DE69706830T2 - 5H,10H-IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZIN-4-ONE DERIVATE ANTAGONISTEN DER REZEPTOREN AMPA UND NMDA, IHRE HERSTELLUNG UND ZWISCHENPRODUKTE UND SIE ENTHALTENDE ARZNEIMITTEL - Google Patents
5H,10H-IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZIN-4-ONE DERIVATE ANTAGONISTEN DER REZEPTOREN AMPA UND NMDA, IHRE HERSTELLUNG UND ZWISCHENPRODUKTE UND SIE ENTHALTENDE ARZNEIMITTELInfo
- Publication number
- DE69706830T2 DE69706830T2 DE69706830T DE69706830T DE69706830T2 DE 69706830 T2 DE69706830 T2 DE 69706830T2 DE 69706830 T DE69706830 T DE 69706830T DE 69706830 T DE69706830 T DE 69706830T DE 69706830 T2 DE69706830 T2 DE 69706830T2
- Authority
- DE
- Germany
- Prior art keywords
- indeno
- ampa
- derivate
- pyrazin
- imidazo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- MGRVRXRGTBOSHW-UHFFFAOYSA-N (aminomethyl)phosphonic acid Chemical compound NCP(O)(O)=O MGRVRXRGTBOSHW-UHFFFAOYSA-N 0.000 title 1
- AQQPIVYLMVOXNA-UHFFFAOYSA-N 5h,10h-imidazo-[1,2-a]indeno[1,2-e]pyrazin-4-one Chemical compound C1=CC=C2C(NC(C3=NC=CN33)=O)=C3CC2=C1 AQQPIVYLMVOXNA-UHFFFAOYSA-N 0.000 title 1
- 102000003678 AMPA Receptors Human genes 0.000 title 1
- 108090000078 AMPA Receptors Proteins 0.000 title 1
- 102000004868 N-Methyl-D-Aspartate Receptors Human genes 0.000 title 1
- 108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 239000013067 intermediate product Substances 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9600192A FR2743366B1 (fr) | 1996-01-10 | 1996-01-10 | Derives de 5h,10h-imidazo(1,2-a)indeno(1,2-e)pyrazine-4-one, leur preparation, leurs intermediaires et les medicaments les contenant |
PCT/FR1997/000019 WO1997025328A1 (fr) | 1996-01-10 | 1997-01-06 | DERIVES DE 5H,10H-IMIDAZO(1,2-a)INDENO(1,2-e)PYRAZINE-4-ONE, LEUR PREPARATION, LEURS INTERMEDIAIRES ET LES MEDICAMENTS LES CONTENANT______________________________________________________________ |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69706830D1 DE69706830D1 (de) | 2001-10-25 |
DE69706830T2 true DE69706830T2 (de) | 2002-04-25 |
Family
ID=9487995
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69706830T Expired - Fee Related DE69706830T2 (de) | 1996-01-10 | 1997-01-06 | 5H,10H-IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZIN-4-ONE DERIVATE ANTAGONISTEN DER REZEPTOREN AMPA UND NMDA, IHRE HERSTELLUNG UND ZWISCHENPRODUKTE UND SIE ENTHALTENDE ARZNEIMITTEL |
Country Status (20)
Country | Link |
---|---|
US (2) | US5990108A (de) |
EP (1) | EP0880522B1 (de) |
JP (1) | JP2000505073A (de) |
KR (1) | KR19990077135A (de) |
AR (1) | AR005424A1 (de) |
AT (1) | ATE205847T1 (de) |
AU (1) | AU1383097A (de) |
BG (1) | BG102618A (de) |
CA (1) | CA2239254A1 (de) |
CZ (1) | CZ216698A3 (de) |
DE (1) | DE69706830T2 (de) |
DK (1) | DK0880522T3 (de) |
ES (1) | ES2164323T3 (de) |
FR (1) | FR2743366B1 (de) |
MX (1) | MX9805167A (de) |
PL (1) | PL327942A1 (de) |
PT (1) | PT880522E (de) |
SK (1) | SK93498A3 (de) |
WO (1) | WO1997025328A1 (de) |
ZA (1) | ZA9786B (de) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999047497A2 (en) * | 1998-03-13 | 1999-09-23 | Merck Frosst Canada & Co. | Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment |
US6242493B1 (en) | 1998-03-13 | 2001-06-05 | Merck Frosst Canada & Co. | Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment |
JP4303109B2 (ja) * | 2001-10-04 | 2009-07-29 | メルク エンド カムパニー インコーポレーテッド | 代謝共役型グルタミン酸受容体−5のヘテロアリール置換テトラゾール調節剤 |
JPWO2003070722A1 (ja) * | 2002-02-21 | 2005-06-09 | アルフレッサファーマ株式会社 | イミダゾール誘導体の改良製法およびその新規中間体 |
GB0415320D0 (en) * | 2004-07-08 | 2004-08-11 | Astrazeneca Ab | Novel compounds |
US7649098B2 (en) * | 2006-02-24 | 2010-01-19 | Lexicon Pharmaceuticals, Inc. | Imidazole-based compounds, compositions comprising them and methods of their use |
TW200920355A (en) * | 2007-09-06 | 2009-05-16 | Lexicon Pharmaceuticals Inc | Compositions and methods for treating immunological and inflammatory diseases and disorders |
US9737531B2 (en) | 2012-07-12 | 2017-08-22 | Glytech, Llc | Composition and method for treatment of depression and psychosis in humans |
CA3067162A1 (en) | 2017-06-12 | 2018-12-20 | Glytech Llc. | Treatment of depression with nmda antagonists and d2/5ht2a or selective 5ht2a antagonists |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2717812B1 (fr) * | 1994-03-28 | 1996-05-10 | Rhone Poulenc Rorer Sa | Indeno[1,2-e]pyrazine-4-ones, leur préparation et les médicaments les contenant. |
FR2732681B1 (fr) * | 1995-04-05 | 1997-07-04 | Rhone Poulenc Rorer Sa | Derives de 10h-imidazo(1,2-a)indeno(1,2-e)pyrazin-4-one, leur preparation et les medicaments les contenant |
-
1996
- 1996-01-10 FR FR9600192A patent/FR2743366B1/fr not_active Expired - Fee Related
-
1997
- 1997-01-06 EP EP97900236A patent/EP0880522B1/de not_active Expired - Lifetime
- 1997-01-06 US US09/101,428 patent/US5990108A/en not_active Expired - Fee Related
- 1997-01-06 CZ CZ982166A patent/CZ216698A3/cs unknown
- 1997-01-06 KR KR1019980705272A patent/KR19990077135A/ko not_active Application Discontinuation
- 1997-01-06 WO PCT/FR1997/000019 patent/WO1997025328A1/fr not_active Application Discontinuation
- 1997-01-06 DE DE69706830T patent/DE69706830T2/de not_active Expired - Fee Related
- 1997-01-06 CA CA002239254A patent/CA2239254A1/fr not_active Abandoned
- 1997-01-06 ES ES97900236T patent/ES2164323T3/es not_active Expired - Lifetime
- 1997-01-06 DK DK97900236T patent/DK0880522T3/da active
- 1997-01-06 AT AT97900236T patent/ATE205847T1/de not_active IP Right Cessation
- 1997-01-06 PT PT97900236T patent/PT880522E/pt unknown
- 1997-01-06 JP JP9524911A patent/JP2000505073A/ja not_active Ceased
- 1997-01-06 AU AU13830/97A patent/AU1383097A/en not_active Abandoned
- 1997-01-06 ZA ZA9786A patent/ZA9786B/xx unknown
- 1997-01-06 PL PL97327942A patent/PL327942A1/xx unknown
- 1997-01-06 SK SK934-98A patent/SK93498A3/sk unknown
- 1997-01-09 AR ARP970100091A patent/AR005424A1/es unknown
-
1998
- 1998-06-25 MX MX9805167A patent/MX9805167A/es unknown
- 1998-07-10 BG BG102618A patent/BG102618A/xx unknown
-
1999
- 1999-07-13 US US09/352,216 patent/US6100264A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DK0880522T3 (da) | 2002-01-21 |
ES2164323T3 (es) | 2002-02-16 |
FR2743366A1 (fr) | 1997-07-11 |
MX9805167A (es) | 1998-10-31 |
ATE205847T1 (de) | 2001-10-15 |
EP0880522A1 (de) | 1998-12-02 |
FR2743366B1 (fr) | 1998-02-06 |
WO1997025328A1 (fr) | 1997-07-17 |
JP2000505073A (ja) | 2000-04-25 |
US5990108A (en) | 1999-11-23 |
BG102618A (en) | 1999-09-30 |
US6100264A (en) | 2000-08-08 |
SK93498A3 (en) | 1998-12-02 |
PL327942A1 (en) | 1999-01-04 |
CA2239254A1 (fr) | 1997-07-17 |
CZ216698A3 (cs) | 1998-10-14 |
DE69706830D1 (de) | 2001-10-25 |
KR19990077135A (ko) | 1999-10-25 |
PT880522E (pt) | 2002-05-31 |
EP0880522B1 (de) | 2001-09-19 |
AR005424A1 (es) | 1999-06-23 |
ZA9786B (en) | 1997-07-17 |
AU1383097A (en) | 1997-08-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8328 | Change in the person/name/address of the agent |
Representative=s name: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN |
|
8339 | Ceased/non-payment of the annual fee |