DE69823657T2 - Reagens, das zur Herstellung von geschwefelten Oligonukleotidanaloga geeignet ist - Google Patents

Reagens, das zur Herstellung von geschwefelten Oligonukleotidanaloga geeignet ist Download PDF

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Publication number
DE69823657T2
DE69823657T2 DE69823657T DE69823657T DE69823657T2 DE 69823657 T2 DE69823657 T2 DE 69823657T2 DE 69823657 T DE69823657 T DE 69823657T DE 69823657 T DE69823657 T DE 69823657T DE 69823657 T2 DE69823657 T2 DE 69823657T2
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DE
Germany
Prior art keywords
group
substituted
heteroatoms
alkyl
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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DE69823657T
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German (de)
English (en)
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DE69823657D1 (de
Inventor
S. Zacharia CHERUVALLATH
C. Daniel CAPALDI
T. Vasulinga RAVIKUMAR
L. Douglas COLE
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Ionis Pharmaceuticals Inc
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Isis Pharmaceuticals Inc
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Publication date
Application filed by Isis Pharmaceuticals Inc filed Critical Isis Pharmaceuticals Inc
Publication of DE69823657D1 publication Critical patent/DE69823657D1/de
Application granted granted Critical
Publication of DE69823657T2 publication Critical patent/DE69823657T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C329/00—Thiocarbonic acids; Halides, esters or anhydrides thereof
    • C07C329/12—Dithiocarbonic acids; Derivatives thereof
    • C07C329/14—Esters of dithiocarbonic acids

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69823657T 1997-03-03 1998-03-03 Reagens, das zur Herstellung von geschwefelten Oligonukleotidanaloga geeignet ist Expired - Fee Related DE69823657T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US811233 1985-12-20
US08/811,233 US5902881A (en) 1997-03-03 1997-03-03 Reagent useful for synthesizing sulfurized oligonucleotide analogs
PCT/US1998/004111 WO1998039290A1 (en) 1997-03-03 1998-03-03 Reagent useful for synthesizing sulfurized oligonucleotide analogs

Publications (2)

Publication Number Publication Date
DE69823657D1 DE69823657D1 (de) 2004-06-09
DE69823657T2 true DE69823657T2 (de) 2005-04-07

Family

ID=25205965

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69823657T Expired - Fee Related DE69823657T2 (de) 1997-03-03 1998-03-03 Reagens, das zur Herstellung von geschwefelten Oligonukleotidanaloga geeignet ist

Country Status (7)

Country Link
US (3) US5902881A (US06399831-20020604-C00005.png)
EP (1) EP0983233B1 (US06399831-20020604-C00005.png)
JP (1) JP2000510872A (US06399831-20020604-C00005.png)
AT (1) ATE266001T1 (US06399831-20020604-C00005.png)
AU (1) AU6680498A (US06399831-20020604-C00005.png)
DE (1) DE69823657T2 (US06399831-20020604-C00005.png)
WO (1) WO1998039290A1 (US06399831-20020604-C00005.png)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5902881A (en) * 1997-03-03 1999-05-11 Isis Pharmaceuticals, Inc. Reagent useful for synthesizing sulfurized oligonucleotide analogs
US6242591B1 (en) * 1997-10-15 2001-06-05 Isis Pharmaceuticals, Inc. Synthesis of sulfurized 2'-substituted oligonucleotides
US6124484A (en) 1998-07-17 2000-09-26 Isis Pharmaceuticals, Inc. Recovery of triarylmethyl halide protecting groups cleaved during oligonucleotide synthesis
US6069243A (en) * 1998-10-06 2000-05-30 Isis Pharmaceuticals, Inc. Process for oligonucleotide synthesis
WO2002081476A1 (en) * 2001-04-06 2002-10-17 Micrologix Biotech, Inc. Thiophosphate nucleic acid-based compounds
US20040241665A1 (en) * 2003-05-30 2004-12-02 Bass Jay K. Methods and devices for identifying a fluid on a substrate surface
JP2007531794A (ja) 2004-04-05 2007-11-08 アルニラム ファーマスーティカルズ インコーポレイテッド オリゴヌクレオチドの合成および精製に使用する方法および反応試薬
WO2012059510A1 (en) 2010-11-02 2012-05-10 Girindus America, Inc. Back pressure control during solid-phase synthesis on polymeric supports
WO2019006455A1 (en) 2017-06-30 2019-01-03 Solstice Biologics, Ltd. AUXILIARIES OF CHIRAL PHOSPHORAMIDITIS AND METHODS OF USE THEREOF

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US4500707A (en) * 1980-02-29 1985-02-19 University Patents, Inc. Nucleosides useful in the preparation of polynucleotides
US4458066A (en) * 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
US4415732A (en) * 1981-03-27 1983-11-15 University Patents, Inc. Phosphoramidite compounds and processes
US4973679A (en) * 1981-03-27 1990-11-27 University Patents, Inc. Process for oligonucleo tide synthesis using phosphormidite intermediates
US4668777A (en) * 1981-03-27 1987-05-26 University Patents, Inc. Phosphoramidite nucleoside compounds
US4373071A (en) * 1981-04-30 1983-02-08 City Of Hope Research Institute Solid-phase synthesis of polynucleotides
US4401796A (en) * 1981-04-30 1983-08-30 City Of Hope Research Institute Solid-phase synthesis of polynucleotides
US4419509A (en) * 1981-08-24 1983-12-06 Eli Lilly And Company Process for de-cyanoethylating blocked nucleotides
DE3301833A1 (de) * 1983-01-20 1984-07-26 Gesellschaft für Biotechnologische Forschung mbH (GBF), 3300 Braunschweig Verfahren zur simultanen synthese mehrerer oligonocleotide an fester phase
US4522735A (en) * 1983-06-17 1985-06-11 The B. F. Goodrich Company Polyphosphoramidite oligomers and stabilizer compositions thereof
USRE34069E (en) * 1983-08-18 1992-09-15 Biosyntech Gmbh Process for the preparation of oligonucleotides
DE3329892A1 (de) * 1983-08-18 1985-03-07 Köster, Hubert, Prof. Dr., 2000 Hamburg Verfahren zur herstellung von oligonucleotiden
US5252760A (en) * 1985-03-28 1993-10-12 Chiron Corporation Method of using colored phosphorylating reagents
US4959463A (en) * 1985-10-15 1990-09-25 Genentech, Inc. Intermediates
US5071974A (en) * 1986-10-31 1991-12-10 Amoco Corporation Compositions and methods for the synthesis of oligonucleotides having 5'-phosphorylated termini
US4816571A (en) * 1987-06-04 1989-03-28 Applied Biosystems, Inc. Chemical capping by phosphitylation during oligonucleotide synthesis
US4965349A (en) * 1987-12-24 1990-10-23 Applied Biosystems, Inc. Method of synthesizing oligonucleotides labeled with ammonia-labile groups on solid phase supports
US5218103A (en) * 1988-05-26 1993-06-08 University Patents, Inc. Nucleoside thiophosphoramidites
GB8822228D0 (en) * 1988-09-21 1988-10-26 Southern E M Support-bound oligonucleotides
US5449769A (en) * 1989-03-06 1995-09-12 Gen-Probe Incorporated Method and reagent for sulfurization of organophosphorous compounds
US5141813A (en) * 1989-08-28 1992-08-25 Clontech Laboratories, Inc. Multifunctional controlled pore glass reagent for solid phase oligonucleotide synthesis
US5003097A (en) * 1989-10-02 1991-03-26 The United States Of America As Represented By The Department Of Health And Human Services Method for the sulfurization of phosphorous groups in compounds
NL8902521A (nl) * 1989-10-11 1991-05-01 Rijksuniversiteit Werkwijze voor het bereiden van fosforothioaatesters.
US5218088A (en) * 1989-11-02 1993-06-08 Purdue Research Foundation Process for preparing dithiophosphate oligonucleotide analogs via nucleoside thiophosphoramidite intermediates
US5359051A (en) * 1990-01-11 1994-10-25 Isis Pharmaceuticals Compounds useful in the synthesis of nucleic acids capable of cleaning RNA
US5514788A (en) * 1993-05-17 1996-05-07 Isis Pharmaceuticals, Inc. Oligonucleotide modulation of cell adhesion
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US5151510A (en) * 1990-04-20 1992-09-29 Applied Biosystems, Inc. Method of synethesizing sulfurized oligonucleotide analogs
US5292875A (en) * 1990-04-20 1994-03-08 Lynx Therapeutics, Inc. Method of synthesizing sulfurized oligonucleotide analogs
WO1992004358A1 (en) * 1990-09-04 1992-03-19 Gen-Probe Incorporated Method and reagent for sulfurization of organophosphorous compounds
US5310894A (en) * 1990-09-11 1994-05-10 Thomas Jefferson University Solid phase polynucleotide syntheses
US5512668A (en) * 1991-03-06 1996-04-30 Polish Academy Of Sciences Solid phase oligonucleotide synthesis using phospholane intermediates
US5359052A (en) * 1991-08-05 1994-10-25 Polish Academy Of Sciences Chalcophospholanes useful in the synthesis of oligonucleoside phosphorothioates, phosphorodithioates and related selenates
AU4674393A (en) * 1992-07-20 1994-02-14 Isis Pharmaceuticals, Inc. Pseudo-half-knot rna formation by hybridization of antisense oligonucleotides to target rna's secondary structure
US5523389A (en) * 1992-09-29 1996-06-04 Isis Pharmaceuticals, Inc. Inhibitors of human immunodeficiency virus
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US5614621A (en) * 1993-07-29 1997-03-25 Isis Pharmaceuticals, Inc. Process for preparing oligonucleotides using silyl-containing diamino phosphorous reagents
US5571902A (en) * 1993-07-29 1996-11-05 Isis Pharmaceuticals, Inc. Synthesis of oligonucleotides
US5510239A (en) * 1993-10-18 1996-04-23 Isis Pharmaceuticals, Inc. Oligonucleotide modulation of multidrug resistance-associated protein
US5514789A (en) * 1994-04-21 1996-05-07 Barrskogen, Inc. Recovery of oligonucleotides by gas phase cleavage
US5510476A (en) * 1994-07-07 1996-04-23 Isis Pharmaceuticals, Inc. Carbocation scavenging during oligonucleotide synthesis
US6001555A (en) * 1994-09-23 1999-12-14 The United States Of America As Represented By The Department Of Health And Human Services Method for identifying and using compounds that inactivate HIV-1 and other retroviruses by attacking highly conserved zinc fingers in the viral nucleocapsid protein
US5705621A (en) * 1995-11-17 1998-01-06 Isis Pharmaceuticals, Inc. Oligomeric phosphite, phosphodiester, Phosphorothioate and phosphorodithioate compounds and intermediates for preparing same
US5902881A (en) * 1997-03-03 1999-05-11 Isis Pharmaceuticals, Inc. Reagent useful for synthesizing sulfurized oligonucleotide analogs
US5760209A (en) * 1997-03-03 1998-06-02 Isis Pharmaceuticals, Inc. Protecting group for synthesizing oligonucleotide analogs

Also Published As

Publication number Publication date
US6399831B1 (en) 2002-06-04
DE69823657D1 (de) 2004-06-09
EP0983233A4 (en) 2002-03-20
EP0983233A1 (en) 2000-03-08
WO1998039290A1 (en) 1998-09-11
EP0983233B1 (en) 2004-05-06
AU6680498A (en) 1998-09-22
JP2000510872A (ja) 2000-08-22
ATE266001T1 (de) 2004-05-15
US6040438A (en) 2000-03-21
US5902881A (en) 1999-05-11

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee