (en) * | 2007-10-22 | 2009-04-30 | Oncolytics Biotech Inc. | Treatment regime for proliferative disorders |
WO2009143468A1 (en) * | 2008-05-22 | 2009-11-26 | Uti Limited Partnership | Tumor suppressor-based susceptibility of hyperproliferative cells to oncolytic viral therapy |
CA2723587C (en) * | 2008-05-27 | 2017-09-26 | Oncolytics Biotech Inc. | Abrogating proinflammatory cytokine production during oncolytic reovirus therapy |
EP2345415B1 (de) * | 2008-09-16 | 2015-01-21 | GenomIdea Inc. | Therapeutisches/prophylaktisches mittel gegen prostatakrebs |
EP2393921B1 (de) | 2009-02-05 | 2015-07-15 | Icahn School of Medicine at Mount Sinai | Chimäres newcastle disease virus und seine verwendungen |
WO2011032180A1 (en) | 2009-09-14 | 2011-03-17 | Jennerex, Inc. | Oncolytic vaccinia virus combination cancer therapy |
EP2327764B1 (de) * | 2009-11-30 | 2011-12-28 | United Cancer Research Institute | Neuer Klon des Geflügelpestvirus, Herstellung und Anwendung bei der medizinischen Behandlung von Krebs |
AU2012204467B2 (en) | 2011-01-04 | 2016-08-18 | Sillajen, Inc. | Generation of antibodies to tumor antigens and generation of tumor specific complement dependent cytotoxicity by administration of oncolytic vaccinia virus |
CN114262690A (zh) | 2011-04-15 | 2022-04-01 | 吉恩勒克斯公司 | 减毒的痘苗病毒的克隆毒株及其使用方法 |
US20130129678A1 (en) * | 2011-11-17 | 2013-05-23 | Zahari Raykov | Co-administration of a parvovirus and a cytokine for therapy of pancreatic cancer |
US20140328798A1 (en) * | 2011-11-17 | 2014-11-06 | Deutsches Krebsforschung-Szentrum | Co-Administration of a Parvovirus and a Cytokine for Therapy of Pancreatic Cancer |
MD4655C1 (ro) | 2013-03-14 | 2020-06-30 | Icahn School Of Medicine At Mount Sinai | Virusurile bolii de Newcastle şi utilizarea acestora |
CA2914790C (en) * | 2013-06-14 | 2024-02-27 | Psioxus Therapeutics Limited | A dosing regime and formulations for type b adenoviruses |
ES2661132T3 (es) | 2013-10-25 | 2018-03-27 | Psioxus Therapeutics Limited | Adenovirus oncolíticos armados con genes heterólogos |
WO2015103438A2 (en) | 2014-01-02 | 2015-07-09 | Genelux Corporation | Oncolytic virus adjunct therapy with agents that increase virus infectivity |
CN107073099B (zh) | 2014-02-27 | 2022-09-27 | 默沙东公司 | 用于治疗癌症的联合方法 |
MY193281A (en) | 2015-12-17 | 2022-09-30 | Psioxus Therapeutics Ltd | Group b adenovirus encoding an anti-tcr-complex antibody or fragment |
GB201713765D0 (en) | 2017-08-28 | 2017-10-11 | Psioxus Therapeutics Ltd | Modified adenovirus |
WO2018041838A1 (en) | 2016-08-29 | 2018-03-08 | Psioxus Therapeutics Limited | Adenovirus armed with bispecific t cell engager (bite) |
JOP20190256A1 (ar) | 2017-05-12 | 2019-10-28 | Icahn School Med Mount Sinai | فيروسات داء نيوكاسل واستخداماتها |
GB201801614D0 (en) | 2018-01-31 | 2018-03-14 | Psioxus Therapeutics Ltd | Formulation |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5833975A (en) * | 1989-03-08 | 1998-11-10 | Virogenetics Corporation | Canarypox virus expressing cytokine and/or tumor-associated antigen DNA sequence |
CN1054192A (zh) * | 1990-02-26 | 1991-09-04 | 张炳团 | 人体内诱导干扰素的制造方法 |
CA2051289C (en) * | 1990-09-14 | 2002-11-26 | Robert L. Martuza | Viral mediated destruction of neoplastic cells |
US5602023A (en) | 1992-03-24 | 1997-02-11 | Csatary; Laszlo K. | Pharmaceutical product containing live, stabilized virus for the therapy of viral and malignant diseases and process for preparing the same |
DZ1706A1 (fr) * | 1992-08-07 | 2002-02-17 | Merck & Co Inc | Vaccin contre le virus de l'hepatite a. |
FR2699082B1 (fr) * | 1993-02-22 | 1995-05-05 | Pasteur Institut | Composition pour le traitement de tumeurs et l'immunisation d'organismes à l'encontre de tumeurs. |
EP1486211B1 (de) * | 1993-04-30 | 2008-10-22 | Wellstat Biologics Corporation | Zusuammensetzungen zur Behandlung von Krebs mittels Viren |
US5585096A (en) | 1994-06-23 | 1996-12-17 | Georgetown University | Replication-competent herpes simplex virus mediates destruction of neoplastic cells |
EP0808364B1 (de) * | 1995-02-10 | 2005-11-30 | The Regents of the University of California | Menschliche pancreas zellinien: entwicklungen und anwendungen |
CA2213439A1 (en) * | 1995-02-24 | 1996-08-29 | The Trustees Of The University Of Pennsylvania | Methods and compositions for administering gene therapy vectors |
ATE371372T1 (de) * | 1997-10-09 | 2007-09-15 | Wellstat Biologics Corp | Behandlung von neoplasmen mit interferon- empfindlichen, klonalen viren |
-
1998
- 1998-10-09 AT AT98949797T patent/ATE371372T1/de active
- 1998-10-09 NZ NZ550147A patent/NZ550147A/en not_active IP Right Cessation
- 1998-10-09 WO PCT/US1998/021230 patent/WO1999018799A1/en active IP Right Grant
- 1998-10-09 NZ NZ503664A patent/NZ503664A/xx not_active IP Right Cessation
- 1998-10-09 JP JP2000515443A patent/JP2001519175A/ja not_active Withdrawn
- 1998-10-09 CN CN98812019A patent/CN1281336A/zh active Pending
- 1998-10-09 ES ES98949797T patent/ES2292207T3/es not_active Expired - Lifetime
- 1998-10-09 NZ NZ553508A patent/NZ553508A/en not_active IP Right Cessation
- 1998-10-09 DE DE69838340T patent/DE69838340T2/de not_active Expired - Lifetime
- 1998-10-09 NZ NZ518945A patent/NZ518945A/en not_active IP Right Cessation
- 1998-10-09 IL IL13550798A patent/IL135507A0/xx unknown
- 1998-10-09 HU HU0003911A patent/HUP0003911A3/hu not_active Application Discontinuation
- 1998-10-09 AU AU96038/98A patent/AU9603898A/en not_active Abandoned
- 1998-10-09 CN CN200910147515A patent/CN101618049A/zh active Pending
- 1998-10-09 CA CA2305269A patent/CA2305269C/en not_active Expired - Fee Related
- 1998-10-09 EP EP98949797A patent/EP1032269B1/de not_active Revoked
- 1998-10-09 EP EP07016086A patent/EP1905304A3/de not_active Withdrawn
-
2000
- 2000-12-05 HK HK00107775A patent/HK1028935A1/xx not_active IP Right Cessation
-
2009
- 2009-04-09 JP JP2009095352A patent/JP2009161558A/ja active Pending
-
2013
- 2013-07-16 JP JP2013147584A patent/JP2013213058A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2013213058A (ja) | 2013-10-17 |
EP1032269A4 (de) | 2001-09-19 |
IL135507A0 (en) | 2001-05-20 |
HK1028935A1 (en) | 2001-03-16 |
HUP0003911A2 (hu) | 2001-02-28 |
EP1032269B1 (de) | 2007-08-29 |
CN1281336A (zh) | 2001-01-24 |
CA2305269A1 (en) | 1999-04-22 |
NZ518945A (en) | 2007-03-30 |
CA2305269C (en) | 2012-07-03 |
JP2009161558A (ja) | 2009-07-23 |
NZ550147A (en) | 2008-09-26 |
NZ503664A (en) | 2002-08-28 |
WO1999018799A1 (en) | 1999-04-22 |
EP1905304A2 (de) | 2008-04-02 |
HUP0003911A3 (en) | 2007-11-28 |
DE69838340T2 (de) | 2008-05-21 |
EP1905304A3 (de) | 2008-08-13 |
CN101618049A (zh) | 2010-01-06 |
JP2001519175A (ja) | 2001-10-23 |
ATE371372T1 (de) | 2007-09-15 |
AU9603898A (en) | 1999-05-03 |
ES2292207T3 (es) | 2008-03-01 |
EP1032269A1 (de) | 2000-09-06 |
NZ553508A (en) | 2008-11-28 |
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