DE69719962D1 - Tieftemperaturspeicher für spin-polarisiertes xenon-129 - Google Patents

Tieftemperaturspeicher für spin-polarisiertes xenon-129

Info

Publication number
DE69719962D1
DE69719962D1 DE69719962T DE69719962T DE69719962D1 DE 69719962 D1 DE69719962 D1 DE 69719962D1 DE 69719962 T DE69719962 T DE 69719962T DE 69719962 T DE69719962 T DE 69719962T DE 69719962 D1 DE69719962 D1 DE 69719962D1
Authority
DE
Germany
Prior art keywords
hyperpolarized
accumulation
spin
temperature storage
deep temperature
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69719962T
Other languages
English (en)
Other versions
DE69719962T2 (de
Inventor
Gordon D Cates Jr
Bastiaan Driehuys
William Happer
Eli Miron
Brian Saam
Daniel Walter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Princeton University
Original Assignee
Princeton University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Princeton University filed Critical Princeton University
Application granted granted Critical
Publication of DE69719962D1 publication Critical patent/DE69719962D1/de
Publication of DE69719962T2 publication Critical patent/DE69719962T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/282Means specially adapted for hyperpolarisation or for hyperpolarised contrast agents, e.g. for the generation of hyperpolarised gases using optical pumping cells, for storing hyperpolarised contrast agents or for the determination of the polarisation of a hyperpolarised contrast agent
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806Suspensions, emulsions, colloids, dispersions
    • A61K49/1815Suspensions, emulsions, colloids, dispersions compo-inhalant, e.g. breath tests
    • CCHEMISTRY; METALLURGY
    • C01INORGANIC CHEMISTRY
    • C01BNON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B23/00Noble gases; Compounds thereof
    • C01B23/001Purification or separation processes of noble gases
    • C01B23/0036Physical processing only
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25JLIQUEFACTION, SOLIDIFICATION OR SEPARATION OF GASES OR GASEOUS OR LIQUEFIED GASEOUS MIXTURES BY PRESSURE AND COLD TREATMENT OR BY BRINGING THEM INTO THE SUPERCRITICAL STATE
    • F25J3/00Processes or apparatus for separating the constituents of gaseous or liquefied gaseous mixtures involving the use of liquefaction or solidification
    • F25J3/06Processes or apparatus for separating the constituents of gaseous or liquefied gaseous mixtures involving the use of liquefaction or solidification by partial condensation
    • F25J3/063Processes or apparatus for separating the constituents of gaseous or liquefied gaseous mixtures involving the use of liquefaction or solidification by partial condensation characterised by the separated product stream
    • F25J3/0685Processes or apparatus for separating the constituents of gaseous or liquefied gaseous mixtures involving the use of liquefaction or solidification by partial condensation characterised by the separated product stream separation of noble gases
    • HELECTRICITY
    • H05ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05HPLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H3/00Production or acceleration of neutral particle beams, e.g. molecular or atomic beams
    • H05H3/02Molecular or atomic beam generation
    • CCHEMISTRY; METALLURGY
    • C01INORGANIC CHEMISTRY
    • C01BNON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B2210/00Purification or separation of specific gases
    • C01B2210/0029Obtaining noble gases
    • C01B2210/0037Xenon
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25JLIQUEFACTION, SOLIDIFICATION OR SEPARATION OF GASES OR GASEOUS OR LIQUEFIED GASEOUS MIXTURES BY PRESSURE AND COLD TREATMENT OR BY BRINGING THEM INTO THE SUPERCRITICAL STATE
    • F25J2205/00Processes or apparatus using other separation and/or other processing means
    • F25J2205/20Processes or apparatus using other separation and/or other processing means using solidification of components
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25JLIQUEFACTION, SOLIDIFICATION OR SEPARATION OF GASES OR GASEOUS OR LIQUEFIED GASEOUS MIXTURES BY PRESSURE AND COLD TREATMENT OR BY BRINGING THEM INTO THE SUPERCRITICAL STATE
    • F25J2210/00Processes characterised by the type or other details of the feed stream
    • F25J2210/42Nitrogen
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25JLIQUEFACTION, SOLIDIFICATION OR SEPARATION OF GASES OR GASEOUS OR LIQUEFIED GASEOUS MIXTURES BY PRESSURE AND COLD TREATMENT OR BY BRINGING THEM INTO THE SUPERCRITICAL STATE
    • F25J2215/00Processes characterised by the type or other details of the product stream
    • F25J2215/36Xenon
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25JLIQUEFACTION, SOLIDIFICATION OR SEPARATION OF GASES OR GASEOUS OR LIQUEFIED GASEOUS MIXTURES BY PRESSURE AND COLD TREATMENT OR BY BRINGING THEM INTO THE SUPERCRITICAL STATE
    • F25J2270/00Refrigeration techniques used
    • F25J2270/60Closed external refrigeration cycle with single component refrigerant [SCR], e.g. C1-, C2- or C3-hydrocarbons
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25JLIQUEFACTION, SOLIDIFICATION OR SEPARATION OF GASES OR GASEOUS OR LIQUEFIED GASEOUS MIXTURES BY PRESSURE AND COLD TREATMENT OR BY BRINGING THEM INTO THE SUPERCRITICAL STATE
    • F25J2270/00Refrigeration techniques used
    • F25J2270/90External refrigeration, e.g. conventional closed-loop mechanical refrigeration unit using Freon or NH3, unspecified external refrigeration
    • F25J2270/904External refrigeration, e.g. conventional closed-loop mechanical refrigeration unit using Freon or NH3, unspecified external refrigeration by liquid or gaseous cryogen in an open loop
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25JLIQUEFACTION, SOLIDIFICATION OR SEPARATION OF GASES OR GASEOUS OR LIQUEFIED GASEOUS MIXTURES BY PRESSURE AND COLD TREATMENT OR BY BRINGING THEM INTO THE SUPERCRITICAL STATE
    • F25J2290/00Other details not covered by groups F25J2200/00 - F25J2280/00
    • F25J2290/62Details of storing a fluid in a tank
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S62/00Refrigeration
    • Y10S62/919Isotope
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S62/00Refrigeration
    • Y10S62/923Inert gas
    • Y10S62/925Xenon or krypton

Landscapes

  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mechanical Engineering (AREA)
  • Thermal Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plasma & Fusion (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Separation By Low-Temperature Treatments (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Image Processing (AREA)
DE69719962T 1996-03-29 1997-03-27 Tieftemperaturspeicher für spin-polarisiertes xenon-129 Expired - Lifetime DE69719962T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/622,865 US5809801A (en) 1996-03-29 1996-03-29 Cryogenic accumulator for spin-polarized xenon-129
PCT/US1997/005004 WO1997037177A1 (en) 1996-03-29 1997-03-27 Cryogenic accumulator for spin-polarized xenon-129

Publications (2)

Publication Number Publication Date
DE69719962D1 true DE69719962D1 (de) 2003-04-24
DE69719962T2 DE69719962T2 (de) 2003-12-18

Family

ID=24495803

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69719962T Expired - Lifetime DE69719962T2 (de) 1996-03-29 1997-03-27 Tieftemperaturspeicher für spin-polarisiertes xenon-129

Country Status (10)

Country Link
US (2) US5809801A (de)
EP (1) EP0890066B1 (de)
JP (2) JP2000507688A (de)
AT (1) ATE235032T1 (de)
AU (1) AU712530B2 (de)
CA (1) CA2250167C (de)
DE (1) DE69719962T2 (de)
DK (1) DK0890066T3 (de)
ES (1) ES2195131T3 (de)
WO (1) WO1997037177A1 (de)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5545396A (en) * 1994-04-08 1996-08-13 The Research Foundation Of State University Of New York Magnetic resonance imaging using hyperpolarized noble gases
BR9711082A (pt) * 1996-03-29 2000-01-11 Lawrence Berkeley National Lab Realce de rmn emri na presença de gases mopbres hiperpolarizados.
US6085743A (en) * 1997-05-30 2000-07-11 The Regent Of The University Of Michigan Polarized gas delivery system/method
AU8910698A (en) * 1997-08-18 1999-03-08 Trustees Of Princeton University, The Alkali metal hybrid spin-exchange optical pumping
US6079213A (en) * 1997-12-12 2000-06-27 Magnetic Imaging Technologies Incorporated Methods of collecting, thawing, and extending the useful life of polarized gases and associated accumulators and heating jackets
US6199385B1 (en) * 1997-12-12 2001-03-13 Medi-Physics, Inc. Polarized gas accumulators and heating jackets and associated gas collection and thaw methods and polarized gas products
AU2003203796B2 (en) * 1997-12-12 2006-10-12 Medi-Physics, Inc. Polarized gas accumulators and heating jackets and associated gas collection and thaw methods and polarized gas products
JP2002507438A (ja) 1998-03-18 2002-03-12 メディ−フィジックス・インコーポレイテッド 溶解化した極性化129Xeを用いる肺および心臓脈管構造の映像化および血流を上昇するMR方法
AU3386799A (en) * 1998-04-13 1999-11-01 Duke University (in vivo) magnetic resonance vascular imaging using laser-polarized gas microbubbles
EP1445622A3 (de) * 1998-06-17 2004-12-15 Medi-Physics, Inc. Transportbehälter für hyperpolarisierte Gase
BR9912163A (pt) 1998-06-17 2001-04-10 Medi Physics Inc Recipientes resilientes para gases hiperpolarizados
US6423387B1 (en) 1998-06-17 2002-07-23 Medi-Physics, Inc. Resilient containers for hyperpolarized gases and associated methods
US6523356B2 (en) 1998-09-30 2003-02-25 Medi-Physics, Inc. Meted hyperpolarized noble gas dispensing methods and associated devices
US6286319B1 (en) 1998-09-30 2001-09-11 Medi-Physics, Inc. Meted hyperpolarized noble gas dispensing methods and associated devices
US6237363B1 (en) 1998-09-30 2001-05-29 Medi-Physics, Inc. Hyperpolarized noble gas extraction methods masking methods and associated transport containers
US6125654A (en) * 1998-10-16 2000-10-03 Syracuse University Bulk production and usage of hyperpolarized 129 Xenon
US6284222B1 (en) 1998-11-03 2001-09-04 Medi--Physics, Inc. Hyperpolarized helium-3 microbubble gas entrapment methods
US6566875B1 (en) 1999-02-23 2003-05-20 Medi-Physics, Inc. Portable hyperpolarized gas monitoring systems, computer program products, and related methods using NMR and/or MRI during transport
US6408849B1 (en) * 1999-06-18 2002-06-25 Aeronex, Inc. Recovery and purification of gases used in medical processes
US6295834B1 (en) * 1999-06-30 2001-10-02 Medi-Physics, Inc. NMR polarization monitoring coils, hyperpolarizers with same, and methods for determining the polarization level of accumulated hyperpolarized noble gases during production
US6611540B1 (en) 1999-07-29 2003-08-26 Otward Maria Mueller Diode-laser system for hyperpolarized He-3 and Xe-129 gas generation and other applications
DE19937566C2 (de) * 1999-08-09 2001-06-28 Forschungszentrum Juelich Gmbh Hochdruckpolarisator für Edelgase und Verfahren zum Betreiben des Polarisators
US6648130B1 (en) * 1999-08-11 2003-11-18 Medi-Physics, Inc. Hyperpolarized gas transport and storage devices and associated transport and storage methods using permanent magnets
US6868099B1 (en) * 1999-11-04 2005-03-15 Wisconsin Alumni Research Foundation Frequency-narrowed high power diode laser system with external cavity
DE10000675C2 (de) * 2000-01-11 2001-11-15 Otten Ernst Wilhelm Lineardurchführung, Vorrichtung und Verfahren zur hochproduktiven Erzeugung von hoch kernspinpolarisiertem Helium-3 Gas
GB0001727D0 (en) * 2000-01-25 2000-03-15 Oxford Instr Uk Ltd Hyperpolarization of a noble gas
EP1265527A2 (de) 2000-03-13 2002-12-18 Medi-Physics, Inc. Diagnostische verfahren unter verwendung direkter injizierung von gasförmigem hyperpolarisiertem 129 xenon
US6696040B2 (en) 2000-07-13 2004-02-24 Medi-Physics, Inc. Diagnostic procedures using 129Xe spectroscopy characteristic chemical shift to detect pathology in vivo
US6444984B1 (en) 2000-08-11 2002-09-03 Drs Sensors & Targeting Systems, Inc. Solid cryogenic optical filter
US6584133B1 (en) 2000-11-03 2003-06-24 Wisconsin Alumni Research Foundation Frequency-narrowed high power diode laser array method and system
CA2427726C (en) * 2000-11-03 2012-01-24 Amersham Health As Methods and devices for polarised nmr samples
EP1387700A2 (de) 2001-04-24 2004-02-11 Medi-Physics, Inc. Verfahren und geräte zur befeuchtung hyperpolarisierten edelgasen insbesondere in arzneimitteln
WO2003016776A1 (en) * 2001-08-17 2003-02-27 Medi-Physics, Inc. Magnetic holding field for cryogenically accumulated polarized 129xenon
US7179450B2 (en) * 2001-09-20 2007-02-20 Medi-Physics, Inc. Methods for in vivo evaluation of pulmonary physiology and/or function using NMR signals of polarized Xe
EP1438599A1 (de) * 2001-10-22 2004-07-21 Medi-Physics, Inc. Automatisierte modulare hyperpolarisatoren
CA2463910A1 (en) * 2001-10-22 2003-05-01 Medi-Physics, Inc. Optical pumping modules, polarized gas blending and dispensing systems, and automated polarized gas distribution systems and related devices and methods
US6846576B1 (en) 2002-04-10 2005-01-25 Seagate Technology Llc Coupling enhancement for medium with anti-ferromagnetic coupling
US20040035182A1 (en) * 2002-05-16 2004-02-26 Steve Kadlecek Methods and systems for determining polarization of a gas based on electron paramagnetic resonance
AU2003248529A1 (en) * 2002-05-17 2003-12-02 Medi-Physics, Inc Methods, systems, circuits, and computer program products for determining polarization of a gas
EP1534990B1 (de) * 2002-07-23 2006-10-25 Medi-Physics, Inc. Automatisierte dynamische druckempfindliche systeme zur abgabe von hyperpolarisiertem gas und zugehörige verfahren und rechnerprogrammprodukte
WO2004059336A1 (en) * 2002-12-20 2004-07-15 Medi-Physics, Inc. Calibration of a polarization measurement station
JP3998243B2 (ja) * 2003-01-10 2007-10-24 東横化学株式会社 核スピン偏極キセノンガスの製造方法及び製造装置
EP1588178B1 (de) 2003-01-17 2011-10-12 Medi-Physics Inc. Verfahren zur herstellung eines optisch gepumpten hyperpolarisierten gases
WO2004096333A1 (en) * 2003-04-22 2004-11-11 Medi-Physics, Inc. Mri/nmr-compatible, tidal volume control and measurement systems, methods, and devices for respiratory and hyperpolarized gas delivery
JP3978159B2 (ja) 2003-07-03 2007-09-19 ジーイー・メディカル・システムズ・グローバル・テクノロジー・カンパニー・エルエルシー 磁気共鳴撮像システム
US7495435B2 (en) * 2004-01-19 2009-02-24 Forschungszentrum Julich Gmbh Method for the hyperpolarisation of atomic nuclei and device for implementing the method
DE102004002639A1 (de) * 2004-01-19 2005-09-15 Forschungszentrum Jülich GmbH Verfahren zur Anreicherung von hyperpolarisierten Atomkernen und Vorrichtung zur Durchführung des Verfahrens
DE102004023345B4 (de) * 2004-01-19 2006-11-09 Forschungszentrum Jülich GmbH Verfahren zur Hyperpolarisation von Atomkernen und Vorrichtung zur Durchführung des Verfahrens
CA2564557A1 (en) * 2004-04-21 2005-11-10 University Of New Hampshire Method and apparatus for accumulating hyperpolarized xenon
US8703102B2 (en) 2008-04-04 2014-04-22 Millikelvin Technologies Llc Systems and methods for producing hyperpolarized materials and mixtures thereof
WO2007136439A2 (en) 2006-02-21 2007-11-29 Avrum Belzer Hyperpolarization methods, systems and compositions
US8456161B2 (en) * 2006-09-05 2013-06-04 The Trustees Of Princeton University Polarizing nuclei solids via spin transfer from an optically-pumped alkali vapor
US8405022B2 (en) 2006-09-20 2013-03-26 University Of New Hampshire Thermal management technology for polarizing xenon
US7928359B2 (en) * 2006-09-20 2011-04-19 University Of New Hampshire Thermal management technology for polarizing Xenon
EP2068709A4 (de) * 2006-10-03 2010-03-31 Univ Duke Systeme und verfahren zur beurteilung des pulmonalen gastransfers mittels mri mit hyperpolasiertem 129xe
US8731640B2 (en) 2007-03-28 2014-05-20 General Electric Company Fluid path system for dissolution and transport of a hyperpolarized material
US20080240998A1 (en) * 2007-03-28 2008-10-02 Urbahn John A Fluid path system for dissolution and transport of a hyperpolarized material
US8763410B2 (en) * 2008-04-21 2014-07-01 General Electric Company Method and apparatus for the dissolution and filtration of a hyperpolarized agent with a neutral dissolution media
WO2009143368A2 (en) * 2008-05-23 2009-11-26 University Of Utah Non-cryogenic storage cell for hyperpolarized 129xe
EP2309283B1 (de) * 2008-08-01 2012-09-19 Osaka University Verfahren zur konzentration von polarisiertem xenon, vorrichtung zur förderung von polarisiertem xenon und mrt-system
DE102008063703B3 (de) * 2008-12-19 2010-06-17 Bruker Biospin Ag Automatische Transportvorrichtung für NMR-Messproben, Kryomagnetsystem mit automatischer Transportvorrichtung, Transportbehälter für automatische Transportvorrichtung und Verfahren zum Befördern einer NMR-Messprobe
US8329122B1 (en) * 2009-07-01 2012-12-11 The United States Of America, As Represented By The Department Of Energy Method for production of an isotopically enriched compound
CA2772190A1 (en) * 2009-08-31 2011-03-03 Millikelvin Technologies Llc Systems and methods for producing hyperpolarized materials and mixtures thereof
US9080710B2 (en) 2011-01-21 2015-07-14 Hamilton Sundstrand Corporation Accumulator reservoir venting
FR2988857B1 (fr) * 2012-03-30 2015-02-20 Commissariat Energie Atomique Procede de determination de la resistance cellulaire aux medicaments.
AU2015218883B2 (en) 2014-02-21 2020-02-27 Duke University Hyperpolarized noble gas production systems with nanocluster suppression, detection and/or filtering and related methods and devices
US10126438B2 (en) 2014-09-19 2018-11-13 University Of Virginia Patent Foundation Systems and methods for polarized nuclear imaging and spectroscopy
CN104921726B (zh) * 2015-05-26 2017-12-19 中国科学院武汉物理与数学研究所 一种用于超极化氙收集的液氮液位控制和显示装置
US11754652B2 (en) 2016-09-15 2023-09-12 University Of Virginia Patent Foundation Systems and methods for polarized nuclear imaging and spectroscopy
WO2019071090A1 (en) * 2017-10-06 2019-04-11 University Of Florida Research Foundation METHODS AND SYSTEMS FOR PRODUCTION, USE, AND ADMINISTRATION OF HYPERPOLARIZED FLUIDS
US11944424B2 (en) 2018-05-18 2024-04-02 Duke University Dynamic 129Xe gas exchange spectroscopy
US11148833B1 (en) 2018-05-21 2021-10-19 Space Systems/Loral, Llc Spacecraft propellant management system
CN114644322B (zh) * 2022-04-15 2024-02-06 宁波诺丁汉大学 超极化稀有气体生产设备

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3748864A (en) * 1969-01-21 1973-07-31 Airco Inc Process for recovery and containment of radioactive gases
DE2426764C2 (de) * 1974-06-01 1981-07-09 Kernforschungsanlage Jülich GmbH, 5170 Jülich Verfahren zum Abtrennen von Krypton aus einem radioaktiven Abgasgemisch und Gastrennanlage zum Durchführen des Verfahrens
US4417909A (en) * 1978-12-04 1983-11-29 Airco, Inc. Gas separation process
US4369048A (en) * 1980-01-28 1983-01-18 Dallas T. Pence Method for treating gaseous effluents emitted from a nuclear reactor
US4599462A (en) * 1983-05-25 1986-07-08 University Of Utah Methods for making solid solutions from normally immiscible components and for modifying the surface structure of solid materials
DE3518283C2 (de) * 1985-05-22 1994-09-22 Messer Griesheim Gmbh Verfahren zur Entfernung leichter flüchtiger Verunreinigungen aus Gasen
US4971258A (en) * 1988-08-26 1990-11-20 Ihi Master Metal Ltd. Method of making high-purity fine particles of reactive metals and manufacturing vessel therefor
US5039500A (en) * 1988-11-18 1991-08-13 Kyodo Oxygen Co., Ltd. Process for producing xenon
US4977749A (en) * 1989-04-25 1990-12-18 Sercel Jeffrey P Apparatus and method for purification of gases used in exciplex (excimer) lasers
US5161382A (en) * 1991-05-24 1992-11-10 Marin Tek, Inc. Combined cryosorption/auto-refrigerating cascade low temperature system
US5545396A (en) * 1994-04-08 1996-08-13 The Research Foundation Of State University Of New York Magnetic resonance imaging using hyperpolarized noble gases
US5617860A (en) * 1995-06-07 1997-04-08 Smithsonian Astrophysical Observatory Method and system for producing polarized 129 Xe gas
US5626137A (en) * 1995-10-02 1997-05-06 General Electric Company Apparatus and methods for magnetic resonance (MR) angiography using fluids polarized at low temperatures
BR9711082A (pt) * 1996-03-29 2000-01-11 Lawrence Berkeley National Lab Realce de rmn emri na presença de gases mopbres hiperpolarizados.

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AU712530B2 (en) 1999-11-11
EP0890066B1 (de) 2003-03-19
ES2195131T3 (es) 2003-12-01
EP0890066A4 (de) 2000-01-19
CA2250167C (en) 2002-05-07
JP2008036443A (ja) 2008-02-21
ATE235032T1 (de) 2003-04-15
EP0890066A1 (de) 1999-01-13
DE69719962T2 (de) 2003-12-18
AU2592097A (en) 1997-10-22
US5860295A (en) 1999-01-19
US5809801A (en) 1998-09-22
JP2000507688A (ja) 2000-06-20
CA2250167A1 (en) 1997-10-09
JP4231533B2 (ja) 2009-03-04
DK0890066T3 (da) 2003-07-14

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