DE69700903D1 - Verfahren zur Isolierung eines pharmazeutisch verträglichen Alkalimetallsalzes der Clavulansäure - Google Patents

Verfahren zur Isolierung eines pharmazeutisch verträglichen Alkalimetallsalzes der Clavulansäure

Info

Publication number
DE69700903D1
DE69700903D1 DE69700903T DE69700903T DE69700903D1 DE 69700903 D1 DE69700903 D1 DE 69700903D1 DE 69700903 T DE69700903 T DE 69700903T DE 69700903 T DE69700903 T DE 69700903T DE 69700903 D1 DE69700903 D1 DE 69700903D1
Authority
DE
Germany
Prior art keywords
clavulanic acid
alkali metal
metal salt
isolation
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69700903T
Other languages
English (en)
Other versions
DE69700903T2 (de
Inventor
Jaoquim P Cardoso
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CIPAN COMP IND PROD
CIPAN Companhia Industrial Produtora de Antibioticos SA
Original Assignee
CIPAN COMP IND PROD
CIPAN Companhia Industrial Produtora de Antibioticos SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CIPAN COMP IND PROD, CIPAN Companhia Industrial Produtora de Antibioticos SA filed Critical CIPAN COMP IND PROD
Publication of DE69700903D1 publication Critical patent/DE69700903D1/de
Application granted granted Critical
Publication of DE69700903T2 publication Critical patent/DE69700903T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69700903T 1997-03-24 1997-03-24 Verfahren zur Isolierung eines pharmazeutisch verträglichen Alkalimetallsalzes der Clavulansäure Expired - Fee Related DE69700903T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97104947A EP0867515B1 (de) 1997-03-24 1997-03-24 Verfahren zur Isolierung eines pharmazeutisch verträglichen Alkalimetallsalzes der Clavulansäure

Publications (2)

Publication Number Publication Date
DE69700903D1 true DE69700903D1 (de) 2000-01-13
DE69700903T2 DE69700903T2 (de) 2000-07-06

Family

ID=8226629

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69700903T Expired - Fee Related DE69700903T2 (de) 1997-03-24 1997-03-24 Verfahren zur Isolierung eines pharmazeutisch verträglichen Alkalimetallsalzes der Clavulansäure

Country Status (12)

Country Link
US (1) US6417352B1 (de)
EP (1) EP0867515B1 (de)
JP (1) JP3474204B2 (de)
AT (1) ATE187498T1 (de)
AU (1) AU740387B2 (de)
DE (1) DE69700903T2 (de)
DK (1) DK0867515T3 (de)
ES (1) ES2142641T3 (de)
GR (1) GR3032882T3 (de)
NZ (1) NZ337476A (de)
PT (1) PT867515E (de)
ZA (1) ZA982437B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1165049T2 (sl) * 1999-04-01 2011-11-30 Dsm Ip Assets Bv Aglomerati s kristalizacijo
GB0022841D0 (en) * 2000-09-18 2000-11-01 Smithkline Beecham Plc Process
WO2008065160A1 (en) * 2006-12-01 2008-06-05 Dsm Ip Assets B.V. Process for the production of clavulanic acid
WO2012039447A1 (ja) * 2010-09-24 2012-03-29 第一三共株式会社 置換シクロアルケン誘導体の結晶
CN103833774A (zh) * 2014-03-21 2014-06-04 山东新时代药业有限公司 一种从克拉维酸钾混粉中回收有效成分的方法
CN109535183A (zh) * 2017-09-21 2019-03-29 联邦制药(内蒙古)有限公司 一种制备克拉维酸叔辛胺的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3770590A (en) * 1971-12-01 1973-11-06 Merck & Co Inc Fermentation process
IE43790B1 (en) * 1975-02-07 1981-06-03 Glaxo Lab Ltd -lactam antibiotic in purified form
SI9200139A (en) * 1992-07-08 1994-03-31 Lek Tovarna Farmacevtskih New inclusion complex of clavulanic acid with hydrophylyc and hydropholyc beta-cyclodextrin derivates for production of them
GB9401969D0 (en) * 1994-02-02 1994-03-30 Smithkline Beecham Plc Process
SI9400107A (en) * 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
SI9500074A (en) * 1995-03-10 1996-10-31 Lek Tovarna Farmacevtskih Process for preparation of alkani salts of clavulanic acid.
GB9515809D0 (en) * 1995-08-02 1995-10-04 Smithkline Beecham Plc Process
GB9521173D0 (en) 1995-10-17 1995-12-20 Univ Southampton Isolation of parasites

Also Published As

Publication number Publication date
GR3032882T3 (en) 2000-07-31
EP0867515B1 (de) 1999-12-08
ES2142641T3 (es) 2000-04-16
NZ337476A (en) 2001-03-30
EP0867515A1 (de) 1998-09-30
ZA982437B (en) 1998-09-28
PT867515E (pt) 2000-05-31
AU7038998A (en) 1998-10-20
US6417352B1 (en) 2002-07-09
JP3474204B2 (ja) 2003-12-08
AU740387B2 (en) 2001-11-01
DE69700903T2 (de) 2000-07-06
DK0867515T3 (da) 2000-06-13
JP2001521393A (ja) 2001-11-06
ATE187498T1 (de) 1999-12-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee