DE69712240D1 - Verfahren zur Glykosylierung von Colchicin-Derivaten und Produkten davon - Google Patents

Verfahren zur Glykosylierung von Colchicin-Derivaten und Produkten davon

Info

Publication number
DE69712240D1
DE69712240D1 DE69712240T DE69712240T DE69712240D1 DE 69712240 D1 DE69712240 D1 DE 69712240D1 DE 69712240 T DE69712240 T DE 69712240T DE 69712240 T DE69712240 T DE 69712240T DE 69712240 D1 DE69712240 D1 DE 69712240D1
Authority
DE
Germany
Prior art keywords
glycosylating
products
colchicine derivatives
colchicine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69712240T
Other languages
English (en)
Other versions
DE69712240T2 (de
Inventor
Ezio Bombardelli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Indena SpA
Original Assignee
Indena SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena SpA filed Critical Indena SpA
Publication of DE69712240D1 publication Critical patent/DE69712240D1/de
Application granted granted Critical
Publication of DE69712240T2 publication Critical patent/DE69712240T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/06—Benzopyran radicals
    • C07H17/065—Benzo[b]pyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69712240T 1996-02-08 1997-01-29 Verfahren zur Glykosylierung von Colchicin-Derivaten und Produkten davon Expired - Lifetime DE69712240T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT96MI000236A IT1282584B1 (it) 1996-02-08 1996-02-08 Processo di glicosidazione di derivati colchicinici e prodotti ottenuti

Publications (2)

Publication Number Publication Date
DE69712240D1 true DE69712240D1 (de) 2002-06-06
DE69712240T2 DE69712240T2 (de) 2002-12-19

Family

ID=11373195

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69712240T Expired - Lifetime DE69712240T2 (de) 1996-02-08 1997-01-29 Verfahren zur Glykosylierung von Colchicin-Derivaten und Produkten davon

Country Status (13)

Country Link
US (1) US5777136A (de)
EP (1) EP0789028B1 (de)
JP (1) JP3029806B2 (de)
KR (1) KR100206357B1 (de)
AT (1) ATE217007T1 (de)
AU (1) AU707718B2 (de)
CA (1) CA2196932C (de)
DE (1) DE69712240T2 (de)
DK (1) DK0789028T3 (de)
ES (1) ES2176533T3 (de)
HK (1) HK1002362A1 (de)
IT (1) IT1282584B1 (de)
PT (1) PT789028E (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2779147B1 (fr) * 1998-05-27 2000-06-30 Synthelabo Derive de thiocolchicoside sa preparation et son application en therapeutique
US6825236B2 (en) 2003-04-14 2004-11-30 California Pacific Medical Center Colchicine derivatives
ITMI20031144A1 (it) * 2003-06-06 2004-12-07 Indena Spa Analoghi del colchicoside.
SG165175A1 (en) * 2004-05-12 2010-10-28 Indena Spa Biotransformation of colchicinoid compounds
DE602008004113D1 (de) * 2008-05-28 2011-02-03 Indena Spa Verfahren zur Glycosidierung von Colchicin und Thiocolchicin
WO2010138670A2 (en) * 2009-05-27 2010-12-02 Mutual Pharmaceutical Company, Inc. Thiocolchicine derivatives, method of making and methods of use thereof
US20110178180A1 (en) * 2010-01-18 2011-07-21 Kurt Nielsen Deuterium-enriched colchicine, thiocolchicine, and derivatives thereof; methods of preparation; and use thereof
EP3086794B1 (de) 2013-12-23 2020-01-08 Alkaloids Corporation Verfahren zur umwandlung von colchicinoiden in ihre 3-glycosylierten derivate über ihre jeweiligen 3-demethylanaloga

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2112131A1 (en) * 1970-11-06 1972-06-16 Roussel Uclaf 2-and 3-glucose-2-yl-demethylthiololchicines - antimitotic agents,prepared from colchicine
FR2112710A5 (en) * 1970-11-06 1972-06-23 Roussel Uclaf Thiocolchicoside prepn - from thiocolchicine in high yield in three stages
US3816396A (en) * 1972-04-27 1974-06-11 Roussel Uclaf Thiocolchicine glucoside
US4692463A (en) * 1985-02-26 1987-09-08 The United States Of America As Represented By The Department Of Health And Human Services Antiinflammatory 2,3-didemethylcolchicine and additional derivatives
US5175342A (en) * 1988-08-24 1992-12-29 The United States Of America As Represented By The Department Of Health And Human Services Esters of 3-demethylthiocolchicine and n-acyl analogs

Also Published As

Publication number Publication date
EP0789028A2 (de) 1997-08-13
ES2176533T3 (es) 2002-12-01
EP0789028A3 (de) 1998-01-28
EP0789028B1 (de) 2002-05-02
US5777136A (en) 1998-07-07
CA2196932C (en) 2000-12-05
AU707718B2 (en) 1999-07-15
AU1253497A (en) 1997-08-14
DK0789028T3 (da) 2002-08-19
CA2196932A1 (en) 1997-08-09
JPH09309896A (ja) 1997-12-02
ITMI960236A0 (de) 1996-02-08
ATE217007T1 (de) 2002-05-15
ITMI960236A1 (it) 1997-08-08
IT1282584B1 (it) 1998-03-31
DE69712240T2 (de) 2002-12-19
PT789028E (pt) 2002-09-30
JP3029806B2 (ja) 2000-04-10
HK1002362A1 (en) 1998-08-21
KR100206357B1 (ko) 1999-07-01
KR970061911A (ko) 1997-09-12

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN

8328 Change in the person/name/address of the agent

Representative=s name: MAIWALD PATENTANWALTSGESELLSCHAFT MBH, 80335 MUENC