DE69719817T2 - Biosensor-vorrichtung und verfahren - Google Patents

Biosensor-vorrichtung und verfahren

Info

Publication number
DE69719817T2
DE69719817T2 DE69719817T DE69719817T DE69719817T2 DE 69719817 T2 DE69719817 T2 DE 69719817T2 DE 69719817 T DE69719817 T DE 69719817T DE 69719817 T DE69719817 T DE 69719817T DE 69719817 T2 DE69719817 T2 DE 69719817T2
Authority
DE
Germany
Prior art keywords
monolayer
ligand
receptor
coil
binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69719817T
Other languages
English (en)
Other versions
DE69719817D1 (de
Inventor
Bruce Lennox
S Hodges
T Irvin
Glen Armstrong
Pavel Kitov
Craig Railton
David Bundle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
McGill University
Pence Inc
Original Assignee
McGill University
Pence Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by McGill University, Pence Inc filed Critical McGill University
Publication of DE69719817D1 publication Critical patent/DE69719817D1/de
Application granted granted Critical
Publication of DE69719817T2 publication Critical patent/DE69719817T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/002—Electrode membranes
    • C12Q1/003—Functionalisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00653—Making arrays on substantially continuous surfaces the compounds being bound to electrodes embedded in or on the solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B01J2219/00704—Processes involving means for analysing and characterising the products integrated with the reactor apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Peptides Or Proteins (AREA)
DE69719817T 1996-04-25 1997-04-25 Biosensor-vorrichtung und verfahren Expired - Fee Related DE69719817T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US1638596P 1996-04-25 1996-04-25
US1619696P 1996-04-25 1996-04-25
US1638496P 1996-04-25 1996-04-25
PCT/CA1997/000276 WO1997041425A1 (en) 1996-04-25 1997-04-25 Biosensor device and method

Publications (2)

Publication Number Publication Date
DE69719817D1 DE69719817D1 (de) 2003-04-17
DE69719817T2 true DE69719817T2 (de) 2003-12-24

Family

ID=27360510

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69719817T Expired - Fee Related DE69719817T2 (de) 1996-04-25 1997-04-25 Biosensor-vorrichtung und verfahren

Country Status (9)

Country Link
EP (1) EP1005644B1 (de)
JP (1) JP2000510233A (de)
AT (1) ATE234462T1 (de)
AU (1) AU711861B2 (de)
CA (1) CA2251674C (de)
DE (1) DE69719817T2 (de)
DK (1) DK1005644T3 (de)
IL (1) IL126581A (de)
WO (1) WO1997041425A1 (de)

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US7045285B1 (en) 1996-11-05 2006-05-16 Clinical Micro Sensors, Inc. Electronic transfer moieties attached to peptide nucleic acids
US7393645B2 (en) 1996-11-05 2008-07-01 Clinical Micro Sensors, Inc. Compositions for the electronic detection of analytes utilizing monolayers
US7160678B1 (en) 1996-11-05 2007-01-09 Clinical Micro Sensors, Inc. Compositions for the electronic detection of analytes utilizing monolayers
US7381525B1 (en) 1997-03-07 2008-06-03 Clinical Micro Sensors, Inc. AC/DC voltage apparatus for detection of nucleic acids
US6306584B1 (en) * 1997-01-21 2001-10-23 President And Fellows Of Harvard College Electronic-property probing of biological molecules at surfaces
US6391558B1 (en) 1997-03-18 2002-05-21 Andcare, Inc. Electrochemical detection of nucleic acid sequences
DE19753056A1 (de) * 1997-11-29 1999-08-05 Wolfbeis Otto S Prof Dr Künstliche Oberfläche mit vorbestimmter Affinität
US6338968B1 (en) 1998-02-02 2002-01-15 Signature Bioscience, Inc. Method and apparatus for detecting molecular binding events
US6395480B1 (en) 1999-02-01 2002-05-28 Signature Bioscience, Inc. Computer program and database structure for detecting molecular binding events
US6287874B1 (en) 1998-02-02 2001-09-11 Signature Bioscience, Inc. Methods for analyzing protein binding events
US6485905B2 (en) 1998-02-02 2002-11-26 Signature Bioscience, Inc. Bio-assay device
JP2002502028A (ja) * 1998-02-02 2002-01-22 シグネチャー バイオサイエンス，インコーポレイティド 分子結合現象を検出するための方法及び装置
US6287776B1 (en) 1998-02-02 2001-09-11 Signature Bioscience, Inc. Method for detecting and classifying nucleic acid hybridization
DE19817180C2 (de) * 1998-04-17 2000-04-27 Biotul Bio Instr Gmbh Biosensor mit modifizierter Edelmetalloberfläche und Verfahren zu seiner Herstellung
US6472224B1 (en) 1998-04-17 2002-10-29 Franz Schleicher Biosensor with modified precious metal surface and process for the preparation thereof
WO1999066322A1 (en) * 1998-06-15 1999-12-23 Biosensor Systems Design, Inc. (1998) A sensor for analyte detection
US6322963B1 (en) 1998-06-15 2001-11-27 Biosensor Systems Design., Inc. Sensor for analyte detection
US6761816B1 (en) 1998-06-23 2004-07-13 Clinical Micro Systems, Inc. Printed circuit boards with monolayers and capture ligands
US6576478B1 (en) 1998-07-14 2003-06-10 Zyomyx, Inc. Microdevices for high-throughput screening of biomolecules
US6406921B1 (en) 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
US6682942B1 (en) 1998-07-14 2004-01-27 Zyomyx, Inc. Microdevices for screening biomolecules
JP2002525587A (ja) 1998-08-28 2002-08-13 フェビット フェラリウス バイオテクノロジー ゲゼルシャフト ミット ベシュレンクテル ハフツング 試料中の分析物を測定するための方法および装置
US6740518B1 (en) 1998-09-17 2004-05-25 Clinical Micro Sensors, Inc. Signal detection techniques for the detection of analytes
WO2000024941A1 (en) 1998-10-27 2000-05-04 Clinical Micro Sensors, Inc. Detection of target analytes using particles and electrodes
DE19860547C1 (de) 1998-12-23 2000-10-12 Genetrix B V I O Affinitätssensor für den Nachweis spezifischer molekularer Bindungsereignisse und dessen Verwendung
US6833267B1 (en) 1998-12-30 2004-12-21 Clinical Micro Sensors, Inc. Tissue collection devices containing biosensors
CA2360927C (en) * 1999-01-23 2018-03-06 Minerva Biotechnologies Corporation Interaction of colloid-immobilized species with species on non-colloidal structures
ATE334226T1 (de) * 1999-01-25 2006-08-15 Micronas Holding Gmbh Immobilisierung von molekülen auf oberflächen über polymerbürsten
EP1035218A1 (de) * 1999-03-03 2000-09-13 BioChip Technologies GmbH Immobilisierung von Molekülen an Oberflächen über verzweigte Polymerketten
WO2000045160A1 (en) * 1999-02-01 2000-08-03 Signature Bioscience Inc. Method and apparatus for detecting molecular binding events
US6300141B1 (en) * 1999-03-02 2001-10-09 Helix Biopharma Corporation Card-based biosensor device
AU2898500A (en) * 1999-03-02 2000-09-21 Helix Biopharma Corporation Biosensor device and method
DE19916638C2 (de) * 1999-04-13 2002-11-07 Jandratek Gmbh Oberflächen zur Verbesserung des Bindungsverhaltens von Analytmolekülen auf der Basis kovalent gebundener hydrophiler Spacer an Hydrogelen
WO2002043864A2 (en) * 2000-11-03 2002-06-06 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
US6503701B1 (en) 1999-06-15 2003-01-07 Biosensor Systems Design, Inc. Analytic sensor apparatus and method
US6342347B1 (en) 1999-10-22 2002-01-29 Biosensor Systems Design., Inc. Electromagnetic sensor
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WO2001002452A1 (en) 1999-07-02 2001-01-11 Symyx Technologies, Inc. Polymer brushes for immobilizing molecules to a surface or substrate, where the polymers have water-soluble or water-dispersible segments and probes bonded thereto
ES2319380T3 (es) 1999-07-26 2009-05-07 Clinical Micro Sensors, Inc. Determinacion de secuencias de acido nucleico usando la deteccion electronica.
AU772250B2 (en) * 2000-01-11 2004-04-22 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
EP1246699B1 (de) * 2000-01-11 2007-01-03 Clinical Micro Sensors, Inc. Patrone, die einen Biochip enthält
US7455975B2 (en) 2000-04-14 2008-11-25 Esa Biosciences, Inc. Electrochemical detection of nucleic acid sequences
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DE10112505C1 (de) * 2001-03-15 2003-01-30 Iongate Biosciences Gmbh Sensoranordnung und Vorrichtung zur amperometrischen und/oder potentiometrischen, pharmakologischen Wirkort- und/oder Wirkstofftestung sowie Verfahren zur amperometrischen und/oder potentiometrischen, pharmakologischen Wirkort- und/oder Wirkstofftestung
EP1386158B1 (de) * 2001-05-09 2008-05-14 Andreas Hofmann Gegenstand mit einer ungeladenen, funktionalisierten hydrogeloberfläche
EP1466014A4 (de) * 2001-10-26 2006-03-15 Integrated Nano Tech Llc Sensorsystem für chemische und biologische gefahren und verfahren dafür
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WO2005016115A2 (en) 2003-01-23 2005-02-24 Montana State University Biosensors utilizing dendrimer-immobilized ligands and their use thereof
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JP2006133137A (ja) * 2004-11-08 2006-05-25 Eiichi Tamiya 被検物質の検出方法
GB2433506A (en) * 2005-12-20 2007-06-27 Sharp Kk A method of producing a multimeric capture agent
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WO2007116811A1 (ja) * 2006-04-07 2007-10-18 Japan Advanced Institute Of Science And Technology 被検物質の測定方法
JP5447716B1 (ja) 2013-04-30 2014-03-19 国立大学法人 東京大学 バイオセンサ及び分子識別部材
JP5565783B1 (ja) * 2013-08-08 2014-08-06 国立大学法人 東京大学 バイオセンサ
WO2023042657A1 (ja) * 2021-09-16 2023-03-23 株式会社デンソー イオンセンサ、及び被検出物質の検出方法

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Also Published As

Publication number Publication date
AU711861B2 (en) 1999-10-21
CA2251674A1 (en) 1997-11-06
DE69719817D1 (de) 2003-04-17
EP1005644A1 (de) 2000-06-07
IL126581A (en) 2004-03-28
CA2251674C (en) 2004-12-14
IL126581A0 (en) 1999-08-17
AU2563997A (en) 1997-11-19
JP2000510233A (ja) 2000-08-08
ATE234462T1 (de) 2003-03-15
EP1005644B1 (de) 2003-03-12
DK1005644T3 (da) 2003-06-23
WO1997041425A1 (en) 1997-11-06

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