DE69807905D1 - Hochgradienten-magnetvorrichtung und verfahren zur abscheidung oder reinigung von zellen - Google Patents
Hochgradienten-magnetvorrichtung und verfahren zur abscheidung oder reinigung von zellenInfo
- Publication number
- DE69807905D1 DE69807905D1 DE69807905T DE69807905T DE69807905D1 DE 69807905 D1 DE69807905 D1 DE 69807905D1 DE 69807905 T DE69807905 T DE 69807905T DE 69807905 T DE69807905 T DE 69807905T DE 69807905 D1 DE69807905 D1 DE 69807905D1
- Authority
- DE
- Germany
- Prior art keywords
- channel
- separating material
- container
- separating
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000004140 cleaning Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000000926 separation method Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/02—Magnetic separation acting directly on the substance being separated
- B03C1/035—Open gradient magnetic separators, i.e. separators in which the gap is unobstructed, characterised by the configuration of the gap
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/84—Manufacture, treatment, or detection of nanostructure
- Y10S977/888—Shaping or removal of materials, e.g. etching
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
Landscapes
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Water Treatment By Electricity Or Magnetism (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/948,357 US6241894B1 (en) | 1997-10-10 | 1997-10-10 | High gradient magnetic device and method for cell separation or purification |
PCT/EP1998/006420 WO1999019071A1 (en) | 1997-10-10 | 1998-10-09 | High gradient magnetic device and method for cell separation or purification |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69807905D1 true DE69807905D1 (de) | 2002-10-17 |
DE69807905T2 DE69807905T2 (de) | 2003-05-22 |
Family
ID=25487708
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69807905T Expired - Fee Related DE69807905T2 (de) | 1997-10-10 | 1998-10-09 | Hochgradienten-magnetvorrichtung und verfahren zur abscheidung oder reinigung von zellen |
Country Status (9)
Country | Link |
---|---|
US (1) | US6241894B1 (de) |
EP (1) | EP1019195B1 (de) |
AT (1) | ATE223759T1 (de) |
AU (1) | AU1226999A (de) |
DE (1) | DE69807905T2 (de) |
DK (1) | DK1019195T3 (de) |
ES (1) | ES2184332T3 (de) |
PT (1) | PT1019195E (de) |
WO (1) | WO1999019071A1 (de) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6913697B2 (en) | 2001-02-14 | 2005-07-05 | Science & Technology Corporation @ Unm | Nanostructured separation and analysis devices for biological membranes |
DE10127069A1 (de) * | 2001-05-23 | 2002-11-28 | Bio Medical Apherese Systeme G | Magnetfilter zur Abtrennung von strömenden magnetischen Objekten |
EP1331035A1 (de) * | 2002-01-23 | 2003-07-30 | F. Hoffmann-La Roche AG | Apparat zum Zurückhalten von Magnetteilchen in einer von einer Flüssigkeit durchströmte Zelle |
AU2003216175A1 (en) * | 2002-02-04 | 2003-09-02 | Colorado School Of Mines | Laminar flow-based separations of colloidal and cellular particles |
US8895298B2 (en) | 2002-09-27 | 2014-11-25 | The General Hospital Corporation | Microfluidic device for cell separation and uses thereof |
EP1648286B1 (de) | 2003-07-12 | 2017-12-20 | Accelerate Diagnostics, Inc. | Empfindliche und schnelle biodetektion |
US20120077206A1 (en) | 2003-07-12 | 2012-03-29 | Accelr8 Technology Corporation | Rapid Microbial Detection and Antimicrobial Susceptibility Testing |
US20050266394A1 (en) * | 2003-12-24 | 2005-12-01 | Massachusette Institute Of Technology | Magnetophoretic cell clarification |
US20050266433A1 (en) * | 2004-03-03 | 2005-12-01 | Ravi Kapur | Magnetic device for isolation of cells and biomolecules in a microfluidic environment |
US20060171846A1 (en) * | 2005-01-10 | 2006-08-03 | Marr David W M | Microfluidic systems incorporating integrated optical waveguides |
US20070196820A1 (en) | 2005-04-05 | 2007-08-23 | Ravi Kapur | Devices and methods for enrichment and alteration of cells and other particles |
US8921102B2 (en) | 2005-07-29 | 2014-12-30 | Gpb Scientific, Llc | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
US20070059716A1 (en) * | 2005-09-15 | 2007-03-15 | Ulysses Balis | Methods for detecting fetal abnormality |
WO2007044642A2 (en) * | 2005-10-06 | 2007-04-19 | President And Fellows Of Harvard College And Children's Medical Center Corporation | Device and method for combined microfluidic-micromagnetic separation of material in continuous flow |
US9885644B2 (en) | 2006-01-10 | 2018-02-06 | Colorado School Of Mines | Dynamic viscoelasticity as a rapid single-cell biomarker |
US9878326B2 (en) * | 2007-09-26 | 2018-01-30 | Colorado School Of Mines | Fiber-focused diode-bar optical trapping for microfluidic manipulation |
US8119976B2 (en) * | 2007-07-03 | 2012-02-21 | Colorado School Of Mines | Optical-based cell deformability |
US9487812B2 (en) | 2012-02-17 | 2016-11-08 | Colorado School Of Mines | Optical alignment deformation spectroscopy |
US20080007838A1 (en) * | 2006-07-07 | 2008-01-10 | Omnitech Partners, Inc. | Field-of-view indicator, and optical system and associated method employing the same |
US10722250B2 (en) | 2007-09-04 | 2020-07-28 | Colorado School Of Mines | Magnetic-field driven colloidal microbots, methods for forming and using the same |
US20090062828A1 (en) * | 2007-09-04 | 2009-03-05 | Colorado School Of Mines | Magnetic field-based colloidal atherectomy |
DE102007043281A1 (de) | 2007-09-11 | 2009-05-28 | Sebastian Dr. med. Chakrit Bhakdi | Vorrichtung, Materialien und Verfahren zur Hochgradientenmagnetseparation biologischen Materials |
DE102008047855A1 (de) * | 2008-09-18 | 2010-04-22 | Siemens Aktiengesellschaft | Trenneinrichtung zur Trennung von in einer durch einen Trennkanal strömenden Suspension transportierten magnetisierbaren und nichtmagnetisierbaren Teilchen |
WO2010123594A2 (en) * | 2009-01-15 | 2010-10-28 | Children's Medical Center Corporation | Device for filtration of fluids there through and accompanying method |
US8083069B2 (en) * | 2009-07-31 | 2011-12-27 | General Electric Company | High throughput magnetic isolation technique and device for biological materials |
TWI362964B (en) | 2009-12-23 | 2012-05-01 | Ind Tech Res Inst | Magnetic separation device and method for separating magnetic substances in bio-samples |
US10254204B2 (en) | 2011-03-07 | 2019-04-09 | Accelerate Diagnostics, Inc. | Membrane-assisted purification |
US9434937B2 (en) | 2011-03-07 | 2016-09-06 | Accelerate Diagnostics, Inc. | Rapid cell purification systems |
TWI407101B (zh) | 2011-04-11 | 2013-09-01 | Ind Tech Res Inst | 磁分離單元、磁性分離裝置以及分離生化試樣內磁性物質之方法 |
AU2012250179B2 (en) * | 2011-04-27 | 2016-08-18 | Becton Dickinson And Company | Devices and methods for separating magnetically labeled moieties in a sample |
WO2014066553A1 (en) * | 2012-10-26 | 2014-05-01 | Becton, Dickinson And Company | Devices and methods for manipulating components in a fluid sample |
WO2014145075A2 (en) | 2013-03-15 | 2014-09-18 | The Trustees Of Princeton University | Methods and devices for high throughpout purification |
US20150064153A1 (en) | 2013-03-15 | 2015-03-05 | The Trustees Of Princeton University | High efficiency microfluidic purification of stem cells to improve transplants |
US9677109B2 (en) | 2013-03-15 | 2017-06-13 | Accelerate Diagnostics, Inc. | Rapid determination of microbial growth and antimicrobial susceptibility |
CN105264127B (zh) | 2013-03-15 | 2019-04-09 | Gpb科学有限责任公司 | 颗粒的片上微流体处理 |
JP6041280B2 (ja) * | 2013-06-28 | 2016-12-07 | 国立研究開発法人産業技術総合研究所 | 磁選機用マトリックス及び磁選機 |
WO2016161022A2 (en) | 2015-03-30 | 2016-10-06 | Accerlate Diagnostics, Inc. | Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing |
US10253355B2 (en) | 2015-03-30 | 2019-04-09 | Accelerate Diagnostics, Inc. | Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing |
US10976232B2 (en) | 2015-08-24 | 2021-04-13 | Gpb Scientific, Inc. | Methods and devices for multi-step cell purification and concentration |
GB201519668D0 (en) * | 2015-11-06 | 2015-12-23 | Ge Healthcare Bio Sciences Ab | Method and chromatography media |
US10625272B2 (en) | 2015-11-18 | 2020-04-21 | Industrial Technology Research Institute | Magnetic separator |
WO2018024819A1 (en) * | 2016-08-05 | 2018-02-08 | Haute Ecole D'ingenierie Et De Gestion Du Canton De Vaud (Heig-Vd) | Device for removing particles from a material in movement |
BR102016022548B1 (pt) * | 2016-09-28 | 2022-03-22 | José Pancrácio Ribeiro | Matriz magnética ondulada para separador magnético de alta intensidade |
JP7393328B2 (ja) | 2017-09-01 | 2023-12-06 | ジーピービー・サイエンティフィック・インコーポレイテッド | マイクロ流体を使用した治療的に活性な細胞を調製する方法 |
WO2020058136A1 (en) * | 2018-09-20 | 2020-03-26 | Hemotune Ag | Assembly for magnetic separation-based body fluid purification |
EP4103518A4 (de) * | 2020-02-11 | 2023-11-01 | Khalifa University of Science and Technology | Systeme und verfahren zur verbesserung der effizienz von trennverfahren |
US11529636B2 (en) | 2020-10-09 | 2022-12-20 | Cláudio Henrique Teixeira Ribeiro | Magnetic matrices and methods of using the same |
CN112553043A (zh) * | 2020-12-09 | 2021-03-26 | 深圳先进技术研究院 | 用于胎儿有核红细胞分离纯化的微流控芯片 |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB236808A (en) * | 1924-12-02 | 1925-07-16 | Krupp Fried Grusonwerk Ag | Improvements in or relating to zone poles for magnetic separators |
US4212651A (en) * | 1979-05-30 | 1980-07-15 | The United States Of America As Represented By The United States Department Of Energy | High gradient magnetic beneficiation of dry pulverized coal via upwardly directed recirculating fluidization |
US4387286A (en) | 1980-03-26 | 1983-06-07 | Inoue-Japax Research Incorporated | Apparatus for controlling splashes and purification of a machining liquid |
US4560484A (en) * | 1980-04-25 | 1985-12-24 | Purdue Research Foundation | Method and apparatus for magnetically separating particles from a liquid |
US4743364A (en) | 1984-03-16 | 1988-05-10 | Kyrazis Demos T | Magnetic separation of electrically conducting particles from non-conducting material |
US4710472A (en) * | 1985-09-25 | 1987-12-01 | The United States Of America As Represented By The Secretary Of The Navy | Magnetic separation device |
US4795698A (en) * | 1985-10-04 | 1989-01-03 | Immunicon Corporation | Magnetic-polymer particles |
US5512332A (en) * | 1985-10-04 | 1996-04-30 | Immunivest Corporation | Process of making resuspendable coated magnetic particles |
US5076950A (en) * | 1985-12-20 | 1991-12-31 | Syntex (U.S.A.) Inc. | Magnetic composition for particle separation |
DE68916843T2 (de) * | 1988-04-26 | 1995-02-02 | Nippon Telegraph & Telephone | Mikropartikel, Verfahren und Gerät zur Sammlung von Proben zur Verwendung bei der Markierung von Immunreaktionen und Verfahren und Gerät zur Bereitung von Proben. |
US5536475A (en) | 1988-10-11 | 1996-07-16 | Baxter International Inc. | Apparatus for magnetic cell separation |
US5385707A (en) | 1988-12-28 | 1995-01-31 | Stefan Miltenyi | Metal matrices for use in high gradient magnetic separation of biological materials and method for coating the same |
ES2067018T3 (es) | 1988-12-28 | 1995-03-16 | Stefan Miltenyi | Procedimiento y materiales para la separacion en alto gradiente magnetico de materiales biologicos. |
US5081030A (en) * | 1989-04-25 | 1992-01-14 | The Johns Hopkins University | Release of cells from affinity matrices |
WO1994011078A1 (en) * | 1992-11-16 | 1994-05-26 | Immunivest Corporation | Magnetic immobilization and manipulation of biological entities |
US5466574A (en) | 1991-03-25 | 1995-11-14 | Immunivest Corporation | Apparatus and methods for magnetic separation featuring external magnetic means |
GB9106284D0 (en) * | 1991-03-25 | 1991-05-08 | Cryogenic Consult | Improvements in and relating to magnetic separators |
EP0589636B1 (de) | 1992-09-24 | 2000-08-02 | Amersham Pharmacia Biotech UK Limited | Verfahren und Vorrichtung zur magnetischen Abscheidung |
US5514340A (en) * | 1994-01-24 | 1996-05-07 | Magnetix Biotechnology, Inc. | Device for separating magnetically labelled cells |
US5520158A (en) * | 1995-01-12 | 1996-05-28 | Gasmaster International, Inc. | Magnetic field fuel treatment device |
AU5360596A (en) * | 1995-04-06 | 1996-10-23 | Miltenyi Biotech, Inc. | Multiparameter cell separation using releasable colloidal ma gnetic particles |
JP2000512434A (ja) | 1995-11-03 | 2000-09-19 | サーノフ コーポレイション | 磁 石 |
-
1997
- 1997-10-10 US US08/948,357 patent/US6241894B1/en not_active Expired - Fee Related
-
1998
- 1998-10-09 EP EP98955422A patent/EP1019195B1/de not_active Expired - Lifetime
- 1998-10-09 DE DE69807905T patent/DE69807905T2/de not_active Expired - Fee Related
- 1998-10-09 WO PCT/EP1998/006420 patent/WO1999019071A1/en active IP Right Grant
- 1998-10-09 AU AU12269/99A patent/AU1226999A/en not_active Abandoned
- 1998-10-09 DK DK98955422T patent/DK1019195T3/da active
- 1998-10-09 AT AT98955422T patent/ATE223759T1/de not_active IP Right Cessation
- 1998-10-09 PT PT98955422T patent/PT1019195E/pt unknown
- 1998-10-09 ES ES98955422T patent/ES2184332T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP1019195B1 (de) | 2002-09-11 |
DE69807905T2 (de) | 2003-05-22 |
ATE223759T1 (de) | 2002-09-15 |
ES2184332T3 (es) | 2003-04-01 |
EP1019195A1 (de) | 2000-07-19 |
AU1226999A (en) | 1999-05-03 |
US6241894B1 (en) | 2001-06-05 |
WO1999019071A1 (en) | 1999-04-22 |
DK1019195T3 (da) | 2002-12-30 |
PT1019195E (pt) | 2003-01-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69807905T2 (de) | Hochgradienten-magnetvorrichtung und verfahren zur abscheidung oder reinigung von zellen | |
ATE399048T1 (de) | Verfahren und vorrichtung zur magnetischen trennung ausgewählter partikel, insbesondere biologischer zellen | |
DE60207412D1 (de) | Verfahren, vorrichtung und einrichtung zur nasstrennung von magnetischen mikroteilchen | |
ATE178506T1 (de) | Vorrichtung zur abscheidung von mikroskopischen teilchen aus der luft | |
DE69701418D1 (de) | Verfahren und Vorrichtung zum Waschen, zur Resuspension, zum Wiedersammeln und zur Lokalisierung von magnetisierbaren Teilchen in der magnetischen Trennungstechnik von Proben | |
FI943144A0 (fi) | Parannettu suodatin ja menetelmä varattujen hiukkasten erottamiseksi nestevirtauksesta | |
DE59909467D1 (de) | Vorrichtung zur Erkennung von Fremdstoffen in strangförmigem textilen Material | |
ATE226726T1 (de) | Verfahren und vorrichtung zur sammlung, lagerung und echtzeitanalyse von blut und anderen körperflüssigkeiten | |
ATE409523T1 (de) | Apparat zur zurückhaltung von magnetteilchen in einer durchflusszelle | |
ATE287296T1 (de) | Trennungssystem und abscheider für in flüssigkeit dispergierte magnetteilchen | |
DE58904411D1 (de) | Verfahren zum abtrennen von hochmolekularen substanzen aus fluessigen naehrmedien sowie vorrichtung zur durchfuehrung des verfahrens. | |
DE69709701T2 (de) | Trennungsverfahren und -apparat von teilchen aus einem elektrisch leitenden flüssigkeitstrom unter verwendung elektromagnetischer kräfte | |
FI945973A (fi) | Menetelmät ja laite heikosti magneettisten aineiden erottamiseksi | |
DE69328541D1 (de) | Vorrichtung zum Erfassen der Merkmale von in einem Luftstrom bewegten Teilchen | |
DE3686714D1 (de) | Elektrophorese-verfahren und vorrichtung zur trennung von teilchen in einem trennmedium. | |
DE3779463D1 (de) | Verfahren und vorrichtung zur agglomerierung von elektrisch ungleichfoermig aufgeladenen, in gasstroemen suspendierten festen oder fluessigen partikeln. | |
ATE256866T1 (de) | Verfahren und vorrichtung zur isoelektrischen teilchentrennung | |
BR9509355A (pt) | Sistema separador e aparelho divisor do tipo classificador | |
SE8107151L (sv) | Forfarande vid magnetseparatorer | |
ATE177350T1 (de) | Vorrichtung zur reinigung von schwermetalle enthaltendem bodenmaterial | |
IT9047594A1 (it) | Metodo e apparecchio per bagnare le particelle contenute in un flusso di gas. | |
DE69612865T2 (de) | Partikelförmiges medium zur genauen trennung von in fluiden suspendierten teilchen | |
RU2197331C2 (ru) | Устройство для обогащения дисперсных систем | |
DE50006545D1 (de) | Vorrichtung zur Aufteilung eines Zustroms von Feststoffpartikeln in Teilströme | |
TH21672A (th) | กรรมวิธีสำหรับการแยกเก็บ พอลิไฮดรอกซิแอลคาโนเอทโดยการใช้การใช้แรงเหวี่ยงหนีศูนย์กลางเพื่อแยกตามลำดับส่วน |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |