DE69827621D1 - Immunogene zusammensetzungen gegen den cck-b-gastrin-rezeptor und verfahren zur behandlung von tumoren - Google Patents
Immunogene zusammensetzungen gegen den cck-b-gastrin-rezeptor und verfahren zur behandlung von tumorenInfo
- Publication number
- DE69827621D1 DE69827621D1 DE69827621T DE69827621T DE69827621D1 DE 69827621 D1 DE69827621 D1 DE 69827621D1 DE 69827621 T DE69827621 T DE 69827621T DE 69827621 T DE69827621 T DE 69827621T DE 69827621 D1 DE69827621 D1 DE 69827621D1
- Authority
- DE
- Germany
- Prior art keywords
- gastrin
- cck
- immunogens
- receptor
- immunogenic compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108010089448 Cholecystokinin B Receptor Proteins 0.000 title abstract 7
- 102000052874 Gastrin receptors Human genes 0.000 title abstract 4
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 230000002163 immunogen Effects 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 102100036016 Gastrin/cholecystokinin type B receptor Human genes 0.000 abstract 3
- 102100021022 Gastrin Human genes 0.000 abstract 2
- 108010052343 Gastrins Proteins 0.000 abstract 2
- AOXOCDRNSPFDPE-UKEONUMOSA-N chembl413654 Chemical compound C([C@H](C(=O)NCC(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@@H](N)CCC(O)=O)C1=CC=C(O)C=C1 AOXOCDRNSPFDPE-UKEONUMOSA-N 0.000 abstract 2
- 230000001419 dependent effect Effects 0.000 abstract 2
- 238000001727 in vivo Methods 0.000 abstract 2
- 238000001574 biopsy Methods 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 230000012010 growth Effects 0.000 abstract 1
- 230000003053 immunization Effects 0.000 abstract 1
- 238000002649 immunization Methods 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000813 peptide hormone Substances 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 125000006850 spacer group Chemical group 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
- 230000004565 tumor cell growth Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57488—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Pathology (AREA)
- Zoology (AREA)
- Analytical Chemistry (AREA)
- Neurology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Hospice & Palliative Care (AREA)
- Food Science & Technology (AREA)
- Toxicology (AREA)
- General Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4620197P | 1997-05-12 | 1997-05-12 | |
US46201P | 1997-05-12 | ||
PCT/US1998/009957 WO1998051337A2 (en) | 1997-05-12 | 1998-05-12 | Immunogenic compositions to the cck-b/gastrin-receptor and methods for the treatment of tumors |
Publications (3)
Publication Number | Publication Date |
---|---|
DE69827621D1 true DE69827621D1 (de) | 2004-12-23 |
DE69827621T2 DE69827621T2 (de) | 2005-03-31 |
DE69827621T9 DE69827621T9 (de) | 2007-06-06 |
Family
ID=21942134
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69827621T Active DE69827621T9 (de) | 1997-05-12 | 1998-05-12 | Immunogene zusammensetzungen gegen den cck-b-gastrin-rezeptor und verfahren zur behandlung von tumoren |
Country Status (14)
Country | Link |
---|---|
US (2) | US6548066B1 (de) |
EP (1) | EP0981369B1 (de) |
JP (2) | JP2002511066A (de) |
CN (1) | CN1170593C (de) |
AT (1) | ATE282429T1 (de) |
AU (1) | AU746754B2 (de) |
BR (1) | BR9811264A (de) |
CA (1) | CA2287872C (de) |
DE (1) | DE69827621T9 (de) |
ES (1) | ES2227833T3 (de) |
HU (1) | HUP0002760A3 (de) |
NZ (2) | NZ500748A (de) |
PT (1) | PT981369E (de) |
WO (1) | WO1998051337A2 (de) |
Families Citing this family (36)
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US6861510B1 (en) * | 1989-01-24 | 2005-03-01 | Aphton Corporation | Immunogenic compositions against gastrin peptides |
JP2000504692A (ja) * | 1996-02-08 | 2000-04-18 | アフトン・コーポレーション | 胃腸癌治療用の免疫学的方法 |
US20040001842A1 (en) * | 1997-05-12 | 2004-01-01 | Dov Michaeli | Immunogenic compositions to the CCK-B/gastrin receptor and methods for the treatment of tumors |
ES2227833T3 (es) | 1997-05-12 | 2005-04-01 | Aphton Corporation | Composiciones inmunogenicas para el receptor cck-b/gastrina y metodos para el tratamiento de tumores. |
US20030068326A1 (en) * | 1998-05-15 | 2003-04-10 | Aphton Corporation | Method for the treatment of gastroesophageal reflux disease |
JP2002515458A (ja) * | 1998-05-15 | 2002-05-28 | アフトン・コーポレーシヨン | 高ガストリン血症の予防および処置 |
US7820393B2 (en) * | 1999-01-14 | 2010-10-26 | Scantibodies Laboratory, Inc. | Methods, kits and antibodies for detecting parathyroid hormone |
US6689566B1 (en) | 1999-01-14 | 2004-02-10 | Scantibodies Laboratory, Inc. | Methods, kits, and antibodies for detecting parathyroid hormone |
WO2000064446A1 (en) * | 1999-04-26 | 2000-11-02 | Emory University | Noscapine derivatives as adjuvant compositions and methods of use thereof |
CU22979A1 (es) * | 2000-12-08 | 2004-09-09 | Centro Inmunologia Molecular | Combinación inmunoterapéutica para el tratamiento de tumores que sobre-expresan receptores con actividad quinasa en residuos de tirosina |
CA2441228A1 (en) * | 2001-03-23 | 2002-10-03 | Aphton Corporation | Combination treatment of pancreatic cancer |
US20090191232A1 (en) * | 2001-05-04 | 2009-07-30 | Gevas Philip C | Combination therapy for the treatment of tumors |
CA2450898A1 (en) * | 2001-07-09 | 2003-01-23 | Aphton Corporation | Treatment and prevention of cancerous and pre-cancerous conditions of the liver, lung and esophagus |
EP1456651B1 (de) * | 2001-11-30 | 2008-05-07 | National Research Council Of Canada | Selbstanordnende moleküle |
WO2003060147A2 (en) * | 2001-12-21 | 2003-07-24 | George Sachs | Method of obtaining purified enterochromaffin cells and methods of using same |
US20050169979A1 (en) * | 2002-07-03 | 2005-08-04 | Dov Michaeli | Liposomal vaccine |
CA2520010C (en) | 2003-03-28 | 2012-07-10 | Aphton Corporation | Gastrin hormone immunoassays |
US20060020119A1 (en) * | 2004-03-29 | 2006-01-26 | Stephen Grimes | Monoclonal antibodies to gastrin hormone |
US8257715B1 (en) | 2004-08-26 | 2012-09-04 | University Of Notre Dame | Tissue vaccines and uses thereof |
JP2008513536A (ja) * | 2004-09-22 | 2008-05-01 | レセプター バイオロジックス インコーポレイテッド | プロガストリンに対するモノクローナル抗体 |
US8778360B2 (en) * | 2005-10-27 | 2014-07-15 | University Of Notre Dame | Extracellular matrix cancer vaccine adjuvant |
US9308252B2 (en) * | 2005-10-27 | 2016-04-12 | Cook Biotech, Inc. | Extracellular matrix materials as vaccine adjuvants for diseases associated with infectious pathogens or toxins |
US8802113B2 (en) * | 2005-10-27 | 2014-08-12 | University Of Notre Dame | Extracellular matrix cancer vaccine adjuvant |
US8778362B2 (en) | 2005-10-27 | 2014-07-15 | University Of Notre Dame | Anti-tumor/cancer heterologous acellular collagenous preparations and uses thereof |
PL2040753T3 (pl) * | 2006-05-22 | 2019-09-30 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Inhibitory progastryny w leczeniu raka okrężnicy |
US9283266B2 (en) * | 2008-02-28 | 2016-03-15 | University Of Notre Dame | Metastasis inhibition preparations and methods |
US8846059B2 (en) | 2009-12-08 | 2014-09-30 | University Of Notre Dame | Extracellular matrix adjuvant and methods for prevention and/or inhibition of ovarian tumors and ovarian cancer |
US20110150934A1 (en) * | 2009-12-18 | 2011-06-23 | University Of Notre Dame | Ovarian Tumor Tissue Cell Preparations/Vaccines for the Treatment/Inhibition of Ovarian Tumors and Ovarian Cancer |
US9487582B2 (en) * | 2010-01-08 | 2016-11-08 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Methods for treating pancreatic cancer |
CN106177930A (zh) * | 2010-12-14 | 2016-12-07 | 吉安特科技股份有限公司 | 抗cxcl13抗体和抗cxcr5抗体在恶性肿瘤的治疗或检测中的用途 |
PL3071206T3 (pl) | 2013-11-22 | 2022-01-17 | CL BioSciences LLC | Antagoniści gastryny (eg yf476, netazepid) do leczenia i zapobiegania osteoporozie |
BR102014007315A2 (pt) * | 2014-03-27 | 2016-08-09 | Ziel Biosciences Pesquisa Desenvolvimento E Diagnostico Ltda | kit e processo para detecção de lesões displásicas e/ou neoplásicas uterinas, peptídeo antigênico, construção gênica, anticorpo e processo para sua obtenção |
WO2017127357A1 (en) * | 2016-01-18 | 2017-07-27 | The Penn State Research Foundation | Dna aptamers targeting the cholecystokinin b receptor and methods of using same |
CA3066756A1 (en) | 2017-06-15 | 2018-12-20 | Cancer Advances Inc. | Compositions and methods for inducing humoral and cellular immunities against tumors and cancer |
CN107664696B (zh) * | 2017-08-28 | 2019-12-06 | 广东医科大学 | 一种用于成人神经胶质瘤诊断的双抗体夹心法elisa试剂盒 |
EP4125399A1 (de) | 2020-02-20 | 2023-02-08 | DuPont Nutrition Biosciences ApS | Zusammensetzung für fermentierte oder angesäuerte milchprodukte, ihre verwendung, produkte damit und verfahren zur herstellung dieser produkte |
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DE2256445C3 (de) * | 1972-11-17 | 1981-11-05 | Hoechst Ag, 6000 Frankfurt | Heptapeptide, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Präparate |
US4526716A (en) * | 1981-11-20 | 1985-07-02 | The Ohio State University | Antigenic modification of polypeptides |
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US4713366A (en) * | 1985-12-04 | 1987-12-15 | The Ohio State University Research Foundation | Antigenic modification of polypeptides |
US5344919A (en) | 1987-02-19 | 1994-09-06 | The Scripps Research Institute | Integrin from human epithelial cells |
US4971792A (en) | 1987-03-27 | 1990-11-20 | The Wistar Institute | Monoclonal antibodies against glycolipid antigens |
ATE133994T1 (de) | 1987-12-09 | 1996-02-15 | Gen Hospital Corp | An karzinoma assoziierte antigene und antikörper, die diese antigene erkennen |
US5162504A (en) | 1988-06-03 | 1992-11-10 | Cytogen Corporation | Monoclonal antibodies to a new antigenic marker in epithelial prostatic cells and serum of prostatic cancer patients |
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US5665874A (en) | 1989-01-17 | 1997-09-09 | John Hopkins University | Cancer related antigen |
US5023077A (en) | 1989-01-24 | 1991-06-11 | Aphton Corporation | Immunogenic compositions and methods for the treatment and prevention of gastric and duodenal ulcer disease |
ES2063912T3 (es) | 1989-01-24 | 1995-01-16 | Aphton Corp | Composiciones inmunogenicas frente a peptidos de gastrina. |
US6861510B1 (en) * | 1989-01-24 | 2005-03-01 | Aphton Corporation | Immunogenic compositions against gastrin peptides |
US5120829A (en) * | 1989-03-20 | 1992-06-09 | La Jolla Cancer Research Foundation | Hydrophobic attachment site for adhesion peptides |
US6020145A (en) | 1989-06-30 | 2000-02-01 | Bristol-Myers Squibb Company | Methods for determining the presence of carcinoma using the antigen binding region of monoclonal antibody BR96 |
US5242799A (en) | 1989-11-02 | 1993-09-07 | Biomira, Inc. | Lectin-antibody immunoassays for TF epitope-bearing antigens |
US5319073A (en) * | 1992-02-07 | 1994-06-07 | The United States Of America, As Represented By The Department Of Health & Human Services | Method of purifying cholecystokinin receptor protein |
US5256542A (en) * | 1992-03-09 | 1993-10-26 | Tanox Biosystems, Inc. | Selecting low frequency antigen-specific single B lymphocytes with correction for background noise |
US5639613A (en) | 1992-05-13 | 1997-06-17 | Board Of Regents, University Of Texas System | Methods for cancer diagnosis and prognosis |
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JP3439490B2 (ja) | 1992-09-28 | 2003-08-25 | 株式会社林原生物化学研究所 | 蛋白質とその蛋白質をコードするdna並びにその蛋白質の製造方法 |
US5879898A (en) | 1992-11-20 | 1999-03-09 | Isis Innovation Limited | Antibodies specific for peptide corresponding to CD44 exon 6, and use of these antibodies for diagnosis of tumors |
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US5750119A (en) | 1994-01-13 | 1998-05-12 | Mount Sinai School Of Medicine Of The City University Of New York | Immunotherapeutic stress protein-peptide complexes against cancer |
US5688506A (en) | 1994-01-27 | 1997-11-18 | Aphton Corp. | Immunogens against gonadotropin releasing hormone |
US5723718A (en) | 1994-12-20 | 1998-03-03 | St. Joseph's Hospital And Medical Center | Induction of immune tolerance to tumor cells |
US5609628A (en) * | 1995-04-20 | 1997-03-11 | Keranen; Victor J. | Intravascular graft and catheter |
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US5712369A (en) * | 1995-08-24 | 1998-01-27 | Ludwig Institute For Cancer Research | Isolated protein which binds to A33 antibody, and peptides corresponding to portions of the protein |
JP2000504692A (ja) * | 1996-02-08 | 2000-04-18 | アフトン・コーポレーション | 胃腸癌治療用の免疫学的方法 |
ES2227833T3 (es) | 1997-05-12 | 2005-04-01 | Aphton Corporation | Composiciones inmunogenicas para el receptor cck-b/gastrina y metodos para el tratamiento de tumores. |
US20040001842A1 (en) * | 1997-05-12 | 2004-01-01 | Dov Michaeli | Immunogenic compositions to the CCK-B/gastrin receptor and methods for the treatment of tumors |
JP2002515458A (ja) * | 1998-05-15 | 2002-05-28 | アフトン・コーポレーシヨン | 高ガストリン血症の予防および処置 |
US20030068326A1 (en) * | 1998-05-15 | 2003-04-10 | Aphton Corporation | Method for the treatment of gastroesophageal reflux disease |
AU768027B2 (en) * | 1999-02-24 | 2003-11-27 | Uab Research Foundation, The | Taxane derivatives for targeted therapy of cancer |
JP4183868B2 (ja) * | 1999-12-07 | 2008-11-19 | 富士通株式会社 | 光記憶装置 |
US20020058040A1 (en) * | 1999-12-23 | 2002-05-16 | Stephen Grimes | Stable immunogenic composition for frozen storage |
CA2441228A1 (en) * | 2001-03-23 | 2002-10-03 | Aphton Corporation | Combination treatment of pancreatic cancer |
CA2450898A1 (en) * | 2001-07-09 | 2003-01-23 | Aphton Corporation | Treatment and prevention of cancerous and pre-cancerous conditions of the liver, lung and esophagus |
US20050169979A1 (en) * | 2002-07-03 | 2005-08-04 | Dov Michaeli | Liposomal vaccine |
US20060020119A1 (en) * | 2004-03-29 | 2006-01-26 | Stephen Grimes | Monoclonal antibodies to gastrin hormone |
CA2520010C (en) * | 2003-03-28 | 2012-07-10 | Aphton Corporation | Gastrin hormone immunoassays |
-
1998
- 1998-05-12 ES ES98923447T patent/ES2227833T3/es not_active Expired - Lifetime
- 1998-05-12 CN CNB988050552A patent/CN1170593C/zh not_active Expired - Lifetime
- 1998-05-12 AT AT98923447T patent/ATE282429T1/de active
- 1998-05-12 AU AU75740/98A patent/AU746754B2/en not_active Expired
- 1998-05-12 CA CA2287872A patent/CA2287872C/en not_active Expired - Lifetime
- 1998-05-12 JP JP54957898A patent/JP2002511066A/ja not_active Ceased
- 1998-05-12 WO PCT/US1998/009957 patent/WO1998051337A2/en active IP Right Grant
- 1998-05-12 EP EP98923447A patent/EP0981369B1/de not_active Expired - Lifetime
- 1998-05-12 BR BR9811264-3A patent/BR9811264A/pt not_active Application Discontinuation
- 1998-05-12 US US09/076,372 patent/US6548066B1/en not_active Expired - Lifetime
- 1998-05-12 NZ NZ500748A patent/NZ500748A/en not_active IP Right Cessation
- 1998-05-12 NZ NZ511550A patent/NZ511550A/en not_active IP Right Cessation
- 1998-05-12 PT PT98923447T patent/PT981369E/pt unknown
- 1998-05-12 DE DE69827621T patent/DE69827621T9/de active Active
- 1998-05-12 HU HU0002760A patent/HUP0002760A3/hu unknown
-
2002
- 2002-09-04 US US10/235,236 patent/US20030086941A1/en not_active Abandoned
-
2006
- 2006-11-09 JP JP2006303697A patent/JP2007063289A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
HUP0002760A2 (hu) | 2000-12-28 |
CN1255860A (zh) | 2000-06-07 |
AU746754B2 (en) | 2002-05-02 |
ES2227833T3 (es) | 2005-04-01 |
US6548066B1 (en) | 2003-04-15 |
CA2287872A1 (en) | 1998-11-19 |
EP0981369B1 (de) | 2004-11-17 |
EP0981369A2 (de) | 2000-03-01 |
AU7574098A (en) | 1998-12-08 |
BR9811264A (pt) | 2000-07-18 |
CN1170593C (zh) | 2004-10-13 |
CA2287872C (en) | 2010-07-27 |
JP2002511066A (ja) | 2002-04-09 |
HUP0002760A3 (en) | 2003-03-28 |
NZ511550A (en) | 2005-03-24 |
PT981369E (pt) | 2005-03-31 |
NZ500748A (en) | 2001-06-29 |
ATE282429T1 (de) | 2004-12-15 |
WO1998051337A3 (en) | 1999-02-04 |
JP2007063289A (ja) | 2007-03-15 |
US20030086941A1 (en) | 2003-05-08 |
WO1998051337A2 (en) | 1998-11-19 |
DE69827621T2 (de) | 2005-03-31 |
DE69827621T9 (de) | 2007-06-06 |
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Owner name: RECEPTOR BIOLOGIX, INC. (N.D.GES.D. STAATES DE, US |