DE69829655T3 - Biofunktionelle polymere im überkritischem fluid hergestellt - Google Patents

Biofunktionelle polymere im überkritischem fluid hergestellt Download PDF

Info

Publication number
DE69829655T3
DE69829655T3 DE69829655T DE69829655T DE69829655T3 DE 69829655 T3 DE69829655 T3 DE 69829655T3 DE 69829655 T DE69829655 T DE 69829655T DE 69829655 T DE69829655 T DE 69829655T DE 69829655 T3 DE69829655 T3 DE 69829655T3
Authority
DE
Germany
Prior art keywords
polymer
biofunctional
supercritical
substrate
fluid medium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69829655T
Other languages
German (de)
English (en)
Other versions
DE69829655T2 (de
DE69829655D1 (de
Inventor
Melvyn Steven HOWDLE
Vladimir Popov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Nottingham
Original Assignee
University of Nottingham
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26311517&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69829655(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9709561.6A external-priority patent/GB9709561D0/en
Application filed by University of Nottingham filed Critical University of Nottingham
Application granted granted Critical
Publication of DE69829655D1 publication Critical patent/DE69829655D1/de
Publication of DE69829655T2 publication Critical patent/DE69829655T2/de
Publication of DE69829655T3 publication Critical patent/DE69829655T3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D3/00—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials
    • B05D3/04—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by exposure to gases
    • B05D3/0433—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by exposure to gases the gas being a reactive gas
    • B05D3/044—Pretreatment
    • B05D3/0446—Pretreatment of a polymeric substrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/831—Preparations for artificial teeth, for filling teeth or for capping teeth comprising non-metallic elements or compounds thereof, e.g. carbon
    • A61K6/838—Phosphorus compounds, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/884—Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/884—Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
    • A61K6/887—Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/884—Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
    • A61K6/891—Compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D7/00—Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials
    • B05D7/02—Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials to macromolecular substances, e.g. rubber
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D2401/00—Form of the coating product, e.g. solution, water dispersion, powders or the like
    • B05D2401/90—Form of the coating product, e.g. solution, water dispersion, powders or the like at least one component of the composition being in supercritical state or close to supercritical state

Landscapes

  • Health & Medical Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Plastic & Reconstructive Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Composite Materials (AREA)
  • Wood Science & Technology (AREA)
  • Materials Engineering (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Cosmetics (AREA)
  • Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
DE69829655T 1997-05-10 1998-05-06 Biofunktionelle polymere im überkritischem fluid hergestellt Expired - Lifetime DE69829655T3 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB9709561.6A GB9709561D0 (en) 1997-05-10 1997-05-10 Biocompatible polymers
GB9709561 1997-05-10
GB9800936 1998-01-19
GBGB9800936.8A GB9800936D0 (en) 1997-05-10 1998-01-19 Biofunctional polymers
PCT/GB1998/001325 WO1998051347A1 (en) 1997-05-10 1998-05-06 Biofunctional polymers prepared in supercritical fluid

Publications (3)

Publication Number Publication Date
DE69829655D1 DE69829655D1 (de) 2005-05-12
DE69829655T2 DE69829655T2 (de) 2006-02-09
DE69829655T3 true DE69829655T3 (de) 2011-02-10

Family

ID=26311517

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69829655T Expired - Lifetime DE69829655T3 (de) 1997-05-10 1998-05-06 Biofunktionelle polymere im überkritischem fluid hergestellt

Country Status (11)

Country Link
US (2) US6414050B1 (enExample)
EP (2) EP0981373B2 (enExample)
JP (1) JP4874447B2 (enExample)
CN (1) CN1163275C (enExample)
AU (1) AU7344498A (enExample)
DE (1) DE69829655T3 (enExample)
DK (1) DK1588700T3 (enExample)
ES (2) ES2241134T5 (enExample)
GB (1) GB9800936D0 (enExample)
PT (1) PT1588700E (enExample)
WO (1) WO1998051347A1 (enExample)

Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9703673D0 (en) * 1997-02-21 1997-04-09 Bradford Particle Design Ltd Method and apparatus for the formation of particles
GB9810559D0 (en) * 1998-05-15 1998-07-15 Bradford Particle Design Ltd Method and apparatus for particle formation
GB0010411D0 (en) * 2000-04-28 2000-06-14 Abonetics Ltd A process for the preparation of carbonated biomedical materials
US6521258B1 (en) 2000-09-08 2003-02-18 Ferro Corporation Polymer matrices prepared by supercritical fluid processing techniques
US6506213B1 (en) 2000-09-08 2003-01-14 Ferro Corporation Manufacturing orthopedic parts using supercritical fluid processing techniques
US6579532B1 (en) * 2000-09-08 2003-06-17 Ferro Corporation Orthopedic mixtures prepared by supercritical fluid processing techniques
GB0027357D0 (en) 2000-11-09 2000-12-27 Bradford Particle Design Plc Particle formation methods and their products
US6919421B2 (en) * 2001-02-06 2005-07-19 Folia, Inc Methods of synthesis of polysuccinimide, copolymers of polysuccinimide and derivatives thereof
US6887971B2 (en) * 2001-02-06 2005-05-03 Folia, Inc. Synthesis of polysuccinimide and copoly(succinimide-aspartate) in a supercritical fluid
BR0210000A (pt) 2001-05-30 2004-05-04 Csir Método de encapsular uma substância ativa
WO2002102432A1 (en) * 2001-06-15 2002-12-27 Johns Hopkins Singapore Pte Ltd Biofunctional fibers
GB0117696D0 (en) * 2001-07-20 2001-09-12 Bradford Particle Design Plc Particle information
JP2005511216A (ja) * 2001-12-12 2005-04-28 デピュイ・プロダクツ・インコーポレイテッド 整形外科装置およびその作製方法
GB0205868D0 (en) * 2002-03-13 2002-04-24 Univ Nottingham Polymer composite with internally distributed deposition matter
GB0205867D0 (en) * 2002-03-13 2002-04-24 Univ Nottingham Polymer composite loaded with functioning matter
GB0216562D0 (en) 2002-04-25 2002-08-28 Bradford Particle Design Ltd Particulate materials
US9339459B2 (en) 2003-04-24 2016-05-17 Nektar Therapeutics Particulate materials
US6998051B2 (en) * 2002-07-03 2006-02-14 Ferro Corporation Particles from supercritical fluid extraction of emulsion
US6966990B2 (en) 2002-10-11 2005-11-22 Ferro Corporation Composite particles and method for preparing
US6931888B2 (en) * 2003-02-07 2005-08-23 Ferro Corporation Lyophilization method and apparatus for producing particles
US7083748B2 (en) * 2003-02-07 2006-08-01 Ferro Corporation Method and apparatus for continuous particle production using supercritical fluid
WO2005005010A2 (en) * 2003-02-21 2005-01-20 Ferro Corporation Methods and apparatus for producing composite particles using supercritical fluid as plasticizing and extracting agent
EP1596969B1 (en) * 2003-02-24 2015-07-22 Ferro Corporation Method for enhanced size reduction of particles
FR2854079B1 (fr) * 2003-04-25 2007-11-30 Pf Medicament Procede de preparation de complexes moleculaires
US20060008531A1 (en) * 2003-05-08 2006-01-12 Ferro Corporation Method for producing solid-lipid composite drug particles
WO2004098561A2 (en) * 2003-05-08 2004-11-18 Nektar Therapeutics Uk Ltd Particulate materials
CU23352A1 (es) * 2003-10-16 2009-03-16 Centro Nacional De Investigaciones Cientificas Biomateriales compuestos para implantes óseos
WO2005042623A1 (en) * 2003-10-23 2005-05-12 University Of Nottingham Preparing active polymer extrudates
FR2863172B1 (fr) * 2003-12-05 2006-07-21 Biocoral Inc Procede de purification du corail
WO2005055972A2 (en) * 2003-12-09 2005-06-23 Nanon A/S A drug delivery device and a method of producing it
FR2874836B1 (fr) * 2004-09-09 2007-04-27 Pierre Fabre Medicament Sa Procede d'enrobage de poudres
US20060078592A1 (en) * 2004-10-12 2006-04-13 Bausch & Lomb Incorporated Drug delivery systems
FR2876910B1 (fr) * 2004-10-21 2007-04-13 Pierre Fabre Medicament Sa Complexe comprenant la mequitazine, une cyclodextrine et un agent d'interaction
US7988987B2 (en) * 2005-01-25 2011-08-02 Boston Scientific Scimed, Inc. Medical devices containing crazed polymeric release regions for drug delivery
US20070009564A1 (en) * 2005-06-22 2007-01-11 Mcclain James B Drug/polymer composite materials and methods of making the same
US20090062909A1 (en) 2005-07-15 2009-03-05 Micell Technologies, Inc. Stent with polymer coating containing amorphous rapamycin
ES2691646T3 (es) 2005-07-15 2018-11-28 Micell Technologies, Inc. Revestimientos poliméricos que contienen polvo de fármaco de morfología controlada
GB0525864D0 (en) * 2005-12-20 2006-02-01 Novartis Ag Organic compounds
AU2007207495A1 (en) * 2006-01-19 2007-07-26 Warsaw Orthopedic, Inc. Porous osteoimplant
US8852625B2 (en) 2006-04-26 2014-10-07 Micell Technologies, Inc. Coatings containing multiple drugs
US8636767B2 (en) 2006-10-02 2014-01-28 Micell Technologies, Inc. Surgical sutures having increased strength
US9539593B2 (en) 2006-10-23 2017-01-10 Micell Technologies, Inc. Holder for electrically charging a substrate during coating
CN101711137B (zh) 2007-01-08 2014-10-22 米歇尔技术公司 具有可生物降解层的支架
US11426494B2 (en) 2007-01-08 2022-08-30 MT Acquisition Holdings LLC Stents having biodegradable layers
CN101815540B (zh) * 2007-05-25 2015-08-19 米歇尔技术公司 用于医疗器材涂层的聚合物膜
US20090286907A1 (en) * 2008-01-23 2009-11-19 Beltz Mark W Fumaric Acid/Diol Polyesters and Their Manufacture and Use
EA020655B1 (ru) 2008-04-17 2014-12-30 Миселл Текнолоджиз, Инк. Стенты, имеющие биорассасывающиеся слои
US20090269480A1 (en) * 2008-04-24 2009-10-29 Medtronic Vascular, Inc. Supercritical Fluid Loading of Porous Medical Devices With Bioactive Agents
GB0812284D0 (en) * 2008-07-04 2008-08-13 Orthoplastics Ltd Process
GB0812742D0 (en) 2008-07-11 2008-08-20 Critical Pharmaceuticals Ltd Process
US9510856B2 (en) 2008-07-17 2016-12-06 Micell Technologies, Inc. Drug delivery medical device
CA2730995C (en) 2008-07-17 2016-11-22 Micell Technologies, Inc. Drug delivery medical device
US8834913B2 (en) 2008-12-26 2014-09-16 Battelle Memorial Institute Medical implants and methods of making medical implants
EP2411083A4 (en) * 2009-03-23 2013-11-13 Micell Technologies Inc MEDICAL ACTIVE COMPOSITION DEVICE
CA2756388C (en) * 2009-03-23 2015-10-27 Micell Technologies, Inc. Biodegradable polymers with low acidic impurity
CN102481195B (zh) 2009-04-01 2015-03-25 米歇尔技术公司 涂覆支架
EP3366326A1 (en) 2009-04-17 2018-08-29 Micell Technologies, Inc. Stents having controlled elution
EP2531140B1 (en) 2010-02-02 2017-11-01 Micell Technologies, Inc. Stent and stent delivery system with improved deliverability
US8409628B2 (en) * 2010-02-04 2013-04-02 Penguin IP Holdings, Inc. Methods and compositions for oxygenation of skin to treat skin disorders
US8795762B2 (en) 2010-03-26 2014-08-05 Battelle Memorial Institute System and method for enhanced electrostatic deposition and surface coatings
EP2560576B1 (en) 2010-04-22 2018-07-18 Micell Technologies, Inc. Stents and other devices having extracellular matrix coating
CA2805631C (en) 2010-07-16 2018-07-31 Micell Technologies, Inc. Drug delivery medical device
JP5672554B2 (ja) * 2010-08-19 2015-02-18 Ｊｃｒファーマ株式会社 皮下又は経皮吸収用組成物
MX350838B (es) 2011-02-11 2017-09-18 Grain Proc Corporation * Composicion de sal.
US10464100B2 (en) 2011-05-31 2019-11-05 Micell Technologies, Inc. System and process for formation of a time-released, drug-eluting transferable coating
WO2013012689A1 (en) 2011-07-15 2013-01-24 Micell Technologies, Inc. Drug delivery medical device
US10188772B2 (en) 2011-10-18 2019-01-29 Micell Technologies, Inc. Drug delivery medical device
US11039943B2 (en) 2013-03-12 2021-06-22 Micell Technologies, Inc. Bioabsorbable biomedical implants
CA2912387C (en) 2013-05-15 2019-04-16 Micell Technologies, Inc. Bioabsorbable biomedical implants
US9974311B2 (en) 2013-09-23 2018-05-22 Stewart Group Trading Inc. Impregnated odour control products and methods of making the same
GB201317756D0 (en) 2013-10-08 2013-11-20 Critical Pharmaceuticals Ltd New process
CN103875923B (zh) * 2014-04-04 2015-08-19 王宏雁 脂肪包膜的生物酶或微生态制剂
CN103933895B (zh) * 2014-04-04 2015-11-04 王宏雁 利用亚临界流体制备固体颗粒肠溶包衣的方法
ES2546566B2 (es) * 2015-07-23 2016-09-14 Universidade De Santiago De Compostela Sistema para la administración de sustancias biológicamente activas preparado por técnicas de espumado empleando gases comprimidos o fluidos supercríticos
JP2022027148A (ja) * 2020-07-31 2022-02-10 株式会社リコー 組成物、製造物、及び組成物の製造方法
CN114010359B (zh) * 2021-04-30 2023-07-14 中国计量大学 用于协助口腔牙齿敷药治疗器具的制取方法
CN113244439A (zh) * 2021-06-24 2021-08-13 北京欣康研医药科技有限公司 一种无抗原胶原聚集体及其制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4598006A (en) * 1985-05-02 1986-07-01 Hercules Incorporated Method for impregnating a thermoplastic polymer
DE3744329A1 (de) * 1987-12-28 1989-07-06 Schwarz Pharma Gmbh Verfahren zur herstellung einer mindestens einen wirkstoff und einen traeger umfassenden zubereitung
CA2017332A1 (en) * 1989-06-29 1990-12-29 Richard W. Greiner Pharmaceutically impregnated catheters
GB8928250D0 (en) * 1989-12-14 1990-02-21 Erba Carlo Spa Use of supercritical fluids to obtain porous sponges of biodegradable polymers
US5290827A (en) 1991-03-27 1994-03-01 University Of Delaware Precipitation of homogeneous polymer mixtures from supercritical fluid solutions
KR950703413A (ko) 1992-11-02 1995-09-20 레오나드 디. 영 코팅물질의 제조 방법(method of preparing coating materrials)
US5340614A (en) * 1993-02-11 1994-08-23 Minnesota Mining And Manufacturing Company Methods of polymer impregnation
US5312882A (en) * 1993-07-30 1994-05-17 The University Of North Carolina At Chapel Hill Heterogeneous polymerization in carbon dioxide
US5766637A (en) * 1996-10-08 1998-06-16 University Of Delaware Microencapsulation process using supercritical fluids
PT1028820E (pt) * 1997-10-15 2010-04-05 Univ South Florida Revestimento de material em partículas com o auxílio de um fluido supercrítico
US6248363B1 (en) * 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions

Also Published As

Publication number Publication date
EP1588700B1 (en) 2013-10-16
EP1588700A1 (en) 2005-10-26
DK1588700T3 (da) 2014-01-13
GB9800936D0 (en) 1998-03-11
US6414050B1 (en) 2002-07-02
AU7344498A (en) 1998-12-08
PT1588700E (pt) 2014-01-20
EP0981373A1 (en) 2000-03-01
US6670407B2 (en) 2003-12-30
CN1163275C (zh) 2004-08-25
ES2441644T3 (es) 2014-02-05
HK1082204A1 (en) 2006-06-02
WO1998051347A1 (en) 1998-11-19
CN1264309A (zh) 2000-08-23
JP4874447B2 (ja) 2012-02-15
JP2002506428A (ja) 2002-02-26
ES2241134T5 (es) 2010-11-04
DE69829655T2 (de) 2006-02-09
US20020155145A1 (en) 2002-10-24
EP0981373B2 (en) 2010-09-08
EP0981373B1 (en) 2005-04-06
DE69829655D1 (de) 2005-05-12
ES2241134T3 (es) 2005-10-16

Similar Documents

Publication Publication Date Title
DE69829655T3 (de) Biofunktionelle polymere im überkritischem fluid hergestellt
DE69625822T2 (de) Implantierbare, bioresorbierbare membran und verfahren zu ihrer herstellung
DE2917037C2 (de) Parenteral arzneimittelhaltige partiell resorbierbare Mehrkomponentenmasse auf Basis von polymeren Stoffen
DE69426414T2 (de) Implantatmaterial
DE69332346T2 (de) Material für Knochenprothese enthaltend in einer bioresorbierbaren Polymermatrix dispergierte Calciumcarbonatteilchen
DE69534759T2 (de) Polyanionische Polysaccharide und hydrophobe, bioabsorbierbare Polymere enthaltende Zusammensetzungen
DE60226242T2 (de) Photoquervernetzung von biologischen materialien aus fumarsäurediethylester/poly(propylenfumarat)
EP0058867B1 (de) Verfahren zur Herstellung einer Trikalziumphosphat-Knochenkeramik zur Verwendung als Knochenimplantat, insbesondere zur Auffüllung von Hohlräumen oder zur Fixierung von Knochenbruchstücken nach Frakturen und hiernach hergestellter Trikalziumphosphat-Keramikformkörper
DE69722440T2 (de) Plastifizierbares implantatmaterial
JP6882312B2 (ja) ポリ（グリセロールセバケート）フィラーを含む複合材料
US20070254035A1 (en) Preparing Active Polymer Extrudates
DE2224614C2 (de) Implantationsmaterial für künstliche Glieder und Verfahren zu seiner Herstellung
JP2005520025A (ja) 内部的に分散沈殿物を有する高分子複合材料
EP1687040B1 (de) Bioresorbierbares kompositmaterial
EP1519713A2 (de) Wirkstofffreisetzungssysteme auf basis von bioabbaubaren oder biokompatiblen polymeren mit formgedaechtniseffekt
EP0550875A1 (de) Pharmazeutische Wirkstoffe enthaltende implantierbare Vorrichtung aus einem polymeren Material sowie Verfahren zu deren Herstellung
EP0804245A1 (de) Kollagenzubereitung zur gesteuerten abgabe von wirkstoffen
EP1818039B1 (de) Verfahren zur Herstellung eines lokalen Wirkstofffreisetzungssystems
EP2686028B1 (de) Granulatmischung, umfassend zwei verschiedene granulate, zur künstlichen kallusdistraktion
EP3159017B1 (de) Resorbierbare matrix zur wundabdeckung
DE102004035182B4 (de) Implantatmaterial, ein Verfahren zu seiner Herstellung und seine Verwendung
HK1082204B (en) Biofunctional polymers prepared in supercritical fluid
HK1103239A (en) Preparing active polymer extrudates

Legal Events

Date Code Title Description
8363 Opposition against the patent
8328 Change in the person/name/address of the agent

Representative=s name: DF-MP, 80333 MUENCHEN

8366 Restricted maintained after opposition proceedings