DE69803729T2 - Mikroteilchen-vergrössertes Streulichtassay und Mikroteilchen-Reagenz dazu - Google Patents

Mikroteilchen-vergrössertes Streulichtassay und Mikroteilchen-Reagenz dazu

Info

Publication number
DE69803729T2
DE69803729T2 DE69803729T DE69803729T DE69803729T2 DE 69803729 T2 DE69803729 T2 DE 69803729T2 DE 69803729 T DE69803729 T DE 69803729T DE 69803729 T DE69803729 T DE 69803729T DE 69803729 T2 DE69803729 T2 DE 69803729T2
Authority
DE
Germany
Prior art keywords
microparticle
light scattering
particles
scattered light
scattering properties
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69803729T
Other languages
English (en)
Other versions
DE69803729D1 (de
Inventor
Shinichi Eda
Joerg Heinrich Kaufmann
Stefan Pohl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of DE69803729D1 publication Critical patent/DE69803729D1/de
Application granted granted Critical
Publication of DE69803729T2 publication Critical patent/DE69803729T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346Nanoparticles
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/962Prevention or removal of interfering materials or reactants or other treatment to enhance results, e.g. determining or preventing nonspecific binding
DE69803729T 1997-08-11 1998-08-04 Mikroteilchen-vergrössertes Streulichtassay und Mikroteilchen-Reagenz dazu Expired - Lifetime DE69803729T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97113873 1997-08-11

Publications (2)

Publication Number Publication Date
DE69803729D1 DE69803729D1 (de) 2002-03-21
DE69803729T2 true DE69803729T2 (de) 2002-09-05

Family

ID=8227200

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69803729T Expired - Lifetime DE69803729T2 (de) 1997-08-11 1998-08-04 Mikroteilchen-vergrössertes Streulichtassay und Mikroteilchen-Reagenz dazu

Country Status (6)

Country Link
US (2) US6248597B1 (de)
JP (1) JP3746902B2 (de)
AT (1) ATE213065T1 (de)
CA (1) CA2244326C (de)
DE (1) DE69803729T2 (de)
ES (1) ES2170984T3 (de)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7457101A (en) * 2000-06-20 2002-01-02 Mitsubishi Rayon Co Micro-array of organism-associated substance
US6764825B1 (en) * 2000-10-13 2004-07-20 Tang J. Wang Methods and device for detecting prostate specific antigen (PSA)
US20020127741A1 (en) * 2000-12-19 2002-09-12 Miquel Sales Amill Free Analyte detection system
EP1385001A4 (de) * 2001-03-30 2007-07-25 Mitsubishi Kagaku Iatron Inc Reagens und verfahren zur immunanalyse von elastase 1 sowie verfahren zum nachweis einer pankreaserkrankung
JP4577747B2 (ja) * 2001-06-05 2010-11-10 和光純薬工業株式会社 免疫学的測定法用凝集促進剤
CN1242270C (zh) * 2001-08-09 2006-02-15 松下电器产业株式会社 生物传感器及测定方法
US6551788B1 (en) * 2001-11-28 2003-04-22 Beckman Coulter, Inc. Particle-based ligand assay with extended dynamic range
CA2523626A1 (en) * 2002-04-26 2003-11-06 Board Of Regents, The University Of Texas System Method and system for the detection of cardiac risk factors
AU2004225599B2 (en) * 2003-03-31 2008-09-04 Denka Company Limited Turbidimetric immunoassy for lipoprotein (a) and reagent therefor
US20040197841A1 (en) * 2003-04-02 2004-10-07 Apffel James Alexander Methods and reagents for multiplexed analyses
DE602004003632T2 (de) * 2003-07-09 2007-10-25 Matsushita Electric Industrial Co., Ltd., Kadoma Turbidimetrisches Immuntestverfahren und zugehörige Vorrichtung
US20050095726A1 (en) * 2003-07-14 2005-05-05 Xiangming Fang Novel high protein tortillas
AU2004274866B2 (en) * 2003-08-01 2007-12-13 Ge Healthcare Bio-Science Ab Method and apparatus for quantitating surface-binding optical resonance profiles
JP4241301B2 (ja) * 2003-09-30 2009-03-18 和光純薬工業株式会社 免疫学的測定用試薬
US7651868B2 (en) 2003-12-11 2010-01-26 The Board Of Regents Of The University Of Texas System Method and system for the analysis of saliva using a sensor array
US8105849B2 (en) 2004-02-27 2012-01-31 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements
US8101431B2 (en) 2004-02-27 2012-01-24 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems
DE102004023402A1 (de) 2004-05-12 2005-12-08 Roche Diagnostics Gmbh Verfahren zur Erhöhung des dynamischen Messbereichs von auf spezifischen Bindereaktionen basierenden, insbesondere immunologischen Testelementen
JP4331073B2 (ja) * 2004-08-31 2009-09-16 デンカ生研株式会社 抗原の測定方法及びそのための試薬
US7678551B2 (en) * 2004-10-25 2010-03-16 Seradyn, Inc. Immunoassays for lamotrigine
US20060115865A1 (en) * 2004-10-25 2006-06-01 Anlong Ouyang Lamotrigine analogs
US7638291B2 (en) 2004-10-25 2009-12-29 Seradyn, Inc. Immunoassays for topiramate
US20060088886A1 (en) * 2004-10-25 2006-04-27 Anlong Ouyang Topiramate analogs
GB0426822D0 (en) * 2004-12-07 2005-01-12 Precisense As Sensor for detection of glucose
US20060246522A1 (en) * 2005-04-28 2006-11-02 Bhullar Balwant S C-reactive protein immunoassay and method
CA2610793A1 (en) 2005-05-31 2007-05-10 Labnow, Inc. Methods and compositions related to determination and use of white blood cell counts
CA2613078A1 (en) * 2005-06-24 2007-01-04 Board Of Regents, The University Of Texas System Systems and methods including self-contained cartridges with detection systems and fluid delivery systems
US20070048795A1 (en) * 2005-08-26 2007-03-01 Xiangming Fang Immunoaffinity separation and analysis compositions and methods
EP1952154B1 (de) * 2005-11-24 2010-05-26 Gentian AS Turbidimetrischer immunoassay zur beurteilung von humanem cystatin c
EP2147312B1 (de) * 2007-05-21 2012-08-15 Gentian AS Turbidimetrischer immunoassay zur beurteilung von humanem cystatin c
JP2009085703A (ja) * 2007-09-28 2009-04-23 Fujifilm Corp 高感度免疫測定方法
WO2010058860A1 (ja) * 2008-11-18 2010-05-27 株式会社シノテスト 試料中のc反応性蛋白質の測定方法及び測定試薬
CA2745610C (en) * 2008-12-04 2017-10-31 Sekisui Medical Co., Ltd. Method for measuring cystatin c in human body fluid
EP2241886A1 (de) 2009-04-15 2010-10-20 Beckman Coulter Biomedical Limited Homogenes Agglutinationsimmunoassay-Verfahren und Kit für ein derartiges Verfahren
WO2011034678A1 (en) * 2009-09-21 2011-03-24 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Use of superhydrophobic surfaces for liquid agglutination assays
KR20120107497A (ko) 2009-12-17 2012-10-02 아박시스, 인크. 샘플 내 분석물을 검출하기 위한 신규 분석 및 그것과 관련된 키트 및 조성물
CN101833010B (zh) * 2010-03-29 2013-02-13 上海太阳生物技术有限公司 纤维蛋白(原)降解产物(fdp)测定试剂盒(胶乳免疫比浊法)
WO2012009760A1 (en) 2010-07-20 2012-01-26 Cephalon Australia Pty Ltd Anti-il-23 heterodimer specific antibodies
WO2012142656A1 (en) 2011-04-18 2012-10-26 Garvan Institute Of Medical Research Method of diagnosing cancer
WO2012161226A1 (ja) * 2011-05-23 2012-11-29 積水メディカル株式会社 Pivka-ii測定試薬における非特異反応の抑制方法
JP5772425B2 (ja) 2011-09-13 2015-09-02 ソニー株式会社 微小粒子測定装置
BR112014007426B1 (pt) 2011-09-30 2023-01-03 Teva Pharmaceuticals Australia Pty Ltd Anticorpos contra tl1a e seus usos
CA2804843C (en) 2012-02-06 2021-02-02 Ortho-Clinical Diagnostics, Inc. Multiple time windows for extending the range of an assay
CN102608325B (zh) * 2012-02-24 2016-08-24 南京诺尔曼生物技术有限公司 心型脂肪酸结合蛋白(h-fabp)测定试剂盒(胶乳增强免疫比浊法)
US9970929B2 (en) 2013-01-18 2018-05-15 Ark Diagnostics, Inc. Voriconazole immunoassays
WO2014117220A1 (en) 2013-02-01 2014-08-07 Transbio Ltd Anti-cd83 antibodies and use thereof
EP4219552A3 (de) 2013-02-07 2023-09-13 CSL Ltd. Il-11r-bindende proteine und verwendungen davon
US9920136B2 (en) 2013-02-13 2018-03-20 Ark Diagnostics, Inc. Posaconazole immunoassays
FR3003353B1 (fr) * 2013-03-14 2015-03-06 Horiba Abx Sas Nouvelle methode de dosage en flux d'un objet d'interet
CN110068678A (zh) 2013-05-31 2019-07-30 积水医疗株式会社 凝集免疫测定法
EP2811300A1 (de) * 2013-06-07 2014-12-10 Roche Diagniostics GmbH Kalibrierung für Mehrkomponenten-Assays
EP3194624B1 (de) 2014-09-15 2022-02-16 Garvan Institute of Medical Research Verfahren zur diagnose, prognose und überwachung von brustkrebs und reagenzien dafür
NZ731491A (en) 2014-10-23 2021-12-24 Kira Biotech Pty Ltd Cd83 binding proteins and uses thereof
WO2016140799A1 (en) 2015-03-03 2016-09-09 Ark Diagnostics, Inc. Pregabalin immunoassays
EP4015624A1 (de) 2015-05-05 2022-06-22 Mesoblast International Sàrl Potenztest
CA3062112A1 (en) 2017-05-04 2018-11-08 Mesoblast International Sarl Mesenchymal lineage precursor or stem cells with enhanced immunosuppression
CN109633167A (zh) * 2018-12-20 2019-04-16 北京贝尔生物工程股份有限公司 一种高灵敏度、宽检测范围的人血清淀粉样蛋白a测定试剂盒
SG11202106794WA (en) 2019-01-02 2021-07-29 Mesoblast Int Sarl Method for treating lower back pain
US11578140B2 (en) 2019-03-26 2023-02-14 Microgenics Corporation Immunoassay for mitragynine
US10745492B1 (en) 2019-04-03 2020-08-18 Ark Diagnostics, Inc. Antibodies to symmetrically dimethylated arginine analytes and use thereof
CN113125699B (zh) * 2019-12-31 2024-03-26 科美博阳诊断技术(上海)有限公司 一种β-hCG均相化学发光检测试剂盒及其应用
WO2021199178A1 (ja) 2020-03-30 2021-10-07 デンカ生研株式会社 ラテックス凝集法による目的物質の測定方法、およびその試薬
KR20230047136A (ko) 2020-08-10 2023-04-06 메조블라스트 인터내셔널 에스에이알엘 중간엽 전구세포 또는 줄기세포를 포함하는 조성물 및 이의 용도
WO2024009226A1 (en) 2022-07-05 2024-01-11 Mesoblast International Sarl Cryopreserved intermediate and potency assay for same

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4210723A (en) 1976-07-23 1980-07-01 The Dow Chemical Company Method of coupling a protein to an epoxylated latex
US4401765A (en) * 1981-09-01 1983-08-30 E. I. Du Pont De Nemours And Company Covalently bonded high refractive index particle reagents and their use in light scattering immunoassays
DE3366740D1 (en) * 1982-08-06 1986-11-13 Int Inst Cellular Molecul Path Particle agglutination assay of antigens
US4590169A (en) 1983-11-18 1986-05-20 Beckman Instruments, Inc. Direct particle agglutination immunoassays avoiding false negatives at high antigen concentrations
US4595661A (en) 1983-11-18 1986-06-17 Beckman Instruments, Inc. Immunoassays and kits for use therein which include low affinity antibodies for reducing the hook effect
NO164622C (no) 1988-05-11 1990-10-24 Tore Lindmo Binaer immunometrisk partikkelbasert metode for maaling av spesifikke serum-antigener ved hjelp av vaeskestroemsmikrofotometri og et ferdigpreparert maaloppsett derav.
US5200315A (en) * 1990-07-25 1993-04-06 Eastman Kodak Company Particulate biologically active reagent containing polyoxyalkylene side chains, analytical element and methods for use of the reagent

Also Published As

Publication number Publication date
JP3746902B2 (ja) 2006-02-22
CA2244326C (en) 2006-03-28
US20010026945A1 (en) 2001-10-04
ATE213065T1 (de) 2002-02-15
JPH11108929A (ja) 1999-04-23
ES2170984T3 (es) 2002-08-16
US6248597B1 (en) 2001-06-19
US6828158B2 (en) 2004-12-07
CA2244326A1 (en) 1999-02-11
DE69803729D1 (de) 2002-03-21

Similar Documents

Publication Publication Date Title
DE69803729T2 (de) Mikroteilchen-vergrössertes Streulichtassay und Mikroteilchen-Reagenz dazu
EP0898169A3 (de) Mikroteilchen-vergrössertes Streulichtassay und Mikroteilchen-Reagenz dazu
AU2002232518A1 (en) Improved assay and reagents or immunological determination of analyte concentration
WO2005065387A3 (en) Waveguide comprising scattered light detectable particles
AU5665696A (en) Novel methods for the assay of troponin i and t and complexe s of troponin i and t and selection of antibodies for use in immunoassays
EP2186910A3 (de) Verfahren und Zusammensetzungen für verbesserte Lumineszenztests unter Verwendung von Mikropartikeln
HK1052217A1 (zh) 用於被分析物濃度測定試驗的方法及裝置
AU2002226876A1 (en) Cells having a spectral signature, and methods of preparation and use thereof
CA2215042A1 (en) Assay reagents and devices
DE60013320D1 (de) Analytassay-vorrichtung mit vorabsorbieren-zone
MY138674A (en) Radiolabeling kit and binding assay
WO2002042427A3 (en) Mass tags for quantitative analysis
ATE201771T1 (de) Spezifische bindungstests und reagenzien dafür
HK1008244A1 (en) Use of synthetic particles as reagents in agglutination reactions
AU3059499A (en) Solid-phase method for antigen and antibody determinations in bloodgroup serology, and test kit
AU5141301A (en) Multi-analyte diagnostic test for thyroid disorders
EP1038939A4 (de) Chemilumineszierende realenzien und verfahren zur chemilumineszenzanalyse
MXPA05009835A (es) Reduccion de efecto de gancho en dispositivos de ensayo.
DE69526875T2 (de) Suppressor von nichtspezifischen Reaktionen in Immuno-Assays
SE8307004D0 (sv) Substrat for fluoroimmunoanalys av biologiska vetskor
ATE182407T1 (de) Bestimmung von denaturierten lipoproteinen
AU2002245206A1 (en) Dendritic chemiluminescent substrates
ATE170927T1 (de) Ionenfang-analysenverfahren, die einen an carboxymethylamylose konjugierten bindungspartner verwenden
SE9500184D0 (sv) Analysmetod som utnyttjar biospecifika affinitetsreaktioner och märkt reaktant samt reagens att användas i föredragen utförandeform
EP1304571A4 (de) Immunoassay unter verwendung von unlöslichen trägerpartikeln und reagenz hierfür