DE69822446D1 - Cyclosporin derivate und deren verwendung - Google Patents

Cyclosporin derivate und deren verwendung

Info

Publication number
DE69822446D1
DE69822446D1 DE69822446T DE69822446T DE69822446D1 DE 69822446 D1 DE69822446 D1 DE 69822446D1 DE 69822446 T DE69822446 T DE 69822446T DE 69822446 T DE69822446 T DE 69822446T DE 69822446 D1 DE69822446 D1 DE 69822446D1
Authority
DE
Germany
Prior art keywords
cyclosporine derivatives
cyclosporine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69822446T
Other languages
English (en)
Other versions
DE69822446T2 (de
Inventor
Chengrong Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dade Behring Inc
Original Assignee
Dade Behring Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dade Behring Inc filed Critical Dade Behring Inc
Application granted granted Critical
Publication of DE69822446D1 publication Critical patent/DE69822446D1/de
Publication of DE69822446T2 publication Critical patent/DE69822446T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9493—Immunosupressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE69822446T 1997-11-25 1998-11-13 Cyclosporin derivate und deren verwendung Expired - Fee Related DE69822446T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US978051 1997-11-25
US08/978,051 US5990274A (en) 1997-11-25 1997-11-25 Cyclosporine derivatives and uses thereof
PCT/US1998/024217 WO1999026965A1 (en) 1997-11-25 1998-11-13 Cyclosporine derivatives and uses thereof

Publications (2)

Publication Number Publication Date
DE69822446D1 true DE69822446D1 (de) 2004-04-22
DE69822446T2 DE69822446T2 (de) 2005-08-11

Family

ID=25525756

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69822446T Expired - Fee Related DE69822446T2 (de) 1997-11-25 1998-11-13 Cyclosporin derivate und deren verwendung

Country Status (6)

Country Link
US (2) US5990274A (de)
EP (1) EP0970107B1 (de)
JP (1) JP2001511820A (de)
DE (1) DE69822446T2 (de)
ES (1) ES2217604T3 (de)
WO (1) WO1999026965A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060216762A1 (en) * 2005-03-24 2006-09-28 Bayer Healthcare Llc Extracting reagent for hydrophobic analyte in whole blood
CN101375157B (zh) * 2006-01-13 2015-06-17 印第安纳大学研究和科技公司 用于治疗涉及对肺中存在的结缔组织自身免疫反应的肺病的分子
JP5391387B2 (ja) * 2007-03-09 2014-01-15 小川 一文 磁気感応性薬剤およびその製造方法
US20090170218A1 (en) * 2008-01-02 2009-07-02 Dade Behring Inc. Methods for detection of cyclosporin a
KR102305423B1 (ko) 2010-12-15 2021-09-27 콘트라빌 파마슈티컬스, 인코퍼레이티드 아미노산 1 및 3에서 변형된 사이클로스포린 유사체 분자
CN104764883A (zh) * 2015-03-31 2015-07-08 上海云泽生物科技有限公司 一种检测环孢霉素a浓度的免疫分析方法和试剂盒
CN104788560B (zh) * 2015-05-16 2018-06-19 苏州博源医疗科技有限公司 环孢霉素a免疫原、抗环孢霉素a特异性抗体和环孢霉素a检测试剂

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4117118A (en) * 1976-04-09 1978-09-26 Sandoz Ltd. Organic compounds
US4396542A (en) * 1980-02-14 1983-08-02 Sandoz Ltd. Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production
IL62965A0 (en) * 1980-07-17 1981-07-31 Scripps Miles Lab Inc Monoclonal antibodies to drugs and theri production
DE3260468D1 (en) * 1981-01-09 1984-09-06 Sandoz Ag Novel cyclosporins
CH667274A5 (de) * 1984-03-23 1988-09-30 Sandoz Ag Cyclosporine, ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen.
JPH074269B2 (ja) * 1984-10-04 1995-01-25 サンド・アクチエンゲゼルシャフト シクロスポリン類に対するモノクロ−ナル抗体
US5169773A (en) * 1984-10-04 1992-12-08 Sandoz Ltd. Monoclonal antibodies to cyclosporins
US4727035A (en) * 1984-11-14 1988-02-23 Mahoney Walter C Immunoassay for cyclosporin
US4661408A (en) * 1986-03-18 1987-04-28 E.I. Du Pont De Nemours And Company Coated chromium dioxide particles
US4764503A (en) * 1986-11-19 1988-08-16 Sandoz Ltd. Novel cyclosporins
EP0283801A3 (de) * 1987-03-27 1990-05-30 Abbott Laboratories Fluoreszenz-Polarisations-Test für Cyclosporin A und Metaboliten und verwandte Immunogene und Antikörper
US5239057A (en) * 1987-03-27 1993-08-24 Abbott Laboratories Fluorescence polarization assay for cyclosporin a and metabolites and related immunogens and antibodies
US4798823A (en) * 1987-06-03 1989-01-17 Merck & Co., Inc. New cyclosporin analogs with modified "C-9 amino acids"
JPH01503808A (ja) * 1987-07-16 1989-12-21 イー・アイ・デユポン・ド・ネモアース・アンド・コンパニー（インコーポレイテツド） 固定化された凝集剤を用いるアフイニテイ分離
US5089390A (en) * 1987-09-04 1992-02-18 Syntex (U.S.A.) Inc. 2-methyl-4-hexene- and 2-methyl-4-heptene-1,2-diol derivatives
AU4958590A (en) * 1988-12-05 1990-07-10 Trustees Of Columbia University In The City Of New York, The Novel derivatives of cyclosporine a, antibodies directed thereto and uses thereof
US5151348A (en) * 1988-12-23 1992-09-29 E. I. Du Pont De Nemours And Company Enzyme-linked immunoassay for measurement of cyclosporin a levels in whole blood samples
EP0473961B1 (de) * 1990-08-15 1996-01-03 Abbott Laboratories Immunotestreagenzien und Verfahren zur Bestimmung von Cyclosporin
DE69133095T2 (de) * 1990-11-20 2003-03-27 Dade Behring Marburg Gmbh Cyclosporin-Immunoassay
JP3351476B2 (ja) * 1993-01-22 2002-11-25 三菱化学株式会社 リン脂質誘導体及びそれを含有するリポソーム

Also Published As

Publication number Publication date
US5990274A (en) 1999-11-23
JP2001511820A (ja) 2001-08-14
WO1999026965A1 (en) 1999-06-03
ES2217604T3 (es) 2004-11-01
EP0970107A1 (de) 2000-01-12
EP0970107B1 (de) 2004-03-17
DE69822446T2 (de) 2005-08-11
US6207398B1 (en) 2001-03-27

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Legal Events

Date Code Title Description
8332 No legal effect for de
8370 Indication related to discontinuation of the patent is to be deleted
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee