DE69731038D1 - Screening-test zur identifikation von inhibitoren des makrophagenmigrationshemmenden faktors - Google Patents

Screening-test zur identifikation von inhibitoren des makrophagenmigrationshemmenden faktors

Info

Publication number
DE69731038D1
DE69731038D1 DE69731038T DE69731038T DE69731038D1 DE 69731038 D1 DE69731038 D1 DE 69731038D1 DE 69731038 T DE69731038 T DE 69731038T DE 69731038 T DE69731038 T DE 69731038T DE 69731038 D1 DE69731038 D1 DE 69731038D1
Authority
DE
Germany
Prior art keywords
screening test
inhibiting factor
macrophage migration
identifying inhibitors
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69731038T
Other languages
English (en)
Other versions
DE69731038T2 (de
Inventor
Richard Bucala
C Ulrich
Xini Xhang
Anthony Cerami
Klaus Bendrat
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PICOWER INST FOR MEDICAL RES M
Original Assignee
PICOWER INST FOR MEDICAL RES M
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PICOWER INST FOR MEDICAL RES M filed Critical PICOWER INST FOR MEDICAL RES M
Application granted granted Critical
Publication of DE69731038D1 publication Critical patent/DE69731038D1/de
Publication of DE69731038T2 publication Critical patent/DE69731038T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69731038T 1996-02-16 1997-02-14 Screening-test zur identifikation von inhibitoren des makrophagenmigrationshemmenden faktors Expired - Lifetime DE69731038T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US602929 1996-02-16
US08/602,929 US6420188B1 (en) 1996-02-16 1996-02-16 Screening assay for the identification of inhibitors for macrophage migration inhibitory factor
PCT/US1997/002448 WO1997029635A1 (en) 1996-02-16 1997-02-14 Screening assay for the identification of inhibitors of macrophage migration inhibitory factor

Publications (2)

Publication Number Publication Date
DE69731038D1 true DE69731038D1 (de) 2004-11-11
DE69731038T2 DE69731038T2 (de) 2006-02-23

Family

ID=24413341

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69731038T Expired - Lifetime DE69731038T2 (de) 1996-02-16 1997-02-14 Screening-test zur identifikation von inhibitoren des makrophagenmigrationshemmenden faktors

Country Status (6)

Country Link
US (1) US6420188B1 (de)
EP (1) EP0821551B1 (de)
JP (1) JP4116077B2 (de)
CA (1) CA2218364C (de)
DE (1) DE69731038T2 (de)
WO (1) WO1997029635A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL137043A0 (en) 1998-05-29 2001-06-14 Wisconsin Alumni Res Found Agent and method for modulation of cell migration
CO5221041A1 (es) * 1998-10-23 2002-11-28 Dow Agrosciences Llc Compuestos de 3-(fenil sustituido)-5-tienil-1.2.4- triazolo con actividad contra la mosca blanca y composiciones insecticidas que lo contienen
US6268151B1 (en) 2000-01-20 2001-07-31 Isis Pharmaceuticals, Inc. Antisense modulation of macrophage migration inhibitory factor expression
ATE473294T1 (de) 2001-03-29 2010-07-15 Cytokine Pharmasciences Inc Verfahren und zusammensetzungen zur verwendung von mhc-klasse ii-invariante-kette-polypeptid als rezeptor für makrophagenwanderung-hemmfaktor
UY27304A1 (es) * 2001-05-24 2002-12-31 Avanir Pharmaceuticals Inhibidores del factor inhibidor de la migración de los macrófagos y métodos para su identificación
WO2003065979A2 (en) * 2001-12-05 2003-08-14 North Shore-Long Island Jewish Research Institute Methods of diagnosis, monitoring and treatment of fertility
WO2003090782A1 (fr) * 2002-04-26 2003-11-06 Takeda Chemical Industries, Ltd. Inhibiteur de la mort cellulaire
AU2003233244B2 (en) * 2002-06-07 2010-05-20 Cortical Pty Ltd Therapeutic molecules and methods-1
TW200418829A (en) * 2003-02-14 2004-10-01 Avanir Pharmaceutics Inhibitors of macrophage migration inhibitory factor and methods for identifying the same
US7361474B2 (en) * 2003-02-24 2008-04-22 United States Of America As Represented By The Department Of Veterans Affairs Serum macrophage migration inhibitory factor (MIF) as marker for prostate cancer
BRPI0413695A (pt) * 2003-08-22 2006-10-24 Avanir Pharmaceuticals derivados de naftiridina substituìda como inibidores do fator inibidor da migração de macrófagos e seu uso no tratamento de doenças humanas
US20050202010A1 (en) 2003-08-29 2005-09-15 Giroir Brett P. Method of treatment and bioassay involving macrophage migration inhibitory factor (MIF) as cardiac-derived myocardial depressant factor
WO2005058304A1 (en) * 2003-12-17 2005-06-30 Cortical Pty Ltd Implantable device containing inhibitor of macrophage migration inhibitory factor
AU2005228417A1 (en) * 2004-03-26 2005-10-13 Cytokine Pharmasciences, Inc. Compouns, compositions, processes of making, and methods of use related to inhibiting macrophage migration inhibitory factor
DE102004029573A1 (de) * 2004-06-18 2005-12-29 Gambro Lundia Ab MIF-Adsorbent
CA2600175A1 (en) * 2005-03-24 2006-03-20 Avanir Pharmaceuticals Thienopyridinone derivatives as macrophage migration inhibitory factor inhibitors
JP2007022946A (ja) * 2005-07-14 2007-02-01 Mitsui Norin Co Ltd マクロファージ遊走阻止因子の酵素活性阻害剤
GB0605689D0 (en) * 2006-03-21 2006-05-03 Novartis Ag Organic compounds
DE102008063046A1 (de) 2008-12-23 2010-06-24 Justus-Liebig-Universität Giessen Medizinische Verwendung des ribosomalen Protein S19 (RPS19)
US20100158829A1 (en) * 2008-12-24 2010-06-24 Conopco, Inc., D/B/A Unilever Method and Composition for Color Modulation
DK2643470T3 (en) * 2010-11-24 2016-05-17 Univ Yale Preparations and methods for treating ischemic injury with D-DT
JP2014530360A (ja) 2011-10-07 2014-11-17 バクスター・ヘルスケヤー・ソシエテ・アノニムＢａｘｔｅｒ Ｈｅａｌｔｈｃａｒｅ ＳＡ 診断マーカーとしてのｏｘＭＩＦ

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4708937A (en) * 1984-10-15 1987-11-24 Brigham & Women's Hospital Purified migration inhibitory factor also having colony stimulating factor activity
US5227459A (en) * 1990-05-18 1993-07-13 Yale University Synthetic melanin
EP1741779A3 (de) * 1993-05-17 2010-03-24 The Picower Institute For Medical Research Inhibition des Migrations-Inhibitions-Faktors in der Behandlung von Krankheiten bei denen eine Cytokin-vermittelte Toxizität eine Rolle spielt

Also Published As

Publication number Publication date
US6420188B1 (en) 2002-07-16
EP0821551B1 (de) 2004-10-06
WO1997029635A1 (en) 1997-08-21
DE69731038T2 (de) 2006-02-23
JP4116077B2 (ja) 2008-07-09
EP0821551A1 (de) 1998-02-04
CA2218364A1 (en) 1997-08-21
EP0821551A4 (de) 2000-07-19
JP2000507811A (ja) 2000-06-27
CA2218364C (en) 2010-06-29

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