DE69732628D1 - Beta 1-4 n-acetylglucosaminyltransferase sowie das für diese kodierende gen - Google Patents
Beta 1-4 n-acetylglucosaminyltransferase sowie das für diese kodierende genInfo
- Publication number
- DE69732628D1 DE69732628D1 DE69732628T DE69732628T DE69732628D1 DE 69732628 D1 DE69732628 D1 DE 69732628D1 DE 69732628 T DE69732628 T DE 69732628T DE 69732628 T DE69732628 T DE 69732628T DE 69732628 D1 DE69732628 D1 DE 69732628D1
- Authority
- DE
- Germany
- Prior art keywords
- gnt
- enzyme
- gene
- beta
- producing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP33241196 | 1996-12-12 | ||
JP33241196 | 1996-12-12 | ||
JP16146297 | 1997-06-18 | ||
JP16146297 | 1997-06-18 | ||
PCT/JP1997/004546 WO1998026053A1 (en) | 1996-12-12 | 1997-12-10 | NOVEL β1→4 N-ACETYLGLUCOSAMINYLTRANSFERASE AND GENE ENCODING THE SAME |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69732628D1 true DE69732628D1 (de) | 2005-04-07 |
DE69732628T2 DE69732628T2 (de) | 2005-12-29 |
Family
ID=26487595
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69732628T Expired - Lifetime DE69732628T2 (de) | 1996-12-12 | 1997-12-10 | Beta 1-4 n-acetylglucosaminyltransferase sowie das für diese kodierende gen |
Country Status (9)
Country | Link |
---|---|
US (1) | US6338955B2 (de) |
EP (1) | EP0905232B1 (de) |
JP (1) | JP4246264B2 (de) |
KR (1) | KR100325552B1 (de) |
CN (1) | CN1273586C (de) |
AT (1) | ATE290068T1 (de) |
DE (1) | DE69732628T2 (de) |
ES (1) | ES2235259T3 (de) |
WO (1) | WO1998026053A1 (de) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030170864A1 (en) * | 2000-05-30 | 2003-09-11 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
US6784123B2 (en) * | 1998-02-05 | 2004-08-31 | Asm Japan K.K. | Insulation film on semiconductor substrate and method for forming same |
JP4160652B2 (ja) * | 1998-05-22 | 2008-10-01 | キリンファーマ株式会社 | エンド−β−N−アセチルグルコサミニダーゼ遺伝子 |
AU771908C (en) * | 1998-12-09 | 2005-03-10 | Phyton Holdings, Llc | A method for manufacturing glycoproteins having human-type glycosylation |
AU2001227900A1 (en) * | 2000-01-14 | 2001-07-24 | Incyte Genomics, Inc. | Drug metabolizing enzymes |
WO2001079468A2 (en) * | 2000-04-13 | 2001-10-25 | Incyte Genomics, Inc. | Drug metabolizing enzymes |
US8022058B2 (en) | 2000-05-10 | 2011-09-20 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
US6489125B1 (en) * | 2000-05-10 | 2002-12-03 | The Trustees Of Columbia University In The City Of New York | Methods for identifying chemical compounds that inhibit dissociation of FKBP12.6 binding protein from type 2 ryanodine receptor |
US20040229781A1 (en) * | 2000-05-10 | 2004-11-18 | Marks Andrew Robert | Compounds and methods for treating and preventing exercise-induced cardiac arrhythmias |
US7718644B2 (en) * | 2004-01-22 | 2010-05-18 | The Trustees Of Columbia University In The City Of New York | Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof |
US7879840B2 (en) * | 2005-08-25 | 2011-02-01 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
US20060293266A1 (en) * | 2000-05-10 | 2006-12-28 | The Trustees Of Columbia | Phosphodiesterase 4D in the ryanodine receptor complex protects against heart failure |
US20040048780A1 (en) * | 2000-05-10 | 2004-03-11 | The Trustees Of Columbia University In The City Of New York | Method for treating and preventing cardiac arrhythmia |
US7393652B2 (en) * | 2000-05-10 | 2008-07-01 | The Trustees Of Columbia University In The City Of New York | Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2) |
US7598055B2 (en) * | 2000-06-28 | 2009-10-06 | Glycofi, Inc. | N-acetylglucosaminyltransferase III expression in lower eukaryotes |
US8697394B2 (en) | 2000-06-28 | 2014-04-15 | Glycofi, Inc. | Production of modified glycoproteins having multiple antennary structures |
US7863020B2 (en) | 2000-06-28 | 2011-01-04 | Glycofi, Inc. | Production of sialylated N-glycans in lower eukaryotes |
US7625756B2 (en) | 2000-06-28 | 2009-12-01 | GycoFi, Inc. | Expression of class 2 mannosidase and class III mannosidase in lower eukaryotic cells |
US7449308B2 (en) | 2000-06-28 | 2008-11-11 | Glycofi, Inc. | Combinatorial DNA library for producing modified N-glycans in lower eukaryotes |
AU7684201A (en) | 2000-06-28 | 2002-01-08 | Glycofi Inc | Methods for producing modified glycoproteins |
ZA200306406B (en) | 2001-01-19 | 2004-09-06 | Dow Chemical Co | Method for secretory production of glycoprotein having human-type sugar chain using plant cell. |
JPWO2002068661A1 (ja) * | 2001-02-26 | 2004-06-24 | 東洋紡績株式会社 | β1,2−N−アセチルグルコサミニルトランスフェラーゼII活性を有する融合タンパク質及びその製造方法 |
AU2003231088B2 (en) | 2002-04-23 | 2008-05-22 | University Of Georgia Research Foundation, Inc. | N-acetylglucosaminyltransferase Vb coding sequence, recombinant cells and methods |
US7544678B2 (en) * | 2002-11-05 | 2009-06-09 | The Trustees Of Columbia University In The City Of New York | Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) |
US7332299B2 (en) | 2003-02-20 | 2008-02-19 | Glycofi, Inc. | Endomannosidases in the modification of glycoproteins in eukaryotes |
AU2004220548A1 (en) | 2003-03-07 | 2004-09-23 | The Trustees Of Columbia University, In The City Of New York | Type 1 ryanodine receptor-based methods |
US8710045B2 (en) * | 2004-01-22 | 2014-04-29 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the ryanodine receptors |
US7704990B2 (en) * | 2005-08-25 | 2010-04-27 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
AU2008237632B2 (en) | 2007-04-17 | 2014-01-16 | Stichting Dienst Landbouwkundig Onderzoek | Mammalian-type glycosylation in plants by expression of non-mammalian glycosyltransferases |
US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2789283B2 (ja) * | 1992-08-21 | 1998-08-20 | 寳酒造株式会社 | ヒト糖転移酵素遺伝子 |
-
1997
- 1997-12-10 AT AT97947881T patent/ATE290068T1/de not_active IP Right Cessation
- 1997-12-10 KR KR1019980706231A patent/KR100325552B1/ko not_active IP Right Cessation
- 1997-12-10 WO PCT/JP1997/004546 patent/WO1998026053A1/ja active IP Right Grant
- 1997-12-10 ES ES97947881T patent/ES2235259T3/es not_active Expired - Lifetime
- 1997-12-10 DE DE69732628T patent/DE69732628T2/de not_active Expired - Lifetime
- 1997-12-10 CN CNB971934770A patent/CN1273586C/zh not_active Expired - Lifetime
- 1997-12-10 US US09/117,860 patent/US6338955B2/en not_active Expired - Lifetime
- 1997-12-10 JP JP52649798A patent/JP4246264B2/ja not_active Expired - Lifetime
- 1997-12-10 EP EP97947881A patent/EP0905232B1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ATE290068T1 (de) | 2005-03-15 |
DE69732628T2 (de) | 2005-12-29 |
US6338955B2 (en) | 2002-01-15 |
KR100325552B1 (ko) | 2002-08-14 |
EP0905232B1 (de) | 2005-03-02 |
EP0905232A4 (de) | 2002-09-25 |
ES2235259T3 (es) | 2005-07-01 |
CN1214732A (zh) | 1999-04-21 |
WO1998026053A1 (en) | 1998-06-18 |
KR19990082498A (ko) | 1999-11-25 |
US20010024814A1 (en) | 2001-09-27 |
JP4246264B2 (ja) | 2009-04-02 |
EP0905232A1 (de) | 1999-03-31 |
CN1273586C (zh) | 2006-09-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |