DE69703619T2 - Steroid-nitrit und nitrat-ester-verbindungen und ihre verwendung als antiphlogistische medikamente - Google Patents

Steroid-nitrit und nitrat-ester-verbindungen und ihre verwendung als antiphlogistische medikamente

Info

Publication number
DE69703619T2
DE69703619T2 DE69703619T DE69703619T DE69703619T2 DE 69703619 T2 DE69703619 T2 DE 69703619T2 DE 69703619 T DE69703619 T DE 69703619T DE 69703619 T DE69703619 T DE 69703619T DE 69703619 T2 DE69703619 T2 DE 69703619T2
Authority
DE
Germany
Prior art keywords
nitrate
nitrite
antiphlogistic
medications
steroid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69703619T
Other languages
English (en)
Other versions
DE69703619D1 (de
Inventor
S Tjoeng
G Currie
E Zupec
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Application granted granted Critical
Publication of DE69703619D1 publication Critical patent/DE69703619D1/de
Publication of DE69703619T2 publication Critical patent/DE69703619T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69703619T 1996-05-02 1997-04-28 Steroid-nitrit und nitrat-ester-verbindungen und ihre verwendung als antiphlogistische medikamente Expired - Fee Related DE69703619T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/643,018 US5837698A (en) 1996-05-02 1996-05-02 Steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs
PCT/US1997/006373 WO1997041144A1 (en) 1996-05-02 1997-04-28 Novel steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs

Publications (2)

Publication Number Publication Date
DE69703619D1 DE69703619D1 (de) 2001-01-04
DE69703619T2 true DE69703619T2 (de) 2001-05-03

Family

ID=24579022

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69703619T Expired - Fee Related DE69703619T2 (de) 1996-05-02 1997-04-28 Steroid-nitrit und nitrat-ester-verbindungen und ihre verwendung als antiphlogistische medikamente

Country Status (12)

Country Link
US (1) US5837698A (de)
EP (1) EP0900233B1 (de)
JP (1) JP2000509072A (de)
AT (1) ATE197799T1 (de)
AU (1) AU2922797A (de)
CA (1) CA2253346A1 (de)
DE (1) DE69703619T2 (de)
DK (1) DK0900233T3 (de)
ES (1) ES2152670T3 (de)
GR (1) GR3035088T3 (de)
PT (1) PT900233E (de)
WO (1) WO1997041144A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5824669A (en) * 1996-03-22 1998-10-20 Nitromed, Inc. Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
IT1285770B1 (it) * 1996-10-04 1998-06-18 Nicox Sa Composti corticoidei
ES2347027T3 (es) 1998-05-22 2010-10-22 The Board Of Trustees Of The Leland Stanford Junior University Moleculas bifuncionales y terapias basadas en las mismas.
AU3703900A (en) * 1999-02-24 2000-09-14 Nitromed, Inc. Nitrosated and nitrosylated steroids for the treatment of cardiovascular diseases and disorders
IT1311922B1 (it) 1999-04-13 2002-03-20 Nicox Sa Composti farmaceutici.
IT1320176B1 (it) * 2000-12-22 2003-11-26 Nicox Sa Dispersioni solide di principi attivi nitrati.
EP2147679B1 (de) 2001-07-25 2014-06-25 Raptor Pharmaceutical, Inc. Zusammensetzungen für den Blut-Hirn-Schrankentransport
ITMI20020148A1 (it) * 2002-01-29 2003-07-29 Nicox Sa Nuovi corticosteroidi
JP4274784B2 (ja) * 2002-05-28 2009-06-10 新光電気工業株式会社 配線形成システムおよびその方法
US6968669B2 (en) * 2002-11-06 2005-11-29 Lancer Partnership Ltd. Flexible packaging
SE0300971D0 (sv) * 2003-04-03 2003-04-03 Aga Ab Nitric oxide in treatment of inflammation
WO2006116718A2 (en) 2005-04-28 2006-11-02 Proteus Biomedical, Inc. Pharma-informatics system
ES2393363T3 (es) * 2005-09-02 2012-12-20 Nicox S.A. Derivados nitrooxi de glucocorticoides
US9062126B2 (en) 2005-09-16 2015-06-23 Raptor Pharmaceuticals Inc. Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof
PL2318427T3 (pl) * 2008-07-31 2014-05-30 Nicox Sa Glukokortykoidy przyłączone do estrów kwasu azotowego poprzez aromatyczną grupę łączącą w pozycji 21 i ich zastosowanie w okulistyce
JP5564517B2 (ja) 2009-02-20 2014-07-30 ティーオー − ビービービー ホールディング ベスローテン フェンノートシャップ グルタチオンをベースとする薬物送達システム
CN102458374A (zh) 2009-05-06 2012-05-16 实验室护肤股份有限公司 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其使用方法
US8716268B2 (en) 2010-06-07 2014-05-06 Chao Liu Nitrate esters of corticoid compounds useful as diuretics
SG11201903209TA (en) * 2016-10-14 2019-05-30 Van Andel Res Institute Structures and mechanism for the design of highly potent glucocorticoids
JP7330101B2 (ja) 2016-11-08 2023-08-21 レゲネロン ファーマシューティカルス，インコーポレーテッド ステロイド及びそのタンパク質コンジュゲート
MX2019013690A (es) 2017-05-18 2020-01-27 Regeneron Pharma Conjugados de farmaco-proteina con ciclodextrina.
CA3086926A1 (en) * 2018-01-08 2019-07-11 Regeneron Pharmaceuticals, Inc. Steroids and antibody-conjugates thereof
JP2021523147A (ja) 2018-05-09 2021-09-02 レゲネロン ファーマシューティカルス，インコーポレーテッド 抗ｍｓｒ１抗体及びその使用方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2990401A (en) * 1958-06-18 1961-06-27 American Cyanamid Co 11-substituted 16alpha, 17alpha-substituted methylenedioxy steroids
US3002010A (en) * 1958-06-18 1961-09-26 American Cyanamid Co Acylated steroids and method of preparing the same
US3215713A (en) * 1960-04-04 1965-11-02 Schering Corp Steroid nitrite esters
US3298941A (en) * 1961-05-29 1967-01-17 Schering Corp Photochemical process for rearranging organic hypohalite and nitrite compounds
US3183252A (en) * 1963-09-05 1965-05-11 Syntex Corp 16-nitratoalkyl-pregnanes
GB1082574A (en) * 1965-02-12 1967-09-06 Boots Pure Drug Co Ltd Steroid esters
US3639434A (en) * 1967-02-02 1972-02-01 Boots Pure Drug Co Ltd 17-acyloxysteroids and their manufacture
DE1643036B2 (de) * 1967-08-16 1976-04-15 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue 11 beta-halogensteroide, diese enthaltende arzneimittel sowie verfahren zu ihrer herstellung
HU164115B (de) * 1971-05-07 1973-12-28
HU163145B (de) * 1971-09-23 1973-06-28
DD113355A1 (de) * 1972-06-15 1975-06-05
DE2236115A1 (de) * 1972-07-20 1974-02-07 Schering Ag Verfahren zur herstellung von delta hoch 4.9(11).16 -3.20diketosteroiden
GB1446126A (en) * 1974-05-16 1976-08-18 Res Inst For Medicine Chemistr Photolytic preparation of diol mononitrates
US5264422A (en) * 1986-06-30 1993-11-23 Fidia S.P.A. Esters of alginic acid with steroidal alcohols
SU1510131A1 (ru) * 1986-11-21 1991-02-15 1-Й Московский Медицинский Институт Им.И.М.Сеченова Состав дл пломбировани корневых каналов зубов
DE4223800A1 (de) * 1992-07-20 1994-01-27 Cassella Farbwerke Mainkur Ag Verwendung von 1.2.5-Oxadiazol-2-oxiden zur Behandlung erektiler Dysfunktionen
EP0656881B1 (de) * 1992-07-30 1998-10-14 Cal International Limited Ester und kombinationen von einem organischen nitrat und einem salicyclat
ES2059264B1 (es) * 1992-11-05 1995-06-16 Berrazueta Fernandez Jose Ramo Utilizacion de los nitrovasodilatadores en la preparacion de medicamentos antiinflamatorios y analgesicos de uso topico.

Also Published As

Publication number Publication date
WO1997041144A1 (en) 1997-11-06
JP2000509072A (ja) 2000-07-18
GR3035088T3 (en) 2001-03-30
ES2152670T3 (es) 2001-02-01
US5837698A (en) 1998-11-17
DK0900233T3 (da) 2001-01-22
PT900233E (pt) 2001-03-30
AU2922797A (en) 1997-11-19
DE69703619D1 (de) 2001-01-04
EP0900233A1 (de) 1999-03-10
EP0900233B1 (de) 2000-11-29
ATE197799T1 (de) 2000-12-15
CA2253346A1 (en) 1997-11-06

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee