DE69721247D1 - Wasserlösliche trisubstituierte 1,2-dioxetanverbindungen mit erhöhter lagerstabilität, syntheseverfahren und zwischenverbindungen - Google Patents
Wasserlösliche trisubstituierte 1,2-dioxetanverbindungen mit erhöhter lagerstabilität, syntheseverfahren und zwischenverbindungenInfo
- Publication number
- DE69721247D1 DE69721247D1 DE69721247T DE69721247T DE69721247D1 DE 69721247 D1 DE69721247 D1 DE 69721247D1 DE 69721247 T DE69721247 T DE 69721247T DE 69721247 T DE69721247 T DE 69721247T DE 69721247 D1 DE69721247 D1 DE 69721247D1
- Authority
- DE
- Germany
- Prior art keywords
- dioxetanes
- water
- storage stability
- substituted
- synthesis procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- -1 TRI-SUBSTITUTED 1,2-DIOXETANE COMPOUNDS Chemical class 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- BVTJGGGYKAMDBN-UHFFFAOYSA-N Dioxetane Chemical class C1COO1 BVTJGGGYKAMDBN-UHFFFAOYSA-N 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 239000003093 cationic surfactant Substances 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 238000001378 electrochemiluminescence detection Methods 0.000 abstract 1
- 239000003623 enhancer Substances 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000001960 triggered effect Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/734—Ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
- C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/12—Esters of phosphoric acids with hydroxyaryl compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/6551—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a four-membered ring
- C07F9/65512—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a four-membered ring condensed with carbocyclic rings or carbocyclic ring systems
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Luminescent Compositions (AREA)
- Epoxy Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Polyethers (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/748,107 US5721370A (en) | 1995-07-31 | 1996-11-08 | Water soluble tri-substituted 1,2-dioxetane compounds and assay compositions having increased storage stability |
| US748107 | 1996-11-08 | ||
| PCT/US1997/019618 WO1998019989A1 (en) | 1996-11-08 | 1997-11-07 | Water soluble tri-substituted 1,2-dioxetane compounds having increased storage stability, synthetic processes and intermediates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69721247D1 true DE69721247D1 (de) | 2003-05-28 |
| DE69721247T2 DE69721247T2 (de) | 2004-03-11 |
Family
ID=25008049
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69721247T Expired - Lifetime DE69721247T2 (de) | 1996-11-08 | 1997-11-07 | Wasserlösliche trisubstituierte 1,2-dioxetanverbindungen mit erhöhter lagerstabilität, syntheseverfahren und zwischenverbindungen |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US5721370A (de) |
| EP (1) | EP0898557B9 (de) |
| JP (1) | JP4199830B2 (de) |
| KR (1) | KR100518977B1 (de) |
| CN (1) | CN1252029C (de) |
| AT (1) | ATE238268T1 (de) |
| AU (1) | AU734753B2 (de) |
| CA (1) | CA2238365C (de) |
| DE (1) | DE69721247T2 (de) |
| DK (1) | DK0898557T3 (de) |
| ES (1) | ES2197376T3 (de) |
| IL (1) | IL124671A (de) |
| WO (1) | WO1998019989A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5856522A (en) * | 1995-05-04 | 1999-01-05 | Tropix, Inc. | Method of using synthesis of 1,2-dioxetanes and kits therefore |
| US5578253A (en) * | 1994-11-23 | 1996-11-26 | Lumigen, Inc. | Chemiluminescent dialkyl-substituted 1,2-dioxetane compounds, methods of synthesis and use |
| DE69622605T2 (de) * | 1995-10-17 | 2003-03-13 | Tropix Inc | Chemilumineszente 1,2-dioxetane mit verbesserter leistung |
| CN1211387C (zh) * | 1998-09-08 | 2005-07-20 | 布里奇·P·吉利 | 化学发光的1,2－二氧丁环 |
| US6555698B1 (en) * | 1998-11-17 | 2003-04-29 | Tropix, Inc. | Chemiluminescent substrates for neuraminidase, assays for detection of neuraminidase and kits therefor |
| US6623971B2 (en) * | 1999-01-11 | 2003-09-23 | Bayer Corporation | Method and apparatus for conducting a stat immunoassay analysis in a capsule chemistry analysis system |
| US6783948B1 (en) * | 1999-07-30 | 2004-08-31 | Bayer Corporation | Chemiluminescent acridinium compounds and analogues thereof as substrates of hydrolytic enzymes |
| WO2006116683A1 (en) * | 2005-04-27 | 2006-11-02 | The Trustees Of The University Of Pennsylvania | Nanostructure enhanced luminescence |
| WO2006116686A2 (en) * | 2005-04-27 | 2006-11-02 | The Trustees Of The University Of Pennsylvania | Nanostructure enhanced luminescent devices |
| WO2006116687A2 (en) * | 2005-04-27 | 2006-11-02 | The Trustees Of The University Of Pennsylvania | Nanoassays |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5004565A (en) * | 1986-07-17 | 1991-04-02 | The Board Of Governors Of Wayne State University | Method and compositions providing enhanced chemiluminescence from 1,2-dioxetanes |
| US4983779A (en) * | 1986-07-17 | 1991-01-08 | The Board Of Governors Of Wayne State University | Process for the preparation of vinyl ethers |
| US4959182A (en) * | 1986-07-17 | 1990-09-25 | Board Of Governors Of Wayne State University | Method and compositions providing enhanced chemiluminescence from 1,2-dioxetanes |
| US5013827A (en) * | 1986-07-17 | 1991-05-07 | Board Of Governors Of Wayne State University | Enhanced chemiluminescence from 1,2-dioxetanes through energy transfer to tethered fluorescers |
| US5068339A (en) * | 1986-07-17 | 1991-11-26 | Board Of Governors Of Wayne State University | Enhanced chemiluminescence from 1,2-dioxetanes through energy transfer to tethered fluorescers |
| US5220005A (en) * | 1986-07-24 | 1993-06-15 | Tropix, Inc. | Substituted adamantyl dioxetanes |
| DE3788203T2 (de) * | 1986-07-24 | 1994-03-31 | Tropix Inc | Verfahren zum nachweis einer verbindung unter verwendung des enzymatisch induzierten zerfalls von dioxethanen. |
| CA1340590C (en) * | 1986-07-24 | 1999-06-08 | John C. Voyta | Chemiluminescence enhancement |
| US5112960A (en) * | 1989-07-17 | 1992-05-12 | Bronstein Irena Y | Chemiluminescent 3-(substituted adamant-2'-ylidene) 1,2-dioxetanes |
| US5582980A (en) * | 1989-07-17 | 1996-12-10 | Tropix, Inc. | Chemiluminescent 1,2-dioxetanes |
| US4952707A (en) * | 1988-06-30 | 1990-08-28 | Tropix, Inc. | Enzymatically-cleavable chemiluminescent fused polycyclic ring-containing 1,2-dioxetanes |
| US5547836A (en) * | 1990-08-30 | 1996-08-20 | Tropix, Inc. | Enhancement of chemiluminescent assays |
| DE473984T1 (de) * | 1990-09-07 | 1992-08-13 | The Board Of Governors Of Wayne State University, Detroit, Mich. | 1,2-dioxetan-verbindungen als chemilumineszierende markierungen fuer organische und biologische molekuele. |
| US5399497A (en) * | 1992-02-26 | 1995-03-21 | Miles, Inc. | Capsule chemistry sample liquid analysis system and method |
| US5393469A (en) * | 1992-03-20 | 1995-02-28 | Lumigen, Inc. | Polymeric phosphonium salts providing enhanced chemiluminescence from 1,2-dioxetanes |
| AU5132993A (en) * | 1992-09-21 | 1994-04-12 | Habley Medical Technology Corporation | Device and method for containing an ampule and transferring liquid within the ampule to a container |
| US5603868A (en) * | 1992-10-30 | 1997-02-18 | Abbott Laboratories | Chemiluminescent electron-rich aryl-substituted 1,2-dioxetanes |
| US5451347A (en) * | 1993-06-24 | 1995-09-19 | Lumigen, Inc. | Methods and compositions providing enhanced chemiluminescence from chemiluminescent compounds using dicationic surfactants |
| US5631167A (en) * | 1995-07-31 | 1997-05-20 | Bayer Corporation | Capsule chemistry analytical methods employing dioxetane chemiluminescence |
| US5777135A (en) * | 1995-07-31 | 1998-07-07 | Lumigen, Inc. | Di-substituted 1,2-dioxetane compounds having increased water solubility and assay compositions |
-
1996
- 1996-11-08 US US08/748,107 patent/US5721370A/en not_active Expired - Lifetime
-
1997
- 1997-07-17 US US08/896,150 patent/US5866045A/en not_active Expired - Lifetime
- 1997-11-07 DE DE69721247T patent/DE69721247T2/de not_active Expired - Lifetime
- 1997-11-07 KR KR1019980705247A patent/KR100518977B1/ko not_active IP Right Cessation
- 1997-11-07 WO PCT/US1997/019618 patent/WO1998019989A1/en active IP Right Grant
- 1997-11-07 CN CNB971916241A patent/CN1252029C/zh not_active Expired - Lifetime
- 1997-11-07 CA CA002238365A patent/CA2238365C/en not_active Expired - Lifetime
- 1997-11-07 EP EP97949349A patent/EP0898557B9/de not_active Expired - Lifetime
- 1997-11-07 DK DK97949349T patent/DK0898557T3/da active
- 1997-11-07 JP JP52153198A patent/JP4199830B2/ja not_active Expired - Lifetime
- 1997-11-07 ES ES97949349T patent/ES2197376T3/es not_active Expired - Lifetime
- 1997-11-07 AT AT97949349T patent/ATE238268T1/de not_active IP Right Cessation
- 1997-11-07 IL IL12467196A patent/IL124671A/xx not_active IP Right Cessation
- 1997-11-07 AU AU69907/98A patent/AU734753B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| AU6990798A (en) | 1998-05-29 |
| KR100518977B1 (ko) | 2006-06-29 |
| IL124671A (en) | 2003-01-12 |
| US5866045A (en) | 1999-02-02 |
| WO1998019989A1 (en) | 1998-05-14 |
| EP0898557B9 (de) | 2003-10-08 |
| AU734753B2 (en) | 2001-06-21 |
| KR19990077111A (ko) | 1999-10-25 |
| CA2238365C (en) | 2008-03-18 |
| ATE238268T1 (de) | 2003-05-15 |
| CN1208399A (zh) | 1999-02-17 |
| EP0898557A4 (de) | 2001-01-10 |
| CN1252029C (zh) | 2006-04-19 |
| CA2238365A1 (en) | 1998-05-14 |
| US5721370A (en) | 1998-02-24 |
| EP0898557A1 (de) | 1999-03-03 |
| EP0898557B1 (de) | 2003-04-23 |
| DE69721247T2 (de) | 2004-03-11 |
| DK0898557T3 (da) | 2003-08-04 |
| IL124671A0 (en) | 1998-12-06 |
| JP2000506544A (ja) | 2000-05-30 |
| ES2197376T3 (es) | 2004-01-01 |
| JP4199830B2 (ja) | 2008-12-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |