DE69638077D1 - Bakterielle Produktion von Interferon-beta Polypeptiden - Google Patents

Bakterielle Produktion von Interferon-beta Polypeptiden

Info

Publication number
DE69638077D1
DE69638077D1 DE69638077T DE69638077T DE69638077D1 DE 69638077 D1 DE69638077 D1 DE 69638077D1 DE 69638077 T DE69638077 T DE 69638077T DE 69638077 T DE69638077 T DE 69638077T DE 69638077 D1 DE69638077 D1 DE 69638077D1
Authority
DE
Germany
Prior art keywords
interferon
beta polypeptides
bacterial production
beta
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69638077T
Other languages
German (de)
English (en)
Inventor
Glenn Dorin
Patrick J Mcalary
Kathleen M Wong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Novartis Vaccines and Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Vaccines and Diagnostics Inc filed Critical Novartis Vaccines and Diagnostics Inc
Application granted granted Critical
Publication of DE69638077D1 publication Critical patent/DE69638077D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69638077T 1995-06-06 1996-06-05 Bakterielle Produktion von Interferon-beta Polypeptiden Expired - Fee Related DE69638077D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/477,310 US5814485A (en) 1995-06-06 1995-06-06 Production of interferon-β (IFN-β) in E. coli
PCT/US1996/009155 WO1996039523A2 (en) 1995-06-06 1996-06-05 Bacterial production of hydrophobic polypeptides

Publications (1)

Publication Number Publication Date
DE69638077D1 true DE69638077D1 (de) 2009-12-31

Family

ID=23895395

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69638077T Expired - Fee Related DE69638077D1 (de) 1995-06-06 1996-06-05 Bakterielle Produktion von Interferon-beta Polypeptiden

Country Status (17)

Country Link
US (1) US5814485A (forum.php)
EP (1) EP0778893B1 (forum.php)
JP (3) JP4131554B2 (forum.php)
AT (1) ATE449175T1 (forum.php)
AU (1) AU6154996A (forum.php)
BR (1) BR9606491A (forum.php)
CA (1) CA2195799C (forum.php)
DE (1) DE69638077D1 (forum.php)
FI (1) FI970445A7 (forum.php)
IL (1) IL120009A0 (forum.php)
IN (1) IN190514B (forum.php)
MX (1) MX9700818A (forum.php)
MY (1) MY118492A (forum.php)
NO (1) NO324529B1 (forum.php)
NZ (1) NZ310710A (forum.php)
TW (1) TW494138B (forum.php)
WO (1) WO1996039523A2 (forum.php)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997048808A1 (en) * 1996-06-19 1997-12-24 Chiron Corporation Bacterial production of interferon-beta using low levels of sodium and potassium ions
US6514729B1 (en) 1999-05-12 2003-02-04 Xencor, Inc. Recombinant interferon-beta muteins
RU2180687C1 (ru) * 2000-07-05 2002-03-20 Общество с ограниченной ответственностью "Биотех" Штамм дрожжей pichia pastoris - продуцент фибробластного интерферона человека, рекомбинантная плазмидная днк phif и способ ее конструирования
US7544354B2 (en) * 2000-10-27 2009-06-09 Novartis Vaccines And Diagnostics Methods of protein purification and recovery
US6812221B2 (en) * 2000-11-21 2004-11-02 The Texas A&M University System FGF-affinity chromatography
NZ525597A (en) * 2000-11-29 2004-11-26 Morinaga Milk Industry Co Ltd Interferon therapeutic effect-potentiating agents
US6887462B2 (en) 2001-04-09 2005-05-03 Chiron Corporation HSA-free formulations of interferon-beta
AR034749A1 (es) * 2001-07-09 2004-03-17 Schering Ag Formulaciones de interferon beta humano
WO2004022593A2 (en) * 2002-09-09 2004-03-18 Nautilus Biotech Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
JP2007530419A (ja) * 2003-07-11 2007-11-01 バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト 改良組換えヒトインターフェロン−β−１ｂポリペプチド
ES2374530T3 (es) * 2003-12-11 2012-02-17 Ares Trading S.A. Formulaciones líquidas de interferón estabilizado.
JP2007519422A (ja) 2004-02-02 2007-07-19 アンブレツクス・インコーポレイテツド 修飾されたヒト四螺旋バンドルポリペプチド及びそれらの使用
US20070179113A1 (en) * 2005-05-19 2007-08-02 Schering Aktiengesellachaft GM-CSF gene therapy for Crohn's disease using an improved regulated expression system
US20080076729A1 (en) * 2005-05-19 2008-03-27 Schering Aktiengesellachaft Interferon-beta gene therapy using an improved, regulated expression system
WO2006122972A1 (en) * 2005-05-19 2006-11-23 Bayer Schering Pharma Aktiengesellschaft Interferon-beta gene therapy using an improved, regulated expression system
DOP2006000116A (es) * 2005-05-19 2007-01-31 Schering Ag Sistema mejorado de expresión regulada y sus usos.
WO2007110231A2 (en) * 2006-03-28 2007-10-04 Nautilus Biotech, S.A. MODIFIED INTERFERON-β (IFN-β) POLYPEPTIDES
US8920808B2 (en) 2006-10-31 2014-12-30 East Carolina University Cytokine-based fusion proteins for treatment of multiple sclerosis
WO2008125222A2 (en) * 2007-04-11 2008-10-23 Bayer Schering Pharma Aktiengesellschaft New modulation molecules for an improved regulated expression system
WO2008137471A2 (en) 2007-05-02 2008-11-13 Ambrx, Inc. Modified interferon beta polypeptides and their uses
EP2207890A4 (en) * 2007-10-05 2010-12-15 Barofold Inc HIGH PRESSURE PROCESSING OF AGGREGATED INTERFERONS
AU2008340058A1 (en) * 2007-12-20 2009-07-02 Merck Serono S.A. PEG-interferon-beta formulations
US9938333B2 (en) 2008-02-08 2018-04-10 Ambrx, Inc. Modified leptin polypeptides and their uses
KR20090124204A (ko) * 2008-05-29 2009-12-03 (주)바이오큐어팜 아미노 말단의 메티오닌이 제거된 재조합 사람 변이인터페론-베타 단백질을 생산하는 재조합 대장균 및 이의제조방법
EP2413958A4 (en) 2009-03-31 2014-04-02 Univ East Carolina CYTOKINS AND NEUROANTIGENE FOR THE TREATMENT OF IMMUNE DISEASES
CA2788607C (en) * 2010-02-01 2018-03-20 Digna Biotech,S.L. Process for the production of interferon alpha 5
MX2012010148A (es) * 2010-03-04 2013-01-22 Pfenex Inc Metodo para producir proteinas de interferon recombinantes solubles sin desnaturalizacion.
RU2473696C1 (ru) * 2011-07-14 2013-01-27 Закрытое акционерное общество "ГЕНЕРИУМ" ПРОМЫШЛЕННЫЙ СПОСОБ ПОЛУЧЕНИЯ И ОЧИСТКИ РЕКОМБИНАНТНОГО ИНТЕРФЕРОНА β-1b ЧЕЛОВЕКА ИЗ ТЕЛЕЦ ВКЛЮЧЕНИЯ
JP6363326B2 (ja) * 2013-03-11 2018-07-25 株式会社コーセー 酵母・細菌共通培養方法およびこれに用いる酵母・細菌共通培養培地
JP7151049B2 (ja) * 2018-03-30 2022-10-12 三井化学株式会社 微生物を増殖させる方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4499188A (en) * 1982-05-05 1985-02-12 Cetus Corporation Bacterial production of heterologous polypeptides under the control of a repressible promoter-operator
FI82266C (fi) * 1982-10-19 1991-02-11 Cetus Corp Foerfarande foer framstaellning av il-2 -mutein.
US4518584A (en) * 1983-04-15 1985-05-21 Cetus Corporation Human recombinant interleukin-2 muteins
JPS60118196A (ja) * 1983-11-30 1985-06-25 Takeda Chem Ind Ltd インタ−フェロンの製造法
US4656132A (en) * 1984-03-28 1987-04-07 Cetus Corporation Method of improving the yield of heterologous protein produced by cultivating recombinant bacteria
JPH0755152B2 (ja) * 1986-06-02 1995-06-14 日本化薬株式会社 組換え遺伝子産物の製法及び培地

Also Published As

Publication number Publication date
BR9606491A (pt) 1997-09-02
JPH11501820A (ja) 1999-02-16
JP2008086331A (ja) 2008-04-17
TW494138B (en) 2002-07-11
FI970445L (fi) 1997-03-26
NO324529B1 (no) 2007-11-12
WO1996039523A3 (en) 1997-01-30
NO970514L (no) 1997-03-17
CA2195799A1 (en) 1996-12-12
ATE449175T1 (de) 2009-12-15
NO970514D0 (no) 1997-02-05
US5814485A (en) 1998-09-29
MY118492A (en) 2004-11-30
FI970445A7 (fi) 1997-03-26
NZ310710A (en) 1999-01-28
EP0778893B1 (en) 2009-11-18
FI970445A0 (fi) 1997-02-03
MX9700818A (es) 1997-05-31
IN190514B (forum.php) 2003-08-02
AU6154996A (en) 1996-12-24
JP4317890B2 (ja) 2009-08-19
IL120009A0 (en) 1997-04-15
EP0778893A2 (en) 1997-06-18
CA2195799C (en) 2010-02-09
WO1996039523A2 (en) 1996-12-12
JP2008283988A (ja) 2008-11-27
JP4131554B2 (ja) 2008-08-13

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee