DE69833059D1 - Verwendung von Botulinumtoxin zur Behandlung von Harninkontinenz - Google Patents

Verwendung von Botulinumtoxin zur Behandlung von Harninkontinenz

Info

Publication number
DE69833059D1
DE69833059D1 DE69833059T DE69833059T DE69833059D1 DE 69833059 D1 DE69833059 D1 DE 69833059D1 DE 69833059 T DE69833059 T DE 69833059T DE 69833059 T DE69833059 T DE 69833059T DE 69833059 D1 DE69833059 D1 DE 69833059D1
Authority
DE
Germany
Prior art keywords
botulinum toxin
treatment
urinary incontinence
neurogenic bladder
patient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69833059T
Other languages
English (en)
Other versions
DE69833059T3 (de
DE69833059T2 (de
Inventor
Richard A Schmidt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Colorado Boulder
University of Colorado
Original Assignee
University of Colorado Boulder
University of Colorado
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21978526&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69833059(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by University of Colorado Boulder, University of Colorado filed Critical University of Colorado Boulder
Publication of DE69833059D1 publication Critical patent/DE69833059D1/de
Application granted granted Critical
Publication of DE69833059T2 publication Critical patent/DE69833059T2/de
Publication of DE69833059T3 publication Critical patent/DE69833059T3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
    • A61K38/4893—Botulinum neurotoxin (3.4.24.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/529—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
DE69833059.5T 1997-07-15 1998-07-15 Verwendung von Botulinumtoxin zur Behandlung von Harninkontinenz Expired - Lifetime DE69833059T3 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5258097P 1997-07-15 1997-07-15
US52580P 1997-07-15
EP04019371.6A EP1475099B2 (de) 1997-07-15 1998-07-15 Verwendung von Botulinumtoxin zur Behandlung von Harninkontinenz

Publications (3)

Publication Number Publication Date
DE69833059D1 true DE69833059D1 (de) 2006-02-02
DE69833059T2 DE69833059T2 (de) 2006-08-03
DE69833059T3 DE69833059T3 (de) 2014-12-18

Family

ID=21978526

Family Applications (4)

Application Number Title Priority Date Filing Date
DE69833942T Expired - Lifetime DE69833942T3 (de) 1997-07-15 1998-07-15 Verwendung einer neurotoxintherapie zur behandlung von prostataerkrankungen
DE69841291T Expired - Lifetime DE69841291D1 (de) 1997-07-15 1998-07-15 Verwendung von Botulinumtoxin zur Behandlung der renitenten Blasenentleerungsstörung
DE69835911T Expired - Lifetime DE69835911T3 (de) 1997-07-15 1998-07-15 Verwendung einer Neurotoxintherapie zur Behandlung der Harnverhaltung
DE69833059.5T Expired - Lifetime DE69833059T3 (de) 1997-07-15 1998-07-15 Verwendung von Botulinumtoxin zur Behandlung von Harninkontinenz

Family Applications Before (3)

Application Number Title Priority Date Filing Date
DE69833942T Expired - Lifetime DE69833942T3 (de) 1997-07-15 1998-07-15 Verwendung einer neurotoxintherapie zur behandlung von prostataerkrankungen
DE69841291T Expired - Lifetime DE69841291D1 (de) 1997-07-15 1998-07-15 Verwendung von Botulinumtoxin zur Behandlung der renitenten Blasenentleerungsstörung
DE69835911T Expired - Lifetime DE69835911T3 (de) 1997-07-15 1998-07-15 Verwendung einer Neurotoxintherapie zur Behandlung der Harnverhaltung

Country Status (16)

Country Link
US (5) US6365164B1 (de)
EP (8) EP2145629B1 (de)
JP (9) JP3692033B2 (de)
KR (1) KR100544060B1 (de)
CN (5) CN1803189B (de)
AT (5) ATE339220T1 (de)
AU (2) AU743085B2 (de)
CA (5) CA2505933C (de)
CY (3) CY1105816T1 (de)
DE (4) DE69833942T3 (de)
DK (6) DK1475099T4 (de)
ES (6) ES2256945T5 (de)
HK (4) HK1080377A1 (de)
LU (2) LU92055I2 (de)
PT (5) PT1658858E (de)
WO (1) WO1999003483A1 (de)

Families Citing this family (139)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7470431B2 (en) 1997-07-15 2008-12-30 The Regents Of The University Of Colorado Use of neurotoxin therapy for treatment of urological-neurological disorders associated with prostate cancer
US9066943B2 (en) * 1997-07-15 2015-06-30 The Regents Of The University Of Colorado Use of botulinum toxin therapy for treatment of urological neurological conditions
CA2505933C (en) 1997-07-15 2008-09-30 Richard A. Schmidt Use of botulinum toxin for treating urinary incontinence
US7455845B2 (en) 1997-07-15 2008-11-25 The Regents Of The University Of Colorado Use of neurotoxin therapy for treatment of urologic and related disorders related to lowering elevated bladder pressure
US7449192B2 (en) 1997-07-15 2008-11-11 The Regents Of The University Of Colorado Use of neurotoxin therapy for treatment of urologic and related disorders related to neurogenic bladder dysfunction
CA2366815C (en) * 1999-04-01 2004-03-02 Heeling Sports Limited Heeling apparatus and method
DE19925739A1 (de) * 1999-06-07 2000-12-21 Biotecon Ges Fuer Biotechnologische Entwicklung & Consulting Mbh Therapeutikum mit einem Botulinum-Neurotoxin
US7838008B2 (en) * 1999-12-07 2010-11-23 Allergan, Inc. Methods for treating diverse cancers
US7838007B2 (en) * 1999-12-07 2010-11-23 Allergan, Inc. Methods for treating mammary gland disorders
US6358513B1 (en) 2000-02-15 2002-03-19 Allergan Sales, Inc. Method for treating Hashimoto's thyroiditis
US6821520B2 (en) 2000-02-15 2004-11-23 Allergan, Inc. Clostridial toxin therapy for Hashimoto's thyroiditis
US6773711B2 (en) 2000-02-15 2004-08-10 Allergan, Inc. Botulinum toxin therapy for Hashimoto's thyroiditis
US6524580B1 (en) 2000-02-15 2003-02-25 Allergan Sales, Inc. Method for treating thyroid disorders
US20050214327A1 (en) * 2000-06-02 2005-09-29 Allergan, Inc. Neurotoxin-containing suppositories and related methods
US20040170665A1 (en) * 2000-06-02 2004-09-02 Allergan, Inc. Intravitreal botulinum toxin implant
US20040033241A1 (en) * 2000-06-02 2004-02-19 Allergan, Inc. Controlled release botulinum toxin system
US6306403B1 (en) * 2000-06-14 2001-10-23 Allergan Sales, Inc. Method for treating parkinson's disease with a botulinum toxin
US7491799B2 (en) * 2000-07-21 2009-02-17 Allergan, Inc. Modified botulinum neurotoxins
US20040219619A1 (en) * 2000-07-21 2004-11-04 Ester Fernandez-Salas Methods of identifying compounds that alter toxin persistence and/or protease activity
US7691983B2 (en) * 2000-07-21 2010-04-06 Allergan, Inc. Chimera botulinum toxin type E
US6903187B1 (en) * 2000-07-21 2005-06-07 Allergan, Inc. Leucine-based motif and clostridial neurotoxins
GB0029125D0 (en) * 2000-11-29 2001-01-10 Specialistkliniken I Varberg H Novel treatment
JP4707254B2 (ja) * 2001-04-24 2011-06-22 クミアイ化学工業株式会社 粒状組成物及びその製造方法
ES2359719T3 (es) * 2001-07-10 2011-05-26 Astellas Pharma Inc. Composición farmacéutica comprendiendo quinuclidin-3'-il 1-fenil-1,2,3,4-tetrahidroisoquinolin-2-carboxilato para el tratamiento de la cistitis instersticial y/o la prostatitis no bacteriana.
US6984375B2 (en) * 2001-08-03 2006-01-10 Allergan, Inc. Nuclei density and nuclei area methods for determining effects of a botulinum toxin on muscles
US8110217B2 (en) * 2001-08-13 2012-02-07 University Of Pittsburgh Sphingomyelin liposomes for the treatment of hyperactive bladder disorders
US20100104631A1 (en) * 2001-08-13 2010-04-29 Lipella Pharmaceuticals Inc. Method of treatment for bladder dysfunction
WO2003015698A2 (en) * 2001-08-13 2003-02-27 University Of Pittsburgh Application of lipid vehicles and use for drug delivery
US6623742B2 (en) 2001-09-17 2003-09-23 Allergan, Inc. Methods for treating fibromyalgia
US7255866B2 (en) 2001-09-17 2007-08-14 Allergan, Inc. Botulinum toxin therapy for fibromyalgia
ES2401570T3 (es) 2001-11-15 2013-04-22 Phytotox Limited Composiciones farmacéuticas que contienen 3,4-propinoperhidropurinas y usos de las mismas para bloquear la transmisión neuronal
US7763663B2 (en) * 2001-12-19 2010-07-27 University Of Massachusetts Polysaccharide-containing block copolymer particles and uses thereof
US6688311B2 (en) 2002-03-14 2004-02-10 Allergan, Inc. Method for determining effect of a clostridial toxin upon a muscle
US7140371B2 (en) 2002-03-14 2006-11-28 Allergan, Inc. Surface topography method for determining effects of a botulinum toxin upon a muscle and for comparing botulinum toxins
US7691394B2 (en) * 2002-05-28 2010-04-06 Botulinum Toxin Research Associates, Inc. High-potency botulinum toxin formulations
US6776991B2 (en) * 2002-06-26 2004-08-17 Allergan, Inc. Methods for treating priapism
AU2003259246A1 (en) * 2002-07-29 2004-02-16 Rajiv Doshi Methods for the use of neurotoxin in the treatment of urologic disorders
US20040086532A1 (en) * 2002-11-05 2004-05-06 Allergan, Inc., Botulinum toxin formulations for oral administration
US7238357B2 (en) * 2002-11-05 2007-07-03 Allergan, Inc. Methods for treating ulcers and gastroesophageal reflux disease
GB2398636A (en) * 2003-02-21 2004-08-25 Ipsen Ltd Method for determining the quantity of pre-synaptic neuromuscular blocking substance contained in a sample
US8071550B2 (en) * 2003-03-03 2011-12-06 Allergan, Inc. Methods for treating uterine disorders
KR20050109969A (ko) * 2003-03-06 2005-11-22 보툴리늄 톡신 리서치 어쏘시에이츠, 인크. 보툴리눔 톡신으로 부비동염 관련 만성 안면통 및 두통을치료하는 방법
MXPA05009424A (es) * 2003-03-06 2006-02-10 Botulinum Toxin Res Ass Inc Tratamiento de chalazion cronico y hordeolum con la toxina botulinica.
US7396535B2 (en) * 2003-04-25 2008-07-08 Ackerman Alan H Therapy for obsessive compulsive head banging
US7390496B2 (en) * 2003-04-25 2008-06-24 Allergan, Inc. Therapeutic treatments for repetitive hand washing
US7393538B2 (en) * 2003-04-25 2008-07-01 Ackerman Alan H Clostridial toxin treatment for dermatillomania
US7422753B2 (en) * 2003-04-25 2008-09-09 Allergan, Inc. Methods for treating trichotillomania
US7393537B2 (en) * 2003-04-25 2008-07-01 Allergan, Inc. Botulinum toxin for treatment of obsessive compulsive finger biting disorder
US6838434B2 (en) * 2003-05-02 2005-01-04 Allergan, Inc. Methods for treating sinus headache
US7220422B2 (en) * 2003-05-20 2007-05-22 Allergan, Inc. Methods and compositions for treating eye disorders
US20040253274A1 (en) * 2003-06-11 2004-12-16 Allergan, Inc. Use of a clostridial toxin to reduce appetite
US20050013850A1 (en) * 2003-07-15 2005-01-20 Caers Jan K. Device to assist hyperhydrosis therapy
US8734810B2 (en) 2003-10-29 2014-05-27 Allergan, Inc. Botulinum toxin treatments of neurological and neuropsychiatric disorders
US8617572B2 (en) 2003-10-29 2013-12-31 Allergan, Inc. Botulinum toxin treatments of depression
US8609112B2 (en) 2003-10-29 2013-12-17 Allergan, Inc. Botulinum toxin treatments of depression
US8609113B2 (en) 2003-10-29 2013-12-17 Allergan, Inc. Botulinum toxin treatments of depression
US20050096629A1 (en) * 2003-10-31 2005-05-05 Medtronic, Inc. Techniques for transurethral delivery of a denervating agent to the prostate gland
US20050096549A1 (en) * 2003-10-31 2005-05-05 Medtronic, Inc. Techniques for transperineal delivery of a denervating agent to the prostate gland
US20050096550A1 (en) * 2003-10-31 2005-05-05 Medtronic, Inc. Techniques for transrectal delivery of a denervating agent to the prostate gland
US7437194B2 (en) * 2003-10-31 2008-10-14 Medtronic, Inc. Stimulating the prostate gland
US7172764B2 (en) * 2003-11-17 2007-02-06 Allergan, Inc. Rescue agents for treating botulinum toxin intoxications
GB0328060D0 (en) * 2003-12-04 2004-01-07 Sod Conseils Rech Applic Botulinum toxin treatment
US20050129677A1 (en) * 2003-12-10 2005-06-16 Shengwen Li Lipid rafts and clostridial toxins
US20050148935A1 (en) * 2003-12-29 2005-07-07 Rozalina Dimitrova Botulinum toxin injection guide
US9211248B2 (en) 2004-03-03 2015-12-15 Revance Therapeutics, Inc. Compositions and methods for topical application and transdermal delivery of botulinum toxins
AU2005244096B2 (en) * 2004-05-07 2011-03-17 Algenis Spa Transdermal administration of phycotoxins
MXPA06012962A (es) * 2004-05-07 2007-06-12 Phytotox Ltd Metodos para el tratamiento de heridas con gonyautoxinas.
US8173797B2 (en) * 2004-07-21 2012-05-08 Cornell Research Foundation, Inc. Therapeutic compounds derived from spider venom and their method of use
US20060024794A1 (en) * 2004-07-30 2006-02-02 Shengwen Li Novel methods for production of di-chain botulinum toxin
ES2526912T3 (es) * 2004-08-04 2015-01-16 Ipsen Biopharm Limited Composición farmacéutica que contiene neurotoxina botulínica A2
ES2526913T3 (es) 2004-08-04 2015-01-16 Ipsen Biopharm Limited Composición farmacéutica que contiene neurotoxina 2 botulínica
US7179474B2 (en) * 2004-09-03 2007-02-20 Allergan, Inc. Methods for treating a buttock deformity
US7429386B2 (en) 2004-09-03 2008-09-30 Allergan, Inc. Stretch mark treatment
US7727537B2 (en) 2005-02-14 2010-06-01 Dpm Therapeutics Corp. Stabilized compositions for topical administration and methods of making same
DK1853623T3 (da) 2005-03-03 2013-07-15 Allergan Inc Dyreprodukt-frit system og fremgangsmåde til oprensning af et botulinumtoksin
US7419675B2 (en) * 2005-05-26 2008-09-02 Allergan, Inc. Method for treating peritoneal adhesions
CA2610885A1 (en) * 2005-06-07 2006-12-14 David R. Staskin Injection guidance system and method
US20070038089A1 (en) * 2005-06-29 2007-02-15 Olympus Medical Systems Corp. Transurethral diagnostic method and treatment method using ultrasonic endoscope
JP5368793B2 (ja) 2005-07-18 2013-12-18 ユニバーシティ オブ マサチューセッツ ロウエル ナノエマルジョンを製造および使用するための組成物および方法
US7910116B2 (en) * 2005-08-24 2011-03-22 Allergan, Inc. Use of a botulinum toxin to improve gastric emptying and/or to treat GERD
EP1933813A4 (de) * 2005-10-11 2013-02-27 Univ Pittsburgh Sphingomyelin-liposome zur behandlung von hyperaktiven blasenstörungen
JP2009518307A (ja) 2005-12-01 2009-05-07 ユニバーシティ オブ マサチューセッツ ロウエル ボツリヌス菌ナノエマルジョン
US9486408B2 (en) 2005-12-01 2016-11-08 University Of Massachusetts Lowell Botulinum nanoemulsions
US20090312696A1 (en) * 2005-12-28 2009-12-17 Copa Vincent G Devices, Systems, and Related Methods for Delivery of Fluid to Tissue
WO2007106874A2 (en) * 2006-03-14 2007-09-20 Autocraft Industries, Inc. Improved wheelchair
US7794386B2 (en) 2006-03-15 2010-09-14 Allergan, Inc. Methods for facilitating weight loss
US7811586B2 (en) * 2006-05-02 2010-10-12 Allergan, Inc. Methods for alleviating testicular pain
WO2008030638A2 (en) * 2006-05-16 2008-03-13 Mayo Foundation For Medical Education And Research Use of dmso and botulinum toxin therapy for urinary incontinence and related disorders
AR061669A1 (es) 2006-06-29 2008-09-10 Merz Pharma Gmbh & Co Kgaa Aplicacion de alta frecuencia de terapia con toxina botulinica
US10792344B2 (en) 2006-06-29 2020-10-06 Merz Pharma Gmbh & Co. Kgaa High frequency application of botulinum toxin therapy
US20080092910A1 (en) * 2006-10-18 2008-04-24 Allergan, Inc. Apparatus and method for treating obesity using neurotoxins in conjunction with bariatric procedures
US20080113051A1 (en) * 2006-11-13 2008-05-15 Allergan, Inc. Methods for alleviating tattoo pain
SG177184A1 (en) * 2006-12-01 2012-01-30 Anterios Inc Amphiphilic entity nanoparticles
EP2091516A2 (de) * 2006-12-01 2009-08-26 Anterios, Inc. Peptid-nanopartikel und verwendungen davon
EP2117584B1 (de) 2007-02-15 2013-10-09 Allergan, Inc. Verwendung von botulinumtoxin und enzymen zur behandlung von blasenleiden
KR20100050443A (ko) 2007-05-31 2010-05-13 안테리오스, 인코퍼레이티드 핵산 나노입자 및 이의 용도
KR20100087019A (ko) 2007-10-23 2010-08-02 알러간, 인코포레이티드 변형 클로스트리듐 독소를 사용한 비뇨생식기-신경학적 질환의 치료 방법
US8470337B2 (en) * 2008-03-13 2013-06-25 Allergan, Inc. Therapeutic treatments using botulinum neurotoxin
SG10201608732VA (en) * 2008-06-26 2016-12-29 Anterios Inc Dermal delivery
EP2364168A1 (de) 2008-12-04 2011-09-14 Botulinum Toxin Research Associates, Inc. Verlängerte botulinustoxin-formulierung zur anwendung bei menschen oder säugetieren
EP2376104A4 (de) * 2008-12-15 2014-09-10 Protox Therapeutics Inc Verfahren zur behandlung von prostatitis anhand von modifiziertem porenformendem protein-proaerolysin
US20100166739A1 (en) * 2008-12-30 2010-07-01 Lipella Paharmaceuticals Inc. Methods and Compositions for Diagnosing Urological Disorders
US8133491B1 (en) 2009-01-30 2012-03-13 The University Of Toledo Compositions and methods for treatment of hyperplastic disorders
EP2403522B1 (de) 2009-03-06 2015-12-16 Allergan, Inc. Clostridium-toxin zur verbesserung des ejakulats
US20100303791A1 (en) * 2009-05-29 2010-12-02 Allergan, Inc. Methods of Treating Chronic Neurogenic Inflammation Using Glucagon Like Hormone Retargeted Endopepidases
US20100303798A1 (en) * 2009-05-29 2010-12-02 Allergan, Inc. Methods of Treating Urogenital-Neurological Disorders Using Neurotrophin Retargeted Endopepidases
US20100303789A1 (en) * 2009-05-29 2010-12-02 Allergan, Inc. Methods of Treating Chronic Neurogenic Inflammation Using Neurotrophin Retargeted Endopepidases
US8198229B2 (en) 2009-05-29 2012-06-12 Allergan, Inc. Methods of treating urogenital-neurological disorders using galanin retargeted endopepidases
US20100303788A1 (en) * 2009-05-29 2010-12-02 Allergan, Inc. Methods of Treating Chronic Neurogenic Inflammation Using Galanin Retargeted Endopepidases
US20100303794A1 (en) * 2009-05-29 2010-12-02 Allergan, Inc. Methods of Treating Urogenital-Neurological Disorders Using Glucagon Like Hormone Retargeted Endopepidases
US20100303756A1 (en) * 2009-05-29 2010-12-02 Allergan, Inc. Methods of Treating Urogenital-Neurological Disorders Using Interleukin Retargeted Endopepidases
US20100303783A1 (en) * 2009-05-29 2010-12-02 Allergan, Inc. Methods of Treating Urogenital-Neurological Disorders Using Tachykinin Retargeted Endopepidases
US8147848B2 (en) 2009-08-26 2012-04-03 Allergan, Inc. Method for treating premature ejaculation with a botulinum neurotoxin
US9125907B2 (en) 2009-09-30 2015-09-08 Christopher Shaari Use of botulinum neurotoxin to treat substance addictions
WO2012024269A2 (en) 2010-08-18 2012-02-23 Medtronic, Inc. Urgency therapy with neuromodulation and c-afferent nerve desensitization
EP2672958A1 (de) 2011-02-08 2013-12-18 Halozyme, Inc. Zusammensetzung und lipidformulierung eines hyaluronan-abbauenden enzym und seine verwendung zur behandlung von benigner prostatahyperplasie
WO2012112426A1 (en) * 2011-02-14 2012-08-23 Allergan, Inc. Arginine vasopressin retargeted clostridial endopeptidases for use in treating benign prostatic hyperplasia
US8992941B2 (en) 2011-07-08 2015-03-31 Allergan, Inc. Method for treatment of esophageal spasm
CA2841139C (en) 2011-07-08 2017-01-17 Allergan, Inc. Method for treatment of autonomic nervous system disorders
JP6092205B2 (ja) 2011-07-14 2017-03-08 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ 性的行為に関連した失禁の治療方法
MX2014000612A (es) 2011-07-20 2014-02-27 Allergan Inc Toxinas botulinicas para usar en un metodo para el tratamiento de depositos adiposos.
US20130171122A1 (en) * 2011-12-29 2013-07-04 Allergan, Inc. Endopeptidase and neurotoxin combination treatment of bladder disorders
EP2836200B1 (de) * 2012-04-08 2020-07-15 Urogen Pharma Ltd. Thermoreversible hydrogelpräparate zur behandlung von erkrankungen des urothels
US9393291B2 (en) 2012-04-12 2016-07-19 Botulinum Toxin Research Associates, Inc. Use of botulinum toxin for the treatment of cerebrovascular disease, renovascular and retinovascular circulatory beds
US10149893B2 (en) 2013-09-24 2018-12-11 Allergan, Inc. Methods for modifying progression of osteoarthritis
US9901627B2 (en) 2014-07-18 2018-02-27 Revance Therapeutics, Inc. Topical ocular preparation of botulinum toxin for use in ocular surface disease
US11484580B2 (en) 2014-07-18 2022-11-01 Revance Therapeutics, Inc. Topical ocular preparation of botulinum toxin for use in ocular surface disease
WO2016124532A1 (en) * 2015-02-03 2016-08-11 Höganäs Ab (Publ) Powder metal composition for easy machining
MA45492A (fr) 2016-06-23 2019-05-01 Hopitaux Paris Assist Publique Vecteurs viraux pour le traitement de l'hyperactivité vésicale neurogène
WO2018038301A1 (en) 2016-08-26 2018-03-01 Hugel Inc. Stabilized liquid formulation of botulinum toxin and preparation method thereof
TW202247855A (zh) 2016-09-13 2022-12-16 美商愛力根公司 非蛋白梭菌毒素組成物
CA3044219A1 (en) 2016-11-21 2018-05-24 Eirion Therapeutics, Inc. Transdermal delivery of large agents
EP3470054B1 (de) 2017-10-11 2023-09-20 Hugel Inc. Mikrostrukturformulierungstechniken für botulinumtoxin
US10792400B2 (en) 2017-10-12 2020-10-06 Hugel Inc. Microstructure formulation techniques for botulinum toxin
US10525111B2 (en) 2017-10-12 2020-01-07 Hugel, Inc. Microstructure formulation techniques for botulinum toxin
RU2687106C1 (ru) * 2017-12-19 2019-05-07 Федеральное государственное бюджетное образовательное учреждение высшего образования "Волгоградский государственный медицинский университет" Министерства здравоохранения Российской Федерации ФГБОУ ВО ВолгГМУ МЗ РФ Способ лечения синдрома гиперактивного мочевого пузыря
EP3825689A3 (de) 2018-11-29 2021-09-15 Hugel Inc. Zellbasiertes verfahren zur bestimmung der aktivität von botulinumtoxin
CN110935009B (zh) * 2019-12-24 2023-07-11 云南南诏药业有限公司 科博肽制剂在制备治疗痔疮药物中的应用
RU2768606C1 (ru) * 2021-04-16 2022-03-24 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр колопроктологии имени А.Н. Рыжих" Министерства здравоохранения Российской Федерации Способ комбинированного хирургического лечения хронической анальной трещины со спазмом сфинктера методом иссечения трещины в сочетании с инъекцией ботулинического токсина типа А в дозировке 40 ЕД во внутренний анальный сфинктер под ультразвуковой навигацией

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4932936A (en) † 1988-01-29 1990-06-12 Regents Of The University Of Minnesota Method and device for pharmacological control of spasticity
JPH0642950Y2 (ja) * 1988-10-15 1994-11-09 株式会社マイコー ケース固定装置
US5919665A (en) * 1989-10-31 1999-07-06 Ophidian Pharmaceuticals, Inc. Vaccine for clostridium botulinum neurotoxin
US5183462A (en) * 1990-08-21 1993-02-02 Associated Synapse Biologics Controlled administration of chemodenervating pharmaceuticals
US5192751A (en) 1992-07-24 1993-03-09 Eli Lilly And Company Use of competitive NMDA receptor antagonists in the treatment of urinary incontinence
EP0702559B1 (de) 1993-06-10 2003-03-19 Allergan, Inc. Multiple Botulinum Toxine zur Behandlung von neuromuskulären Störungen und Zuständen
US5437291A (en) 1993-08-26 1995-08-01 Univ Johns Hopkins Method for treating gastrointestinal muscle disorders and other smooth muscle dysfunction
EP1421948B1 (de) 1993-12-28 2008-10-08 Allergan, Inc. Verwendung von Botulinum Toxine gegen Schwitzen bei Menschen
GB9508204D0 (en) * 1995-04-21 1995-06-07 Speywood Lab Ltd A novel agent able to modify peripheral afferent function
US5837265A (en) * 1996-03-08 1998-11-17 The Regents Of The University Of California Chemically-modified clostridiatoxin with improved properties
US5939070A (en) * 1996-10-28 1999-08-17 Wisconsin Alumni Research Foundation Hybrid botulinal neurotoxins
CA2505933C (en) * 1997-07-15 2008-09-30 Richard A. Schmidt Use of botulinum toxin for treating urinary incontinence
US7449192B2 (en) * 1997-07-15 2008-11-11 The Regents Of The University Of Colorado Use of neurotoxin therapy for treatment of urologic and related disorders related to neurogenic bladder dysfunction
US7470431B2 (en) * 1997-07-15 2008-12-30 The Regents Of The University Of Colorado Use of neurotoxin therapy for treatment of urological-neurological disorders associated with prostate cancer
US9066943B2 (en) 1997-07-15 2015-06-30 The Regents Of The University Of Colorado Use of botulinum toxin therapy for treatment of urological neurological conditions
US7455845B2 (en) * 1997-07-15 2008-11-25 The Regents Of The University Of Colorado Use of neurotoxin therapy for treatment of urologic and related disorders related to lowering elevated bladder pressure
JP3655061B2 (ja) * 1997-07-31 2005-06-02 株式会社ニデック 紫外線吸収性基材
JP2000214813A (ja) * 1999-01-22 2000-08-04 Mercury Enterprise:Kk 二輪及び三輪車輌・トラック・四輪車両へ搭載可能な可動式省エネ広告塔
US6306423B1 (en) * 2000-06-02 2001-10-23 Allergan Sales, Inc. Neurotoxin implant
JP2002132198A (ja) * 2000-10-25 2002-05-09 Sukenori Kiuchi 三輪自転車一体型移動式回転広告塔
JP2002306290A (ja) * 2001-04-19 2002-10-22 Takumi:Kk ターンテーブル
JP2007037725A (ja) * 2005-08-02 2007-02-15 Masahiro Matsubara 多機能立方体展示ユニット
JP3121792U (ja) * 2005-10-28 2006-06-01 株式会社イマジンクリエイション ラック付３ｄレンズ使用立体型看板

Also Published As

Publication number Publication date
AU8300798A (en) 1999-02-10
DK1658858T3 (da) 2010-04-06
DK1502601T3 (da) 2007-01-15
HK1119396A1 (en) 2009-03-06
EP1949909A1 (de) 2008-07-30
EP1475099B1 (de) 2005-12-28
JP4672676B2 (ja) 2011-04-20
CN1803189B (zh) 2010-05-26
JP3692033B2 (ja) 2005-09-07
EP1011695B2 (de) 2009-11-04
ES2450747T3 (es) 2014-03-25
JP2008208136A (ja) 2008-09-11
CA2570406C (en) 2012-02-14
ES2268567T3 (es) 2007-03-16
DE69833059T3 (de) 2014-12-18
JP4815468B2 (ja) 2011-11-16
DE69833942T2 (de) 2006-09-07
EP1011695A4 (de) 2004-05-26
US7001602B2 (en) 2006-02-21
WO1999003483A1 (en) 1999-01-28
DK1658858T4 (da) 2014-04-07
PT2145629E (pt) 2012-04-16
JP4696082B2 (ja) 2011-06-08
CA2505930C (en) 2008-01-29
ES2255025T5 (es) 2014-06-16
CN1651074A (zh) 2005-08-10
CN1135988C (zh) 2004-01-28
ATE320815T1 (de) 2006-04-15
EP1475099A1 (de) 2004-11-10
EP1502601A1 (de) 2005-02-02
CN1321683C (zh) 2007-06-20
CN1480212A (zh) 2004-03-10
DK1475099T4 (da) 2014-05-19
EP2145629A3 (de) 2010-06-09
US20020025327A1 (en) 2002-02-28
CY1105816T1 (el) 2011-02-02
DE69833942T3 (de) 2010-06-10
JP5005753B2 (ja) 2012-08-22
HK1064044A1 (en) 2005-01-21
LU92055I2 (fr) 2013-10-10
AU2005234633B9 (en) 2009-09-03
JP2007126477A (ja) 2007-05-24
ATE448792T1 (de) 2009-12-15
CA2570406A1 (en) 1999-01-28
ES2336924T3 (es) 2010-04-19
CA2296720A1 (en) 1999-01-28
ATE552006T1 (de) 2012-04-15
HK1091750A1 (en) 2007-01-26
EP1475099B2 (de) 2014-04-09
EP2246066A1 (de) 2010-11-03
CA2505933C (en) 2008-09-30
DE69841291D1 (de) 2009-12-31
PT1011695E (pt) 2006-07-31
CN100518816C (zh) 2009-07-29
DK1949909T3 (en) 2014-03-24
EP2145629B1 (de) 2012-04-04
CA2296720C (en) 2008-01-29
EP2145629A2 (de) 2010-01-20
DE69835911T3 (de) 2011-01-13
ATE314085T1 (de) 2006-01-15
ES2385130T3 (es) 2012-07-18
EP1658858A3 (de) 2006-07-05
US7153514B2 (en) 2006-12-26
DE69835911D1 (de) 2006-10-26
US6667041B2 (en) 2003-12-23
PT1949909E (pt) 2014-03-11
US20040126380A1 (en) 2004-07-01
DE69833942D1 (de) 2006-05-11
DK1011695T4 (da) 2010-02-01
DK1011695T3 (da) 2006-05-01
CN1480212B (zh) 2013-12-04
AU743085B2 (en) 2002-01-17
AU2005234633B2 (en) 2007-04-19
PT1658858E (pt) 2010-02-26
ES2256945T5 (es) 2010-03-26
US20050159337A1 (en) 2005-07-21
DK1475099T3 (da) 2006-03-13
JP2001510163A (ja) 2001-07-31
EP1658858B1 (de) 2009-11-18
US6365164B1 (en) 2002-04-02
EP1502601B2 (de) 2010-07-21
HK1080377A1 (en) 2006-04-28
JP2005089479A (ja) 2005-04-07
KR20010021941A (ko) 2001-03-15
AU2005234633C1 (en) 2011-02-10
EP1637157A1 (de) 2006-03-22
EP1011695B1 (de) 2006-03-22
US7429387B2 (en) 2008-09-30
JP2005089478A (ja) 2005-04-07
CA2521392A1 (en) 1999-01-28
JP3955061B2 (ja) 2007-08-08
DK1502601T4 (da) 2010-11-08
CA2505930A1 (en) 1999-01-28
DE69833059T2 (de) 2006-08-03
JP2007091756A (ja) 2007-04-12
CN1939531A (zh) 2007-04-04
CN1270527A (zh) 2000-10-18
CN1803189A (zh) 2006-07-19
CY1109827T1 (el) 2014-09-10
JP4053559B2 (ja) 2008-02-27
EP1658858B2 (de) 2014-03-26
CA2505933A1 (en) 1999-01-28
ES2255025T3 (es) 2006-06-16
PT1502601E (pt) 2006-12-29
AU2005234633A1 (en) 2005-12-15
EP1949909B1 (de) 2014-01-08
US20040259788A1 (en) 2004-12-23
JP2010043127A (ja) 2010-02-25
EP1658858A2 (de) 2006-05-24
JP2006104221A (ja) 2006-04-20
DK2145629T3 (da) 2012-05-29
CY1113355T1 (el) 2016-06-22
ATE339220T1 (de) 2006-10-15
DE69835911T2 (de) 2007-01-11
ES2336924T5 (es) 2014-04-30
ES2268567T5 (es) 2010-11-02
EP1502601B1 (de) 2006-09-13
EP1011695A1 (de) 2000-06-28
ES2256945T3 (es) 2006-07-16
KR100544060B1 (ko) 2006-01-23
LU92250I2 (fr) 2013-09-10
JP2006063089A (ja) 2006-03-09

Similar Documents

Publication Publication Date Title
DE69833059D1 (de) Verwendung von Botulinumtoxin zur Behandlung von Harninkontinenz
WO2003063898A3 (en) Method of treating pain with botulinum toxin
ATE477816T1 (de) Botulinum toxin zur behandlung von akuten verletzungen der skelettmuskeln
ATE485825T1 (de) Therapeutische inhibitoren der zellen der glatten gefässmuskulatur
DE69210654T2 (de) Verwendung von Tomoxetine zur Behandlung von Funktionsstörungen der niedrigen Harnwege
DK0856312T3 (da) Anvendelse af trospiumchlorid til fremstilling af et lægemiddel til behandling af blæresygdomme
SE9202208D0 (sv) Vaevnadsfoerstaerkning
DE69625918D1 (de) Lang wirksames mittel zur rektalen verabreichung
ATE475429T1 (de) Behandlung der spastischen blase mit botulinustoxin
SU706090A1 (ru) Способ лечени контрактуры дюпюитрена
DE69904712D1 (de) Verwendung von deltorphin zur behandlung von zytokin-vermittelter leberschädigung
SU1171035A1 (ru) Способ лечени сифилиса
ATE322284T1 (de) Adrenomedullin zur behandlung von störungen des harnlassens
GB2402879A (en) Method of treating pain with botulinum toxin
RU2001103838A (ru) Способ лечения галактофорита
RU96109846A (ru) Способ профилактики генерализации септической инфекции в раннем послеродовом периоде
RU97102947A (ru) Способ лечения диффузного токсического зоба
MD996G2 (ro) Metodă de tratament a cistitei
RU96114051A (ru) Способ лечения экземы у травматолого-ортопедических больных с гнойной инфекцией