DE69816502D1 - Ein Interleukin-18 enthaltender Agent, der Osteoclastzellen inhibiert - Google Patents

Ein Interleukin-18 enthaltender Agent, der Osteoclastzellen inhibiert

Info

Publication number
DE69816502D1
DE69816502D1 DE69816502T DE69816502T DE69816502D1 DE 69816502 D1 DE69816502 D1 DE 69816502D1 DE 69816502 T DE69816502 T DE 69816502T DE 69816502 T DE69816502 T DE 69816502T DE 69816502 D1 DE69816502 D1 DE 69816502D1
Authority
DE
Germany
Prior art keywords
agent containing
inhibits osteoclast
osteoclast cells
containing interleukin
interleukin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69816502T
Other languages
English (en)
Other versions
DE69816502T2 (de
Inventor
Matthew Todd Gillespie
Nicole Joy Horwood
Nobuyuki Udagawa
Masashi Kurimoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hayashibara Seibutsu Kagaku Kenkyujo KK
Original Assignee
Hayashibara Seibutsu Kagaku Kenkyujo KK
Hayashibara Biochemical Laboratories Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hayashibara Seibutsu Kagaku Kenkyujo KK, Hayashibara Biochemical Laboratories Co Ltd filed Critical Hayashibara Seibutsu Kagaku Kenkyujo KK
Application granted granted Critical
Publication of DE69816502D1 publication Critical patent/DE69816502D1/de
Publication of DE69816502T2 publication Critical patent/DE69816502T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69816502T 1997-02-25 1998-02-24 Ein Interleukin-18 enthaltender Agent, der Osteoclastzellen inhibiert Expired - Fee Related DE69816502T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP05546897A JP3955352B2 (ja) 1997-02-25 1997-02-25 破骨細胞形成阻害剤
JP5546897 1997-02-25

Publications (2)

Publication Number Publication Date
DE69816502D1 true DE69816502D1 (de) 2003-08-28
DE69816502T2 DE69816502T2 (de) 2004-06-09

Family

ID=12999446

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69816502T Expired - Fee Related DE69816502T2 (de) 1997-02-25 1998-02-24 Ein Interleukin-18 enthaltender Agent, der Osteoclastzellen inhibiert

Country Status (6)

Country Link
US (2) US20030095946A1 (de)
EP (1) EP0861663B1 (de)
JP (1) JP3955352B2 (de)
KR (1) KR100520723B1 (de)
DE (1) DE69816502T2 (de)
TW (1) TW570801B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1669454A3 (de) * 1996-06-27 2009-04-01 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Genomische DNS, die für ein Polypeptid kodiert, welches die Fähigkeit besitzt, die Interferon-Gamma Herstellung zu induzieren
US6790442B1 (en) 1996-06-27 2004-09-14 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Genomic DNA encoding a polypeptide capable of inducing the production of interferon-γ
JP2001103964A (ja) * 1999-10-05 2001-04-17 Teijin Ltd 破骨細胞形成抑制方法または骨吸収抑制方法
JPWO2002066063A1 (ja) * 2001-02-23 2004-06-17 星野　友昭 代謝性骨疾患治療剤
YU103003A (sh) * 2001-06-26 2006-05-25 Abgenix Inc. Antitela za opgl
KR100454508B1 (ko) * 2002-07-05 2004-11-03 허명준 소취기능과 다제내성균에 대한 멸균력을 갖는 자연기능수및 그의 제조방법
ES2284774T3 (es) * 2002-12-27 2007-11-16 Universitatsklinikum Munster Uso de interleucina-18 para el tratamiento de transtornos de la piel asociados con la radiacon uv.
US20060286084A1 (en) * 2003-09-30 2006-12-21 Yoshikazu Morita Agent for promoting osteogenesis and/or inhibiting bone resorption
WO2005075648A1 (en) * 2004-01-28 2005-08-18 Gifu University Interleukin-18 mutant proteins
US8168165B2 (en) * 2008-12-23 2012-05-01 Abbott Laboratories Alkylated interleukin-18 compositions
IL305370A (en) * 2017-09-06 2023-10-01 Univ Yale Variants of interleukin-18 and methods of use
US12029778B2 (en) 2019-05-13 2024-07-09 Yale University Interleukin-18 mimics and methods of use
EP4236990A1 (de) 2020-11-02 2023-09-06 Simcha Il-18, Inc. Interleukin-18-varianten und verfahren zur verwendung
WO2024102587A2 (en) * 2022-11-11 2024-05-16 Mural Oncology, Inc. Interleukin 18 variants

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4588585A (en) 1982-10-19 1986-05-13 Cetus Corporation Human recombinant cysteine depleted interferon-β muteins
US5714585A (en) 1987-10-26 1998-02-03 Sterling Winthrop, Inc. Antibodies that are immunoreactive with interleukin-7
JP3109018B2 (ja) 1994-07-14 2000-11-13 株式会社林原生物化学研究所 インターフェロン−γの産生を誘導する蛋白質
EP0692536B1 (de) * 1994-07-14 2000-11-22 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Protein, das Interferon-Gamma Herstellung induziert und monoklonaler Antikörper dagegen
TW581771B (en) * 1994-11-15 2004-04-01 Hayashibara Biochem Lab Recombinant production of a polypeptide for inducing interferon-gamma production, and monoclonal antibody against the polypeptide
JP2952750B2 (ja) 1995-02-23 1999-09-27 株式会社林原生物化学研究所 モノクローナル抗体
JP2724987B2 (ja) 1994-11-15 1998-03-09 株式会社林原生物化学研究所 インターフェロン−γの産生を誘導するポリペプチド
US6207641B1 (en) * 1995-03-10 2001-03-27 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Pharmaceutical composition containing IFN-γ inducing polypeptide or factor for treating and/or preventing IFN-γ susceptive diseases
JP4004088B2 (ja) 1995-09-26 2007-11-07 株式会社林原生物化学研究所 免疫担当細胞においてインターフェロン−γの産生を誘導する蛋白質
EP0721780A3 (de) * 1994-12-16 1997-12-17 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Mittel zur Förderung von Plättchen und/oder Leucozytenherstellung
US5776731A (en) 1996-02-21 1998-07-07 Immunex Corporation DNA encoding type-I interleukin-I receptor-like protein designated 2F1
JP2000511418A (ja) 1996-05-20 2000-09-05 シェーリング コーポレイション ヒトインターロイキン―１ｊおよびそのアンタゴニスト
JP4024366B2 (ja) 1996-11-29 2007-12-19 株式会社林原生物化学研究所 ポリペプチド

Also Published As

Publication number Publication date
KR100520723B1 (ko) 2007-12-21
TW570801B (en) 2004-01-11
EP0861663B1 (de) 2003-07-23
JPH10236974A (ja) 1998-09-08
DE69816502T2 (de) 2004-06-09
EP0861663A3 (de) 2000-03-29
US20030095946A1 (en) 2003-05-22
US20020150555A1 (en) 2002-10-17
US6896880B2 (en) 2005-05-24
EP0861663A2 (de) 1998-09-02
KR19980071708A (ko) 1998-10-26
JP3955352B2 (ja) 2007-08-08

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee