DE69730241D1 - Feste lösung eines fungizids mit erhöhter bioverfügbarkeit - Google Patents
Feste lösung eines fungizids mit erhöhter bioverfügbarkeitInfo
- Publication number
- DE69730241D1 DE69730241D1 DE69730241T DE69730241T DE69730241D1 DE 69730241 D1 DE69730241 D1 DE 69730241D1 DE 69730241 T DE69730241 T DE 69730241T DE 69730241 T DE69730241 T DE 69730241T DE 69730241 D1 DE69730241 D1 DE 69730241D1
- Authority
- DE
- Germany
- Prior art keywords
- solid solution
- fungicide
- increased bioavailability
- formula
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000006104 solid solution Substances 0.000 title abstract 2
- 230000000855 fungicidal effect Effects 0.000 title 1
- 239000000417 fungicide Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 abstract 2
- 229920000642 polymer Polymers 0.000 abstract 2
- 230000000843 anti-fungal effect Effects 0.000 abstract 1
- 229940121375 antifungal agent Drugs 0.000 abstract 1
- 229960000913 crospovidone Drugs 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 abstract 1
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 abstract 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 1
- 229940069328 povidone Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67270696A | 1996-06-28 | 1996-06-28 | |
| US672706 | 1996-06-28 | ||
| PCT/US1997/010120 WO1998000113A1 (en) | 1996-06-28 | 1997-06-25 | Solid solution of an antifungal agent with enhanced bioavailability |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69730241D1 true DE69730241D1 (de) | 2004-09-16 |
| DE69730241T2 DE69730241T2 (de) | 2005-08-11 |
Family
ID=24699673
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69730241T Expired - Lifetime DE69730241T2 (de) | 1996-06-28 | 1997-06-25 | Feste lösung eines fungizids mit erhöhter bioverfügbarkeit |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0954288B1 (de) |
| JP (1) | JP2000514057A (de) |
| AT (1) | ATE273002T1 (de) |
| AU (1) | AU3483497A (de) |
| DE (1) | DE69730241T2 (de) |
| ES (1) | ES2224256T3 (de) |
| WO (1) | WO1998000113A1 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6524832B1 (en) | 1994-02-04 | 2003-02-25 | Arch Development Corporation | DNA damaging agents in combination with tyrosine kinase inhibitors |
| MY126580A (en) * | 1997-12-22 | 2006-10-31 | Merck Sharp & Dohme | Molecular dispersion composition with enchanced bioavailabity |
| US6632455B2 (en) | 1997-12-22 | 2003-10-14 | Schering Corporation | Molecular dispersion composition with enhanced bioavailability |
| US6350786B1 (en) * | 1998-09-22 | 2002-02-26 | Hoffmann-La Roche Inc. | Stable complexes of poorly soluble compounds in ionic polymers |
| US6316462B1 (en) * | 1999-04-09 | 2001-11-13 | Schering Corporation | Methods of inducing cancer cell death and tumor regression |
| PT1239831E (pt) * | 1999-12-23 | 2013-01-23 | Mayne Pharma International Pty Ltd | Composições farmacêuticas melhoradas para fármacos fracamente solúveis |
| GB0019296D0 (en) * | 2000-08-07 | 2000-09-27 | Nipa Lab Limited | Treatment for part processed leather |
| ITMI20022748A1 (it) | 2002-12-23 | 2004-06-24 | Eurand Int | Dispersioni solide stabilizzate di farmaco in un carrier organico e procedimento per la loro preparazione. |
| ITMI20032020A1 (it) | 2003-10-17 | 2005-04-18 | Italfarmaco Spa | Nuovi agenti antifungini azolici con diminuita interazione con i citocromi metabolici |
| EP2155166A2 (de) * | 2007-05-11 | 2010-02-24 | F. Hoffmann-Roche AG | Pharmazeutische zusammensetzung für schwer lösliche heilmittel |
| US8921374B2 (en) | 2012-06-21 | 2014-12-30 | Mayne Pharma International Pty Ltd | Itraconazole compositions and dosage forms, and methods of using the same |
| WO2017025292A1 (en) | 2015-08-08 | 2017-02-16 | Alfred E. Tiefenbacher (Gmbh & Co. Kg) | Gastro-resistant formulation containing posaconazole |
| EP3925601B1 (de) | 2016-02-26 | 2024-07-17 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Magenresistente formulierung mit posaconazol und polymerfällungsinhibitor |
| TR201620462A2 (tr) | 2016-12-31 | 2018-07-23 | Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi | POSAKONAZOL İÇEREN FARMASÖTİK BİLEŞİMLER ve ÜRETİM YÖNTEMİ |
| US10702520B1 (en) | 2019-01-29 | 2020-07-07 | Slayback Pharma Llc | Pharmaceutical compositions of posaconazole |
| EP4196096A1 (de) | 2020-08-13 | 2023-06-21 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Magenresistente hochfeste formulierung mit posaconazol |
| EP4181883A1 (de) | 2021-11-25 | 2023-05-24 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Posaconazol enthaltende granulate |
| EP4091604B1 (de) | 2021-11-25 | 2024-04-03 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Posaconazol-haltige granulate |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2109377T3 (es) * | 1991-12-18 | 1998-01-16 | Warner Lambert Co | Proceso para la preparacion de una dispersion solida. |
| ES2159623T3 (es) * | 1993-12-21 | 2001-10-16 | Schering Corp | Antifungicos de tetrahidrofurano. |
-
1997
- 1997-06-25 DE DE69730241T patent/DE69730241T2/de not_active Expired - Lifetime
- 1997-06-25 JP JP10504146A patent/JP2000514057A/ja not_active Ceased
- 1997-06-25 EP EP97931119A patent/EP0954288B1/de not_active Expired - Lifetime
- 1997-06-25 WO PCT/US1997/010120 patent/WO1998000113A1/en active IP Right Grant
- 1997-06-25 ES ES97931119T patent/ES2224256T3/es not_active Expired - Lifetime
- 1997-06-25 AT AT97931119T patent/ATE273002T1/de not_active IP Right Cessation
- 1997-06-25 AU AU34834/97A patent/AU3483497A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ATE273002T1 (de) | 2004-08-15 |
| EP0954288A1 (de) | 1999-11-10 |
| EP0954288B1 (de) | 2004-08-11 |
| ES2224256T3 (es) | 2005-03-01 |
| JP2000514057A (ja) | 2000-10-24 |
| AU3483497A (en) | 1998-01-21 |
| DE69730241T2 (de) | 2005-08-11 |
| WO1998000113A1 (en) | 1998-01-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |