DE69835705D1 - Verfahren zur Herstellung von optisch aktiven Imidazolverbindungen, Zwischenprodukte zu deren Herstellung und ihre Herstellung - Google Patents

Verfahren zur Herstellung von optisch aktiven Imidazolverbindungen, Zwischenprodukte zu deren Herstellung und ihre Herstellung

Info

Publication number
DE69835705D1
DE69835705D1 DE69835705T DE69835705T DE69835705D1 DE 69835705 D1 DE69835705 D1 DE 69835705D1 DE 69835705 T DE69835705 T DE 69835705T DE 69835705 T DE69835705 T DE 69835705T DE 69835705 D1 DE69835705 D1 DE 69835705D1
Authority
DE
Germany
Prior art keywords
preparation
optically active
compound
intermediates
imidazole compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69835705T
Other languages
English (en)
Inventor
Kazuyuki Kawasaki
Haruhito Kobayashi
Syuji Ehara
Hideaki Sato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Pharma Corp
Original Assignee
Mitsubishi Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Pharma Corp filed Critical Mitsubishi Pharma Corp
Application granted granted Critical
Publication of DE69835705D1 publication Critical patent/DE69835705D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE69835705T 1997-01-23 1998-01-14 Verfahren zur Herstellung von optisch aktiven Imidazolverbindungen, Zwischenprodukte zu deren Herstellung und ihre Herstellung Expired - Lifetime DE69835705D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP09010114A JP2000290259A (ja) 1997-01-23 1997-01-23 光学活性なイミダゾール化合物の製造方法およびその合成中間体

Publications (1)

Publication Number Publication Date
DE69835705D1 true DE69835705D1 (de) 2006-10-05

Family

ID=11741291

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69835705T Expired - Lifetime DE69835705D1 (de) 1997-01-23 1998-01-14 Verfahren zur Herstellung von optisch aktiven Imidazolverbindungen, Zwischenprodukte zu deren Herstellung und ihre Herstellung
DE69818983T Expired - Fee Related DE69818983T2 (de) 1997-01-23 1998-01-14 Verfahren zur herstellung optisch aktiver imidazolverbindungen, zwischenprodukte zu ihrer herstellung und verfahren zu ihrer herstellung

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69818983T Expired - Fee Related DE69818983T2 (de) 1997-01-23 1998-01-14 Verfahren zur herstellung optisch aktiver imidazolverbindungen, zwischenprodukte zu ihrer herstellung und verfahren zu ihrer herstellung

Country Status (11)

Country Link
US (2) US6066739A (de)
EP (2) EP1378507B1 (de)
JP (1) JP2000290259A (de)
KR (1) KR100490891B1 (de)
CN (1) CN1133623C (de)
AT (2) ATE337306T1 (de)
AU (1) AU5496698A (de)
CA (1) CA2278509C (de)
DE (2) DE69835705D1 (de)
ES (1) ES2209104T3 (de)
WO (1) WO1998032740A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000290259A (ja) * 1997-01-23 2000-10-17 Welfide Corp 光学活性なイミダゾール化合物の製造方法およびその合成中間体
US20070161803A1 (en) * 2004-02-27 2007-07-12 Hiroyuki Ushio Method of asymmetrically reducing 4-[5-(imidazol-1-yl)-2-methylbenzoyl]-3,5- dimethylbenzoic acid or ester thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5770884A (en) * 1980-10-21 1982-05-01 Kyowa Hakko Kogyo Co Ltd Novel piperidine derivative and its preparation
JPS6314771A (ja) * 1986-07-08 1988-01-21 Sankyo Co Ltd 光学活性イミダゾ−ル誘導体およびその製法
JPH02215771A (ja) * 1989-02-14 1990-08-28 Yoshitomi Pharmaceut Ind Ltd 光学活性なイミダゾール化合物の製造方法およびその合成中間体
US5633377A (en) * 1990-12-28 1997-05-27 Neurogen Corporation 4-piperidino- and piperazinomethyl-2-cyclohexyl imidazole derivatives; dopamine receptor subtype specific ligands
JP2000290259A (ja) * 1997-01-23 2000-10-17 Welfide Corp 光学活性なイミダゾール化合物の製造方法およびその合成中間体

Also Published As

Publication number Publication date
AU5496698A (en) 1998-08-18
KR100490891B1 (ko) 2005-05-24
US6166221A (en) 2000-12-26
DE69818983T2 (de) 2004-09-09
EP0972768A4 (de) 2001-06-27
EP0972768A1 (de) 2000-01-19
ES2209104T3 (es) 2004-06-16
WO1998032740A1 (fr) 1998-07-30
EP1378507A2 (de) 2004-01-07
CN1133623C (zh) 2004-01-07
CA2278509C (en) 2007-03-20
EP1378507A3 (de) 2004-02-04
JP2000290259A (ja) 2000-10-17
CA2278509A1 (en) 1998-07-30
EP1378507B1 (de) 2006-08-23
ATE337306T1 (de) 2006-09-15
ATE252085T1 (de) 2003-11-15
KR20000070362A (ko) 2000-11-25
DE69818983D1 (de) 2003-11-20
US6066739A (en) 2000-05-23
CN1251093A (zh) 2000-04-19
EP0972768B1 (de) 2003-10-15

Similar Documents

Publication Publication Date Title
ATE353081T1 (de) Verfahren zur herstellung von duloxetin und deren verwendeten zwischenprodukten
ATE157647T1 (de) Verfahren zur herstellung von alpha- ketoamidderivaten
ATE509914T1 (de) Verfahren zur herstellung optisch aktiver oxoheptensäureester
EP0937703A4 (de) Verfahren zur reinigung von brenztraubensäureverbindungen
DE69835705D1 (de) Verfahren zur Herstellung von optisch aktiven Imidazolverbindungen, Zwischenprodukte zu deren Herstellung und ihre Herstellung
EP1460065A4 (de) Verfahren zur herstellung von cyclischen diaminverbindungen bzw. deren salzen
ATE201410T1 (de) Verfahren zur herstellung von 1-(4,5-dihydro)2- thiazolyl-3-azetidinthiolderivaten
DE69507887D1 (de) Verfahren zur herstellung von n-biphenylmethylthiadiazolin derivaten oder deren salzen sowie dafür benötigte zwischen verbindungen
EP0427435B1 (de) Prozess zur direkten Isolierung von Captopril
ATE334972T1 (de) Verfahren für die herstellung von 4(5)-amino-5(4)-carboxamidoimidazolen und deren zwischenprodukte
DE60232308D1 (de) Verfahren zur herstellung von fluorinverbindungen
DE69629661D1 (de) VERFAHREN ZUR HERSTELLUNG VON N-(D-alpha-METHYL-beta-MERCAPTOPROPIONYL)-L-PROLIN UND INTERMEDIATEN DAVON
ATE251135T1 (de) Verfahren zur herstellung von 1-substituierten pyrrol-3-carbonsäure-derivaten
DE69821763D1 (de) Verfahren zur herstellung von 2-alkylthio-substituierten benzoesäurederivaten
ATE460383T1 (de) Verfahren zur herstellung von stickstofftrifluorid
ATE236909T1 (de) Verfahren zur herstellung von phosphorohalidaten
DE60239793D1 (de) Verfahren zur herstellung von 7-chinolinyl-3,5-dihydroxyhept-6-enoat
DE69909646T2 (de) Derivate der aminoacryl-säure und ein verfahren zur herstellung derselben
ATE249434T1 (de) Ein verfahren zur herstellung von pyrrolidinon- derivaten
ATE341642T1 (de) Verfahren zur herstellung von d- asparaginderivaten
ATE476409T1 (de) Verfahren zur herstellung von optisch aktiver carbonsäure
ATE555089T1 (de) Verfahren zur herstellung von -ketoacetalen
ATE177737T1 (de) Verfahren zur herstellung von 5-arylhydantoin
DE69904652D1 (de) Verfahren zur Herstellung von optisch aktiven Aminoalkoholen
ATE253553T1 (de) Verfahren zur herstellung von 2- alkylthiobenzonitril-derivaten

Legal Events

Date Code Title Description
8332 No legal effect for de