DE69834109D1 - 3-epi-vitamin d2 verbindungen und ihre anwendungen - Google Patents

3-epi-vitamin d2 verbindungen und ihre anwendungen

Info

Publication number
DE69834109D1
DE69834109D1 DE69834109T DE69834109T DE69834109D1 DE 69834109 D1 DE69834109 D1 DE 69834109D1 DE 69834109 T DE69834109 T DE 69834109T DE 69834109 T DE69834109 T DE 69834109T DE 69834109 D1 DE69834109 D1 DE 69834109D1
Authority
DE
Germany
Prior art keywords
vitamin
compounds
epi
beta
applications
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69834109T
Other languages
English (en)
Other versions
DE69834109T2 (de
Inventor
G Reddy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Woman & Infants Hospital Provi
Original Assignee
Woman & Infants Hospital Provi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Woman & Infants Hospital Provi filed Critical Woman & Infants Hospital Provi
Publication of DE69834109D1 publication Critical patent/DE69834109D1/de
Application granted granted Critical
Publication of DE69834109T2 publication Critical patent/DE69834109T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/592—9,10-Secoergostane derivatives, e.g. ergocalciferol, i.e. vitamin D2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69834109T 1997-05-16 1998-05-15 3-epi-vitamin d2 verbindungen und ihre anwendungen Expired - Fee Related DE69834109T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4664197P 1997-05-16 1997-05-16
US46641P 1997-05-16
PCT/US1998/010063 WO1998051664A1 (en) 1997-05-16 1998-05-15 3-epi vitamin d2 compounds and uses thereof

Publications (2)

Publication Number Publication Date
DE69834109D1 true DE69834109D1 (de) 2006-05-18
DE69834109T2 DE69834109T2 (de) 2007-04-19

Family

ID=21944565

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69834109T Expired - Fee Related DE69834109T2 (de) 1997-05-16 1998-05-15 3-epi-vitamin d2 verbindungen und ihre anwendungen

Country Status (8)

Country Link
US (1) US6017908A (de)
EP (1) EP0981514B1 (de)
JP (1) JP2002506429A (de)
AT (1) ATE322477T1 (de)
AU (1) AU744471B2 (de)
CA (1) CA2288710A1 (de)
DE (1) DE69834109T2 (de)
WO (1) WO1998051664A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE253555T1 (de) * 1999-04-23 2003-11-15 Leo Pharma As Vitamin d-analogen und ihre pharmazeutische verwendung
ES2674563T3 (es) * 1999-04-23 2018-07-02 Leo Pharma A/S Pomada para el tratamiento tópico de la psoriasis
JP2003516386A (ja) * 1999-12-02 2003-05-13 ザ・ペン・ステート・リサーチ・ファンデーション ビタミンｄ化合物での炎症性腸疾患の治療
US6358939B1 (en) * 1999-12-21 2002-03-19 Northern Lights Pharmaceuticals, Llc Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease
WO2001091794A2 (en) 2000-05-30 2001-12-06 Virginia Commonwealth University Vitamin d3 analogs as radiosensitizers for the treatment of cancer
US20020019010A1 (en) * 2000-07-07 2002-02-14 Stockwell Brent R. Methods for identifying combinations of entities as therapeutics
AU2003291810A1 (en) * 2002-11-18 2004-06-15 Teva Pharmaceutical Industries Ltd. A crystallization method for purification of calcipotriene
WO2004098522A2 (en) * 2003-04-30 2004-11-18 Bioxell S.P.A. Gemini vitamin d3 compounds and methods of use thereof
EP1631799A2 (de) * 2003-06-06 2006-03-08 Combinatorx Incorporated Vorrichtung und verfahren zur mehrdimensionalen auswertung von kombinationen aus zusammensetzungen
US20050192255A1 (en) * 2003-07-30 2005-09-01 Jin Tian Use of Vitamin Ds or Vitamin D analogs to treat cardiovascular disease
CA2557809A1 (en) 2004-03-01 2005-09-09 Bioxell Spa Treatment of interstitial cystitis with vitamin d compounds
AU2005303773A1 (en) 2004-11-12 2006-05-18 Bioxell Spa Combined use of vitamin D derivatives and anti-proliferative agents for treating bladder cancer
CN101505725A (zh) * 2006-08-29 2009-08-12 特瓦制药工业有限公司 包含含维生素D的化合物和皮质类固醇化合物的具有低pH相容性的稳定的药理学活性组合物
CA2750659C (en) 2009-01-27 2017-11-21 Berg Biosystems, Llc Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy
EP3603646B1 (de) 2009-08-14 2024-04-03 BPGbio, Inc. Vitamin d3 und analoge davon zur behandlung von alopezie
KR20160013201A (ko) 2013-05-29 2016-02-03 버그 엘엘씨 비타민 d를 이용한 화학요법 유발 탈모증의 예방 또는 완화
DE102013215580A1 (de) 2013-08-07 2015-02-12 Orgentec Diagnostika Gmbh 25-OH Vitamin D Derivate zur Bestimmung von Vitamin D Metaboliten

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4038272A (en) * 1975-10-20 1977-07-26 Hoffmann-La Roche Inc. Stereospecific syntheses of 24r,25- and 24s,25-dihydroxycholesterol and alkanoyl derivatives thereof
US4021423A (en) * 1976-03-08 1977-05-03 Hoffmann-La Roche Inc. Syntheses of 24R,25- and 24S,25-dihydroxycholecalciferol
US4595776A (en) * 1983-03-21 1986-06-17 Hoffmann-La Roche Inc. Synthesis of 1α,25-dihydroxyergocalciferol
FR2545824B1 (fr) * 1983-05-09 1987-11-20 Wisconsin Alumni Res Found Derive 1a, 25-dihydroxyles de la vitamine d2 et produits intermediaires pour leur preparation et compositions pharmaceutiques renfermant ces derives
JPS6144860A (ja) * 1984-08-10 1986-03-04 Taisho Pharmaceut Co Ltd １α．２５−ジヒドロキシ−２６．２７−ジメチルビタミンＤ↓３
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
US5145846A (en) * 1988-01-20 1992-09-08 Hoffmann-La Roche Inc. Vitamin D3 analogs
US5104864A (en) * 1988-08-02 1992-04-14 Bone Care International, Inc. Method for treating and preventing loss of bone mass
US5547947A (en) * 1993-03-11 1996-08-20 Hoffmann-La Roche Inc. Methods of treatment
US5401733A (en) * 1993-10-01 1995-03-28 Hoffmann-La Roche Inc. Stable and active metabolites of 1,25-dihydroxy-16-ene-cholecalciferol
US5428029A (en) * 1993-11-24 1995-06-27 Hoffmann-La Roche Inc. Vitamin D3 fluorinated analogs
ZA95906B (en) * 1994-02-07 1996-08-06 Res Developments Foundation Non-viral vector
NO971934L (no) * 1996-05-23 1997-11-24 Hoffmann La Roche Flourinerte vitamin D3 -analoger
SG70009A1 (en) * 1996-05-23 2000-01-25 Hoffmann La Roche Vitamin d3 analogs

Also Published As

Publication number Publication date
WO1998051664A1 (en) 1998-11-19
AU7390398A (en) 1998-12-08
AU744471B2 (en) 2002-02-21
EP0981514A1 (de) 2000-03-01
US6017908A (en) 2000-01-25
JP2002506429A (ja) 2002-02-26
ATE322477T1 (de) 2006-04-15
CA2288710A1 (en) 1998-11-19
EP0981514B1 (de) 2006-04-05
DE69834109T2 (de) 2007-04-19

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee