DE69834109D1 - 3-epi-vitamin d2 verbindungen und ihre anwendungen - Google Patents

3-epi-vitamin d2 verbindungen und ihre anwendungen

Info

Publication number
DE69834109D1
DE69834109D1 DE69834109T DE69834109T DE69834109D1 DE 69834109 D1 DE69834109 D1 DE 69834109D1 DE 69834109 T DE69834109 T DE 69834109T DE 69834109 T DE69834109 T DE 69834109T DE 69834109 D1 DE69834109 D1 DE 69834109D1
Authority
DE
Germany
Prior art keywords
vitamin
compounds
epi
beta
applications
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69834109T
Other languages
English (en)
Other versions
DE69834109T2 (de
Inventor
G Reddy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Woman & Infants Hospital Provi
Original Assignee
Woman & Infants Hospital Provi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Woman & Infants Hospital Provi filed Critical Woman & Infants Hospital Provi
Application granted granted Critical
Publication of DE69834109D1 publication Critical patent/DE69834109D1/de
Publication of DE69834109T2 publication Critical patent/DE69834109T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/592—9,10-Secoergostane derivatives, e.g. ergocalciferol, i.e. vitamin D2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69834109T 1997-05-16 1998-05-15 3-epi-vitamin d2 verbindungen und ihre anwendungen Expired - Fee Related DE69834109T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4664197P 1997-05-16 1997-05-16
US46641P 1997-05-16
PCT/US1998/010063 WO1998051664A1 (en) 1997-05-16 1998-05-15 3-epi vitamin d2 compounds and uses thereof

Publications (2)

Publication Number Publication Date
DE69834109D1 true DE69834109D1 (de) 2006-05-18
DE69834109T2 DE69834109T2 (de) 2007-04-19

Family

ID=21944565

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69834109T Expired - Fee Related DE69834109T2 (de) 1997-05-16 1998-05-15 3-epi-vitamin d2 verbindungen und ihre anwendungen

Country Status (8)

Country Link
US (1) US6017908A (de)
EP (1) EP0981514B1 (de)
JP (1) JP2002506429A (de)
AT (1) ATE322477T1 (de)
AU (1) AU744471B2 (de)
CA (1) CA2288710A1 (de)
DE (1) DE69834109T2 (de)
WO (1) WO1998051664A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2671785T3 (es) * 1999-04-23 2018-06-08 Leo Pharma A/S Composición farmacéutica para uso dérmico para el tratamiento de la psoriasis que comprende vitamina D y un corticosteroide
DE60006379T2 (de) * 1999-04-23 2004-08-26 Leo Pharma A/S Vitamin d-analogen und ihre pharmazeutische verwendung
EP1233942A2 (de) * 1999-12-02 2002-08-28 The Penn State Research Foundation Behandlung von entzündlichen darmerkrankungen mit vitamin d-verbindungen
US6358939B1 (en) * 1999-12-21 2002-03-19 Northern Lights Pharmaceuticals, Llc Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease
WO2001091794A2 (en) 2000-05-30 2001-12-06 Virginia Commonwealth University Vitamin d3 analogs as radiosensitizers for the treatment of cancer
US20020019010A1 (en) * 2000-07-07 2002-02-14 Stockwell Brent R. Methods for identifying combinations of entities as therapeutics
EP1458678A1 (de) * 2002-11-18 2004-09-22 Teva Pharmaceutical Industries Limited Kristallisationsverfahren zur reinigung von calcipotriene
AU2004235775A1 (en) * 2003-04-30 2004-11-18 Bioxell S.P.A. Gemini vitamin D3 compounds and methods of use thereof
JP2007526438A (ja) * 2003-06-06 2007-09-13 コンビナトルックス インコーポレイテッド 組成物の組み合わせの多次元評価システムおよび方法
US20050192255A1 (en) * 2003-07-30 2005-09-01 Jin Tian Use of Vitamin Ds or Vitamin D analogs to treat cardiovascular disease
AU2005216651A1 (en) * 2004-03-01 2005-09-09 Bioxell Spa Treatment of interstitial cystitis with vitamin D compounds
AU2005303773A1 (en) 2004-11-12 2006-05-18 Bioxell Spa Combined use of vitamin D derivatives and anti-proliferative agents for treating bladder cancer
CN101505725A (zh) * 2006-08-29 2009-08-12 特瓦制药工业有限公司 包含含维生素D的化合物和皮质类固醇化合物的具有低pH相容性的稳定的药理学活性组合物
JP5932339B2 (ja) * 2009-01-27 2016-06-08 バーグ エルエルシー 化学療法に付随する副作用を軽減するためのビタミンｄ３およびその類似体
IN2012DN02137A (de) 2009-08-14 2015-08-07 Berg Biosystems Llc
SG10201709894RA (en) 2013-05-29 2018-01-30 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin d
DE102013215580A1 (de) 2013-08-07 2015-02-12 Orgentec Diagnostika Gmbh 25-OH Vitamin D Derivate zur Bestimmung von Vitamin D Metaboliten

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4038272A (en) * 1975-10-20 1977-07-26 Hoffmann-La Roche Inc. Stereospecific syntheses of 24r,25- and 24s,25-dihydroxycholesterol and alkanoyl derivatives thereof
US4021423A (en) * 1976-03-08 1977-05-03 Hoffmann-La Roche Inc. Syntheses of 24R,25- and 24S,25-dihydroxycholecalciferol
US4595776A (en) * 1983-03-21 1986-06-17 Hoffmann-La Roche Inc. Synthesis of 1α,25-dihydroxyergocalciferol
BE899612A (fr) * 1983-05-09 1984-08-31 Wisconsin Alumni Res Found Derives 1 alpha, 25-dihydroxiles de la vitamine d2 et produits intermediaires pour leur preparation et compositions pharmaceutiques renfermant ces derives.
JPS6144860A (ja) * 1984-08-10 1986-03-04 Taisho Pharmaceut Co Ltd １α．２５−ジヒドロキシ−２６．２７−ジメチルビタミンＤ↓３
US5145846A (en) * 1988-01-20 1992-09-08 Hoffmann-La Roche Inc. Vitamin D3 analogs
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
US5104864A (en) * 1988-08-02 1992-04-14 Bone Care International, Inc. Method for treating and preventing loss of bone mass
US5547947A (en) * 1993-03-11 1996-08-20 Hoffmann-La Roche Inc. Methods of treatment
US5401733A (en) * 1993-10-01 1995-03-28 Hoffmann-La Roche Inc. Stable and active metabolites of 1,25-dihydroxy-16-ene-cholecalciferol
US5428029A (en) * 1993-11-24 1995-06-27 Hoffmann-La Roche Inc. Vitamin D3 fluorinated analogs
ZA95906B (en) * 1994-02-07 1996-08-06 Res Developments Foundation Non-viral vector
NO971934L (no) * 1996-05-23 1997-11-24 Hoffmann La Roche Flourinerte vitamin D3 -analoger
SG70009A1 (en) * 1996-05-23 2000-01-25 Hoffmann La Roche Vitamin d3 analogs

Also Published As

Publication number Publication date
AU7390398A (en) 1998-12-08
EP0981514B1 (de) 2006-04-05
ATE322477T1 (de) 2006-04-15
JP2002506429A (ja) 2002-02-26
CA2288710A1 (en) 1998-11-19
DE69834109T2 (de) 2007-04-19
US6017908A (en) 2000-01-25
WO1998051664A1 (en) 1998-11-19
EP0981514A1 (de) 2000-03-01
AU744471B2 (en) 2002-02-21

Similar Documents

Publication Publication Date Title
DE69834109D1 (de) 3-epi-vitamin d2 verbindungen und ihre anwendungen
FI952797A0 (fi) D-vitamiinianalogin uusi kiteinen muoto
AU7125291A (en) Inhibitors of nitric oxide biosynthesis
FI943749A0 (fi) Taksaanijohdannaisten fosfono-oksimetyylieetterit
TW370450B (en) Substituted 1H-3-aryl-pyrrolidine-2,4-dione derivatives
HUP0100270A2 (hu) Eljárások és vegyületek béta-amiloid peptid kibocsátás és/vagy szintézisgátló peptidek, ezeket tartalmazó gyógyászati készítmények és alkalmazásuk
AU2002327747A1 (en) Substituted pentacene semiconductors
HUP0001232A2 (hu) Béta-amiloid peptid kibocsátást és/vagy szintézist gátló cikloalkil-, laktám-, laktonszármazékok, és ezek tio-analógjai, valamint e vegyületeket tartalmazó gyógyászati készítmények
MY116845A (en) New 19-nor-pregnene derivatives
WO1998051663A3 (en) 3-epi compounds of vitamin d3 and uses thereof
AU5715294A (en) Use of 2-amino-6-A-propylamino-4,5,6, 7-tetrahydrobenzothiazole (pramipexol) as an anti-depressantdrug
ES2192031T3 (es) Nuevas amidas aromaticas, su procedimiento de preparacion y su aplicacion como medicamentos.
FI961233A0 (fi) Katekolin syntetisointi biomassaperäisistä hiililähteistä
GB0227655D0 (en) Use
AU5699494A (en) Novel liquid phenolic antioxidants
AU2003232815A1 (en) Amorphous solid modification of bis(2,4-dicumylphenyl) pentaerythritol diphosphite
PT100961A (pt) Oximas de azabiciclo-arilacetileno e -arilenino como agentes colinergicos e composicoes farmaceuticas que as contem
DE3784585T2 (de) Pigmentzusammensetzung.
BG103789A (en) Fungicidal compositions
MY141507A (en) Slider block radial compliance mechanism with integral deflection bearing
FI951588A (fi) Öljykoostumuksia
BG103271A (en) Derivatives of n-(benzothiazol-2-yl) piperidine-1-ethaneamines, method for their preparation and application as therapeutical means
ES2103104T3 (es) Nuevos compuestos di- y poliaminicos utiles en la preparacion de poliuretanos.
DK0904272T3 (da) Dihydrobenzofuran og beslægtede forbindelser, der er nyttige som antiinflammatoriske midler
ES2046923A1 (es) Procedimiento para la estabilizacion de elastomeros.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee