PT1019195E - Aparelho de elevado gradiente magnetico e metodo de separacao de celulas ou purificacao - Google Patents

Aparelho de elevado gradiente magnetico e metodo de separacao de celulas ou purificacao

Info

Publication number
PT1019195E
PT1019195E PT98955422T PT98955422T PT1019195E PT 1019195 E PT1019195 E PT 1019195E PT 98955422 T PT98955422 T PT 98955422T PT 98955422 T PT98955422 T PT 98955422T PT 1019195 E PT1019195 E PT 1019195E
Authority
PT
Portugal
Prior art keywords
channel
separating material
cells
container
purification
Prior art date
Application number
PT98955422T
Other languages
English (en)
Inventor
Srikanth Ranga Chary
Richard Merrill Schwartz
Donald David Briggs
Shang-Chih Jen
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PT1019195E publication Critical patent/PT1019195E/pt

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00Magnetic separation
    • B03C1/02Magnetic separation acting directly on the substance being separated
    • B03C1/035Open gradient magnetic separators, i.e. separators in which the gap is unobstructed, characterised by the configuration of the gap
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/84Manufacture, treatment, or detection of nanostructure
    • Y10S977/888Shaping or removal of materials, e.g. etching
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/902Specified use of nanostructure

Landscapes

  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Water Treatment By Electricity Or Magnetism (AREA)
PT98955422T 1997-10-10 1998-10-09 Aparelho de elevado gradiente magnetico e metodo de separacao de celulas ou purificacao PT1019195E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/948,357 US6241894B1 (en) 1997-10-10 1997-10-10 High gradient magnetic device and method for cell separation or purification

Publications (1)

Publication Number Publication Date
PT1019195E true PT1019195E (pt) 2003-01-31

Family

ID=25487708

Family Applications (1)

Application Number Title Priority Date Filing Date
PT98955422T PT1019195E (pt) 1997-10-10 1998-10-09 Aparelho de elevado gradiente magnetico e metodo de separacao de celulas ou purificacao

Country Status (9)

Country Link
US (1) US6241894B1 (pt)
EP (1) EP1019195B1 (pt)
AT (1) ATE223759T1 (pt)
AU (1) AU1226999A (pt)
DE (1) DE69807905T2 (pt)
DK (1) DK1019195T3 (pt)
ES (1) ES2184332T3 (pt)
PT (1) PT1019195E (pt)
WO (1) WO1999019071A1 (pt)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6913697B2 (en) 2001-02-14 2005-07-05 Science & Technology Corporation @ Unm Nanostructured separation and analysis devices for biological membranes
DE10127069A1 (de) * 2001-05-23 2002-11-28 Bio Medical Apherese Systeme G Magnetfilter zur Abtrennung von strömenden magnetischen Objekten
EP1331035A1 (en) * 2002-01-23 2003-07-30 F. Hoffmann-La Roche AG Apparatus for retaining magnetic particles within a flow-through cell
AU2003216175A1 (en) * 2002-02-04 2003-09-02 Colorado School Of Mines Laminar flow-based separations of colloidal and cellular particles
WO2004029221A2 (en) 2002-09-27 2004-04-08 The General Hospital Corporation Microfluidic device for cell separation and uses thereof
CA2532414C (en) 2003-07-12 2017-03-14 Accelr8 Technology Corporation Sensitive and rapid biodetection
US20120077206A1 (en) 2003-07-12 2012-03-29 Accelr8 Technology Corporation Rapid Microbial Detection and Antimicrobial Susceptibility Testing
WO2005065267A2 (en) * 2003-12-24 2005-07-21 Massachusetts Institute Of Technology Magnetophoretic cell clarification
WO2005084374A2 (en) * 2004-03-03 2005-09-15 The General Hospital Corporation Magnetic device for isolation of cells and biomolecules in a microfluidic environment
US20060171846A1 (en) * 2005-01-10 2006-08-03 Marr David W M Microfluidic systems incorporating integrated optical waveguides
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070059716A1 (en) * 2005-09-15 2007-03-15 Ulysses Balis Methods for detecting fetal abnormality
WO2007044642A2 (en) * 2005-10-06 2007-04-19 President And Fellows Of Harvard College And Children's Medical Center Corporation Device and method for combined microfluidic-micromagnetic separation of material in continuous flow
US9487812B2 (en) 2012-02-17 2016-11-08 Colorado School Of Mines Optical alignment deformation spectroscopy
US9885644B2 (en) 2006-01-10 2018-02-06 Colorado School Of Mines Dynamic viscoelasticity as a rapid single-cell biomarker
US9878326B2 (en) * 2007-09-26 2018-01-30 Colorado School Of Mines Fiber-focused diode-bar optical trapping for microfluidic manipulation
US8119976B2 (en) * 2007-07-03 2012-02-21 Colorado School Of Mines Optical-based cell deformability
US20080007838A1 (en) * 2006-07-07 2008-01-10 Omnitech Partners, Inc. Field-of-view indicator, and optical system and associated method employing the same
US10722250B2 (en) 2007-09-04 2020-07-28 Colorado School Of Mines Magnetic-field driven colloidal microbots, methods for forming and using the same
US20090062828A1 (en) * 2007-09-04 2009-03-05 Colorado School Of Mines Magnetic field-based colloidal atherectomy
DE102007043281A1 (de) 2007-09-11 2009-05-28 Sebastian Dr. med. Chakrit Bhakdi Vorrichtung, Materialien und Verfahren zur Hochgradientenmagnetseparation biologischen Materials
DE102008047855A1 (de) * 2008-09-18 2010-04-22 Siemens Aktiengesellschaft Trenneinrichtung zur Trennung von in einer durch einen Trennkanal strömenden Suspension transportierten magnetisierbaren und nichtmagnetisierbaren Teilchen
WO2010123594A2 (en) * 2009-01-15 2010-10-28 Children's Medical Center Corporation Device for filtration of fluids there through and accompanying method
US8083069B2 (en) * 2009-07-31 2011-12-27 General Electric Company High throughput magnetic isolation technique and device for biological materials
TWI362964B (en) 2009-12-23 2012-05-01 Ind Tech Res Inst Magnetic separation device and method for separating magnetic substances in bio-samples
EP2683831B1 (en) 2011-03-07 2015-09-23 Accelerate Diagnostics, Inc. Rapid cell purification systems
US10254204B2 (en) 2011-03-07 2019-04-09 Accelerate Diagnostics, Inc. Membrane-assisted purification
TWI407101B (zh) 2011-04-11 2013-09-01 Ind Tech Res Inst 磁分離單元、磁性分離裝置以及分離生化試樣內磁性物質之方法
BR112013024148B1 (pt) 2011-04-27 2022-01-25 Becton, Dickinson And Company Dispositivo, método e sistema para separar partes marcadas magneticamente em uma amostra, método de separar partes marcadas magneticamente em uma amostra
WO2014066553A1 (en) * 2012-10-26 2014-05-01 Becton, Dickinson And Company Devices and methods for manipulating components in a fluid sample
WO2014145152A2 (en) 2013-03-15 2014-09-18 Gpb Scientific, Llc On-chip microfluidic processing of particles
US10324011B2 (en) 2013-03-15 2019-06-18 The Trustees Of Princeton University Methods and devices for high throughput purification
US9677109B2 (en) 2013-03-15 2017-06-13 Accelerate Diagnostics, Inc. Rapid determination of microbial growth and antimicrobial susceptibility
US20150064153A1 (en) 2013-03-15 2015-03-05 The Trustees Of Princeton University High efficiency microfluidic purification of stem cells to improve transplants
CN105339090B (zh) * 2013-06-28 2017-03-08 独立行政法人产业技术综合研究所 磁选机用介质以及磁选机
US10253355B2 (en) 2015-03-30 2019-04-09 Accelerate Diagnostics, Inc. Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
EP3278115A2 (en) 2015-03-30 2018-02-07 Accelerate Diagnostics, Inc. Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
US10976232B2 (en) 2015-08-24 2021-04-13 Gpb Scientific, Inc. Methods and devices for multi-step cell purification and concentration
GB201519668D0 (en) * 2015-11-06 2015-12-23 Ge Healthcare Bio Sciences Ab Method and chromatography media
TWI673105B (zh) 2015-11-18 2019-10-01 財團法人工業技術研究院 磁分離器
WO2018024819A1 (en) * 2016-08-05 2018-02-08 Haute Ecole D'ingenierie Et De Gestion Du Canton De Vaud (Heig-Vd) Device for removing particles from a material in movement
BR102016022548B1 (pt) * 2016-09-28 2022-03-22 José Pancrácio Ribeiro Matriz magnética ondulada para separador magnético de alta intensidade
WO2019046052A1 (en) 2017-09-01 2019-03-07 Gpb Scientific, Llc METHODS FOR PREPARING THERAPEUTICALLY ACTIVE CELLS USING MICROFLUIDIC
WO2020058136A1 (en) * 2018-09-20 2020-03-26 Hemotune Ag Assembly for magnetic separation-based body fluid purification
WO2021161221A1 (en) * 2020-02-11 2021-08-19 Khalifa University of Science and Technology Systems and methods for enhancing the efficiency of separation processes
US11529636B2 (en) 2020-10-09 2022-12-20 Cláudio Henrique Teixeira Ribeiro Magnetic matrices and methods of using the same
CN112553043A (zh) * 2020-12-09 2021-03-26 深圳先进技术研究院 用于胎儿有核红细胞分离纯化的微流控芯片

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB236808A (en) * 1924-12-02 1925-07-16 Krupp Fried Grusonwerk Ag Improvements in or relating to zone poles for magnetic separators
US4212651A (en) * 1979-05-30 1980-07-15 The United States Of America As Represented By The United States Department Of Energy High gradient magnetic beneficiation of dry pulverized coal via upwardly directed recirculating fluidization
US4387286A (en) 1980-03-26 1983-06-07 Inoue-Japax Research Incorporated Apparatus for controlling splashes and purification of a machining liquid
US4560484A (en) * 1980-04-25 1985-12-24 Purdue Research Foundation Method and apparatus for magnetically separating particles from a liquid
US4743364A (en) 1984-03-16 1988-05-10 Kyrazis Demos T Magnetic separation of electrically conducting particles from non-conducting material
US4710472A (en) * 1985-09-25 1987-12-01 The United States Of America As Represented By The Secretary Of The Navy Magnetic separation device
US5512332A (en) * 1985-10-04 1996-04-30 Immunivest Corporation Process of making resuspendable coated magnetic particles
US4795698A (en) * 1985-10-04 1989-01-03 Immunicon Corporation Magnetic-polymer particles
US5076950A (en) * 1985-12-20 1991-12-31 Syntex (U.S.A.) Inc. Magnetic composition for particle separation
DE68916843T2 (de) * 1988-04-26 1995-02-02 Nippon Telegraph & Telephone Mikropartikel, Verfahren und Gerät zur Sammlung von Proben zur Verwendung bei der Markierung von Immunreaktionen und Verfahren und Gerät zur Bereitung von Proben.
US5536475A (en) 1988-10-11 1996-07-16 Baxter International Inc. Apparatus for magnetic cell separation
US5385707A (en) 1988-12-28 1995-01-31 Stefan Miltenyi Metal matrices for use in high gradient magnetic separation of biological materials and method for coating the same
WO1990007380A2 (en) * 1988-12-28 1990-07-12 Stefan Miltenyi Methods and materials for high gradient magnetic separation of biological materials
US5081030A (en) * 1989-04-25 1992-01-14 The Johns Hopkins University Release of cells from affinity matrices
WO1994011078A1 (en) * 1992-11-16 1994-05-26 Immunivest Corporation Magnetic immobilization and manipulation of biological entities
GB9106284D0 (en) * 1991-03-25 1991-05-08 Cryogenic Consult Improvements in and relating to magnetic separators
US5466574A (en) 1991-03-25 1995-11-14 Immunivest Corporation Apparatus and methods for magnetic separation featuring external magnetic means
EP0589636B1 (en) 1992-09-24 2000-08-02 Amersham Pharmacia Biotech UK Limited Magnetic separation method and apparatus therefor
US5514340A (en) * 1994-01-24 1996-05-07 Magnetix Biotechnology, Inc. Device for separating magnetically labelled cells
US5520158A (en) * 1995-01-12 1996-05-28 Gasmaster International, Inc. Magnetic field fuel treatment device
EP0819250B1 (en) * 1995-04-06 2006-09-20 Miltenyi Biotec Inc. Multiparameter cell separation using releasable colloidal magnetic particles
WO1997016835A1 (en) 1995-11-03 1997-05-09 David Sarnoff Research Center Magnet

Also Published As

Publication number Publication date
WO1999019071A1 (en) 1999-04-22
US6241894B1 (en) 2001-06-05
ES2184332T3 (es) 2003-04-01
DE69807905T2 (de) 2003-05-22
AU1226999A (en) 1999-05-03
DE69807905D1 (de) 2002-10-17
ATE223759T1 (de) 2002-09-15
DK1019195T3 (da) 2002-12-30
EP1019195B1 (en) 2002-09-11
EP1019195A1 (en) 2000-07-19

Similar Documents

Publication Publication Date Title
PT1019195E (pt) Aparelho de elevado gradiente magnetico e metodo de separacao de celulas ou purificacao
WO1998058725A8 (en) Apparatus for separation and concentration of particles from a fluid stream
EP0475533A3 (en) Method and apparatus for the introduction of a volume of at least one fluid in a tube, in particular suitable for capillary electrophoresis systems and method and apparatus for separating and/or analyzing a fluid material
DE60207412D1 (de) Verfahren, vorrichtung und einrichtung zur nasstrennung von magnetischen mikroteilchen
SE9702291D0 (sv) Anordning för att tillföra en vätska under tryck
EP0359900A3 (en) Process for separating highly molecular substances from liquid culture media, and device for carrying out the process
IT8023465A0 (it) Procedimento e dispositivo per analizzare l'aliquota di sostanze solide in una corrente di convogliamento idraulica composta di particelle solide e di un liquido vettore.
DE59606602D1 (de) Vorrichtung zum filtern und trennen von strömungsmedien
IL134404A (en) Method and apparatus for separating particulate matter from a liquid specimen
FI961832A (fi) Menetelmä ja laite rajapinnan säätämiseksi kahden hallitusti virtaavanja toisistaan erottuvan liuoksen välillä sekä molempien liuosten ulosjohtamiseksi erotustilasta
ATE8848T1 (de) Elektrostatische filtervorrichtung zur reinigung von gasen.
DE60212647D1 (de) Antimikrobielles mittel
EP0199470A3 (en) Method and apparatus for separating complex mixtures of bio-organic materials
DE3686714D1 (de) Elektrophorese-verfahren und vorrichtung zur trennung von teilchen in einem trennmedium.
BR9509355A (pt) Sistema separador e aparelho divisor do tipo classificador
ATE256866T1 (de) Verfahren und vorrichtung zur isoelektrischen teilchentrennung
ES2001874A6 (es) Metodo y aparato para hacer flocular continuamente una pasta de particulas minerales y mejorar su filtracion.
IT1240081B (it) Metodo e apparecchio per bagnare le particelle contenute in un flusso di gas.
SE0004352D0 (sv) System och metod för anslutning av vätskor i ett mikrofluidiskt flödescellsystem
DE69508238D1 (de) Vorrichtung zur reinigung von schwermetalle enthaltendem bodenmaterial
EP0005408A3 (en) Recovery of small particles by flow centrifugation
EA199900607A1 (ru) Устройство для пропускания газа через спекаемый материал
HUT39100A (en) Apparatus for clearing away the floating solid material particles from gaseous medium
SE8602816L (sv) Pa centrifugalprincipen verkande anordning
RU94037161A (ru) Способ разделения жидких гетерогенных систем и устройство для его осуществления