DE69806582D1 - Verfahren zur herstellung eines therapeutischen puders durch copräzipitation von insulin und einem absorptionsverstärker - Google Patents

Verfahren zur herstellung eines therapeutischen puders durch copräzipitation von insulin und einem absorptionsverstärker

Info

Publication number
DE69806582D1
DE69806582D1 DE69806582T DE69806582T DE69806582D1 DE 69806582 D1 DE69806582 D1 DE 69806582D1 DE 69806582 T DE69806582 T DE 69806582T DE 69806582 T DE69806582 T DE 69806582T DE 69806582 D1 DE69806582 D1 DE 69806582D1
Authority
DE
Germany
Prior art keywords
insulin
coprecipitating
producing
drying
therapeutic powder
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69806582T
Other languages
English (en)
Other versions
DE69806582T2 (de
Inventor
Steen Jensen
Philip Hansen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Application granted granted Critical
Publication of DE69806582D1 publication Critical patent/DE69806582D1/de
Publication of DE69806582T2 publication Critical patent/DE69806582T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
DE69806582T 1997-03-20 1998-03-20 Verfahren zur herstellung eines therapeutischen puders durch copräzipitation von insulin und einem absorptionsverstärker Expired - Fee Related DE69806582T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK31897 1997-03-20
PCT/DK1998/000107 WO1998042367A1 (en) 1997-03-20 1998-03-20 Method for preparation of a therapeutic powder through coprecipitation of insulin and absorption enhancer

Publications (2)

Publication Number Publication Date
DE69806582D1 true DE69806582D1 (de) 2002-08-22
DE69806582T2 DE69806582T2 (de) 2003-02-13

Family

ID=8092209

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69806582T Expired - Fee Related DE69806582T2 (de) 1997-03-20 1998-03-20 Verfahren zur herstellung eines therapeutischen puders durch copräzipitation von insulin und einem absorptionsverstärker

Country Status (6)

Country Link
EP (1) EP0969860B1 (de)
JP (1) JP2001518915A (de)
AT (1) ATE220555T1 (de)
AU (1) AU6611898A (de)
DE (1) DE69806582T2 (de)
WO (1) WO1998042367A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL142011A0 (en) * 1998-10-16 2002-03-10 Novo Nordisk As Stable concentrated insulin preparations for pulmonary delivery
US6211144B1 (en) 1998-10-16 2001-04-03 Novo Nordisk A/S Stable concentrated insulin preparations for pulmonary delivery
US7001892B1 (en) 1999-06-11 2006-02-21 Purdue Research Foundation Pharmaceutical materials and methods for their preparation and use
EP1196445A1 (de) * 1999-06-29 2002-04-17 Eli Lilly And Company Insulinkristalle zur verabreichung über die lunge
WO2001000675A1 (en) * 1999-06-29 2001-01-04 Eli Lilly And Company Protamine-free insoluble acylated insulin compositions
AU2004261353B2 (en) 2003-08-05 2009-12-10 Novo Nordisk A/S Novel insulin derivatives
JP2006199589A (ja) * 2003-09-03 2006-08-03 Ltt Bio-Pharma Co Ltd 生理活性タンパク質またはペプチドを含有するナノ粒子およびその製造方法、ならびに当該ナノ粒子からなる外用剤
AU2005209199B2 (en) 2004-01-16 2008-09-11 Biodel Inc. Sublingual drug delivery device
US20080090753A1 (en) 2004-03-12 2008-04-17 Biodel, Inc. Rapid Acting Injectable Insulin Compositions
ATE519780T1 (de) * 2005-12-28 2011-08-15 Novo Nordisk As Ein acyliertes insulin und zink enthaltende zusammensetzungen und verfahren zur herstellung dieser zusammensetzungen
EP2167032B1 (de) 2007-06-13 2019-08-07 Novo Nordisk A/S Pharmazeutische formulierung enthaltend ein insulinderivat
CN102202683A (zh) 2008-10-30 2011-09-28 诺沃-诺迪斯克有限公司 用少于每日一次的注射频率注射胰岛素来治疗糖尿病
US9060927B2 (en) 2009-03-03 2015-06-23 Biodel Inc. Insulin formulations for rapid uptake
RU2013123515A (ru) 2010-10-27 2014-12-10 Ново Нордиск А/С Лечение сахарного диабета с помощью инъекций инсулина, вводимых с различными интервалами
EP2991672A1 (de) 2013-04-30 2016-03-09 Novo Nordisk A/S Neuartiges verabreichungsschema
US10335464B1 (en) 2018-06-26 2019-07-02 Novo Nordisk A/S Device for titrating basal insulin

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2837956B2 (ja) * 1993-06-21 1998-12-16 ノボ ノルディスク アクティーゼルスカブ Ａｓｐ▲上Ｂ２８▼インスリン結晶
US5661130A (en) * 1993-06-24 1997-08-26 The Uab Research Foundation Absorption enhancers for drug administration
US5504188A (en) * 1994-06-16 1996-04-02 Eli Lilly And Company Preparation of stable zinc insulin analog crystals

Also Published As

Publication number Publication date
EP0969860B1 (de) 2002-07-17
AU6611898A (en) 1998-10-20
EP0969860A1 (de) 2000-01-12
DE69806582T2 (de) 2003-02-13
WO1998042367A1 (en) 1998-10-01
JP2001518915A (ja) 2001-10-16
ATE220555T1 (de) 2002-08-15

Similar Documents

Publication Publication Date Title
DE69806582T2 (de) Verfahren zur herstellung eines therapeutischen puders durch copräzipitation von insulin und einem absorptionsverstärker
ATE219942T1 (de) Therapeutische pulverformulierung zur pulmonaren anwendung, welche kristallines insulin enthält
GEP20012345B (en) Dispersible Macromolecule Compositions and Methods for Their Preparation and Use
CA2183577A1 (en) Methods and compositions for pulmonary delivery of insulin
KR970703366A (ko) 인터페론의 건조 분말 제형물을 제조하기 위한 방법 및 조성물(methods and compositions for the dry powder formulation of interferons)
DE69628160D1 (de) Herstellung von natrium chlorid aerosol formulierungen
EP1704864A3 (de) Verfahren zur Herstellung einer injizierbaren Arzneimittelzubereitung
MX9404762A (es) Composiciones para inhalacion y proceso para su preparacion.
IS4178A (is) Lyfjablanda til innöndunar sem inniheldur insúlín
ATE79763T1 (de) Verwendung von mindestens ein cytokin zur herstellung eines arzneimittels zur systemischen behandlung von praeneoplastischen laesionen.
DE69126935T2 (de) Aerosolformulierung feste polypeptid mikroteilchen enthaltend und verfahren zu ihrer herstellung
MX9602246A (es) Uso de furoato de mometasona para crear pasaje de aire y para enfermedades del pulmon.
DE69737510D1 (de) Verwendung eines unverkapselten anti-krebs-wirkstoffs zur herstellung einer zubereitung zur behandlung von neoplasmen durch inhalation
DE69810355T2 (de) Verwendung von phospholipiden zur herstellung eines arzneimittels zur behandlung von asthma
ATE206067T1 (de) Verfahren zur lieferung von zusammensetzungen aus dichten teilchen zur anwendung in transdermale teilchen abgabe
DE69634046T2 (de) Trockene zusammensetzungen enthaltend hydrophobe stabilisatoren
ATE150314T1 (de) Pharmazeutisch wirksame zusammensetzung aus tanacetum parthenium sowie verfahren zu deren extraktion und mit der pharmazeutisch wirksamen zusammensetzung hergestelltes arzneimittel
DE69907119D1 (de) Pulverisierte-Sorbitol und ihr Verfahren zur Herstellung
HUP9902675A2 (hu) Fluorozott-szénhidrogén-hajtógázt tartalmazó mometazon-furoát aeroszol
DE69823045D1 (de) Neuartige formulierung zur inhalation mit einer bulkdichte zwischen 0.28 und 0.38 g/ml, mit terbutalinsulphat, verfahren zur herstellung der formulierung sowie anwendung derselben
HU201685B (en) For producing pharmaceutical compositions for inhalation and compositions for scenting air containing volatile active component in cyclodextrine inclusion, and air-scenting composition
ATE298567T1 (de) Pharmazeutische zusammensetzung enthaltend ibuprofen und ein verfahren zur deren herstellung
KR101509883B1 (ko) 접착성을 지닌 고성능 냄새 제거제
DE3680183D1 (de) Verfahren zum gleichzeitigen trocknen und granulieren von extraktstoffen aus enteiweisstem kaelberblut, nach diesem verfahren erhaltenes granulat und dessen verwendung zur herstellung von pharmazeutischen praeparaten.
DE69110139D1 (de) Verfahren zur Herstellung eines Gegenstands aus vorlegierten Pulvern und nach diesem Verfahren hergestellter Gegenstand.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee