DE69812711D1 - Kohlenhydraten verwendbar in feste verabreichungssysteme - Google Patents

Kohlenhydraten verwendbar in feste verabreichungssysteme

Info

Publication number
DE69812711D1
DE69812711D1 DE69812711T DE69812711T DE69812711D1 DE 69812711 D1 DE69812711 D1 DE 69812711D1 DE 69812711 T DE69812711 T DE 69812711T DE 69812711 T DE69812711 T DE 69812711T DE 69812711 D1 DE69812711 D1 DE 69812711D1
Authority
DE
Germany
Prior art keywords
carbohydrates
solid
variety
delivery systems
derivatized carbohydrates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69812711T
Other languages
English (en)
Other versions
DE69812711T2 (de
Inventor
Alexander Blair
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Quadrant Drug Delivery Ltd
Original Assignee
Elan Drug Delivery Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Drug Delivery Ltd filed Critical Elan Drug Delivery Ltd
Application granted granted Critical
Publication of DE69812711D1 publication Critical patent/DE69812711D1/de
Publication of DE69812711T2 publication Critical patent/DE69812711T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/04—Disaccharides
DE69812711T 1997-12-23 1998-12-23 Kohlenhydraten verwendbar in feste verabreichungssysteme Expired - Fee Related DE69812711T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6875497P 1997-12-23 1997-12-23
PCT/GB1998/003888 WO1999033853A2 (en) 1997-12-23 1998-12-23 Carbohydrates, useful in solid delivery systems

Publications (2)

Publication Number Publication Date
DE69812711D1 true DE69812711D1 (de) 2003-04-30
DE69812711T2 DE69812711T2 (de) 2003-11-06

Family

ID=22084508

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69812711T Expired - Fee Related DE69812711T2 (de) 1997-12-23 1998-12-23 Kohlenhydraten verwendbar in feste verabreichungssysteme

Country Status (12)

Country Link
US (2) US6352722B1 (de)
EP (1) EP1042339B1 (de)
JP (1) JP2001527087A (de)
AT (1) ATE235503T1 (de)
AU (1) AU2062999A (de)
CA (1) CA2316275A1 (de)
DE (1) DE69812711T2 (de)
DK (1) DK1042339T3 (de)
ES (1) ES2191367T3 (de)
PT (1) PT1042339E (de)
WO (1) WO1999033853A2 (de)
ZA (1) ZA9811843B (de)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3957400A (en) 1999-04-16 2000-11-02 Novo Nordisk A/S Dry, mouldable drug formulation
GB9916316D0 (en) * 1999-07-12 1999-09-15 Quadrant Holdings Cambridge Dry powder compositions
CN1431919A (zh) 2000-04-03 2003-07-23 巴特勒记忆研究所 装置和制剂
ES2323940T3 (es) 2000-05-01 2009-07-28 Accera, Inc. Uso de trigliceridos de cadena media para el tratamiento y prevencion de la enfermedad de alzheimer.
US6835750B1 (en) 2000-05-01 2004-12-28 Accera, Inc. Use of medium chain triglycerides for the treatment and prevention of alzheimer's disease and other diseases resulting from reduced neuronal metabolism II
GB0020616D0 (en) * 2000-08-21 2000-10-11 Quadrant Holdings Cambridge Particulates
GB0025437D0 (en) * 2000-10-17 2000-11-29 Unilever Plc Esters
GB0026593D0 (en) * 2000-10-31 2000-12-13 Quadrant Holdings Cambridge Derivatised carbohydrates and their use in solid delivery systems
EP1343521A2 (de) 2000-12-01 2003-09-17 Battelle Memorial Institute Verfahren zur stabilisierung von biomolekülen (z.b. insulin) in flüssigen formulierungen
GB0124710D0 (en) * 2001-10-15 2001-12-05 Quadrant Healthcare Uk Ltd Therapeutic composition
DE10157124A1 (de) * 2001-11-21 2003-05-28 Lohmann Therapie Syst Lts Mikrofaserhaltige Vorrichtung zur kontrollierten Freisetzung von Stoffen
US8454997B2 (en) 2001-12-18 2013-06-04 Novo Nordisk A/S Solid dose micro implant
WO2003086443A1 (en) * 2002-04-11 2003-10-23 Medimmune Vaccines, Inc. Spray freeze dry of compositions for intranasal administration
GB0208608D0 (en) * 2002-04-13 2002-05-22 Glaxo Group Ltd Composition
GB0208609D0 (en) * 2002-04-13 2002-05-22 Glaxo Group Ltd Compositions
US6945952B2 (en) * 2002-06-25 2005-09-20 Theraject, Inc. Solid solution perforator for drug delivery and other applications
US8062573B2 (en) * 2002-09-16 2011-11-22 Theraject, Inc. Solid micro-perforators and methods of use
US7057852B1 (en) * 2002-10-31 2006-06-06 Western Digital Technologies, Inc. Disk drive including surface coated disk clamp screws with reduced coefficient of friction for mitigating disk clamp movement
GB2395900A (en) * 2002-12-04 2004-06-09 Elan Drug Delivery Ltd Therapeutic composition for respiratory delivery
CA2517929A1 (en) * 2003-03-06 2004-09-16 Accera Inc. Novel-chemical entities and methods for their use in treatment of metabolic disorders
EP1643974A1 (de) * 2003-07-11 2006-04-12 Glaxo Group Limited Pharmazeutische zusammensetzungen enthaltend einen zuckerester
US8961477B2 (en) * 2003-08-25 2015-02-24 3M Innovative Properties Company Delivery of immune response modifier compounds
US7175858B2 (en) * 2004-07-26 2007-02-13 Skeletal Kinetics Llc Calcium phosphate cements and methods for using the same
CA2629393C (en) * 2005-09-06 2014-06-10 Theraject, Inc. Solid solution perforator containing drug particle and/or drug-adsorbed particles
WO2007061781A1 (en) * 2005-11-18 2007-05-31 3M Innovative Properties Company Coatable compositions, coatings derived therefrom and microarrays having such coatings
EP1962942A1 (de) * 2005-12-21 2008-09-03 3M Innovative Properties Company Mikronadelvorrichtungen
ES2362940T3 (es) * 2006-03-27 2011-07-15 Otsuka Chemical Co., Ltd. Compuesto de trehalosa y producto farmacéutico que comprende dicho compuesto.
EP2001293B9 (de) 2006-04-03 2019-04-17 Accera, Inc. Verwendung ketogener verbindungen zur behandlung altersbedingter gedächtnisschwächen
US20070270744A1 (en) 2006-05-17 2007-11-22 Bruno Dacquay Limited Reuse Assembly For Ophthalmic Injection Device
US7811252B2 (en) 2006-05-17 2010-10-12 Alcon Research, Ltd. Dosage control device
US20070270750A1 (en) 2006-05-17 2007-11-22 Alcon, Inc. Drug delivery device
US7887521B2 (en) 2006-05-17 2011-02-15 Alcon Research, Ltd. Ophthalmic injection system
US7862540B2 (en) 2006-05-17 2011-01-04 Alcon Research, Ltd. Ophthalmic injection device using shape memory alloy
US7674243B2 (en) 2006-05-17 2010-03-09 Alcon Inc. Ophthalmic injection device using piezoelectric array
US8084022B2 (en) * 2006-06-23 2011-12-27 Aegis Therapeutics, Llc Stabilizing alkylglycoside compositions and methods thereof
US20100148091A1 (en) 2006-09-29 2010-06-17 Glaxo Group Limited Method and system for rapid phase luminescense spectroscopy analysis
US9022970B2 (en) 2006-10-16 2015-05-05 Alcon Research, Ltd. Ophthalmic injection device including dosage control device
US20080281292A1 (en) 2006-10-16 2008-11-13 Hickingbotham Dyson W Retractable Injection Port
PT2650378E (pt) 2007-07-31 2016-01-14 Accera Inc Utilização de testagem genómica e compostos cetogénicos para o tratamento de função cognitiva reduzida
US7740619B2 (en) 2007-08-01 2010-06-22 Alcon Research, Ltd. Spring driven ophthalmic injection device with safety actuator lockout feature
US7629768B2 (en) 2007-08-03 2009-12-08 Alcon Research, Ltd. Easy cleaning C-shaped charging base
AU2009249610B2 (en) * 2008-05-21 2014-01-16 Theraject, Inc. Method of manufacturing solid solution perforator patches and uses thereof
US8105809B2 (en) 2008-07-03 2012-01-31 Accera, Inc. Enzymatic synthesis of acetoacetate esters and derivatives
CN105640931A (zh) 2008-07-03 2016-06-08 艾克塞拉公司 用于治疗神经性障碍的乙酰乙酸的单甘油酯及其衍生物
US8632511B2 (en) 2009-05-06 2014-01-21 Alcon Research, Ltd. Multiple thermal sensors in a multiple processor environment for temperature control in a drug delivery device
US8177747B2 (en) 2009-12-22 2012-05-15 Alcon Research, Ltd. Method and apparatus for drug delivery
EP2397484A1 (de) * 2010-06-11 2011-12-21 Immunovo B.V. Trisaccharidderivate und ihre Verwendung als Adjuvantien
WO2016079332A1 (en) * 2014-11-21 2016-05-26 Technical University Of Denmark Gel formulations for improving immunotherapy
CN107249570B (zh) * 2014-11-21 2022-08-09 丹麦技术大学 用于局部药物释放的凝胶制剂
WO2016079331A1 (en) * 2014-11-21 2016-05-26 Technical University Of Denmark Gel formulations for enhancing the effect of radiotherapy
US10182939B2 (en) 2015-09-16 2019-01-22 Novartis Ag Hydraulic injector and methods for intra-ocular lens insertion
CN109453106B (zh) * 2019-01-09 2021-06-25 山东大学 一种海藻糖栓剂及其制备方法和应用
WO2020249801A1 (en) 2019-06-12 2020-12-17 Technical University Of Denmark Dissacharide formulations for controlled drug release
EP4282435A1 (de) 2022-05-23 2023-11-29 Danmarks Tekniske Universitet Formulierungen von api's und hilfsstoffen in icells durch hydrophobe ionenpaarung

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE558655A (de) * 1956-06-27
US3284664A (en) * 1959-10-01 1966-11-08 Sylvania Electric Prod Pressure regulation of fluorescent lamps by peltier cooling means
US3309565A (en) * 1959-12-14 1967-03-14 Mc Graw Edison Co Light output of fluorescent lamps automatically held constant by means of peltier type coolers
US3192724A (en) * 1961-04-03 1965-07-06 Northrop Corp Regulated thermoelectric cooling system
US3112890A (en) * 1961-05-16 1963-12-03 Charles D Snelling Fluorescent lamp fixture
GB1399978A (en) * 1973-06-26 1975-07-02 Kicon Ag Lighting fixture and sub-ceiling structure
US3948263A (en) 1974-08-14 1976-04-06 Minnesota Mining And Manufacturing Company Ballistic animal implant
US4070570A (en) * 1976-06-29 1978-01-24 General Energy Development Corporation Lighting apparatus
US4244949A (en) 1978-04-06 1981-01-13 The Population Council, Inc. Manufacture of long term contraceptive implant
GB2074781B (en) * 1980-03-13 1984-03-14 Tokyo Shibaura Electric Co Fluorescent lamp assemblies
US4326524A (en) 1980-09-30 1982-04-27 Minnesota Mining And Manufacturing Company Solid dose ballistic projectile
US4401912A (en) * 1981-05-04 1983-08-30 General Electric Company Metal vapor arc lamp having thermal link diminishable in heat conduction
US4533853A (en) * 1983-03-25 1985-08-06 Xerox Corporation Mechanism and method for controlling the temperature and output of a fluorescent lamp
US4533854A (en) * 1983-03-25 1985-08-06 Xerox Corporation Mechanism and method for controlling the temperature and output of a fluorescent lamp
US4518895A (en) * 1983-03-25 1985-05-21 Xerox Corporation Mechanism and method for controlling the temperature and output of a fluorescent lamp
US4529912A (en) * 1983-03-25 1985-07-16 Xerox Corporation Mechanism and method for controlling the temperature and light output of a fluorescent lamp
JPS60258195A (ja) 1984-06-05 1985-12-20 Ss Pharmaceut Co Ltd α．α―トレハロース脂肪酸ジエステル誘導体
US4746832A (en) * 1985-12-31 1988-05-24 Gte Products Corporation Controlling the vapor pressure of a mercury lamp
US4906463A (en) 1986-12-22 1990-03-06 Cygnus Research Corporation Transdermal drug-delivery composition
US4750096A (en) * 1987-01-13 1988-06-07 Lumatech Corp. Fluorescent light fixture
JPH0218857A (ja) * 1988-07-04 1990-01-23 Japan Aviation Electron Ind Ltd 蛍光ランプ装置
US5049664A (en) 1988-08-26 1991-09-17 Sawai Pharmaceutical Co., Ltd. Trehalose derivatives
US5006343A (en) 1988-12-29 1991-04-09 Benson Bradley J Pulmonary administration of pharmaceutically active substances
US5011678A (en) 1989-02-01 1991-04-30 California Biotechnology Inc. Composition and method for administration of pharmaceutically active substances
GB8903593D0 (en) 1989-02-16 1989-04-05 Pafra Ltd Storage of materials
NL8900406A (nl) * 1989-02-20 1990-09-17 Philips Nv Elektrodeloze lagedrukontladingslamp.
US5554388A (en) * 1989-02-25 1996-09-10 Danbiosyst Uk Limited Systemic drug delivery compositions comprising a polycationi substance
AU5414990A (en) 1989-04-12 1990-11-05 Aberdeen University Slow release vitreous systems
DE69110974T2 (de) * 1990-04-06 1996-03-07 Philips Electronics Nv Elektrodenlose Niederdruckentladungslampe.
US5450336A (en) 1991-03-05 1995-09-12 Aradigm Corporation Method for correcting the drift offset of a transducer
US5229842A (en) * 1991-04-12 1993-07-20 Dolan-Jenner Industries, Inc. Method and apparatus for controlling fluorescent lamp mercury vapor pressure
GB9123953D0 (en) 1991-11-12 1992-01-02 Minnesota Mining & Mfg Inhalation device
WO1993010758A1 (en) 1991-12-05 1993-06-10 Pitman-Moore, Inc. A carbohydrate glass matrix for the sustained release of a therapeutic agent
US5581157A (en) * 1992-05-20 1996-12-03 Diablo Research Corporation Discharge lamps and methods for making discharge lamps
US5591835A (en) 1992-06-29 1997-01-07 Glycomed Incorporated Substituted lactose derivatives
US5239993A (en) 1992-08-26 1993-08-31 Glaxo Inc. Dosage inhalator providing optimized compound inhalation trajectory
BR9307270A (pt) 1992-10-19 1999-06-01 Dura Pharma Inc Inalador de pó seco
SE9203743D0 (sv) 1992-12-11 1992-12-11 Astra Ab Efficient use
WO1996001832A1 (en) 1994-07-11 1996-01-25 The United States Of America, Represented By The Secretary Of The Department Of Agriculture Chemically synthesized sugar esters for the control of soft-bodied arthropods
CA2197982C (en) 1994-08-04 2010-03-23 Bruce Joseph Roser Solid delivery systems for controlled release of molecules incorporated therein and methods of making same
JPH08157491A (ja) 1994-11-30 1996-06-18 Hayashibara Biochem Lab Inc トレハロース誘導体の製造方法
JP2912843B2 (ja) * 1995-03-17 1999-06-28 東洋水産株式会社 アルキルβ−ルチノシドの製造方法および新規アルキルβ−ルチノシド
NZ309841A (en) 1995-06-07 1999-10-28 Quadrant Holdings Cambridge Methods for producing foamed glass matrices (fgm) and compositions obtained thereby
US6457654B1 (en) * 1995-06-12 2002-10-01 Georgia Tech Research Corporation Micromachined synthetic jet actuators and applications thereof
US6123145A (en) * 1995-06-12 2000-09-26 Georgia Tech Research Corporation Synthetic jet actuators for cooling heated bodies and environments
US5612593A (en) * 1995-08-30 1997-03-18 Rockwell International Fluorescent tube thermal management system utilizing thermal electric cooler units
ZA9711732B (en) * 1996-12-31 1998-12-28 Quadrant Holdings Cambridge Methods and compositions for improvement bioavailability of bioactive agents for mucosal delivery
US5909085A (en) * 1997-03-17 1999-06-01 Korry Electronics Co. Hybrid luminosity control system for a fluorescent lamp
DK0994887T3 (da) 1997-07-03 2003-03-17 Elan Drug Delivery Ltd Modificerede glycosider, præparater omfattet deraf og fremgangsmåder til anvendelse deraf
US5808418A (en) * 1997-11-07 1998-09-15 Honeywell Inc. Control mechanism for regulating the temperature and output of a fluorescent lamp
US6411042B1 (en) * 1999-12-29 2002-06-25 Honeywell International Inc. Display cold spot temperature regulator
US6682381B1 (en) * 2000-07-31 2004-01-27 General Electric Company Analysis of mercury in fluorescent lamps by cold spotting
US6578988B2 (en) * 2001-05-07 2003-06-17 General Electric Company Apparatus and method for dissipating heat sensitive components in lighting fixtures by dissipating heat therefrom
US6588497B1 (en) * 2002-04-19 2003-07-08 Georgia Tech Research Corporation System and method for thermal management by synthetic jet ejector channel cooling techniques

Also Published As

Publication number Publication date
EP1042339B1 (de) 2003-03-26
ES2191367T3 (es) 2003-09-01
PT1042339E (pt) 2003-07-31
WO1999033853A3 (en) 1999-09-30
DK1042339T3 (da) 2003-07-21
JP2001527087A (ja) 2001-12-25
EP1042339A2 (de) 2000-10-11
ZA9811843B (en) 1999-06-24
US20020058067A1 (en) 2002-05-16
DE69812711T2 (de) 2003-11-06
WO1999033853A2 (en) 1999-07-08
US6352722B1 (en) 2002-03-05
ATE235503T1 (de) 2003-04-15
CA2316275A1 (en) 1999-07-08
AU2062999A (en) 1999-07-19

Similar Documents

Publication Publication Date Title
DE69812711D1 (de) Kohlenhydraten verwendbar in feste verabreichungssysteme
BR9911070A (pt) Sistema de liberação de droga compreendendo uma matéria-prima de medicamento sólido acentuadamente compacto
DE3780222T2 (de) Pharmazeutische zusammensetzung mit kontrollierter wirkstofffreisetzung.
EP2266542A3 (de) Nanopartikelformulierungen mit kontrollierter Wirkstofffreisetzung
MX9202407A (es) Composicion farmaceutica que contiene un compuesto de alilamina como el agente activo y proceso para su preparacion.
EP0693924A4 (de) Verfahren für die in-vivo-verabreichung von biologischen substanzen und hierfür verwendbare zusammensetzungen
ATE222500T1 (de) Enythropoietin enthaltendes arzneimittelabgabesystem
ATE245450T1 (de) Haftende mikrokügelchen umfassende zusammensetzung zur arzneimittelgabe
KR910007508A (ko) 서방출 드레싱용 제제 및 이의 용도
ES2052016T3 (es) Composicion emulsionada.
AR012998A1 (es) Uso de un sensibilizador a insulina y de un agente antihiperglucemico para la preparacion de un medicamento y composicion farmaceutica que comprende dichosensibilizador y dicho agente.
DK0670160T3 (da) Granulært præparat eller tablet omfattende et brusemiddel og et aktivt farmaceutisk stof samt fremgangsmåde til dets fremst
ES2185654T3 (es) Sistema para la administracion de farmacos.
SE9704401D0 (sv) Matrix pellets for greasy, oily or sticky drug substances
ES2187038T3 (es) Glicosidos modificados, composiciones que los comprenden y procedimientos para su utilizacion.
ES2016620B3 (es) Sistema para liberar medicamentos con bioaceptabilidad mejorada.
SE9704400D0 (sv) Porous inorganic particles as carriers for drug substances
PL315127A1 (en) Deuterised biologically active substances for percutaneous administration
AU1576092A (en) Improved retard systems for delayed release of medical and/or biological valuable substances from a depot-carrier material
NZ513981A (en) Delivery of microparticle formulations using needleless syringe device for sustained-release of bioactive compounds
WO1997009971A3 (en) High capacity, superabsorbent drug reservoirs for use in transdermal drug delivery systems
AU6886987A (en) Veterinary compositions incorporating a water swellable polymer
SE8601563D0 (sv) Matrismaterial, forfarande for framstellning derav och anvendning derav
PT1144420E (pt) Fosfatidilinositois sulfatados a sua preparacao e a sua utilizacao
Little et al. Novel immunopharmacologic uses for amphotericin B

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: QUADRANT DRUG DELIVERY LTD., RUDDINGTON, NOTTINGHA

8339 Ceased/non-payment of the annual fee