DE69837678D1 - Compositions zur inhibierung der proliferation glatter muskulatur und verfahren zur diagnose von arteriosklerose - Google Patents
Compositions zur inhibierung der proliferation glatter muskulatur und verfahren zur diagnose von arterioskleroseInfo
- Publication number
- DE69837678D1 DE69837678D1 DE69837678T DE69837678T DE69837678D1 DE 69837678 D1 DE69837678 D1 DE 69837678D1 DE 69837678 T DE69837678 T DE 69837678T DE 69837678 T DE69837678 T DE 69837678T DE 69837678 D1 DE69837678 D1 DE 69837678D1
- Authority
- DE
- Germany
- Prior art keywords
- arteriosclerosis
- composition
- apm1
- diagnosis
- obesity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/5759—Products of obesity genes, e.g. leptin, obese (OB), tub, fat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4703—Regulators; Modulating activity
- G01N2333/4704—Inhibitors; Supressors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/32—Cardiovascular disorders
- G01N2800/323—Arteriosclerosis, Stenosis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
- Y10S530/809—Fused cells, e.g. hybridoma
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Endocrinology (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Pulmonology (AREA)
- Obesity (AREA)
- Physiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Child & Adolescent Psychology (AREA)
- Toxicology (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP29756997 | 1997-10-29 | ||
JP29756997 | 1997-10-29 | ||
PCT/JP1998/004862 WO1999021577A1 (fr) | 1997-10-29 | 1998-10-27 | Compositions inhibant la proliferation des muscles lisses, procede de diagnostic de l'arteriosclerose et trousses correspondantes |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69837678D1 true DE69837678D1 (de) | 2007-06-06 |
DE69837678T2 DE69837678T2 (de) | 2007-12-27 |
Family
ID=17848257
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69837678T Expired - Lifetime DE69837678T2 (de) | 1997-10-29 | 1998-10-27 | Compositions zur inhibierung der proliferation glatter muskulatur und verfahren zur diagnose von arteriosklerose |
DE98950411T Pending DE98950411T1 (de) | 1997-10-29 | 1998-10-27 | Zusammensetzung zur Inhibierung der Proliferation glatter Muskulatur, Verfahren zur Diagnose von Arteriosklerose, sowie Kits hierzu |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE98950411T Pending DE98950411T1 (de) | 1997-10-29 | 1998-10-27 | Zusammensetzung zur Inhibierung der Proliferation glatter Muskulatur, Verfahren zur Diagnose von Arteriosklerose, sowie Kits hierzu |
Country Status (10)
Country | Link |
---|---|
US (3) | US6461821B1 (de) |
EP (1) | EP1033134B8 (de) |
JP (2) | JP3538711B2 (de) |
AT (1) | ATE360433T1 (de) |
CY (1) | CY1106616T1 (de) |
DE (2) | DE69837678T2 (de) |
DK (1) | DK1033134T3 (de) |
ES (1) | ES2285786T3 (de) |
PT (1) | PT1033134E (de) |
WO (1) | WO1999021577A1 (de) |
Families Citing this family (76)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2767135B1 (fr) | 1997-08-06 | 2002-07-12 | Genset Sa | Recepteur complexe lsr, activite, clonage, et application au diagnostic, a la prevention et/ou au traitement de d'obesite et des risques ou complications associes |
JP2002528118A (ja) | 1998-11-04 | 2002-09-03 | ジェンセット | ヒト脂肪細胞に特異的なAPM1のゲノム配列および全cDNA配列ならびにそのバイアレリックマーカー |
CA2359757A1 (en) | 1999-02-10 | 2000-08-17 | Genset S.A. | Polymorphic markers of the lsr gene |
HUP0105284A3 (en) | 1999-02-19 | 2003-12-29 | Zymogenetics Inc Seattle | Inhibitors for use in hemostasis and immune function |
US6544946B1 (en) | 1999-02-19 | 2003-04-08 | Zymogenetics, Inc. | Inhibitors for use in hemostasis and immune function |
JP4689787B2 (ja) * | 1999-04-12 | 2011-05-25 | 住友化学株式会社 | 腹腔内脂肪組織量の分析方法 |
WO2001032868A1 (en) * | 1999-11-04 | 2001-05-10 | Genset | Apm1 biallelic markers and uses thereof |
US6989367B2 (en) | 2000-01-14 | 2006-01-24 | Genset S.A. | OBG3 globular head and uses thereof |
US20020058617A1 (en) | 2000-01-14 | 2002-05-16 | Joachim Fruebis | OBG3 globular head and uses thereof for decreasing body mass |
US6579852B2 (en) | 2000-01-14 | 2003-06-17 | Genset S.A. | OBG3 globular head and uses thereof for decreasing body mass |
US6566332B2 (en) | 2000-01-14 | 2003-05-20 | Genset S.A. | OBG3 globular head and uses thereof for decreasing body mass |
CA2383136C (en) * | 2000-01-14 | 2012-09-18 | Genset S.A. | Obg3 globular head and uses thereof for decreasing body mass |
US7338787B2 (en) | 2000-01-14 | 2008-03-04 | Serono Genetics Institute S.A. | Nucleic acids encoding OBG3 globular head and uses thereof |
ATE464378T1 (de) * | 2000-05-31 | 2010-04-15 | Serono Genetics Inst Sa | Verwendung des globulären kopfes von acrp30 zur verstärkung der zunahme von muskelmasse und - differenzierung |
CA2440144A1 (en) * | 2001-03-14 | 2002-09-19 | Oklahoma Medical Research Foundation | Methods for reducing fat by administration of adiponectin |
WO2003009862A1 (en) * | 2001-07-20 | 2003-02-06 | Genset S.A. | Agonists and antagonists of modumet for use in the treatment of metabolic disorders |
WO2003009864A1 (en) * | 2001-07-23 | 2003-02-06 | Genset S.A. | Agonists and antagonists of disomet for the treatment of metabolic disorders |
WO2003009861A1 (en) * | 2001-07-24 | 2003-02-06 | Genset S.A. | Agonists and antagonists of metabolix in the treatment of metabolic disorders |
WO2003009865A1 (en) * | 2001-07-25 | 2003-02-06 | Genset S.A. | Agonists and antagonists of energen for use in the treatment of metabolic disorders |
WO2003009863A1 (en) * | 2001-07-26 | 2003-02-06 | Genset S.A. | Agonists and antagonists of cofoxin for use in the treatment of metabolic disorders |
WO2003011325A1 (en) * | 2001-07-27 | 2003-02-13 | Genset S.A. | Agonists and antagonists of moceptin for the treatment of metabolic disorders |
WO2003011323A1 (en) * | 2001-07-30 | 2003-02-13 | Genset S.A. | Agonists and antagonists of contabix for use in the treatment of metabolic disorders |
WO2003011324A1 (en) * | 2001-07-31 | 2003-02-13 | Genset S.A. | Agonists and antagonists of moxifin for the treatment of metabolic disorders |
WO2003011321A1 (en) * | 2001-07-31 | 2003-02-13 | Genset S.A. | Agonists and antagonists of cobesin for the treatment of metabolic disorders |
WO2003011318A1 (en) * | 2001-08-01 | 2003-02-13 | Genset S.A. | Agonists and antagonists of famoset for use in the treatment of metabolic disorders |
US20070129291A1 (en) * | 2001-08-01 | 2007-06-07 | Genset S.A. | Genobix agonists and antagonists for use in the treatment of metabolic disorders |
WO2003011320A1 (en) * | 2001-08-02 | 2003-02-13 | Genset S.A. | Agonists and antagonists of obesingen for the treatment of metabolic disorders |
WO2003011322A1 (en) * | 2001-08-02 | 2003-02-13 | Genset S.A. | Agonists and antagonists of genoxin for use in the treatment of metabolic disorders |
WO2003011319A1 (en) * | 2001-08-02 | 2003-02-13 | Genset S.A | Xobesin agonists and antagonists for the treatment of metabolic disorders |
WO2003013579A1 (en) * | 2001-08-03 | 2003-02-20 | Genset S.A. | Lypergix agonists and antagonists for use in the treatment of metabolic disorders |
WO2003013581A1 (en) * | 2001-08-03 | 2003-02-20 | Genset S.A. | Agonists and antagonists of genceptin for the treatment of metabolic disorders |
WO2003013580A1 (en) * | 2001-08-03 | 2003-02-20 | Genset S.A. | Tr xidatin agonists and antagonists treatment of metabolic disorders |
WO2003013582A1 (en) * | 2001-08-06 | 2003-02-20 | Genset S.A. | Genoxit agonists and antagonists for use in the treatment of metabolic disorders |
AU2002328173A1 (en) * | 2001-08-07 | 2003-02-24 | Genset S.A. | Omoxin agonists and antagonists for use in the treatment of metabolic disorders |
WO2003013585A1 (en) * | 2001-08-08 | 2003-02-20 | Genset S.A. | Mifaxin agonists and antagonists for use in the treatment of metabolic |
WO2003013584A1 (en) * | 2001-08-09 | 2003-02-20 | Genset S.A. | Xafinix agonists and antagonists for use in the treatment of metabolic disorders |
AU2002339213A1 (en) * | 2001-08-09 | 2003-02-24 | Genset S.A. | Migenix agonists and antagonists for use in the treatment of metabolic disorders |
WO2003013583A1 (en) * | 2001-08-10 | 2003-02-20 | Genset S.A. | Faxigen agonists and antagonists in the treatment of metabolic disorders |
DE60239622D1 (de) * | 2001-08-17 | 2011-05-12 | Fujirebio Kk | Verfahren zur diagnose oder überwachung eines fehlers im zuckerstoffwechsel |
WO2003026695A1 (en) * | 2001-09-21 | 2003-04-03 | Genset S.A. | Agonists and antagonists of cylixin for the treatment of metabolic disorders |
WO2003041738A1 (en) * | 2001-11-15 | 2003-05-22 | Genset S.A. | Treatment of metabolic disorders with xitar agonists and antagonists |
WO2003041730A1 (en) * | 2001-11-16 | 2003-05-22 | Genset S.A. | Ditacin agonists and antagonists for use in the treatment of metabolic disorders |
WO2003045421A1 (en) * | 2001-11-28 | 2003-06-05 | Genset S.A. | Agonists and antagonists of ryzn for the treatment of metabolic disorders |
AU2002339691A1 (en) | 2001-11-29 | 2003-06-10 | Genset | Agonists and antagonists of prolixin for the treatment of metabolic disorders |
WO2003047614A1 (en) * | 2001-12-05 | 2003-06-12 | Genset S.A. | Agonist and antagonists of redax for the treatment of metabolic disorders |
AU2002339689A1 (en) * | 2001-12-05 | 2003-06-17 | Genset S.A. | Dexar agonists and antagonists for use in the treatment of metabolic disorders |
WO2003049757A1 (en) * | 2001-12-12 | 2003-06-19 | Genset S.A. | Agonists and antagonists of glucomin for the treatment of metabolic disorders |
WO2003049759A1 (en) * | 2001-12-13 | 2003-06-19 | Genset S.A. | Agonists and antagonists of oxifan for the treatment of metabolic disorders |
AU2002339682A1 (en) * | 2001-12-13 | 2003-06-23 | Genset S.A. | Emergen agonists and antagonists for use in the treatment of metabolic disorders |
AU2002339679A1 (en) * | 2001-12-13 | 2003-06-23 | Genset S.A. | Glucomin agonists and antagonists for use in the treatment of metabolic disorders |
WO2003051386A1 (en) * | 2001-12-14 | 2003-06-26 | Genset S.A. | Glucoset agonists and antagonists for use in the treatment of metabolic disorders |
AU2002339680A1 (en) * | 2001-12-26 | 2003-07-15 | Genset S.A. | Agonists and antagonists of bromix for the treatment of metabolic disorders |
CA2473781A1 (en) * | 2002-01-18 | 2003-07-31 | Protemix Corporation Limited | Glycoisoforms of adiponectin and uses thereof |
DE60329000D1 (de) * | 2002-05-24 | 2009-10-08 | Japan Science & Tech Agency | C-terminale globulardomäne von adiponectin zur behandlung von arteriosklerose |
ATE534903T1 (de) * | 2003-03-24 | 2011-12-15 | Mitsubishi Chem Medience Corp | Latex-reaktionsmittel zur adiponectinanalyse und verfahren zur adiponectinanalyse |
GB0312122D0 (en) * | 2003-05-27 | 2003-07-02 | Pharmagene Lab Ltd | Therapeutic method |
US20060099608A1 (en) * | 2004-03-29 | 2006-05-11 | Medstar Research Institute | Methods of diagnosing cardiovascular disease |
DE102004042530B4 (de) * | 2004-09-02 | 2006-10-19 | Mosaiques Diagnostics And Therapeutics Ag | Verfahren zur Diagnose von Arteriosklerose |
WO2006062422A1 (en) * | 2004-12-10 | 2006-06-15 | Protemix Corporation Limited | Glyponectin (glycosylated adiponectin) for the treatment of diseases and conditions |
US7678886B2 (en) * | 2005-01-07 | 2010-03-16 | Xencor, Inc. | Pharmaceutical compositions of adiponectin variants and methods of storage |
US7749956B2 (en) * | 2005-01-07 | 2010-07-06 | Xencor, Inc. | Method of treatment using adiponectin variants |
US7592423B2 (en) * | 2005-01-07 | 2009-09-22 | Xencor, Inc. | Globular adiponectin variants |
CA2585733A1 (en) * | 2005-01-07 | 2006-07-13 | Arthur J. Chirino | Adiponectin variants |
US20070054359A1 (en) * | 2005-07-11 | 2007-03-08 | Jonathan Zalevsky | Rational Chemical Modification of Adiponectin Variants |
US8636995B2 (en) * | 2006-08-31 | 2014-01-28 | Cardiac Pacemakers, Inc. | Methods and devices to regulate stem cell homing |
US20080058922A1 (en) * | 2006-08-31 | 2008-03-06 | Cardiac Pacemakers, Inc. | Methods and devices employing vap-1 inhibitors |
US8372399B2 (en) * | 2006-08-31 | 2013-02-12 | Cardiac Pacemakers, Inc. | Bispecific antibodies and agents to enhance stem cell homing |
WO2008153725A2 (en) | 2007-05-25 | 2008-12-18 | North Carolina State University | Viral nanoparticle cell-targeted delivery platform |
CA2707182C (en) * | 2007-11-30 | 2017-12-12 | Siemens Healthcare Diagnostics Inc. | Adiponectin receptor fragments and methods of use |
US8268604B2 (en) * | 2007-12-20 | 2012-09-18 | Abbott Point Of Care Inc. | Compositions for forming immobilized biological layers for sensing |
US8241697B2 (en) | 2007-12-20 | 2012-08-14 | Abbott Point Of Care Inc. | Formation of immobilized biological layers for sensing |
EP2088156A1 (de) * | 2008-02-08 | 2009-08-12 | Institut Pasteur | Verwendung von Adiponektin zur Diagnose und/oder Behandlung von Presbyakusis |
TW201500053A (zh) * | 2008-08-27 | 2015-01-01 | Otsuka Pharma Co Ltd | 用於治療肺部疾病之藥劑(二) |
US8865648B2 (en) | 2009-04-23 | 2014-10-21 | Siemens Healthcare Diagnostics Inc. | Monomeric and dimeric forms of adiponectin receptor fragments and methods of use |
MX353186B (es) * | 2009-09-03 | 2018-01-05 | Genentech Inc | Metodos para el tratamiento, diagnosis y monitoreo de artritis reumatoide. |
KR101868620B1 (ko) * | 2015-08-12 | 2018-07-23 | 중앙대학교 산학협력단 | Fgf12를 이용한 혈관 평활근세포 증식성 질환의 진단, 예방 또는 치료용 조성물 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5869330A (en) * | 1995-06-05 | 1999-02-09 | Whitehead Institute For Biomedical Research | DNA encoding a novel serum protein produced exclusively in adipocytes |
US5858682A (en) * | 1996-08-02 | 1999-01-12 | Pharmingen | E2A/pbx1 fusion protein specific monoclonal antibodies |
JP4253815B2 (ja) * | 1997-10-29 | 2009-04-15 | 大塚製薬株式会社 | 平滑筋増殖抑制組成物、動脈硬化症予防及び治療組成物及び血管再建術後の再狭窄予防及び治療組成物 |
-
1998
- 1998-10-27 EP EP98950411A patent/EP1033134B8/de not_active Expired - Lifetime
- 1998-10-27 DK DK98950411T patent/DK1033134T3/da active
- 1998-10-27 ES ES98950411T patent/ES2285786T3/es not_active Expired - Lifetime
- 1998-10-27 DE DE69837678T patent/DE69837678T2/de not_active Expired - Lifetime
- 1998-10-27 DE DE98950411T patent/DE98950411T1/de active Pending
- 1998-10-27 WO PCT/JP1998/004862 patent/WO1999021577A1/ja active IP Right Grant
- 1998-10-27 JP JP2000517735A patent/JP3538711B2/ja not_active Expired - Lifetime
- 1998-10-27 PT PT98950411T patent/PT1033134E/pt unknown
- 1998-10-27 AT AT98950411T patent/ATE360433T1/de active
- 1998-10-27 US US09/530,423 patent/US6461821B1/en not_active Expired - Lifetime
-
2002
- 2002-07-08 US US10/189,493 patent/US20030166551A1/en not_active Abandoned
-
2005
- 2005-04-04 US US11/097,334 patent/US7285275B2/en not_active Expired - Fee Related
-
2007
- 2007-05-22 CY CY20071100696T patent/CY1106616T1/el unknown
-
2008
- 2008-11-05 JP JP2008284353A patent/JP4859904B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
WO1999021577A1 (fr) | 1999-05-06 |
PT1033134E (pt) | 2007-07-11 |
DK1033134T3 (da) | 2007-07-16 |
CY1106616T1 (el) | 2012-01-25 |
ES2285786T3 (es) | 2007-11-16 |
US20030166551A1 (en) | 2003-09-04 |
JP2009079064A (ja) | 2009-04-16 |
EP1033134B8 (de) | 2007-09-19 |
DE98950411T1 (de) | 2005-10-20 |
US6461821B1 (en) | 2002-10-08 |
US7285275B2 (en) | 2007-10-23 |
EP1033134B1 (de) | 2007-04-25 |
JP3538711B2 (ja) | 2004-06-14 |
JP4859904B2 (ja) | 2012-01-25 |
EP1033134A4 (de) | 2004-10-13 |
ATE360433T1 (de) | 2007-05-15 |
EP1033134A1 (de) | 2000-09-06 |
US20050163779A1 (en) | 2005-07-28 |
DE69837678T2 (de) | 2007-12-27 |
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