DE69717841D1 - Substituierte n-arylmethylamino-cyclobuten-3,4-dion-derivate - Google Patents
Substituierte n-arylmethylamino-cyclobuten-3,4-dion-derivateInfo
- Publication number
- DE69717841D1 DE69717841D1 DE69717841T DE69717841T DE69717841D1 DE 69717841 D1 DE69717841 D1 DE 69717841D1 DE 69717841 T DE69717841 T DE 69717841T DE 69717841 T DE69717841 T DE 69717841T DE 69717841 D1 DE69717841 D1 DE 69717841D1
- Authority
- DE
- Germany
- Prior art keywords
- arylmethylamino
- cyclobuten
- substituted
- dion derivatives
- dion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- RGBVWCQARBEPPW-UHFFFAOYSA-N cyclobut-3-ene-1,2-dione Chemical class O=C1C=CC1=O RGBVWCQARBEPPW-UHFFFAOYSA-N 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 206010002383 Angina Pectoris Diseases 0.000 abstract 1
- 206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 102000004257 Potassium Channel Human genes 0.000 abstract 1
- 208000006399 Premature Obstetric Labor Diseases 0.000 abstract 1
- 206010036600 Premature labour Diseases 0.000 abstract 1
- 206010046543 Urinary incontinence Diseases 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 230000002490 cerebral effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000002551 irritable bowel syndrome Diseases 0.000 abstract 1
- 108020001213 potassium channel Proteins 0.000 abstract 1
- 208000026440 premature labor Diseases 0.000 abstract 1
- 230000016160 smooth muscle contraction Effects 0.000 abstract 1
- 208000019553 vascular disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/20—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/41—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68220796A | 1996-07-17 | 1996-07-17 | |
| US67843096A | 1996-07-17 | 1996-07-17 | |
| US68427996A | 1996-07-17 | 1996-07-17 | |
| US68427896A | 1996-07-17 | 1996-07-17 | |
| US08/889,163 US5750574A (en) | 1996-07-17 | 1997-07-07 | Fluorinated N-arylmethylamino derivatives of cyclobutene-3,4-diones |
| US08/889,166 US5780505A (en) | 1996-07-17 | 1997-07-07 | Substituted N-arylmethylamino derivatives of cyclobutene-3, 4-diones |
| US08/889,164 US5763474A (en) | 1996-07-17 | 1997-07-07 | Substituted N-arylmethylamino derivatives of cyclobutene-3,4-diones |
| US08/889,165 US5846999A (en) | 1996-07-17 | 1997-07-07 | Substituted N-arylmethylamino derivatives of cyclobutene-3,4-diones |
| PCT/US1997/011992 WO1998002413A1 (en) | 1996-07-17 | 1997-07-16 | Substituted n-arylmethylamino derivatives of cyclobutene-3,4-diones |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69717841D1 true DE69717841D1 (de) | 2003-01-23 |
| DE69717841T2 DE69717841T2 (de) | 2003-05-28 |
Family
ID=27575501
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69717841T Expired - Fee Related DE69717841T2 (de) | 1996-07-17 | 1997-07-16 | Substituierte n-arylmethylamino-cyclobuten-3,4-dion-derivate |
Country Status (8)
| Country | Link |
|---|---|
| EP (2) | EP0934257B1 (de) |
| JP (1) | JP2000513729A (de) |
| KR (1) | KR20000023769A (de) |
| CN (1) | CN1230173A (de) |
| AT (1) | ATE229501T1 (de) |
| CA (1) | CA2261072A1 (de) |
| DE (1) | DE69717841T2 (de) |
| WO (1) | WO1998002413A1 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ290178B6 (cs) | 1999-07-22 | 2002-06-12 | Sankyo Company Limited | Deriváty cyklobutenu |
| US6495576B2 (en) | 2001-02-07 | 2002-12-17 | Abbott Laboratories | Aminal diones as potassium channel openers |
| US20040106794A1 (en) * | 2001-04-16 | 2004-06-03 | Schering Corporation | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
| CN106631843A (zh) * | 2016-11-23 | 2017-05-10 | 山东友帮生化科技有限公司 | 一种3‑氧代环丁基氨的制备方法 |
| CN116640071B (zh) * | 2023-05-04 | 2024-08-30 | 四川青木制药有限公司 | 一种制备2-甲基4-甲醛肟基苯甲酸及其酯类衍生物的方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI832520A7 (fi) * | 1982-07-12 | 1984-01-13 | Bristol Myers Co | Farmaseuttisia menetelmiä ja koostumuksia. |
| US5168103A (en) * | 1991-01-22 | 1992-12-01 | American Home Products Corporation | [[2-(amino-3,4-dioxo-1-cyclobuten-1-yl) amino]alkyl]-acid derivatives |
| JPH0692915A (ja) * | 1992-07-28 | 1994-04-05 | Sumitomo Metal Ind Ltd | １，２−ジアミノシクロブテン−３，４−ジオン誘導体及びその用途 |
| US5466712A (en) * | 1994-11-04 | 1995-11-14 | American Home Products Corporation | Substituted n-aryl-1,2-diaminocyclobutene-3,4-diones |
-
1997
- 1997-07-16 CA CA002261072A patent/CA2261072A1/en not_active Abandoned
- 1997-07-16 EP EP97936050A patent/EP0934257B1/de not_active Expired - Lifetime
- 1997-07-16 DE DE69717841T patent/DE69717841T2/de not_active Expired - Fee Related
- 1997-07-16 AT AT97936050T patent/ATE229501T1/de not_active IP Right Cessation
- 1997-07-16 EP EP01119663A patent/EP1151990A1/de not_active Withdrawn
- 1997-07-16 WO PCT/US1997/011992 patent/WO1998002413A1/en not_active Ceased
- 1997-07-16 JP JP10506136A patent/JP2000513729A/ja active Pending
- 1997-07-16 CN CN97197755A patent/CN1230173A/zh active Pending
-
1999
- 1999-01-14 KR KR1019997000239A patent/KR20000023769A/ko not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| KR20000023769A (ko) | 2000-04-25 |
| CN1230173A (zh) | 1999-09-29 |
| JP2000513729A (ja) | 2000-10-17 |
| CA2261072A1 (en) | 1998-01-22 |
| EP1151990A1 (de) | 2001-11-07 |
| WO1998002413A1 (en) | 1998-01-22 |
| ATE229501T1 (de) | 2002-12-15 |
| EP0934257A1 (de) | 1999-08-11 |
| DE69717841T2 (de) | 2003-05-28 |
| EP0934257B1 (de) | 2002-12-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |