DE69838179D1 - Chronische bolusgabe von d-threo methylphenidat - Google Patents
Chronische bolusgabe von d-threo methylphenidatInfo
- Publication number
- DE69838179D1 DE69838179D1 DE69838179T DE69838179T DE69838179D1 DE 69838179 D1 DE69838179 D1 DE 69838179D1 DE 69838179 T DE69838179 T DE 69838179T DE 69838179 T DE69838179 T DE 69838179T DE 69838179 D1 DE69838179 D1 DE 69838179D1
- Authority
- DE
- Germany
- Prior art keywords
- chronic
- bolusd
- threo
- attention deficit
- threo methylphenidate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4458—Non condensed piperidines, e.g. piperocaine only substituted in position 2, e.g. methylphenidate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
- C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Analytical Chemistry (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/937,684 US5922736A (en) | 1995-12-04 | 1997-09-29 | Chronic, bolus administration of D-threo methylphenidate |
US937684 | 1997-09-29 | ||
PCT/US1998/012676 WO1999016439A1 (en) | 1997-09-29 | 1998-06-17 | CHRONIC, BOLUS ADMINISTRATION OF D-threo METHYLPHENIDATE |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69838179D1 true DE69838179D1 (de) | 2007-09-13 |
DE69838179T2 DE69838179T2 (de) | 2008-04-17 |
Family
ID=25470261
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69838179T Expired - Lifetime DE69838179T2 (de) | 1997-09-29 | 1998-06-17 | Chronische bolusgabe von d-threo methylphenidat |
Country Status (13)
Country | Link |
---|---|
US (11) | US5922736A (de) |
EP (2) | EP1032389B8 (de) |
AT (1) | ATE368458T1 (de) |
AU (1) | AU738521B2 (de) |
CA (2) | CA2241611C (de) |
CY (1) | CY1107748T1 (de) |
DE (1) | DE69838179T2 (de) |
DK (1) | DK1032389T3 (de) |
ES (1) | ES2289787T3 (de) |
IL (2) | IL135288A0 (de) |
NZ (1) | NZ503571A (de) |
PT (1) | PT1032389E (de) |
WO (1) | WO1999016439A1 (de) |
Families Citing this family (45)
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CA2222713C (en) | 1995-07-14 | 2003-04-22 | Andrew John Mcglashan Richards | Composition comprising d-threo-methylphenidate and another drug |
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US6486177B2 (en) * | 1995-12-04 | 2002-11-26 | Celgene Corporation | Methods for treatment of cognitive and menopausal disorders with D-threo methylphenidate |
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US6673367B1 (en) * | 1998-12-17 | 2004-01-06 | Euro-Celtique, S.A. | Controlled/modified release oral methylphenidate formulations |
US6419960B1 (en) * | 1998-12-17 | 2002-07-16 | Euro-Celtique S.A. | Controlled release formulations having rapid onset and rapid decline of effective plasma drug concentrations |
US7083808B2 (en) * | 1998-12-17 | 2006-08-01 | Euro-Celtique S.A. | Controlled/modified release oral methylphenidate formulations |
US6127385A (en) * | 1999-03-04 | 2000-10-03 | Pharmaquest Limited | Method of treating depression using l-threo-methylphenidate |
US6395752B1 (en) * | 1999-03-04 | 2002-05-28 | Pharmaquest Limited | Method of treating depression using 1-threo-methylphenidate |
GB9913458D0 (en) * | 1999-06-09 | 1999-08-11 | Medeva Europ Ltd | The therapeutic use of d-threo-methylphenidate |
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US6855324B2 (en) * | 2000-11-20 | 2005-02-15 | Adrian Sandler | Therapeutic placebo enhancement of commonly-used medications |
US20020187192A1 (en) * | 2001-04-30 | 2002-12-12 | Yatindra Joshi | Pharmaceutical composition which reduces or eliminates drug abuse potential |
US20030049272A1 (en) * | 2001-08-30 | 2003-03-13 | Yatindra Joshi | Pharmaceutical composition which produces irritation |
US6638533B2 (en) * | 2002-01-03 | 2003-10-28 | George Krsek | Pulse dosage formulations of methylphenidate and method to prepare same |
IL163666A0 (en) | 2002-02-22 | 2005-12-18 | New River Pharmaceuticals Inc | Active agent delivery systems and methods for protecting and administering active agents |
CA2477004C (en) | 2002-02-22 | 2011-05-10 | Thomas Piccariello | Novel sustained release pharmaceutical compounds to prevent abuse of controlled substances |
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JP5271540B2 (ja) | 2005-01-20 | 2013-08-21 | インスティチュート フォー モレキュラー メディスン インコーポレイテッド | メチルフェニデート誘導体を含む治療剤及び医薬組成物 |
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US11241391B2 (en) | 2011-03-23 | 2022-02-08 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
US8916588B2 (en) | 2011-03-23 | 2014-12-23 | Ironshore Pharmaceuticals & Development, Inc. | Methods for treatment of attention deficit hyperactivity disorder |
US9498447B2 (en) | 2011-03-23 | 2016-11-22 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
US10905652B2 (en) | 2011-03-23 | 2021-02-02 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
US8927010B2 (en) | 2011-03-23 | 2015-01-06 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
US10292937B2 (en) | 2011-03-23 | 2019-05-21 | Ironshore Pharmaceuticals & Development, Inc. | Methods of treatment of attention deficit hyperactivity disorder |
EP2688557B1 (de) | 2011-03-23 | 2017-08-23 | Ironshore Pharmaceuticals & Development, Inc. | Verfahren und zusammensetzungen zur behandlung von aufmerksamkeitsstörungen |
US9603809B2 (en) | 2011-03-23 | 2017-03-28 | Ironshore Pharmaceuticals & Development, Inc. | Methods of treatment of attention deficit hyperactivity disorder |
US9119809B2 (en) | 2011-03-23 | 2015-09-01 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
CA2936741C (en) | 2014-10-31 | 2018-11-06 | Purdue Pharma | Methods and compositions particularly for treatment of attention deficit disorder |
US10722473B2 (en) | 2018-11-19 | 2020-07-28 | Purdue Pharma L.P. | Methods and compositions particularly for treatment of attention deficit disorder |
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1997
- 1997-09-29 US US08/937,684 patent/US5922736A/en not_active Expired - Lifetime
-
1998
- 1998-06-17 NZ NZ503571A patent/NZ503571A/xx not_active IP Right Cessation
- 1998-06-17 PT PT98930358T patent/PT1032389E/pt unknown
- 1998-06-17 WO PCT/US1998/012676 patent/WO1999016439A1/en active Search and Examination
- 1998-06-17 ES ES98930358T patent/ES2289787T3/es not_active Expired - Lifetime
- 1998-06-17 AT AT98930358T patent/ATE368458T1/de active
- 1998-06-17 DE DE69838179T patent/DE69838179T2/de not_active Expired - Lifetime
- 1998-06-17 EP EP98930358A patent/EP1032389B8/de not_active Expired - Lifetime
- 1998-06-17 AU AU79765/98A patent/AU738521B2/en not_active Expired
- 1998-06-17 EP EP07014078A patent/EP1844777A1/de not_active Withdrawn
- 1998-06-17 DK DK98930358T patent/DK1032389T3/da active
- 1998-06-17 IL IL13528898A patent/IL135288A0/xx active IP Right Grant
- 1998-06-22 CA CA002241611A patent/CA2241611C/en not_active Expired - Lifetime
- 1998-06-22 CA CA002468370A patent/CA2468370C/en not_active Expired - Lifetime
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1999
- 1999-06-21 US US09/337,310 patent/US6255325B1/en not_active Expired - Lifetime
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2000
- 2000-03-27 IL IL135288A patent/IL135288A/en not_active IP Right Cessation
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2001
- 2001-05-24 US US09/864,617 patent/US6602887B2/en not_active Expired - Lifetime
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2003
- 2003-03-24 US US10/395,444 patent/US20030232857A1/en not_active Abandoned
-
2004
- 2004-10-08 US US10/961,122 patent/US20050119307A1/en not_active Abandoned
- 2004-10-12 US US10/963,460 patent/US20050049279A1/en not_active Abandoned
-
2005
- 2005-10-06 US US11/244,924 patent/US20060030587A1/en not_active Abandoned
-
2007
- 2007-10-02 CY CY20071101250T patent/CY1107748T1/el unknown
-
2008
- 2008-12-09 US US12/331,127 patent/US20090088455A1/en not_active Abandoned
-
2009
- 2009-10-16 US US12/580,800 patent/US20100035928A1/en not_active Abandoned
-
2011
- 2011-04-26 US US13/093,917 patent/US20110201645A1/en not_active Abandoned
-
2012
- 2012-12-20 US US13/721,224 patent/US20130109719A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1844777A1 (de) | 2007-10-17 |
WO1999016439A1 (en) | 1999-04-08 |
EP1032389A1 (de) | 2000-09-06 |
US20050049279A1 (en) | 2005-03-03 |
NZ503571A (en) | 2003-04-29 |
US20100035928A1 (en) | 2010-02-11 |
CA2241611C (en) | 2004-08-17 |
CA2468370C (en) | 2009-02-24 |
EP1032389B1 (de) | 2007-08-01 |
DK1032389T3 (da) | 2007-11-12 |
ES2289787T3 (es) | 2008-02-01 |
US20030232857A1 (en) | 2003-12-18 |
US20110201645A1 (en) | 2011-08-18 |
US6255325B1 (en) | 2001-07-03 |
US20050119307A1 (en) | 2005-06-02 |
ATE368458T1 (de) | 2007-08-15 |
CA2468370A1 (en) | 1999-03-29 |
US20090088455A1 (en) | 2009-04-02 |
US20060030587A1 (en) | 2006-02-09 |
AU7976598A (en) | 1999-04-23 |
US5922736A (en) | 1999-07-13 |
EP1032389B8 (de) | 2008-05-28 |
CA2241611A1 (en) | 1999-03-29 |
IL135288A (en) | 2007-06-03 |
US20130109719A1 (en) | 2013-05-02 |
DE69838179T2 (de) | 2008-04-17 |
PT1032389E (pt) | 2007-09-05 |
IL135288A0 (en) | 2001-05-20 |
US20010041717A1 (en) | 2001-11-15 |
EP1032389A4 (de) | 2002-07-03 |
AU738521B2 (en) | 2001-09-20 |
US6602887B2 (en) | 2003-08-05 |
CY1107748T1 (el) | 2013-04-18 |
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