DE69836980D1 - Arylthiazolidindion-derivate - Google Patents

Arylthiazolidindion-derivate

Info

Publication number
DE69836980D1
DE69836980D1 DE69836980T DE69836980T DE69836980D1 DE 69836980 D1 DE69836980 D1 DE 69836980D1 DE 69836980 T DE69836980 T DE 69836980T DE 69836980 T DE69836980 T DE 69836980T DE 69836980 D1 DE69836980 D1 DE 69836980D1
Authority
DE
Germany
Prior art keywords
arylthiazolidindion
derivatives
ppar
thiazolidinediones
hypertriglyceridemia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69836980T
Other languages
English (en)
Other versions
DE69836980T2 (de
Inventor
P Sahoo
L Tolman
Wei Han
Jeffrey Bergmann
Conrad Santini
R Lombardo
Ranjit Desai
K Boueres
F Gratale
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9816279.5A external-priority patent/GB9816279D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE69836980D1 publication Critical patent/DE69836980D1/de
Publication of DE69836980T2 publication Critical patent/DE69836980T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/44—Two oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
DE69836980T 1997-12-19 1998-12-18 Arylthiazolidindion-derivate Expired - Fee Related DE69836980T2 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US6827197P 1997-12-19 1997-12-19
US68271P 1997-12-19
GB9816279 1998-07-27
GBGB9816279.5A GB9816279D0 (en) 1998-07-27 1998-07-27 Arylthiazolidinedione derivatives
US10523898P 1998-10-22 1998-10-22
US105238P 1998-10-22
PCT/US1998/027139 WO1999032465A1 (en) 1997-12-19 1998-12-18 Arylthiazolidinedione derivatives

Publications (2)

Publication Number Publication Date
DE69836980D1 true DE69836980D1 (de) 2007-03-15
DE69836980T2 DE69836980T2 (de) 2007-11-15

Family

ID=27269416

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69836980T Expired - Fee Related DE69836980T2 (de) 1997-12-19 1998-12-18 Arylthiazolidindion-derivate

Country Status (21)

Country Link
EP (1) EP1040102B1 (de)
JP (1) JP3373198B2 (de)
KR (1) KR20010033355A (de)
CN (1) CN1282325A (de)
AT (1) ATE352545T1 (de)
AU (1) AU740733B2 (de)
BG (1) BG104602A (de)
BR (1) BR9813801A (de)
CA (1) CA2315397C (de)
DE (1) DE69836980T2 (de)
EA (1) EA200000687A1 (de)
ES (1) ES2281146T3 (de)
HU (1) HUP0101366A2 (de)
ID (1) ID24878A (de)
IL (1) IL136138A0 (de)
IS (1) IS5506A (de)
NO (1) NO20003112L (de)
PL (1) PL340958A1 (de)
SK (1) SK9212000A3 (de)
TR (1) TR200001753T2 (de)
WO (1) WO1999032465A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9824614D0 (en) 1998-11-11 1999-01-06 Glaxo Group Ltd Chemical compounds
EP1053989B1 (de) * 1999-05-20 2007-07-25 Ciba SC Holding AG Hydroxydiphenyletherverbindungen
WO2000078314A1 (en) * 1999-06-18 2000-12-28 Merck & Co., Inc. Process for making arylthiazolidinedione derivatives
AU773505B2 (en) * 1999-06-18 2004-05-27 Merck & Co., Inc. Arylthiazolidinedione and aryloxazolidinedione derivatives
PT1206457E (pt) * 1999-08-27 2004-03-31 Lilly Co Eli Derivados de diaril-oxa(tia)zol e seu uso como moduladores dos ppars
AU1303301A (en) * 1999-11-10 2001-06-06 Takeda Chemical Industries Ltd. Body weight gain inhibitors
AU2001298065A1 (en) * 2001-01-12 2003-09-02 Abbott Laboratories Process for the preparation of matrix metalloproteinase inhibitors
US20040077689A1 (en) * 2001-04-25 2004-04-22 Yasuo Sugiyama Abc expression promoters
AU2003256655A1 (en) * 2002-07-25 2004-02-16 Merck And Co., Inc. Therapeutic compounds for treating dyslipidemic conditions
AU2003276596B8 (en) * 2002-11-26 2009-03-05 Pfizer Products Inc. Piperidine compounds useful as PPAR activators
CN1319956C (zh) * 2003-09-12 2007-06-06 深圳市海粤门生物科技开发有限公司 一种噻唑烷二酮的衍生物及其药用制剂的制备方法和应用
DK2243766T3 (en) 2003-09-19 2015-10-12 Janssen Pharmaceutica Nv 4 - ((phenoxyalkyl) thio) -phenoxyeddikesyrer for use in the treatment of PPAR delta mediated conditions
SI1667964T1 (sl) * 2003-09-19 2009-12-31 Janssen Pharmaceutica Nv 4-((fenoksialkil)tio)-fenoksiocetne kisline in analogi
ES2287908T3 (es) * 2004-01-20 2007-12-16 MERCK & CO., INC. Oxazolidindionas y tiazolidindionas antidiabeticas.
WO2006138328A1 (en) * 2005-06-14 2006-12-28 Merck & Co., Inc. Process for the production of antidiabetic oxazolidinediones
AU2006269503A1 (en) 2005-07-06 2007-01-18 Merck & Co., Inc. Antidiabetic oxazolidinediones and thiazolidinediones
WO2007018956A2 (en) * 2005-07-20 2007-02-15 Merck & Co., Inc. Antidiabetic oxazolidinediones and thiazolidinediones
US7858666B2 (en) 2007-06-08 2010-12-28 Mannkind Corporation IRE-1α inhibitors
CN105001174A (zh) * 2015-07-14 2015-10-28 佛山市赛维斯医药科技有限公司 含苯并异恶唑和末端腈基苄基类结构的化合物及其用途
CN104987314A (zh) * 2015-07-14 2015-10-21 佛山市赛维斯医药科技有限公司 含苯并异恶唑和末端硝基苄基类结构的化合物及其用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3053490B2 (ja) * 1991-02-25 2000-06-19 杏林製薬株式会社 チアゾリジン−２，４−ジオン誘導体とその塩及び製造法
JP3906935B2 (ja) * 1995-12-18 2007-04-18 杏林製薬株式会社 Ｎ−置換ジオキソチアゾリジルベンズアミド誘導体及びその製造法
AU708055B2 (en) * 1996-02-02 1999-07-29 Merck & Co., Inc. Heterocyclic derivatives as antidiabetic and antiobesity agents
AU721452B2 (en) * 1996-02-02 2000-07-06 Merck & Co., Inc. Antidiabetic agents
EP0904079B1 (de) * 1996-02-02 2004-03-24 Merck & Co., Inc. Antidiabetisches mittel
US5801173A (en) * 1996-05-06 1998-09-01 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
ID24878A (id) 2000-08-31
KR20010033355A (ko) 2001-04-25
IS5506A (is) 2000-05-23
CA2315397C (en) 2007-08-07
EP1040102A1 (de) 2000-10-04
AU740733B2 (en) 2001-11-15
DE69836980T2 (de) 2007-11-15
AU1833499A (en) 1999-07-12
BG104602A (bg) 2001-01-31
EA200000687A1 (ru) 2000-12-25
ATE352545T1 (de) 2007-02-15
BR9813801A (pt) 2000-10-03
NO20003112D0 (no) 2000-06-16
EP1040102A4 (de) 2002-11-27
NO20003112L (no) 2000-08-18
CA2315397A1 (en) 1999-07-01
SK9212000A3 (en) 2001-02-12
JP3373198B2 (ja) 2003-02-04
PL340958A1 (en) 2001-03-12
CN1282325A (zh) 2001-01-31
EP1040102B1 (de) 2007-01-24
HUP0101366A2 (hu) 2001-09-28
IL136138A0 (en) 2001-05-20
ES2281146T3 (es) 2007-09-16
WO1999032465A1 (en) 1999-07-01
TR200001753T2 (tr) 2000-11-21
JP2001526278A (ja) 2001-12-18

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee