DK0789028T3 - Fremgangsmåde til glycosidering af colchicin-derivater og opnåede produkter - Google Patents

Fremgangsmåde til glycosidering af colchicin-derivater og opnåede produkter

Info

Publication number
DK0789028T3
DK0789028T3 DK97101317T DK97101317T DK0789028T3 DK 0789028 T3 DK0789028 T3 DK 0789028T3 DK 97101317 T DK97101317 T DK 97101317T DK 97101317 T DK97101317 T DK 97101317T DK 0789028 T3 DK0789028 T3 DK 0789028T3
Authority
DK
Denmark
Prior art keywords
glycosidation
obtained products
colchicine derivatives
colchicine
derivatives
Prior art date
Application number
DK97101317T
Other languages
English (en)
Inventor
Ezio Bombardelli
Original Assignee
Indena Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena Spa filed Critical Indena Spa
Application granted granted Critical
Publication of DK0789028T3 publication Critical patent/DK0789028T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/06—Benzopyran radicals
    • C07H17/065—Benzo[b]pyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK97101317T 1996-02-08 1997-01-29 Fremgangsmåde til glycosidering af colchicin-derivater og opnåede produkter DK0789028T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT96MI000236A IT1282584B1 (it) 1996-02-08 1996-02-08 Processo di glicosidazione di derivati colchicinici e prodotti ottenuti

Publications (1)

Publication Number Publication Date
DK0789028T3 true DK0789028T3 (da) 2002-08-19

Family

ID=11373195

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97101317T DK0789028T3 (da) 1996-02-08 1997-01-29 Fremgangsmåde til glycosidering af colchicin-derivater og opnåede produkter

Country Status (13)

Country Link
US (1) US5777136A (da)
EP (1) EP0789028B1 (da)
JP (1) JP3029806B2 (da)
KR (1) KR100206357B1 (da)
AT (1) ATE217007T1 (da)
AU (1) AU707718B2 (da)
CA (1) CA2196932C (da)
DE (1) DE69712240T2 (da)
DK (1) DK0789028T3 (da)
ES (1) ES2176533T3 (da)
HK (1) HK1002362A1 (da)
IT (1) IT1282584B1 (da)
PT (1) PT789028E (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2779147B1 (fr) * 1998-05-27 2000-06-30 Synthelabo Derive de thiocolchicoside sa preparation et son application en therapeutique
US6825236B2 (en) 2003-04-14 2004-11-30 California Pacific Medical Center Colchicine derivatives
ITMI20031144A1 (it) * 2003-06-06 2004-12-07 Indena Spa Analoghi del colchicoside.
SG165175A1 (en) * 2004-05-12 2010-10-28 Indena Spa Biotransformation of colchicinoid compounds
DE602008004113D1 (de) * 2008-05-28 2011-02-03 Indena Spa Verfahren zur Glycosidierung von Colchicin und Thiocolchicin
WO2010138670A2 (en) * 2009-05-27 2010-12-02 Mutual Pharmaceutical Company, Inc. Thiocolchicine derivatives, method of making and methods of use thereof
US20110178180A1 (en) * 2010-01-18 2011-07-21 Kurt Nielsen Deuterium-enriched colchicine, thiocolchicine, and derivatives thereof; methods of preparation; and use thereof
EP3086794B1 (en) 2013-12-23 2020-01-08 Alkaloids Corporation Process for the conversion of colchicinoids to their 3-glycosylated derivatives via their respective 3-demethyl analogues

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2112131A1 (en) * 1970-11-06 1972-06-16 Roussel Uclaf 2-and 3-glucose-2-yl-demethylthiololchicines - antimitotic agents,prepared from colchicine
FR2112710A5 (en) * 1970-11-06 1972-06-23 Roussel Uclaf Thiocolchicoside prepn - from thiocolchicine in high yield in three stages
US3816396A (en) * 1972-04-27 1974-06-11 Roussel Uclaf Thiocolchicine glucoside
US4692463A (en) * 1985-02-26 1987-09-08 The United States Of America As Represented By The Department Of Health And Human Services Antiinflammatory 2,3-didemethylcolchicine and additional derivatives
US5175342A (en) * 1988-08-24 1992-12-29 The United States Of America As Represented By The Department Of Health And Human Services Esters of 3-demethylthiocolchicine and n-acyl analogs

Also Published As

Publication number Publication date
EP0789028A2 (en) 1997-08-13
ES2176533T3 (es) 2002-12-01
EP0789028A3 (en) 1998-01-28
EP0789028B1 (en) 2002-05-02
US5777136A (en) 1998-07-07
DE69712240D1 (de) 2002-06-06
CA2196932C (en) 2000-12-05
AU707718B2 (en) 1999-07-15
AU1253497A (en) 1997-08-14
CA2196932A1 (en) 1997-08-09
JPH09309896A (ja) 1997-12-02
ITMI960236A0 (da) 1996-02-08
ATE217007T1 (de) 2002-05-15
ITMI960236A1 (it) 1997-08-08
IT1282584B1 (it) 1998-03-31
DE69712240T2 (de) 2002-12-19
PT789028E (pt) 2002-09-30
JP3029806B2 (ja) 2000-04-10
HK1002362A1 (en) 1998-08-21
KR100206357B1 (ko) 1999-07-01
KR970061911A (ko) 1997-09-12

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