DE69737857D1 - Biodetektoren für spezifische liganden - Google Patents
Biodetektoren für spezifische ligandenInfo
- Publication number
- DE69737857D1 DE69737857D1 DE69737857T DE69737857T DE69737857D1 DE 69737857 D1 DE69737857 D1 DE 69737857D1 DE 69737857 T DE69737857 T DE 69737857T DE 69737857 T DE69737857 T DE 69737857T DE 69737857 D1 DE69737857 D1 DE 69737857D1
- Authority
- DE
- Germany
- Prior art keywords
- biodetectors
- relates
- specific ligands
- detecting
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0069—Oxidoreductases (1.) acting on single donors with incorporation of molecular oxygen, i.e. oxygenases (1.13)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/66—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving luciferase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
- G01N33/56988—HIV or HTLV
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Virology (AREA)
- Food Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Toxicology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1563396P | 1996-04-19 | 1996-04-19 | |
US15633P | 1996-04-19 | ||
US844336 | 1997-04-18 | ||
US08/844,336 US8349602B1 (en) | 1996-04-19 | 1997-04-18 | Biodetectors targeted to specific ligands |
PCT/US1997/006578 WO1997040381A1 (en) | 1996-04-19 | 1997-04-21 | Biodetectors targeted to specific ligands |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69737857D1 true DE69737857D1 (de) | 2007-08-09 |
DE69737857T2 DE69737857T2 (de) | 2008-02-28 |
Family
ID=26687637
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69737857T Expired - Lifetime DE69737857T2 (de) | 1996-04-19 | 1997-04-21 | Biodetektoren für spezifische liganden |
Country Status (10)
Country | Link |
---|---|
US (3) | US8349602B1 (de) |
EP (1) | EP0900376B8 (de) |
JP (1) | JP3692149B2 (de) |
CN (1) | CN1154845C (de) |
AT (1) | ATE365916T1 (de) |
BR (1) | BR9708713A (de) |
CA (1) | CA2251826A1 (de) |
DE (1) | DE69737857T2 (de) |
IL (1) | IL126605A (de) |
WO (1) | WO1997040381A1 (de) |
Families Citing this family (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6649143B1 (en) | 1994-07-01 | 2003-11-18 | The Board Of Trustees Of The Leland Stanford Junior University | Non-invasive localization of a light-emitting conjugate in a mammal |
US7255851B2 (en) | 1994-07-01 | 2007-08-14 | The Board Of Trustees Of The Leland Stanford Junior University | Non-invasive localization of a light-emitting conjugate in a mammal |
GB9827584D0 (en) * | 1998-12-15 | 1999-02-10 | Celsis Int Plc | Hygiene Monitoring |
WO2000036106A2 (en) | 1998-12-17 | 2000-06-22 | Xenogen Corporation | Non-invasive evaluation of physiological response in a mammal |
US6610503B1 (en) | 1999-03-17 | 2003-08-26 | Xenogen Corporation | Animal models for predicting sepsis mortality |
JP2003504014A (ja) * | 1999-06-30 | 2003-02-04 | エボテック オーアーイー アクチェンゲゼルシャフト | ウイルス状粒子、それらの調製及び好ましくは薬学的スクリーニング及び機能的ゲノムにおけるそれらの使用 |
US6737245B1 (en) | 1999-09-08 | 2004-05-18 | Xenogen Corporation | Luciferase expression cassettes and methods of use |
TWI237695B (en) * | 1999-12-14 | 2005-08-11 | Joy Biomedical Corp | Helicobacter pylori antigens in blood |
US6867348B1 (en) | 1999-12-16 | 2005-03-15 | Xenogen Corporation | Methods and compositions for screening for angiogenesis modulating compounds |
IT1311335B1 (it) | 1999-12-21 | 2002-03-12 | Otc Optical Technologies Ct S | Procedimento e dispositivo per realizzare reticoli in fibra ottica. |
US20020192726A1 (en) * | 2000-04-25 | 2002-12-19 | Jay Leng | Cell proliferation assay |
SE0001642D0 (sv) * | 2000-05-04 | 2000-05-04 | Sahltech Ab | Reagent for detection of biomolecules, and use thereof |
US7056728B2 (en) | 2000-07-06 | 2006-06-06 | Xenogen Corporation | Compositions and methods for use thereof in modifying the genomes of microorganisms |
US8489176B1 (en) | 2000-08-21 | 2013-07-16 | Spectrum Dynamics Llc | Radioactive emission detector equipped with a position tracking system and utilization thereof with medical systems and in medical procedures |
US7826889B2 (en) | 2000-08-21 | 2010-11-02 | Spectrum Dynamics Llc | Radioactive emission detector equipped with a position tracking system and utilization thereof with medical systems and in medical procedures |
US8036731B2 (en) | 2001-01-22 | 2011-10-11 | Spectrum Dynamics Llc | Ingestible pill for diagnosing a gastrointestinal tract |
US8909325B2 (en) | 2000-08-21 | 2014-12-09 | Biosensors International Group, Ltd. | Radioactive emission detector equipped with a position tracking system and utilization thereof with medical systems and in medical procedures |
US8565860B2 (en) | 2000-08-21 | 2013-10-22 | Biosensors International Group, Ltd. | Radioactive emission detector equipped with a position tracking system |
WO2002048195A2 (en) * | 2000-10-23 | 2002-06-20 | Engeneos, Inc. | Engineered stimulus-responsive switches |
EP1359845B1 (de) | 2001-01-22 | 2012-11-14 | Spectrum Dynamics LLC | Einnehmbare vorrichtung |
US7403812B2 (en) | 2001-05-17 | 2008-07-22 | Xenogen Corporation | Method and apparatus for determining target depth, brightness and size within a body region |
US7298415B2 (en) | 2001-07-13 | 2007-11-20 | Xenogen Corporation | Structured light imaging apparatus |
US20030053951A1 (en) * | 2001-07-26 | 2003-03-20 | Millennium Pharmaceuticals, Inc. | Use of non-invasive imaging technologies to monitor in vivo gene-expression |
US20060074034A1 (en) * | 2001-09-17 | 2006-04-06 | Collins Douglas A | Cobalamin mediated delivery of nucleic acids, analogs and derivatives thereof |
US7663022B1 (en) | 2002-07-15 | 2010-02-16 | Bruce Eric Hudkins | Transgenic bioluminescent plants |
US7049483B1 (en) * | 2002-07-15 | 2006-05-23 | Bruce Eric Hudkins | Transgenic bioluminescent plants |
EP1573495B1 (de) * | 2002-11-04 | 2009-11-04 | Spectrum Dynamics LLC | Vorrichtungen und verfahren zur abbildungund dämpfungskorrektur |
WO2007010534A2 (en) | 2005-07-19 | 2007-01-25 | Spectrum Dynamics Llc | Imaging protocols |
WO2006075333A2 (en) | 2005-01-13 | 2006-07-20 | Spectrum Dynamics Llc | Multi-dimensional image reconstruction and analysis for expert-system diagnosis |
US8586932B2 (en) | 2004-11-09 | 2013-11-19 | Spectrum Dynamics Llc | System and method for radioactive emission measurement |
WO2006051531A2 (en) * | 2004-11-09 | 2006-05-18 | Spectrum Dynamics Llc | Radioimaging |
US9470801B2 (en) | 2004-01-13 | 2016-10-18 | Spectrum Dynamics Llc | Gating with anatomically varying durations |
US8571881B2 (en) | 2004-11-09 | 2013-10-29 | Spectrum Dynamics, Llc | Radiopharmaceutical dispensing, administration, and imaging |
US7176466B2 (en) | 2004-01-13 | 2007-02-13 | Spectrum Dynamics Llc | Multi-dimensional image reconstruction |
WO2007010537A2 (en) | 2005-07-19 | 2007-01-25 | Spectrum Dynamics Llc | Reconstruction stabilizer and active vision |
US7968851B2 (en) | 2004-01-13 | 2011-06-28 | Spectrum Dynamics Llc | Dynamic spect camera |
US9040016B2 (en) | 2004-01-13 | 2015-05-26 | Biosensors International Group, Ltd. | Diagnostic kit and methods for radioimaging myocardial perfusion |
EP1766550A2 (de) | 2004-06-01 | 2007-03-28 | Spectrum Dynamics LLC | Verfahren zur ansichtsauswahl für messungen radioaktiver emission |
EP1778957A4 (de) | 2004-06-01 | 2015-12-23 | Biosensors Int Group Ltd | Optimierung der messung radioaktiver strahlung an besonderen körperstrukturen |
US8423125B2 (en) | 2004-11-09 | 2013-04-16 | Spectrum Dynamics Llc | Radioimaging |
US9943274B2 (en) | 2004-11-09 | 2018-04-17 | Spectrum Dynamics Medical Limited | Radioimaging using low dose isotope |
US9316743B2 (en) | 2004-11-09 | 2016-04-19 | Biosensors International Group, Ltd. | System and method for radioactive emission measurement |
US8615405B2 (en) | 2004-11-09 | 2013-12-24 | Biosensors International Group, Ltd. | Imaging system customization using data from radiopharmaceutical-associated data carrier |
WO2008059489A2 (en) | 2006-11-13 | 2008-05-22 | Spectrum Dynamics Llc | Radioimaging applications of and novel formulations of teboroxime |
US20060214141A1 (en) * | 2005-03-23 | 2006-09-28 | Yankielun Norbert E | Luminescent illumination adjunct for night vision |
US8044996B2 (en) | 2005-05-11 | 2011-10-25 | Xenogen Corporation | Surface construction using combined photographic and structured light information |
US8837793B2 (en) | 2005-07-19 | 2014-09-16 | Biosensors International Group, Ltd. | Reconstruction stabilizer and active vision |
US7705316B2 (en) | 2005-11-09 | 2010-04-27 | Spectrum Dynamics Llc | Dynamic SPECT camera |
WO2007074466A2 (en) | 2005-12-28 | 2007-07-05 | Starhome Gmbh | Late forwarding to local voicemail system of calls to roaming users |
US8894974B2 (en) | 2006-05-11 | 2014-11-25 | Spectrum Dynamics Llc | Radiopharmaceuticals for diagnosis and therapy |
US10775308B2 (en) | 2006-08-24 | 2020-09-15 | Xenogen Corporation | Apparatus and methods for determining optical tissue properties |
US10335038B2 (en) | 2006-08-24 | 2019-07-02 | Xenogen Corporation | Spectral unmixing for in-vivo imaging |
US9275451B2 (en) | 2006-12-20 | 2016-03-01 | Biosensors International Group, Ltd. | Method, a system, and an apparatus for using and processing multidimensional data |
WO2009036070A1 (en) * | 2007-09-10 | 2009-03-19 | University Of Kentucky Research Foundation | Spores for the stabilization and on-site application of bacterial whole-cell biosensing systems |
US8521253B2 (en) | 2007-10-29 | 2013-08-27 | Spectrum Dynamics Llc | Prostate imaging |
US8227965B2 (en) * | 2008-06-20 | 2012-07-24 | Arradiance, Inc. | Microchannel plate devices with tunable resistive films |
WO2010062787A1 (en) | 2008-11-03 | 2010-06-03 | Washington University | Bioluminescence imaging of myeloperoxidase activity in vivo, methods, compositions and apparatuses therefor |
EP2230793A3 (de) | 2009-03-16 | 2011-09-07 | Technische Universität München | On-Chip elektrische Wellen: Ein Ansatz mit Analogschaltungen für physikalisch unklonbare Funktionen: PUF |
AU2010240670B2 (en) * | 2009-04-20 | 2015-08-20 | Oxford Nanopore Technologies Limited | Lipid bilayer sensor array |
US8338788B2 (en) | 2009-07-29 | 2012-12-25 | Spectrum Dynamics Llc | Method and system of optimized volumetric imaging |
WO2012045754A1 (de) | 2010-10-07 | 2012-04-12 | Boehringer Ingelheim Microparts Gmbh | Verfahren zum waschen einer mikrofluidischen kavität |
US8859256B2 (en) | 2011-10-05 | 2014-10-14 | Genelux Corporation | Method for detecting replication or colonization of a biological therapeutic |
EP2835146B1 (de) | 2013-08-09 | 2020-09-30 | Boehringer Ingelheim International GmbH | Zerstäuber |
RU2596398C1 (ru) | 2015-02-25 | 2016-09-10 | Закрытое акционерное общество "ЕВРОГЕН" | Метод и реактивы для детекции активности люциферазы |
US12081063B2 (en) | 2021-07-12 | 2024-09-03 | PassiveLogic, Inc. | Device energy use determination |
US20230071312A1 (en) * | 2021-09-08 | 2023-03-09 | PassiveLogic, Inc. | External Activation of Quiescent Device |
IL313024A (en) * | 2021-12-10 | 2024-07-01 | Massachusetts Inst Technology | Prediction, biosynthesis and integration as biosensors of compounds with unique light absorption signatures and remote sensing detections using multispectral or hyperspectral cameras |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8422650D0 (en) | 1984-09-07 | 1984-10-10 | Technology Licence Co Ltd | Monoclonal antibodies |
GB8422653D0 (en) | 1984-09-07 | 1984-10-10 | Technology Licence Co Ltd | Monoclonal antibodies |
SE444025B (sv) | 1984-09-15 | 1986-03-17 | Sigarth Ind Ab | Lasanordning for fastlasning av exempelvis en kedja |
US4745181A (en) | 1986-10-06 | 1988-05-17 | Ciba Corning Diagnostics Corp. | Polysubstituted aryl acridinium esters |
US4762701A (en) | 1986-10-31 | 1988-08-09 | Smithkline Beckman Corporation | In vivo cellular tracking |
US4912031A (en) | 1987-10-23 | 1990-03-27 | E. I. Du Pont De Nemours And Company | Method for detecting carcinomatous and precarcinomatous colo-rectal disease |
US5200051A (en) | 1988-11-14 | 1993-04-06 | I-Stat Corporation | Wholly microfabricated biosensors and process for the manufacture and use thereof |
US5622868A (en) | 1989-04-27 | 1997-04-22 | Microbiological Research Authority Camr (Centre For Applied Microbiology & Research) | Analytical apparatus utilizing a colorimetric or other optically detectable effect |
GB8916806D0 (en) | 1989-07-22 | 1989-09-06 | Univ Wales Medicine | Modified proteins |
AU6753390A (en) | 1989-10-02 | 1991-04-28 | University Of Michigan, The | Bioanalytical detection system |
US5283179A (en) | 1990-09-10 | 1994-02-01 | Promega Corporation | Luciferase assay method |
DE4122598C1 (de) | 1991-07-08 | 1992-07-30 | Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts, 6900 Heidelberg, De | |
AU2422792A (en) | 1991-07-30 | 1993-03-02 | Bio-Technical Resources | Device for detecting aqueous contaminants |
US5348867A (en) | 1991-11-15 | 1994-09-20 | George Georgiou | Expression of proteins on bacterial surface |
US5418132A (en) | 1992-06-18 | 1995-05-23 | Washington University | Genetically engineered cell line for detecting infectious herpes simplex virus and method therefore |
US5521066A (en) * | 1993-09-13 | 1996-05-28 | Bristol-Myers Squibb Company | Periplasmic membrane-bound system for detecting protein-protein interactions |
US5650135A (en) | 1994-07-01 | 1997-07-22 | The Board Of Trustees Of The Leland Stanford Junior University | Non-invasive localization of a light-emitting conjugate in a mammal |
JPH08217693A (ja) | 1995-02-17 | 1996-08-27 | Yoshihisa Naito | 新規医薬組成物 |
WO1997008553A1 (en) | 1995-08-22 | 1997-03-06 | The Regents Of The University Of California | Targeting of proteins to the cell wall of gram-positive bacteria |
-
1997
- 1997-04-18 US US08/844,336 patent/US8349602B1/en not_active Expired - Fee Related
- 1997-04-21 JP JP53822497A patent/JP3692149B2/ja not_active Expired - Lifetime
- 1997-04-21 IL IL12660597A patent/IL126605A/en not_active IP Right Cessation
- 1997-04-21 EP EP97921279A patent/EP0900376B8/de not_active Expired - Lifetime
- 1997-04-21 CA CA002251826A patent/CA2251826A1/en not_active Abandoned
- 1997-04-21 CN CNB971938946A patent/CN1154845C/zh not_active Expired - Fee Related
- 1997-04-21 BR BR9708713-0A patent/BR9708713A/pt not_active Application Discontinuation
- 1997-04-21 WO PCT/US1997/006578 patent/WO1997040381A1/en active IP Right Grant
- 1997-04-21 AT AT97921279T patent/ATE365916T1/de not_active IP Right Cessation
- 1997-04-21 DE DE69737857T patent/DE69737857T2/de not_active Expired - Lifetime
-
1998
- 1998-10-30 US US09/183,566 patent/US6638752B2/en not_active Expired - Lifetime
-
2003
- 2003-09-18 US US10/666,925 patent/US20040235003A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US8349602B1 (en) | 2013-01-08 |
JP3692149B2 (ja) | 2005-09-07 |
IL126605A0 (en) | 1999-08-17 |
DE69737857T2 (de) | 2008-02-28 |
EP0900376A4 (de) | 2004-08-11 |
JP2001502048A (ja) | 2001-02-13 |
BR9708713A (pt) | 2000-01-04 |
EP0900376A1 (de) | 1999-03-10 |
CN1154845C (zh) | 2004-06-23 |
US20020086424A1 (en) | 2002-07-04 |
IL126605A (en) | 2004-12-15 |
CN1219239A (zh) | 1999-06-09 |
WO1997040381A1 (en) | 1997-10-30 |
EP0900376B8 (de) | 2008-05-28 |
EP0900376B1 (de) | 2007-06-27 |
US6638752B2 (en) | 2003-10-28 |
CA2251826A1 (en) | 1997-10-30 |
ATE365916T1 (de) | 2007-07-15 |
US20040235003A1 (en) | 2004-11-25 |
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