DE69831156T2 - Integrin-zielvektoren mit transfektionaktivität - Google Patents

Integrin-zielvektoren mit transfektionaktivität Download PDF

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Publication number
DE69831156T2
DE69831156T2 DE69831156T DE69831156T DE69831156T2 DE 69831156 T2 DE69831156 T2 DE 69831156T2 DE 69831156 T DE69831156 T DE 69831156T DE 69831156 T DE69831156 T DE 69831156T DE 69831156 T2 DE69831156 T2 DE 69831156T2
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DE
Germany
Prior art keywords
mixture
nucleic acid
complex
component
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69831156T
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German (de)
English (en)
Other versions
DE69831156D1 (de
Inventor
Lewis Stephen HART
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ICH Productions Ltd
Original Assignee
ICH Productions Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ICH Productions Ltd filed Critical ICH Productions Ltd
Publication of DE69831156D1 publication Critical patent/DE69831156D1/de
Application granted granted Critical
Publication of DE69831156T2 publication Critical patent/DE69831156T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906—Drug delivery
    • Y10S977/907—Liposome

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compression Or Coding Systems Of Tv Signals (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Electrotherapy Devices (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE69831156T 1997-05-29 1998-05-29 Integrin-zielvektoren mit transfektionaktivität Expired - Lifetime DE69831156T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9711115 1997-05-29
GBGB9711115.7A GB9711115D0 (en) 1997-05-29 1997-05-29 Integrin-targeting vectors having enhanced transfection activity
PCT/GB1998/001577 WO1998054347A1 (en) 1997-05-29 1998-05-29 Integrin-targeting vectors having transfection activity

Publications (2)

Publication Number Publication Date
DE69831156D1 DE69831156D1 (de) 2005-09-15
DE69831156T2 true DE69831156T2 (de) 2006-06-08

Family

ID=10813246

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69831156T Expired - Lifetime DE69831156T2 (de) 1997-05-29 1998-05-29 Integrin-zielvektoren mit transfektionaktivität

Country Status (9)

Country Link
US (2) US6458026B1 (https=)
EP (1) EP1003898B1 (https=)
JP (1) JP4293292B2 (https=)
AT (1) ATE301722T1 (https=)
AU (1) AU7667398A (https=)
CA (1) CA2288840A1 (https=)
DE (1) DE69831156T2 (https=)
GB (1) GB9711115D0 (https=)
WO (1) WO1998054347A1 (https=)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2405469C (en) 2000-04-12 2012-03-20 Amersham Health As Integrin binding peptide derivatives
AU2001260467A1 (en) * 2000-05-30 2001-12-11 Ich Productions Limited Integrin-targeting vectors having enhanced transfection activity
EP1178117A1 (en) * 2000-08-02 2002-02-06 Erasmus Universiteit Rotterdam Targeting through integrins
NO20004795D0 (no) 2000-09-26 2000-09-26 Nycomed Imaging As Peptidbaserte forbindelser
US8613907B2 (en) * 2000-10-12 2013-12-24 University Of Rochester Compositions that inhibit proliferation of cancer cells
GB0106315D0 (en) 2001-03-14 2001-05-02 Ich Productions Ltd Transfection complexes
RU2294192C2 (ru) * 2001-05-30 2007-02-27 Дзе Скриппс Рисерч Инститьют Система доставки нуклеиновых кислот
BRPI0210886B8 (pt) 2001-07-10 2021-05-25 Amersham Health As composto, composição farmacêutica, uso de um composto, e, métodos de geração de imagens, de monitoração do efeito do tratamento de um corpo humano ou animal com uma droga para combater uma condição associada com câncer e de tratamento de câncer ou de uma doença relacionada em um corpo humano ou animal
US7598421B2 (en) 2002-05-08 2009-10-06 Ucl Biomedica Plc Materials for the delivery of biologically-active material to cells
GB0210538D0 (en) * 2002-05-08 2002-06-19 Univ London Lipids and gene delivery
AU2004233873B2 (en) * 2003-04-25 2010-11-18 The Penn State Research Foundation Method and system for systemic delivery of growth arresting, lipid-derived bioactive compounds
GB0313132D0 (en) * 2003-06-06 2003-07-09 Ich Productions Ltd Peptide ligands
US20090123468A1 (en) 2003-10-24 2009-05-14 Gencia Corporation Transducible polypeptides for modifying metabolism
US8507277B2 (en) 2003-10-24 2013-08-13 Gencia Corporation Nonviral vectors for delivering polynucleotides
US8062891B2 (en) 2003-10-24 2011-11-22 Gencia Corporation Nonviral vectors for delivering polynucleotides to plants
CA2543257C (en) 2003-10-24 2013-12-31 Gencia Corporation Methods and compositions for delivering polynucleotides
US8133733B2 (en) 2003-10-24 2012-03-13 Gencia Corporation Nonviral vectors for delivering polynucleotides to target tissues
WO2007089871A2 (en) * 2006-02-01 2007-08-09 The Johns Hopkins University Polypeptide-nucleic acid conjugate for immunoprophylaxis or immunotherapy for neoplastic or infectious disorders
US10034674B2 (en) * 2006-02-02 2018-07-31 Steven C Chudik Universal anterior cruciate ligament repair and reconstruction system
GB0610636D0 (en) * 2006-05-30 2006-07-05 Univ London Materials and complexes for the delivery of biologically-active material to cells
RU2010107199A (ru) * 2007-07-31 2011-09-10 Дзе Джонс Хопкинс Юниверсити (Us) Конъюгат полипептид-нуклеиновая кислота для иммунопрофилактики или иммунотерапии для неопластических или инфекционных нарушений
KR101863136B1 (ko) 2008-01-24 2018-05-31 에스퍼란스 파마슈티컬스, 인코포레이티드 용해 도메인 융합 구성물 및 이를 제조하고 사용하는 방법
US20110256055A1 (en) 2008-12-23 2011-10-20 Ge Healthcare Limited Application of 99mtc peptide-based compound as a bone marrow imaging agent
CN118271422A (zh) 2015-08-28 2024-07-02 分子传递有限公司 转染络合物和其使用方法
EP3423438A4 (en) 2016-03-01 2020-05-06 Molecular Transfer, Inc. PLANT VIRUS MOTOR PROTEINS AND METHOD FOR USE THEREOF
GB201604235D0 (en) 2016-03-11 2016-04-27 Ucl Business Plc Lipids and complexes for the delivery of biologically-active material to cells
GB201803419D0 (en) * 2018-03-02 2018-04-18 Ucl Business Plc Complex for the delivery of cas9 proteins guide RNA to cells

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5981478A (en) 1993-11-24 1999-11-09 La Jolla Cancer Research Foundation Integrin-binding peptides
AU3876695A (en) 1994-11-17 1996-06-17 Imperial College Of Science, Technology And Medicine Internalisation of dna, using conjugates of poly-l-lysine and an integrin receptor ligand
EP0874910A4 (en) 1995-06-07 1999-04-21 Life Technologies Inc ENHANCED CATIONIC LIPID TRANSFECTION BY PEPTIDES
US5908777A (en) 1995-06-23 1999-06-01 University Of Pittsburgh Lipidic vector for nucleic acid delivery

Also Published As

Publication number Publication date
EP1003898A1 (en) 2000-05-31
US20020042384A1 (en) 2002-04-11
US20030013644A1 (en) 2003-01-16
AU7667398A (en) 1998-12-30
DE69831156D1 (de) 2005-09-15
ATE301722T1 (de) 2005-08-15
EP1003898B1 (en) 2005-08-10
JP2002502243A (ja) 2002-01-22
GB9711115D0 (en) 1997-07-23
JP4293292B2 (ja) 2009-07-08
CA2288840A1 (en) 1998-12-03
WO1998054347A1 (en) 1998-12-03
US6458026B1 (en) 2002-10-01

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