DE69809222T2 - Vorrichtungen zur intravaginalen verabreichung von testosteron und testosteron-vorläuferverbindungen - Google Patents

Vorrichtungen zur intravaginalen verabreichung von testosteron und testosteron-vorläuferverbindungen

Info

Publication number
DE69809222T2
DE69809222T2 DE69809222T DE69809222T DE69809222T2 DE 69809222 T2 DE69809222 T2 DE 69809222T2 DE 69809222 T DE69809222 T DE 69809222T DE 69809222 T DE69809222 T DE 69809222T DE 69809222 T2 DE69809222 T2 DE 69809222T2
Authority
DE
Germany
Prior art keywords
testosterone
preconditional
compounds
devices
intravaginal administration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69809222T
Other languages
English (en)
Other versions
DE69809222D1 (de
Inventor
Clare Passmore
Claire Gilligan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Chilcott Ireland Ltd
Original Assignee
Galen Chemicals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galen Chemicals Ltd filed Critical Galen Chemicals Ltd
Publication of DE69809222D1 publication Critical patent/DE69809222D1/de
Application granted granted Critical
Publication of DE69809222T2 publication Critical patent/DE69809222T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
DE69809222T 1997-05-07 1998-05-07 Vorrichtungen zur intravaginalen verabreichung von testosteron und testosteron-vorläuferverbindungen Expired - Lifetime DE69809222T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IE970333 1997-05-07
PCT/IE1998/000033 WO1998050016A2 (en) 1997-05-07 1998-05-07 Intravaginal drug delivery devices for the administration of testosterone and testosterone precursors

Publications (2)

Publication Number Publication Date
DE69809222D1 DE69809222D1 (de) 2002-12-12
DE69809222T2 true DE69809222T2 (de) 2003-08-14

Family

ID=11041465

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69809222T Expired - Lifetime DE69809222T2 (de) 1997-05-07 1998-05-07 Vorrichtungen zur intravaginalen verabreichung von testosteron und testosteron-vorläuferverbindungen

Country Status (15)

Country Link
US (1) US6416780B1 (de)
EP (1) EP0981327B1 (de)
JP (1) JP2001524124A (de)
CN (1) CN1184957C (de)
AT (1) ATE227120T1 (de)
AU (1) AU741482B2 (de)
CA (1) CA2288046C (de)
DE (1) DE69809222T2 (de)
DK (1) DK0981327T3 (de)
ES (1) ES2187024T3 (de)
IL (1) IL132702A0 (de)
NO (1) NO995419L (de)
NZ (1) NZ501236A (de)
PT (1) PT981327E (de)
WO (1) WO1998050016A2 (de)

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US8399013B2 (en) * 2003-06-26 2013-03-19 Poly-Med, Inc. Partially absorbable fiber-reinforced composites for controlled drug delivery
US8404272B2 (en) * 2003-06-26 2013-03-26 Poly-Med, Inc. Fiber-reinforced composite rings for intravaginal controlled drug delivery
AU2005269988B2 (en) 2004-07-02 2012-02-02 Mati Therapeutics Inc. Treatment medium delivery device and methods for delivery
MY145694A (en) 2005-04-11 2012-03-30 Xenon Pharmaceuticals Inc Spiroheterocyclic compounds and their uses as therapeutic agents
MY158766A (en) 2005-04-11 2016-11-15 Xenon Pharmaceuticals Inc Spiro-oxindole compounds and their uses as therapeutic agents
CA2618349C (en) * 2005-08-11 2016-05-31 Massachusetts Institute Of Technology Intravesical drug delivery device and method
KR20090006153A (ko) 2006-03-31 2009-01-14 큐엘티 플러그 딜리버리, 인코포레이티드 비루관계에 대한 약물 전달 방법, 구조, 및 조성물
WO2008060789A2 (en) 2006-10-12 2008-05-22 Xenon Pharmaceuticals Inc. Use of spiro-oxindole compounds as therapeutic agents
BRPI0820800B8 (pt) * 2007-12-11 2021-06-22 Massachusetts Inst Technology dispositivo médico implantável para liberação controlada de droga
JP5507467B2 (ja) * 2008-02-04 2014-05-28 テバ ウィメンズ ヘルス インコーポレイテッド プロゲステロンを含むモノリシック膣内リングならびにそれらの製造方法および使用
US9034365B2 (en) 2008-05-20 2015-05-19 Poly-Med, Inc. Biostable, multipurpose, microbicidal intravaginal devices
CN102176931B (zh) 2008-08-09 2015-03-04 麻省理工学院 治疗男性泌尿生殖组织和外周组织的可植入药物递送设备和方法
US8101647B2 (en) 2008-10-17 2012-01-24 Xenon Pharmaceuticals Inc. Spiro-oxindole compounds and their use as therapeutic agents
RU2011119626A (ru) 2008-10-17 2012-11-27 Ксенон Фармасьютикалз Инк. Спирооксиндольные соединения и их применение в качестве терапевтичеких средств
US20110269788A1 (en) 2008-12-29 2011-11-03 Xenon Pharmaceuticals Inc. Spiro-oxindole-derivatives as sodium channel blockers
ES2401007T3 (es) 2009-06-26 2013-04-16 Taris Biomedical, Inc. Dispositivos de administración de fármaco implantables y procedimientos de fabricación de los mismos
AR077252A1 (es) 2009-06-29 2011-08-10 Xenon Pharmaceuticals Inc Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos
US9017312B2 (en) 2009-09-10 2015-04-28 Taris Biomedical Llc Implantable device for controlled drug delivery
CN102753556B (zh) 2009-10-14 2015-05-13 泽农医药公司 螺-羟吲哚化合物的合成方法
MX343215B (es) 2010-02-26 2016-10-27 Xenon Pharmaceuticals Inc Composiciones farmacéuticas del compuesto espiro-oxindol para administración tópica y sus usos como agentes terapéuticos.
CA2823783C (en) 2011-01-10 2023-03-21 Taris Biomedical, Inc. Lidocaine regimen for the use of sustained treatment of bladder pain and irritative voiding
CN103379902B (zh) 2011-02-04 2015-11-25 塔里斯生物医药公司 用于低溶解度药物的控制释放的可植入装置
US9974685B2 (en) 2011-08-29 2018-05-22 Mati Therapeutics Drug delivery system and methods of treating open angle glaucoma and ocular hypertension
DK3290024T3 (da) 2011-08-29 2019-06-03 Mati Therapeutics Inc Vedvarende indgivelse af aktive midler til behandling af glaukom og okulær hypertension
RU2014121984A (ru) 2011-10-31 2015-12-10 Ксенон Фармасьютикалз Инк. Бензолсульфонамидные соединения и их применение в качестве терапевтических средств
RU2666684C2 (ru) 2013-03-15 2018-09-11 ТАРИС Биомедикал ЛЛК Устройство для доставки лекарственных средств с проницаемым для лекарственного средства компонентом и способ доставки лекарственных средств
CN105377888A (zh) 2013-03-15 2016-03-02 加利福尼亚大学董事会 纤维蛋白溶解的双反应性的有效的Kunitz抑制剂
CN113413393A (zh) 2013-08-19 2021-09-21 塔里斯生物医药公司 多单元药物递送装置和方法
CN104546668B (zh) * 2013-10-23 2019-03-05 国家卫生计生委科学技术研究所 液体硅橡胶为载体的药物缓控释系统的制备及应用
DK2982352T3 (en) * 2014-06-28 2018-11-26 Laboratorios Andromaco S A CERVICALLY PESSAR CONTAINING PROGESTERON FOR EXTENDED, LONG AND CONTINUOUS RELEASE USED TO PREVENT EARLY BIRTHS
AR103636A1 (es) 2015-02-05 2017-05-24 Teva Pharmaceuticals Int Gmbh Métodos de tratamiento de neuralgia postherpética con una formulación tópica de un compuesto de espiro-oxindol
WO2016172704A1 (en) 2015-04-23 2016-10-27 Taris Biomedical Llc Drug delivery devices with drug-permeable component and methods
ES2858753T3 (es) 2016-02-19 2021-09-30 Phoenix Molecular Designs Derivados de 6-oxo-N-(1-(bencil)-1H-pirazol-4-il)-6,7,8,9-tetrahidropirido[3',2':4,5]pirrolo[1,2-a]pirazin-2-carboxamida como inhibidores de cinasa S6 ribosómica (RSK) p90 para el tratamiento del cáncer
BR112018073849A2 (pt) 2016-05-20 2019-02-26 Xenon Pharmaceuticals Inc. compostos benzenossulfonamida e seu uso como agentes terapêuticos
CA3042004A1 (en) 2016-12-09 2018-06-14 Xenon Pharmaceuticals Inc. Benzenesulfonamide compounds and their use as therapeutic agents
PE20211389A1 (es) 2018-06-13 2021-07-27 Xenon Pharmaceuticals Inc Compuestos de bencenosulfonamida y su uso como agentes terapeuticos
MA53329A (fr) 2018-07-27 2022-03-02 Xenon Pharmaceuticals Inc Méthodes de traitement de l'épilepsie
JOP20200337A1 (ar) 2018-08-31 2020-12-24 Xenon Pharmaceuticals Inc مركبات سولفوناميد بها استبدال بأريل غير متجانس واستخدامها كعوامل علاجية
US10752623B2 (en) 2018-08-31 2020-08-25 Xenon Pharmaceuticals Inc. Heteroaryl-substituted sulfonamide compounds and their use as sodium channel inhibitors
US11813354B1 (en) 2019-01-11 2023-11-14 Shear Kershman Laboratories, Inc Trans-mucosal delivery system for testosterone
CN113677681A (zh) 2019-02-11 2021-11-19 凤凰分子设计公司 Rsk抑制剂的结晶形式
TW202328120A (zh) 2021-09-24 2023-07-16 加拿大商再諾製藥公司 做為鈉通道活化劑之吡啶衍生物及其用途
AU2022351156A1 (en) 2021-09-24 2024-04-11 Xenon Pharmaceuticals Inc. Pyridinylacetamide derivatives as sodium channel activators
US20230150972A1 (en) 2021-09-24 2023-05-18 Xenon Pharmaceuticals Inc. Pyridinyl derivatives as sodium channel activators
US20240101531A1 (en) 2022-06-08 2024-03-28 Xenon Pharmaceuticals Inc. Pyridinamine derivatives and their use as potassium channel modulators

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3920805A (en) 1971-12-09 1975-11-18 Upjohn Co Pharmaceutical devices and method
AU538961B2 (en) * 1980-06-09 1984-09-06 Alex Harvey Industries Limited Intra-vaginal device
US5340585A (en) * 1991-04-12 1994-08-23 University Of Southern California Method and formulations for use in treating benign gynecological disorders
IL116433A (en) 1994-12-19 2002-02-10 Galen Chemicals Ltd INTRAVAGINAL DRUG DELIVERY DEVICES FOR THE ADMINISTRATION OF 17β-OESTRADIOL PRECURSORS

Also Published As

Publication number Publication date
DE69809222D1 (de) 2002-12-12
ES2187024T3 (es) 2003-05-16
NO995419D0 (no) 1999-11-05
CA2288046C (en) 2006-10-03
EP0981327B1 (de) 2002-11-06
DK0981327T3 (da) 2003-03-10
US6416780B1 (en) 2002-07-09
ATE227120T1 (de) 2002-11-15
WO1998050016A2 (en) 1998-11-12
EP0981327A2 (de) 2000-03-01
CN1184957C (zh) 2005-01-19
JP2001524124A (ja) 2001-11-27
AU741482B2 (en) 2001-11-29
CN1255056A (zh) 2000-05-31
IL132702A0 (en) 2001-03-19
CA2288046A1 (en) 1998-11-12
NZ501236A (en) 2002-02-01
PT981327E (pt) 2003-02-28
NO995419L (no) 2000-01-07
AU7446998A (en) 1998-11-27
WO1998050016A3 (en) 1999-02-04

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Legal Events

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8364 No opposition during term of opposition