ATE223759T1 - Hochgradienten-magnetvorrichtung und verfahren zur abscheidung oder reinigung von zellen - Google Patents
Hochgradienten-magnetvorrichtung und verfahren zur abscheidung oder reinigung von zellenInfo
- Publication number
- ATE223759T1 ATE223759T1 AT98955422T AT98955422T ATE223759T1 AT E223759 T1 ATE223759 T1 AT E223759T1 AT 98955422 T AT98955422 T AT 98955422T AT 98955422 T AT98955422 T AT 98955422T AT E223759 T1 ATE223759 T1 AT E223759T1
- Authority
- AT
- Austria
- Prior art keywords
- channel
- separating material
- container
- separating
- cells
- Prior art date
Links
- 238000004140 cleaning Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000000926 separation method Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/02—Magnetic separation acting directly on the substance being separated
- B03C1/035—Open gradient magnetic separators, i.e. separators in which the gap is unobstructed, characterised by the configuration of the gap
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/84—Manufacture, treatment, or detection of nanostructure
- Y10S977/888—Shaping or removal of materials, e.g. etching
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
Landscapes
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Water Treatment By Electricity Or Magnetism (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/948,357 US6241894B1 (en) | 1997-10-10 | 1997-10-10 | High gradient magnetic device and method for cell separation or purification |
| PCT/EP1998/006420 WO1999019071A1 (en) | 1997-10-10 | 1998-10-09 | High gradient magnetic device and method for cell separation or purification |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE223759T1 true ATE223759T1 (de) | 2002-09-15 |
Family
ID=25487708
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98955422T ATE223759T1 (de) | 1997-10-10 | 1998-10-09 | Hochgradienten-magnetvorrichtung und verfahren zur abscheidung oder reinigung von zellen |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6241894B1 (de) |
| EP (1) | EP1019195B1 (de) |
| AT (1) | ATE223759T1 (de) |
| AU (1) | AU1226999A (de) |
| DE (1) | DE69807905T2 (de) |
| DK (1) | DK1019195T3 (de) |
| ES (1) | ES2184332T3 (de) |
| PT (1) | PT1019195E (de) |
| WO (1) | WO1999019071A1 (de) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6913697B2 (en) | 2001-02-14 | 2005-07-05 | Science & Technology Corporation @ Unm | Nanostructured separation and analysis devices for biological membranes |
| DE10127069A1 (de) * | 2001-05-23 | 2002-11-28 | Bio Medical Apherese Systeme G | Magnetfilter zur Abtrennung von strömenden magnetischen Objekten |
| EP1331035A1 (de) * | 2002-01-23 | 2003-07-30 | F. Hoffmann-La Roche AG | Apparat zum Zurückhalten von Magnetteilchen in einer von einer Flüssigkeit durchströmte Zelle |
| US7318902B2 (en) * | 2002-02-04 | 2008-01-15 | Colorado School Of Mines | Laminar flow-based separations of colloidal and cellular particles |
| ES2375724T3 (es) | 2002-09-27 | 2012-03-05 | The General Hospital Corporation | Dispositivo microflu�?dico para seperación de células y sus usos. |
| USD490531S1 (en) | 2002-11-22 | 2004-05-25 | Stemcell Technologies Inc. | Magnetic separator housing |
| US20120077206A1 (en) | 2003-07-12 | 2012-03-29 | Accelr8 Technology Corporation | Rapid Microbial Detection and Antimicrobial Susceptibility Testing |
| CA2956645A1 (en) | 2003-07-12 | 2005-03-31 | David A. Goldberg | Sensitive and rapid biodetection |
| US20050266394A1 (en) * | 2003-12-24 | 2005-12-01 | Massachusette Institute Of Technology | Magnetophoretic cell clarification |
| CA2557819A1 (en) * | 2004-03-03 | 2005-09-15 | The General Hospital Corporation | Magnetic device for isolation of cells and biomolecules in a microfluidic environment |
| US20060171846A1 (en) * | 2005-01-10 | 2006-08-03 | Marr David W M | Microfluidic systems incorporating integrated optical waveguides |
| US20070196820A1 (en) | 2005-04-05 | 2007-08-23 | Ravi Kapur | Devices and methods for enrichment and alteration of cells and other particles |
| US8921102B2 (en) | 2005-07-29 | 2014-12-30 | Gpb Scientific, Llc | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
| US20070059716A1 (en) * | 2005-09-15 | 2007-03-15 | Ulysses Balis | Methods for detecting fetal abnormality |
| US9220831B2 (en) * | 2005-10-06 | 2015-12-29 | Children's Medical Center Corporation | Device and method for combined microfluidic-micromagnetic separation of material in continuous flow |
| US9487812B2 (en) | 2012-02-17 | 2016-11-08 | Colorado School Of Mines | Optical alignment deformation spectroscopy |
| US9885644B2 (en) | 2006-01-10 | 2018-02-06 | Colorado School Of Mines | Dynamic viscoelasticity as a rapid single-cell biomarker |
| US9878326B2 (en) * | 2007-09-26 | 2018-01-30 | Colorado School Of Mines | Fiber-focused diode-bar optical trapping for microfluidic manipulation |
| US8119976B2 (en) * | 2007-07-03 | 2012-02-21 | Colorado School Of Mines | Optical-based cell deformability |
| US20080007838A1 (en) * | 2006-07-07 | 2008-01-10 | Omnitech Partners, Inc. | Field-of-view indicator, and optical system and associated method employing the same |
| US10722250B2 (en) | 2007-09-04 | 2020-07-28 | Colorado School Of Mines | Magnetic-field driven colloidal microbots, methods for forming and using the same |
| US20090062828A1 (en) * | 2007-09-04 | 2009-03-05 | Colorado School Of Mines | Magnetic field-based colloidal atherectomy |
| DE102007043281A1 (de) | 2007-09-11 | 2009-05-28 | Sebastian Dr. med. Chakrit Bhakdi | Vorrichtung, Materialien und Verfahren zur Hochgradientenmagnetseparation biologischen Materials |
| DE102008047855A1 (de) * | 2008-09-18 | 2010-04-22 | Siemens Aktiengesellschaft | Trenneinrichtung zur Trennung von in einer durch einen Trennkanal strömenden Suspension transportierten magnetisierbaren und nichtmagnetisierbaren Teilchen |
| US9156037B2 (en) | 2009-01-15 | 2015-10-13 | Children's Medical Center Corporation | Microfluidic device and uses thereof |
| US8083069B2 (en) * | 2009-07-31 | 2011-12-27 | General Electric Company | High throughput magnetic isolation technique and device for biological materials |
| TWI362964B (en) | 2009-12-23 | 2012-05-01 | Ind Tech Res Inst | Magnetic separation device and method for separating magnetic substances in bio-samples |
| US9434937B2 (en) | 2011-03-07 | 2016-09-06 | Accelerate Diagnostics, Inc. | Rapid cell purification systems |
| US10254204B2 (en) | 2011-03-07 | 2019-04-09 | Accelerate Diagnostics, Inc. | Membrane-assisted purification |
| TWI407101B (zh) | 2011-04-11 | 2013-09-01 | Ind Tech Res Inst | 磁分離單元、磁性分離裝置以及分離生化試樣內磁性物質之方法 |
| WO2012148648A2 (en) * | 2011-04-27 | 2012-11-01 | Becton Dickinson & Co. | Devices and methods for separating magnetically labeled moieties in a sample |
| CN104736718A (zh) * | 2012-10-26 | 2015-06-24 | 贝克顿·迪金森公司 | 用于操纵流体样品中的组分的装置和方法 |
| CN110186835B (zh) | 2013-03-15 | 2022-05-31 | Gpb科学有限公司 | 颗粒的片上微流体处理 |
| CN105247042B (zh) | 2013-03-15 | 2021-06-11 | 普林斯顿大学理事会 | 用于高通量纯化的方法和设备 |
| US9677109B2 (en) | 2013-03-15 | 2017-06-13 | Accelerate Diagnostics, Inc. | Rapid determination of microbial growth and antimicrobial susceptibility |
| US20150064153A1 (en) | 2013-03-15 | 2015-03-05 | The Trustees Of Princeton University | High efficiency microfluidic purification of stem cells to improve transplants |
| US9884326B2 (en) * | 2013-06-28 | 2018-02-06 | National Institute Of Advanced Industrial Science And Technology | Matrix for magnetic separator and magnetic separator |
| US10253355B2 (en) | 2015-03-30 | 2019-04-09 | Accelerate Diagnostics, Inc. | Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing |
| WO2016161022A2 (en) | 2015-03-30 | 2016-10-06 | Accerlate Diagnostics, Inc. | Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing |
| US10976232B2 (en) | 2015-08-24 | 2021-04-13 | Gpb Scientific, Inc. | Methods and devices for multi-step cell purification and concentration |
| GB201519668D0 (en) * | 2015-11-06 | 2015-12-23 | Ge Healthcare Bio Sciences Ab | Method and chromatography media |
| US10625272B2 (en) | 2015-11-18 | 2020-04-21 | Industrial Technology Research Institute | Magnetic separator |
| WO2018024819A1 (en) * | 2016-08-05 | 2018-02-08 | Haute Ecole D'ingenierie Et De Gestion Du Canton De Vaud (Heig-Vd) | Device for removing particles from a material in movement |
| BR102016022548B1 (pt) * | 2016-09-28 | 2022-03-22 | José Pancrácio Ribeiro | Matriz magnética ondulada para separador magnético de alta intensidade |
| JP7393328B2 (ja) | 2017-09-01 | 2023-12-06 | ジーピービー・サイエンティフィック・インコーポレイテッド | マイクロ流体を使用した治療的に活性な細胞を調製する方法 |
| WO2020058136A1 (en) * | 2018-09-20 | 2020-03-26 | Hemotune Ag | Assembly for magnetic separation-based body fluid purification |
| US20230099118A1 (en) * | 2020-02-11 | 2023-03-30 | Khalifa University of Science and Technology | Systems and methods for enhancing the efficiency of separation processes |
| US11529636B2 (en) | 2020-10-09 | 2022-12-20 | Cláudio Henrique Teixeira Ribeiro | Magnetic matrices and methods of using the same |
| CN112553043A (zh) * | 2020-12-09 | 2021-03-26 | 深圳先进技术研究院 | 用于胎儿有核红细胞分离纯化的微流控芯片 |
| CN118834752B (zh) * | 2023-04-24 | 2025-09-19 | 深圳赛桥生物创新技术有限公司 | 磁分选装置及方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB236808A (en) * | 1924-12-02 | 1925-07-16 | Krupp Fried Grusonwerk Ag | Improvements in or relating to zone poles for magnetic separators |
| US4212651A (en) * | 1979-05-30 | 1980-07-15 | The United States Of America As Represented By The United States Department Of Energy | High gradient magnetic beneficiation of dry pulverized coal via upwardly directed recirculating fluidization |
| US4387286A (en) | 1980-03-26 | 1983-06-07 | Inoue-Japax Research Incorporated | Apparatus for controlling splashes and purification of a machining liquid |
| US4560484A (en) * | 1980-04-25 | 1985-12-24 | Purdue Research Foundation | Method and apparatus for magnetically separating particles from a liquid |
| US4743364A (en) | 1984-03-16 | 1988-05-10 | Kyrazis Demos T | Magnetic separation of electrically conducting particles from non-conducting material |
| US4710472A (en) * | 1985-09-25 | 1987-12-01 | The United States Of America As Represented By The Secretary Of The Navy | Magnetic separation device |
| US5512332A (en) * | 1985-10-04 | 1996-04-30 | Immunivest Corporation | Process of making resuspendable coated magnetic particles |
| US4795698A (en) * | 1985-10-04 | 1989-01-03 | Immunicon Corporation | Magnetic-polymer particles |
| US5076950A (en) * | 1985-12-20 | 1991-12-31 | Syntex (U.S.A.) Inc. | Magnetic composition for particle separation |
| DE68916843T2 (de) * | 1988-04-26 | 1995-02-02 | Nippon Telegraph & Telephone | Mikropartikel, Verfahren und Gerät zur Sammlung von Proben zur Verwendung bei der Markierung von Immunreaktionen und Verfahren und Gerät zur Bereitung von Proben. |
| US5536475A (en) | 1988-10-11 | 1996-07-16 | Baxter International Inc. | Apparatus for magnetic cell separation |
| US5385707A (en) | 1988-12-28 | 1995-01-31 | Stefan Miltenyi | Metal matrices for use in high gradient magnetic separation of biological materials and method for coating the same |
| ATE114507T1 (de) | 1988-12-28 | 1994-12-15 | Stefan Miltenyi | Verfahren sowie materialien zur hochgraduierten magnetischen abspaltung biologischer materialien. |
| US5081030A (en) * | 1989-04-25 | 1992-01-14 | The Johns Hopkins University | Release of cells from affinity matrices |
| WO1994011078A1 (en) * | 1992-11-16 | 1994-05-26 | Immunivest Corporation | Magnetic immobilization and manipulation of biological entities |
| US5466574A (en) | 1991-03-25 | 1995-11-14 | Immunivest Corporation | Apparatus and methods for magnetic separation featuring external magnetic means |
| GB9106284D0 (en) * | 1991-03-25 | 1991-05-08 | Cryogenic Consult | Improvements in and relating to magnetic separators |
| EP0589636B1 (de) | 1992-09-24 | 2000-08-02 | Amersham Pharmacia Biotech UK Limited | Verfahren und Vorrichtung zur magnetischen Abscheidung |
| US5514340A (en) * | 1994-01-24 | 1996-05-07 | Magnetix Biotechnology, Inc. | Device for separating magnetically labelled cells |
| US5520158A (en) * | 1995-01-12 | 1996-05-28 | Gasmaster International, Inc. | Magnetic field fuel treatment device |
| EP0819250B1 (de) * | 1995-04-06 | 2006-09-20 | Miltenyi Biotec Inc. | Verfahren zur freisetzung von magnetischen teilchen, die an zelloberflächen gebunden sind |
| EP0876668A1 (de) | 1995-11-03 | 1998-11-11 | David Sarnoff Research Center, Inc. | Magnet |
-
1997
- 1997-10-10 US US08/948,357 patent/US6241894B1/en not_active Expired - Fee Related
-
1998
- 1998-10-09 EP EP98955422A patent/EP1019195B1/de not_active Expired - Lifetime
- 1998-10-09 ES ES98955422T patent/ES2184332T3/es not_active Expired - Lifetime
- 1998-10-09 DK DK98955422T patent/DK1019195T3/da active
- 1998-10-09 AT AT98955422T patent/ATE223759T1/de not_active IP Right Cessation
- 1998-10-09 DE DE69807905T patent/DE69807905T2/de not_active Expired - Fee Related
- 1998-10-09 PT PT98955422T patent/PT1019195E/pt unknown
- 1998-10-09 AU AU12269/99A patent/AU1226999A/en not_active Abandoned
- 1998-10-09 WO PCT/EP1998/006420 patent/WO1999019071A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU1226999A (en) | 1999-05-03 |
| WO1999019071A1 (en) | 1999-04-22 |
| DE69807905D1 (de) | 2002-10-17 |
| EP1019195A1 (de) | 2000-07-19 |
| DK1019195T3 (da) | 2002-12-30 |
| ES2184332T3 (es) | 2003-04-01 |
| PT1019195E (pt) | 2003-01-31 |
| DE69807905T2 (de) | 2003-05-22 |
| EP1019195B1 (de) | 2002-09-11 |
| US6241894B1 (en) | 2001-06-05 |
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Legal Events
| Date | Code | Title | Description |
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| EEIH | Change in the person of patent owner | ||
| UEP | Publication of translation of european patent specification |
Ref document number: 1019195 Country of ref document: EP |
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| REN | Ceased due to non-payment of the annual fee |