DE69719962T2 - Tieftemperaturspeicher für spin-polarisiertes xenon-129 - Google Patents
Tieftemperaturspeicher für spin-polarisiertes xenon-129Info
- Publication number
- DE69719962T2 DE69719962T2 DE69719962T DE69719962T DE69719962T2 DE 69719962 T2 DE69719962 T2 DE 69719962T2 DE 69719962 T DE69719962 T DE 69719962T DE 69719962 T DE69719962 T DE 69719962T DE 69719962 T2 DE69719962 T2 DE 69719962T2
- Authority
- DE
- Germany
- Prior art keywords
- hyperpolarized
- enrichment
- gas
- reservoir
- hyperpolarization
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- FHNFHKCVQCLJFQ-YPZZEJLDSA-N xenon-129 atom Chemical compound [129Xe] FHNFHKCVQCLJFQ-YPZZEJLDSA-N 0.000 title claims abstract description 196
- 239000007789 gas Substances 0.000 claims abstract description 242
- 238000000034 method Methods 0.000 claims abstract description 96
- 230000002102 hyperpolarization Effects 0.000 claims abstract description 80
- 238000003860 storage Methods 0.000 claims abstract description 27
- 238000009825 accumulation Methods 0.000 claims abstract 6
- 230000010287 polarization Effects 0.000 claims description 93
- 229910052724 xenon Inorganic materials 0.000 claims description 72
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 claims description 72
- 150000001340 alkali metals Chemical class 0.000 claims description 62
- 229910052783 alkali metal Inorganic materials 0.000 claims description 56
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 55
- 230000008569 process Effects 0.000 claims description 47
- 230000003287 optical effect Effects 0.000 claims description 45
- 239000000203 mixture Substances 0.000 claims description 36
- 230000005291 magnetic effect Effects 0.000 claims description 29
- 229910052734 helium Inorganic materials 0.000 claims description 28
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 claims description 27
- 229910052757 nitrogen Inorganic materials 0.000 claims description 27
- 238000001816 cooling Methods 0.000 claims description 26
- 239000001307 helium Substances 0.000 claims description 26
- 239000007788 liquid Substances 0.000 claims description 22
- 238000010791 quenching Methods 0.000 claims description 19
- 230000000171 quenching effect Effects 0.000 claims description 19
- 238000005057 refrigeration Methods 0.000 claims description 14
- 239000001257 hydrogen Substances 0.000 claims description 10
- 229910052739 hydrogen Inorganic materials 0.000 claims description 10
- 230000005855 radiation Effects 0.000 claims description 9
- 230000000694 effects Effects 0.000 claims description 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 7
- 230000028161 membrane depolarization Effects 0.000 claims description 7
- 230000008014 freezing Effects 0.000 claims description 6
- 238000007710 freezing Methods 0.000 claims description 6
- 238000009833 condensation Methods 0.000 claims description 4
- 230000005494 condensation Effects 0.000 claims description 4
- 238000010924 continuous production Methods 0.000 claims description 3
- 238000004891 communication Methods 0.000 claims description 2
- 239000012530 fluid Substances 0.000 claims 1
- 230000005415 magnetization Effects 0.000 claims 1
- 238000010257 thawing Methods 0.000 claims 1
- 238000003384 imaging method Methods 0.000 abstract description 10
- 238000002595 magnetic resonance imaging Methods 0.000 abstract description 10
- 238000000746 purification Methods 0.000 abstract description 4
- 230000001667 episodic effect Effects 0.000 abstract description 3
- 241001465754 Metazoa Species 0.000 abstract description 2
- 230000007717 exclusion Effects 0.000 abstract description 2
- 238000011031 large-scale manufacturing process Methods 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 description 71
- 238000005086 pumping Methods 0.000 description 62
- 229910052756 noble gas Inorganic materials 0.000 description 49
- 229910052701 rubidium Inorganic materials 0.000 description 28
- IGLNJRXAVVLDKE-UHFFFAOYSA-N rubidium atom Chemical compound [Rb] IGLNJRXAVVLDKE-UHFFFAOYSA-N 0.000 description 28
- 238000005481 NMR spectroscopy Methods 0.000 description 22
- 238000004519 manufacturing process Methods 0.000 description 20
- 239000011521 glass Substances 0.000 description 16
- 238000010521 absorption reaction Methods 0.000 description 13
- 150000002835 noble gases Chemical class 0.000 description 12
- 239000000463 material Substances 0.000 description 11
- 229910052751 metal Inorganic materials 0.000 description 10
- 239000002184 metal Substances 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 239000007787 solid Substances 0.000 description 8
- 229910052792 caesium Inorganic materials 0.000 description 7
- 238000013461 design Methods 0.000 description 7
- 239000012535 impurity Substances 0.000 description 7
- 238000012544 monitoring process Methods 0.000 description 7
- 238000000926 separation method Methods 0.000 description 7
- 238000003491 array Methods 0.000 description 6
- TVFDJXOCXUVLDH-UHFFFAOYSA-N caesium atom Chemical compound [Cs] TVFDJXOCXUVLDH-UHFFFAOYSA-N 0.000 description 6
- 230000003595 spectral effect Effects 0.000 description 6
- 238000013459 approach Methods 0.000 description 5
- 230000036961 partial effect Effects 0.000 description 5
- 230000006378 damage Effects 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- 238000000711 polarimetry Methods 0.000 description 4
- -1 rubidium Chemical class 0.000 description 4
- 230000008901 benefit Effects 0.000 description 3
- 230000005540 biological transmission Effects 0.000 description 3
- 239000002826 coolant Substances 0.000 description 3
- 150000002431 hydrogen Chemical class 0.000 description 3
- 238000009434 installation Methods 0.000 description 3
- 230000000155 isotopic effect Effects 0.000 description 3
- 239000012071 phase Substances 0.000 description 3
- 239000004033 plastic Substances 0.000 description 3
- 229920003023 plastic Polymers 0.000 description 3
- 238000010926 purge Methods 0.000 description 3
- 230000002829 reductive effect Effects 0.000 description 3
- 229920006395 saturated elastomer Polymers 0.000 description 3
- 238000012546 transfer Methods 0.000 description 3
- 239000006200 vaporizer Substances 0.000 description 3
- 238000004480 129Xe NMR spectroscopy Methods 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 2
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- 230000003667 anti-reflective effect Effects 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000003990 capacitor Substances 0.000 description 2
- 210000002421 cell wall Anatomy 0.000 description 2
- 239000000356 contaminant Substances 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 230000002999 depolarising effect Effects 0.000 description 2
- 230000006866 deterioration Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 238000011835 investigation Methods 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 238000005457 optimization Methods 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000005297 pyrex Substances 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 230000003068 static effect Effects 0.000 description 2
- 238000000859 sublimation Methods 0.000 description 2
- 230000008022 sublimation Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000007704 transition Effects 0.000 description 2
- 238000012800 visualization Methods 0.000 description 2
- XMTQQYYKAHVGBJ-UHFFFAOYSA-N 3-(3,4-DICHLOROPHENYL)-1,1-DIMETHYLUREA Chemical compound CN(C)C(=O)NC1=CC=C(Cl)C(Cl)=C1 XMTQQYYKAHVGBJ-UHFFFAOYSA-N 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 238000000862 absorption spectrum Methods 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 239000005354 aluminosilicate glass Substances 0.000 description 1
- 239000006117 anti-reflective coating Substances 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
- 239000005388 borosilicate glass Substances 0.000 description 1
- 230000009172 bursting Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 238000005094 computer simulation Methods 0.000 description 1
- 238000005112 continuous flow technique Methods 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 229910001873 dinitrogen Inorganic materials 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000005293 duran Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000003302 ferromagnetic material Substances 0.000 description 1
- 239000007888 film coating Substances 0.000 description 1
- 238000009501 film coating Methods 0.000 description 1
- 238000002575 gastroscopy Methods 0.000 description 1
- 238000005247 gettering Methods 0.000 description 1
- 238000007511 glassblowing Methods 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 238000005067 remediation Methods 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 239000012808 vapor phase Substances 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 238000013022 venting Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
- G01R33/282—Means specially adapted for hyperpolarisation or for hyperpolarised contrast agents, e.g. for the generation of hyperpolarised gases using optical pumping cells, for storing hyperpolarised contrast agents or for the determination of the polarisation of a hyperpolarised contrast agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1806—Suspensions, emulsions, colloids, dispersions
- A61K49/1815—Suspensions, emulsions, colloids, dispersions compo-inhalant, e.g. breath tests
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B23/00—Noble gases; Compounds thereof
- C01B23/001—Purification or separation processes of noble gases
- C01B23/0036—Physical processing only
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25J—LIQUEFACTION, SOLIDIFICATION OR SEPARATION OF GASES OR GASEOUS OR LIQUEFIED GASEOUS MIXTURES BY PRESSURE AND COLD TREATMENT OR BY BRINGING THEM INTO THE SUPERCRITICAL STATE
- F25J3/00—Processes or apparatus for separating the constituents of gaseous or liquefied gaseous mixtures involving the use of liquefaction or solidification
- F25J3/06—Processes or apparatus for separating the constituents of gaseous or liquefied gaseous mixtures involving the use of liquefaction or solidification by partial condensation
- F25J3/063—Processes or apparatus for separating the constituents of gaseous or liquefied gaseous mixtures involving the use of liquefaction or solidification by partial condensation characterised by the separated product stream
- F25J3/0685—Processes or apparatus for separating the constituents of gaseous or liquefied gaseous mixtures involving the use of liquefaction or solidification by partial condensation characterised by the separated product stream separation of noble gases
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
- H05H3/00—Production or acceleration of neutral particle beams, e.g. molecular or atomic beams
- H05H3/02—Molecular or atomic-beam generation, e.g. resonant beam generation
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B2210/00—Purification or separation of specific gases
- C01B2210/0029—Obtaining noble gases
- C01B2210/0037—Xenon
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25J—LIQUEFACTION, SOLIDIFICATION OR SEPARATION OF GASES OR GASEOUS OR LIQUEFIED GASEOUS MIXTURES BY PRESSURE AND COLD TREATMENT OR BY BRINGING THEM INTO THE SUPERCRITICAL STATE
- F25J2205/00—Processes or apparatus using other separation and/or other processing means
- F25J2205/20—Processes or apparatus using other separation and/or other processing means using solidification of components
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25J—LIQUEFACTION, SOLIDIFICATION OR SEPARATION OF GASES OR GASEOUS OR LIQUEFIED GASEOUS MIXTURES BY PRESSURE AND COLD TREATMENT OR BY BRINGING THEM INTO THE SUPERCRITICAL STATE
- F25J2210/00—Processes characterised by the type or other details of the feed stream
- F25J2210/42—Nitrogen
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25J—LIQUEFACTION, SOLIDIFICATION OR SEPARATION OF GASES OR GASEOUS OR LIQUEFIED GASEOUS MIXTURES BY PRESSURE AND COLD TREATMENT OR BY BRINGING THEM INTO THE SUPERCRITICAL STATE
- F25J2215/00—Processes characterised by the type or other details of the product stream
- F25J2215/36—Xenon
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25J—LIQUEFACTION, SOLIDIFICATION OR SEPARATION OF GASES OR GASEOUS OR LIQUEFIED GASEOUS MIXTURES BY PRESSURE AND COLD TREATMENT OR BY BRINGING THEM INTO THE SUPERCRITICAL STATE
- F25J2270/00—Refrigeration techniques used
- F25J2270/60—Closed external refrigeration cycle with single component refrigerant [SCR], e.g. C1-, C2- or C3-hydrocarbons
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25J—LIQUEFACTION, SOLIDIFICATION OR SEPARATION OF GASES OR GASEOUS OR LIQUEFIED GASEOUS MIXTURES BY PRESSURE AND COLD TREATMENT OR BY BRINGING THEM INTO THE SUPERCRITICAL STATE
- F25J2270/00—Refrigeration techniques used
- F25J2270/90—External refrigeration, e.g. conventional closed-loop mechanical refrigeration unit using Freon or NH3, unspecified external refrigeration
- F25J2270/904—External refrigeration, e.g. conventional closed-loop mechanical refrigeration unit using Freon or NH3, unspecified external refrigeration by liquid or gaseous cryogen in an open loop
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25J—LIQUEFACTION, SOLIDIFICATION OR SEPARATION OF GASES OR GASEOUS OR LIQUEFIED GASEOUS MIXTURES BY PRESSURE AND COLD TREATMENT OR BY BRINGING THEM INTO THE SUPERCRITICAL STATE
- F25J2290/00—Other details not covered by groups F25J2200/00 - F25J2280/00
- F25J2290/62—Details of storing a fluid in a tank
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S62/00—Refrigeration
- Y10S62/919—Isotope
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S62/00—Refrigeration
- Y10S62/923—Inert gas
- Y10S62/925—Xenon or krypton
Landscapes
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Analytical Chemistry (AREA)
- Inorganic Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Plasma & Fusion (AREA)
- Radiology & Medical Imaging (AREA)
- Thermal Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dispersion Chemistry (AREA)
- Mechanical Engineering (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Separation By Low-Temperature Treatments (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Developing Agents For Electrophotography (AREA)
- Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
- Image Processing (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/622,865 US5809801A (en) | 1996-03-29 | 1996-03-29 | Cryogenic accumulator for spin-polarized xenon-129 |
| PCT/US1997/005004 WO1997037177A1 (en) | 1996-03-29 | 1997-03-27 | Cryogenic accumulator for spin-polarized xenon-129 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69719962D1 DE69719962D1 (de) | 2003-04-24 |
| DE69719962T2 true DE69719962T2 (de) | 2003-12-18 |
Family
ID=24495803
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69719962T Expired - Lifetime DE69719962T2 (de) | 1996-03-29 | 1997-03-27 | Tieftemperaturspeicher für spin-polarisiertes xenon-129 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US5809801A (enExample) |
| EP (1) | EP0890066B1 (enExample) |
| JP (2) | JP2000507688A (enExample) |
| AT (1) | ATE235032T1 (enExample) |
| AU (1) | AU712530B2 (enExample) |
| CA (1) | CA2250167C (enExample) |
| DE (1) | DE69719962T2 (enExample) |
| DK (1) | DK0890066T3 (enExample) |
| ES (1) | ES2195131T3 (enExample) |
| WO (1) | WO1997037177A1 (enExample) |
Families Citing this family (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5545396A (en) | 1994-04-08 | 1996-08-13 | The Research Foundation Of State University Of New York | Magnetic resonance imaging using hyperpolarized noble gases |
| JP2001503646A (ja) * | 1996-03-29 | 2001-03-21 | ローレンス バークレー ナショナル ラボラトリィ | 過分極化希ガス存在下でのｎｍｒまたはｍｒｉの増強 |
| US6085743A (en) * | 1997-05-30 | 2000-07-11 | The Regent Of The University Of Michigan | Polarized gas delivery system/method |
| US6318092B1 (en) | 1997-08-18 | 2001-11-20 | The Trustees Of Princeton University | Alkali metal hybrid spin-exchange optical pumping |
| CN1284158A (zh) * | 1997-12-12 | 2001-02-14 | 磁成象技术公司 | 极化气体储蓄器和加热夹套及相关的气体收集和熔化方法以及极化气体产品 |
| AU2003203796B2 (en) * | 1997-12-12 | 2006-10-12 | Medi-Physics, Inc. | Polarized gas accumulators and heating jackets and associated gas collection and thaw methods and polarized gas products |
| US6079213A (en) * | 1997-12-12 | 2000-06-27 | Magnetic Imaging Technologies Incorporated | Methods of collecting, thawing, and extending the useful life of polarized gases and associated accumulators and heating jackets |
| JP2002507438A (ja) | 1998-03-18 | 2002-03-12 | メディ−フィジックス・インコーポレイテッド | 溶解化した極性化１２９Ｘｅを用いる肺および心臓脈管構造の映像化および血流を上昇するＭＲ方法 |
| AU3386799A (en) * | 1998-04-13 | 1999-11-01 | Duke University | (in vivo) magnetic resonance vascular imaging using laser-polarized gas microbubbles |
| NZ508720A (en) | 1998-06-17 | 2003-08-29 | Medi Physics Inc | Resilient containers for hyperpolarized gases |
| US6423387B1 (en) | 1998-06-17 | 2002-07-23 | Medi-Physics, Inc. | Resilient containers for hyperpolarized gases and associated methods |
| NZ508719A (en) * | 1998-06-17 | 2002-10-25 | Medi Physics Inc | Hyperpolarized gas transport device with at least one gas chamber and a electromagnet providing a magnetic holding field |
| US6237363B1 (en) | 1998-09-30 | 2001-05-29 | Medi-Physics, Inc. | Hyperpolarized noble gas extraction methods masking methods and associated transport containers |
| US6523356B2 (en) | 1998-09-30 | 2003-02-25 | Medi-Physics, Inc. | Meted hyperpolarized noble gas dispensing methods and associated devices |
| US6286319B1 (en) | 1998-09-30 | 2001-09-11 | Medi-Physics, Inc. | Meted hyperpolarized noble gas dispensing methods and associated devices |
| US6125654A (en) * | 1998-10-16 | 2000-10-03 | Syracuse University | Bulk production and usage of hyperpolarized 129 Xenon |
| US6284222B1 (en) | 1998-11-03 | 2001-09-04 | Medi--Physics, Inc. | Hyperpolarized helium-3 microbubble gas entrapment methods |
| US6566875B1 (en) | 1999-02-23 | 2003-05-20 | Medi-Physics, Inc. | Portable hyperpolarized gas monitoring systems, computer program products, and related methods using NMR and/or MRI during transport |
| US6408849B1 (en) * | 1999-06-18 | 2002-06-25 | Aeronex, Inc. | Recovery and purification of gases used in medical processes |
| US6295834B1 (en) | 1999-06-30 | 2001-10-02 | Medi-Physics, Inc. | NMR polarization monitoring coils, hyperpolarizers with same, and methods for determining the polarization level of accumulated hyperpolarized noble gases during production |
| US6611540B1 (en) | 1999-07-29 | 2003-08-26 | Otward Maria Mueller | Diode-laser system for hyperpolarized He-3 and Xe-129 gas generation and other applications |
| DE19937566C2 (de) * | 1999-08-09 | 2001-06-28 | Forschungszentrum Juelich Gmbh | Hochdruckpolarisator für Edelgase und Verfahren zum Betreiben des Polarisators |
| US6648130B1 (en) | 1999-08-11 | 2003-11-18 | Medi-Physics, Inc. | Hyperpolarized gas transport and storage devices and associated transport and storage methods using permanent magnets |
| US6868099B1 (en) * | 1999-11-04 | 2005-03-15 | Wisconsin Alumni Research Foundation | Frequency-narrowed high power diode laser system with external cavity |
| DE10000675C2 (de) | 2000-01-11 | 2001-11-15 | Otten Ernst Wilhelm | Lineardurchführung, Vorrichtung und Verfahren zur hochproduktiven Erzeugung von hoch kernspinpolarisiertem Helium-3 Gas |
| GB0001727D0 (en) * | 2000-01-25 | 2000-03-15 | Oxford Instr Uk Ltd | Hyperpolarization of a noble gas |
| CA2401308A1 (en) | 2000-03-13 | 2001-09-20 | Klaus D. Hagspiel | Diagnostic procedures using direct injection of gaseous hyperpolarized 129xe and associated systems and products |
| US6696040B2 (en) | 2000-07-13 | 2004-02-24 | Medi-Physics, Inc. | Diagnostic procedures using 129Xe spectroscopy characteristic chemical shift to detect pathology in vivo |
| US6444984B1 (en) | 2000-08-11 | 2002-09-03 | Drs Sensors & Targeting Systems, Inc. | Solid cryogenic optical filter |
| AU1403902A (en) * | 2000-11-03 | 2002-05-15 | Amersham Health As | Methods and devices for polarised nmr samples |
| US6584133B1 (en) | 2000-11-03 | 2003-06-24 | Wisconsin Alumni Research Foundation | Frequency-narrowed high power diode laser array method and system |
| AU2002258961A1 (en) | 2001-04-24 | 2002-11-05 | Medi-Physics, Inc. | Methods and devices for moisturizing hyperpolarized noble gases and pharmaceutical products thereof |
| CA2466991C (en) * | 2001-08-17 | 2011-03-29 | Medi-Physics, Inc. | Magnetic holding field for cryogenically accumulated polarized 129xenon |
| US7179450B2 (en) * | 2001-09-20 | 2007-02-20 | Medi-Physics, Inc. | Methods for in vivo evaluation of pulmonary physiology and/or function using NMR signals of polarized Xe |
| WO2003036317A2 (en) * | 2001-10-22 | 2003-05-01 | Medi-Physics, Inc. | Optical pumping modules, polarized gas blending and dispensing systems, and automated polarized gas distribution systems |
| US7287391B2 (en) * | 2001-10-22 | 2007-10-30 | Medi-Physics, Inc. | Automated modular hyperpolarizers and related devices and methods |
| US6846576B1 (en) | 2002-04-10 | 2005-01-25 | Seagate Technology Llc | Coupling enhancement for medium with anti-ferromagnetic coupling |
| AU2003269207A1 (en) * | 2002-05-16 | 2003-12-02 | Medi-Physics, Inc | Methods and systems for determining polarization of a gas based on electron paramagnetic resonance |
| CA2485200C (en) * | 2002-05-17 | 2012-12-18 | Medi-Physics, Inc | Methods, systems, circuits, and computer program products for determining polarization of a gas |
| ATE343760T1 (de) * | 2002-07-23 | 2006-11-15 | Medi Physics Inc | Automatisierte dynamische druckempfindliche systeme zur abgabe von hyperpolarisiertem gas und zugehörige verfahren und rechnerprogrammprodukte |
| AU2003301172B2 (en) * | 2002-12-20 | 2010-02-18 | Medi-Physics, Inc. | Calibration of a polarization measurement station |
| JP3998243B2 (ja) * | 2003-01-10 | 2007-10-24 | 東横化学株式会社 | 核スピン偏極キセノンガスの製造方法及び製造装置 |
| CA2509801A1 (en) | 2003-01-17 | 2004-08-05 | Medi-Physics Inc. | Method of producing optically pumped hyperpolarized gas |
| US7275540B2 (en) * | 2003-04-22 | 2007-10-02 | Medi-Physics, Inc. | MRI/NMR-compatible, tidal volume control and measurement systems, methods, and devices for respiratory and hyperpolarized gas delivery |
| JP3978159B2 (ja) * | 2003-07-03 | 2007-09-19 | ジーイー・メディカル・システムズ・グローバル・テクノロジー・カンパニー・エルエルシー | 磁気共鳴撮像システム |
| DE102004023345B4 (de) * | 2004-01-19 | 2006-11-09 | Forschungszentrum Jülich GmbH | Verfahren zur Hyperpolarisation von Atomkernen und Vorrichtung zur Durchführung des Verfahrens |
| DE102004002639A1 (de) * | 2004-01-19 | 2005-09-15 | Forschungszentrum Jülich GmbH | Verfahren zur Anreicherung von hyperpolarisierten Atomkernen und Vorrichtung zur Durchführung des Verfahrens |
| US7495435B2 (en) * | 2004-01-19 | 2009-02-24 | Forschungszentrum Julich Gmbh | Method for the hyperpolarisation of atomic nuclei and device for implementing the method |
| US7281393B2 (en) * | 2004-04-21 | 2007-10-16 | University Of New Hampshire | Method and apparatus for accumulating hyperpolarized xenon |
| US8703102B2 (en) | 2008-04-04 | 2014-04-22 | Millikelvin Technologies Llc | Systems and methods for producing hyperpolarized materials and mixtures thereof |
| KR101095943B1 (ko) | 2006-02-21 | 2011-12-19 | 밀리켈빈 테크놀로지스 엘엘씨 | 과분극화 방법, 시스템 및 조성물 |
| WO2008030545A2 (en) * | 2006-09-05 | 2008-03-13 | Princeton University | Polarizing nuclei in solids via spin transfer from an optically-pumped alkali vapor |
| US7928359B2 (en) * | 2006-09-20 | 2011-04-19 | University Of New Hampshire | Thermal management technology for polarizing Xenon |
| US8405022B2 (en) | 2006-09-20 | 2013-03-26 | University Of New Hampshire | Thermal management technology for polarizing xenon |
| NZ575856A (en) * | 2006-10-03 | 2011-06-30 | Univ Duke | Assessing pulmonary gas transfer in lungs using hyperpolarized 129xe mri |
| US8731640B2 (en) | 2007-03-28 | 2014-05-20 | General Electric Company | Fluid path system for dissolution and transport of a hyperpolarized material |
| US20080240998A1 (en) * | 2007-03-28 | 2008-10-02 | Urbahn John A | Fluid path system for dissolution and transport of a hyperpolarized material |
| US8763410B2 (en) * | 2008-04-21 | 2014-07-01 | General Electric Company | Method and apparatus for the dissolution and filtration of a hyperpolarized agent with a neutral dissolution media |
| WO2009143368A2 (en) * | 2008-05-23 | 2009-11-26 | University Of Utah | Non-cryogenic storage cell for hyperpolarized 129xe |
| EP2309283B1 (en) * | 2008-08-01 | 2012-09-19 | Osaka University | Polarized xenon gas concentration method, polarized xenon gas manufacturing supply device, and mri system |
| DE102008063703B3 (de) * | 2008-12-19 | 2010-06-17 | Bruker Biospin Ag | Automatische Transportvorrichtung für NMR-Messproben, Kryomagnetsystem mit automatischer Transportvorrichtung, Transportbehälter für automatische Transportvorrichtung und Verfahren zum Befördern einer NMR-Messprobe |
| US8329122B1 (en) * | 2009-07-01 | 2012-12-11 | The United States Of America, As Represented By The Department Of Energy | Method for production of an isotopically enriched compound |
| CA2772190A1 (en) * | 2009-08-31 | 2011-03-03 | Millikelvin Technologies Llc | Systems and methods for producing hyperpolarized materials and mixtures thereof |
| US9080710B2 (en) | 2011-01-21 | 2015-07-14 | Hamilton Sundstrand Corporation | Accumulator reservoir venting |
| FR2988857B1 (fr) * | 2012-03-30 | 2015-02-20 | Commissariat Energie Atomique | Procede de determination de la resistance cellulaire aux medicaments. |
| CN106456808B (zh) | 2014-02-21 | 2019-11-19 | 杜克大学 | 具有纳米簇抑制、检测和/或过滤的超偏振稀有气体生产系统及相关的方法和装置 |
| US10126438B2 (en) | 2014-09-19 | 2018-11-13 | University Of Virginia Patent Foundation | Systems and methods for polarized nuclear imaging and spectroscopy |
| CN104921726B (zh) * | 2015-05-26 | 2017-12-19 | 中国科学院武汉物理与数学研究所 | 一种用于超极化氙收集的液氮液位控制和显示装置 |
| US11754652B2 (en) | 2016-09-15 | 2023-09-12 | University Of Virginia Patent Foundation | Systems and methods for polarized nuclear imaging and spectroscopy |
| WO2019071090A1 (en) * | 2017-10-06 | 2019-04-11 | University Of Florida Research Foundation | METHODS AND SYSTEMS FOR PRODUCTION, USE, AND ADMINISTRATION OF HYPERPOLARIZED FLUIDS |
| US11944424B2 (en) | 2018-05-18 | 2024-04-02 | Duke University | Dynamic 129Xe gas exchange spectroscopy |
| US11148833B1 (en) | 2018-05-21 | 2021-10-19 | Space Systems/Loral, Llc | Spacecraft propellant management system |
| CN114644322B (zh) * | 2022-04-15 | 2024-02-06 | 宁波诺丁汉大学 | 超极化稀有气体生产设备 |
| WO2025151298A1 (en) | 2024-01-10 | 2025-07-17 | Polarean, Inc. | Hyperpolarizers with a load-lock chamber for alkali metal |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3748864A (en) * | 1969-01-21 | 1973-07-31 | Airco Inc | Process for recovery and containment of radioactive gases |
| DE2426764C2 (de) * | 1974-06-01 | 1981-07-09 | Kernforschungsanlage Jülich GmbH, 5170 Jülich | Verfahren zum Abtrennen von Krypton aus einem radioaktiven Abgasgemisch und Gastrennanlage zum Durchführen des Verfahrens |
| US4417909A (en) * | 1978-12-04 | 1983-11-29 | Airco, Inc. | Gas separation process |
| US4369048A (en) * | 1980-01-28 | 1983-01-18 | Dallas T. Pence | Method for treating gaseous effluents emitted from a nuclear reactor |
| US4599462A (en) * | 1983-05-25 | 1986-07-08 | University Of Utah | Methods for making solid solutions from normally immiscible components and for modifying the surface structure of solid materials |
| DE3518283C2 (de) * | 1985-05-22 | 1994-09-22 | Messer Griesheim Gmbh | Verfahren zur Entfernung leichter flüchtiger Verunreinigungen aus Gasen |
| US4971258A (en) * | 1988-08-26 | 1990-11-20 | Ihi Master Metal Ltd. | Method of making high-purity fine particles of reactive metals and manufacturing vessel therefor |
| US5039500A (en) * | 1988-11-18 | 1991-08-13 | Kyodo Oxygen Co., Ltd. | Process for producing xenon |
| US4977749A (en) * | 1989-04-25 | 1990-12-18 | Sercel Jeffrey P | Apparatus and method for purification of gases used in exciplex (excimer) lasers |
| US5161382A (en) * | 1991-05-24 | 1992-11-10 | Marin Tek, Inc. | Combined cryosorption/auto-refrigerating cascade low temperature system |
| US5545396A (en) * | 1994-04-08 | 1996-08-13 | The Research Foundation Of State University Of New York | Magnetic resonance imaging using hyperpolarized noble gases |
| US5617860A (en) * | 1995-06-07 | 1997-04-08 | Smithsonian Astrophysical Observatory | Method and system for producing polarized 129 Xe gas |
| US5626137A (en) * | 1995-10-02 | 1997-05-06 | General Electric Company | Apparatus and methods for magnetic resonance (MR) angiography using fluids polarized at low temperatures |
| JP2001503646A (ja) * | 1996-03-29 | 2001-03-21 | ローレンス バークレー ナショナル ラボラトリィ | 過分極化希ガス存在下でのｎｍｒまたはｍｒｉの増強 |
-
1996
- 1996-03-29 US US08/622,865 patent/US5809801A/en not_active Expired - Lifetime
-
1997
- 1997-03-27 AT AT97917656T patent/ATE235032T1/de active
- 1997-03-27 WO PCT/US1997/005004 patent/WO1997037177A1/en not_active Ceased
- 1997-03-27 CA CA002250167A patent/CA2250167C/en not_active Expired - Lifetime
- 1997-03-27 EP EP97917656A patent/EP0890066B1/en not_active Expired - Lifetime
- 1997-03-27 AU AU25920/97A patent/AU712530B2/en not_active Ceased
- 1997-03-27 DE DE69719962T patent/DE69719962T2/de not_active Expired - Lifetime
- 1997-03-27 DK DK97917656T patent/DK0890066T3/da active
- 1997-03-27 ES ES97917656T patent/ES2195131T3/es not_active Expired - Lifetime
- 1997-03-27 JP JP9535422A patent/JP2000507688A/ja active Pending
-
1998
- 1998-02-09 US US09/020,529 patent/US5860295A/en not_active Expired - Lifetime
-
2007
- 2007-08-22 JP JP2007216138A patent/JP4231533B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69719962D1 (de) | 2003-04-24 |
| EP0890066A4 (en) | 2000-01-19 |
| JP2000507688A (ja) | 2000-06-20 |
| AU712530B2 (en) | 1999-11-11 |
| EP0890066A1 (en) | 1999-01-13 |
| WO1997037177A1 (en) | 1997-10-09 |
| AU2592097A (en) | 1997-10-22 |
| ES2195131T3 (es) | 2003-12-01 |
| DK0890066T3 (da) | 2003-07-14 |
| CA2250167A1 (en) | 1997-10-09 |
| JP4231533B2 (ja) | 2009-03-04 |
| US5809801A (en) | 1998-09-22 |
| ATE235032T1 (de) | 2003-04-15 |
| JP2008036443A (ja) | 2008-02-21 |
| EP0890066B1 (en) | 2003-03-19 |
| CA2250167C (en) | 2002-05-07 |
| US5860295A (en) | 1999-01-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69719962T2 (de) | Tieftemperaturspeicher für spin-polarisiertes xenon-129 | |
| DE69726720T2 (de) | Vorrichtung zur hyperpolarisation von spin-polarisiertem edelgas mit hoher kapazität | |
| DE69813904T2 (de) | Verfahren zum sägen und auftauen eines xenon enthaltenden polarisierten gases | |
| Rosen et al. | Polarized Xe 129 optical pumping/spin exchange and delivery system for magnetic resonance spectroscopy and imaging studies | |
| DE69931060T2 (de) | Verfahren und vorrichtung zur identifikation des hyperpolarisationszustandes eines gases | |
| DE19937566C2 (de) | Hochdruckpolarisator für Edelgase und Verfahren zum Betreiben des Polarisators | |
| DE10000675C2 (de) | Lineardurchführung, Vorrichtung und Verfahren zur hochproduktiven Erzeugung von hoch kernspinpolarisiertem Helium-3 Gas | |
| DE69717254T2 (de) | Anlage und verfahren zur herstellung von in dampfphase polarisiertem helium-3, insbesondere für nmr-bildgebung | |
| US7495435B2 (en) | Method for the hyperpolarisation of atomic nuclei and device for implementing the method | |
| WO2005068359A2 (de) | Verfahren zur anreicherung von hyperpolarisierten atomkernen und vorrichtung zur durchführung des verfahrens | |
| EP1880227B9 (de) | Hyperpolarisation von li und weiteren kernen | |
| CA2349069C (en) | Cryogenic accumulator for spin-polarized xenon-129 | |
| DE19927159C1 (de) | Vorrichtung für die Polarisation von Edelgasen mit einem Verbindungselement für zwei Leitungen, von denen wenigstens eine aus Glas besteht | |
| EP1192476A2 (de) | Probenzelle für einen polarisator von edelgasen | |
| Rosen et al. | Polarized 129Xe129Xe optical pumping/spin exchange and delivery system for magnetic resonance spectroscopy and imaging studies |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |