DE69722592D1 - Histamin h 3 rezeptorliganden - Google Patents

Histamin h 3 rezeptorliganden

Info

Publication number
DE69722592D1
DE69722592D1 DE69722592T DE69722592T DE69722592D1 DE 69722592 D1 DE69722592 D1 DE 69722592D1 DE 69722592 T DE69722592 T DE 69722592T DE 69722592 T DE69722592 T DE 69722592T DE 69722592 D1 DE69722592 D1 DE 69722592D1
Authority
DE
Germany
Prior art keywords
alkyl
group
groups
pct
independently
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69722592T
Other languages
English (en)
Inventor
Barret Kalindjian
Paul Shankley
John Tozer
Mair Mcdonald
John Pether
Anne Harper
Fairfull Watt
Tracey Cooke
Minli Low
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
James Black Foundation Ltd
Original Assignee
James Black Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9602649.7A external-priority patent/GB9602649D0/en
Application filed by James Black Foundation Ltd filed Critical James Black Foundation Ltd
Application granted granted Critical
Publication of DE69722592D1 publication Critical patent/DE69722592D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69722592T 1996-02-09 1997-02-10 Histamin h 3 rezeptorliganden Expired - Lifetime DE69722592D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9602649.7A GB9602649D0 (en) 1996-02-09 1996-02-09 Histamine h3 receptor ligands
GBGB9624215.1A GB9624215D0 (en) 1996-02-09 1996-11-21 Histamine H3 receptor ligands
PCT/GB1997/000358 WO1997029092A1 (en) 1996-02-09 1997-02-10 Histamine h3 receptor ligands

Publications (1)

Publication Number Publication Date
DE69722592D1 true DE69722592D1 (de) 2003-07-10

Family

ID=26308645

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69722592T Expired - Lifetime DE69722592D1 (de) 1996-02-09 1997-02-10 Histamin h 3 rezeptorliganden

Country Status (14)

Country Link
US (1) US6080871A (de)
EP (1) EP0882023B1 (de)
JP (1) JP2000505428A (de)
CN (1) CN1215392A (de)
AT (1) ATE242219T1 (de)
AU (1) AU709611B2 (de)
CA (1) CA2244745A1 (de)
DE (1) DE69722592D1 (de)
HU (1) HUP9901190A3 (de)
NO (1) NO312762B1 (de)
NZ (1) NZ331272A (de)
PL (1) PL328369A1 (de)
RU (1) RU2182904C2 (de)
WO (1) WO1997029092A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000507584A (ja) * 1996-04-03 2000-06-20 メルク エンド カンパニー インコーポレーテッド ファルネシル―タンパク質転移酵素の阻害剤
US6407132B1 (en) * 1997-07-25 2002-06-18 James Black Foundation Limited Substituted imidazole derivatives and their use as histamine H3 receptor ligands
GB9715814D0 (en) 1997-07-25 1997-10-01 Black James Foundation Histamine H3 receptor ligands
GB2344588B (en) * 1997-07-25 2001-11-14 Black James Foundation 1H-4(5)-substituted imidazole derivatives their preparation and their use as histamine H 3 receptor ligands
GB9803536D0 (en) * 1998-02-19 1998-04-15 Black James Foundation Histamine H,receptor ligands
US6503935B1 (en) 1998-08-07 2003-01-07 Abbott Laboratories Imidazoles and related compounds as α1A agonists
PT1735278E (pt) 2004-04-01 2010-03-09 Lilly Co Eli Agentes receptores h3 de histamina, sua preparação e utilizações terapêuticas
EP1595881A1 (de) 2004-05-12 2005-11-16 Pfizer Limited Tetrahydronaphthyridin-Derivate, verwendbar als Histamin H3 Rezeptor-Liganden
FR2870846B1 (fr) * 2004-05-25 2006-08-04 Sanofi Synthelabo Derives de tetrahydroisoquinolylsulfonamides, leur preparation et leur utilisation en therapeutique
JP4942654B2 (ja) 2004-08-23 2012-05-30 イーライ リリー アンド カンパニー ヒスタミンｈ３受容体薬剤、製剤及び治療的使用
AU2005277134A1 (en) * 2004-08-24 2006-03-02 Janssen Pharmaceutica N.V. Novel benzo-fused heteroaryl sulfamide derivatives useful as anticonvulsant agents
ES2318565T3 (es) 2004-10-18 2009-05-01 Eli Lilly And Company Inhibidores del receptor de la histamina h3, su preparacion y sus usos terapeuticos.
CN101151244B (zh) 2005-04-01 2014-09-03 伊莱利利公司 组胺h3受体活性剂、制备和治疗用途
EP1707203A1 (de) 2005-04-01 2006-10-04 Bioprojet Verwendung von Alkylaminen, die kein Imidazole enthalten, als Histamin H3 Rezeptor Liganden, zur Behandlung von Morbus Parkinson, obstruktiver Schlafapnoe, vaskularer Demenz, Demenz mit Lewy Korpen
EP1717233A1 (de) * 2005-04-29 2006-11-02 Bioprojet Liganden für den Histamin H3-Rezeptor und ihre therapeutische Anwendung
EP1717235A3 (de) 2005-04-29 2007-02-28 Bioprojet Phenoxypropylpiperidine und -pyrrolidine und ihre Verwendung als Liganden für den Histamin H3-Rezeptor

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2372066A (en) * 1940-12-23 1945-03-20 Parke Davis & Co Biological product and process of obtaining same
US3497591A (en) * 1968-11-19 1970-02-24 Colgate Palmolive Co Dental preparations containing imidazole derivative
EP0082648A3 (de) * 1981-12-21 1984-09-26 Imperial Chemical Industries Plc Cephalosporinderivate
DE3219113A1 (de) * 1982-05-21 1983-11-24 Bayer Ag, 5090 Leverkusen Verwendung von n-substituierten 2,3-diaminocarbonsaeuren in arzneimitteln und ihre herstellung
AU5410786A (en) * 1985-03-04 1986-09-11 Fujisawa Pharmaceutical Co., Ltd. Amino acid derivatives and processes for preparation thereof
US5447728A (en) * 1992-06-15 1995-09-05 Emisphere Technologies, Inc. Desferrioxamine oral delivery system
FR2686084B1 (fr) * 1992-01-10 1995-12-22 Bioprojet Soc Civ Nouveaux derives de l'imidazole, leur preparation et leurs applications therapeutiques.
AU7823894A (en) * 1993-08-27 1995-03-21 Vrije Universiteit New imidazole derivatives having agonistic or antagonistic activity on the histamine h3 receptor

Also Published As

Publication number Publication date
PL328369A1 (en) 1999-01-18
EP0882023B1 (de) 2003-06-04
AU709611B2 (en) 1999-09-02
NO983596L (no) 1998-09-16
RU2182904C2 (ru) 2002-05-27
NO312762B1 (no) 2002-07-01
CA2244745A1 (en) 1997-08-14
JP2000505428A (ja) 2000-05-09
ATE242219T1 (de) 2003-06-15
HUP9901190A2 (hu) 1999-09-28
US6080871A (en) 2000-06-27
CN1215392A (zh) 1999-04-28
NZ331272A (en) 2000-01-28
NO983596D0 (no) 1998-08-05
HUP9901190A3 (en) 2002-05-28
EP0882023A1 (de) 1998-12-09
WO1997029092A1 (en) 1997-08-14
AU1613697A (en) 1997-08-28

Similar Documents

Publication Publication Date Title
ATE242219T1 (de) Histamin h 3 rezeptorliganden
DK1309544T3 (da) Forbindelser, der virker som melanocortinreceptorligander
HK1035724A1 (en) Compounds as selective agonists at alpha 2B or 2B/2C adrenergic receptors.
IL110091A (en) POLYSUBSTITUTED IMIDAZO £4, 5-c| PYRIDIN-4-AMINES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
DK0665844T3 (da) Substituerede benzylaminoquinuclidinforbindelser som antagonister af substans P
TW328089B (en) New azolidinediones as antihyperglycemic agents
FI863019A0 (fi) Foerfarande foer framstaellning av heterocykliska foereningar.
GR861927B (en) Process for preparing heterocyclic compounds
IL100164A0 (en) Indan derivatives
HUP9900679A2 (hu) Simaizom sejtburjánzást gátló benzimidazolszármazékok, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények
GB2341861A (en) Substituted imidazole derivatives and their use as histamine H 3 receptor ligands
AP9801410A0 (en) Indoline derivatives useful as 5-HT-2C receptor antagonists.
ES2170802T3 (es) Carboxamidas biciclicas como ligandos de los receptores 5-ht1a.
GB2341862A (en) Histamine H3 receptor ligands
ES514634A0 (es) "un procedimiento para la preparacion de 2-(1,4-benzodioxan-2-il-metil)-imidazolina".
KR960007560A (ko) 신규한 아민 유도체, 그의 제조방법 및 항부정맥제로서의 용도
DK1068199T3 (da) N-Aryloxyethyl-indolyl-alkylaminer til behandling af depression
MX9709833A (es) Uso de benzimidazoles para la fabricacion de un medicamento para el tratamiento de leucemia.
ES2009463A6 (es) Procedimiento de preparacion de derivados de 2-propanol.

Legal Events

Date Code Title Description
8332 No legal effect for de