DE69632548D1 - ISOXAZOLIN, ISOTHIAZOLIN UND PYRAZOLIN ALS FAKTOR Xa INHIBITOREN - Google Patents

ISOXAZOLIN, ISOTHIAZOLIN UND PYRAZOLIN ALS FAKTOR Xa INHIBITOREN

Info

Publication number
DE69632548D1
DE69632548D1 DE69632548T DE69632548T DE69632548D1 DE 69632548 D1 DE69632548 D1 DE 69632548D1 DE 69632548 T DE69632548 T DE 69632548T DE 69632548 T DE69632548 T DE 69632548T DE 69632548 D1 DE69632548 D1 DE 69632548D1
Authority
DE
Germany
Prior art keywords
inhibitors
factor
isothiazoline
isoxazoline
pyrazoline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69632548T
Other languages
English (en)
Other versions
DE69632548T2 (de
Inventor
Lifen Quan
John Wityak
Anthony Galemmo
F Stouten
Russell Pruitt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Pharma Co
Original Assignee
Bristol Myers Squibb Pharma Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Pharma Co filed Critical Bristol Myers Squibb Pharma Co
Application granted granted Critical
Publication of DE69632548D1 publication Critical patent/DE69632548D1/de
Publication of DE69632548T2 publication Critical patent/DE69632548T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DE69632548T 1995-12-21 1996-12-17 ISOXAZOLIN, ISOTHIAZOLIN UND PYRAZOLIN ALS FAKTOR Xa INHIBITOREN Expired - Lifetime DE69632548T2 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US950895P 1995-12-21 1995-12-21
US9508P 1995-12-21
US64690396A 1996-05-08 1996-05-08
US646903 1996-05-08
US3066696P 1996-11-12 1996-11-12
US30666P 1996-11-12
PCT/US1996/020076 WO1997023212A1 (en) 1995-12-21 1996-12-17 ISOXAZOLINE, ISOTHIAZOLINE AND PYRAZOLINE FACTOR Xa INHIBITORS

Publications (2)

Publication Number Publication Date
DE69632548D1 true DE69632548D1 (de) 2004-06-24
DE69632548T2 DE69632548T2 (de) 2005-06-02

Family

ID=27358875

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69632548T Expired - Lifetime DE69632548T2 (de) 1995-12-21 1996-12-17 ISOXAZOLIN, ISOTHIAZOLIN UND PYRAZOLIN ALS FAKTOR Xa INHIBITOREN

Country Status (9)

Country Link
EP (1) EP0874629B1 (de)
JP (1) JP2001502655A (de)
AT (1) ATE267011T1 (de)
AU (1) AU1335897A (de)
CA (1) CA2240946C (de)
DE (1) DE69632548T2 (de)
ES (1) ES2219706T3 (de)
HR (1) HRP960597A2 (de)
WO (1) WO1997023212A1 (de)

Families Citing this family (40)

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US6153754A (en) 1995-12-21 2000-11-28 Albany Molecular Research, Inc. Process for production of piperidine derivatives
ZA985247B (en) * 1997-06-19 1999-12-17 Du Pont Merck Pharma Guanidine mimics as factor Xa inhibitors.
EP0993448A1 (de) * 1997-06-19 2000-04-19 The Du Pont Merck Pharmaceutical Company (amidino)6-gliedrige aromaten als factor xa inhibitoren
US6339099B1 (en) 1997-06-20 2002-01-15 Dupont Pharmaceuticals Company Guanidine mimics as factor Xa inhibitors
WO1999000127A1 (en) 1997-06-26 1999-01-07 Eli Lilly And Company Antithrombotic agents
ATE266636T1 (de) * 1997-09-09 2004-05-15 Bristol Myers Squibb Pharma Co Benzimidazolinone, benzoxazolinone, benzopiperazinone, indanone und deren derivate als faktor xa inhibitoren
DE19755268A1 (de) * 1997-12-12 1999-06-17 Merck Patent Gmbh Benzamidinderivate
KR20010082515A (ko) 1998-02-17 2001-08-30 우에노 도시오 아미디노 유도체 및 그 유도체를 유효 성분으로서함유하는 약제
ES2230841T3 (es) 1998-03-27 2005-05-01 Bristol-Myers Squibb Pharma Company Pirazolinas y triazolinas disustituidas como inhibidores del factor xa.
GB9809349D0 (en) 1998-05-02 1998-07-01 Zeneca Ltd Heterocyclic derivatives
SI1082321T1 (en) * 1998-05-02 2005-06-30 Astrazeneca Ab Heterocyclic derivatives which inhibit factor xa
EP1119568B1 (de) * 1998-10-09 2004-02-18 Janssen Pharmaceutica N.V. 4,5-dehydroisoxazole derivate und ihre pharmazeutische verwendung
US6319937B1 (en) * 1998-11-18 2001-11-20 Dupont Pharmaceuticals Company Isoxazoline fibrinogen receptor antagonists
EP1058549A4 (de) * 1998-12-23 2003-11-12 Bristol Myers Squibb Pharma Co THROMBIN- ODER FAKTOR-Xa HEMMER
US6855715B1 (en) 1999-06-14 2005-02-15 Eli Lilly And Company Serine protease inhibitors
PL357108A1 (en) 1999-07-16 2004-07-12 Bristol-Myers Squibb Pharma Company Nitrogen containing heterobicycles as factor xa inhibitors
GB9928568D0 (en) * 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
GB0009803D0 (en) 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
MXPA02012895A (es) * 2000-06-23 2003-05-14 Bristol Myers Squibb Pharma Co Derivados de pirazol condensado con 1-(heteroaril-fenil) como inhibidores del factor xa.
WO2002000647A1 (en) 2000-06-23 2002-01-03 Bristol-Myers Squibb Pharma Company Heteroaryl-phenyl substituted factor xa inhibitors
WO2002000651A2 (en) * 2000-06-27 2002-01-03 Bristol-Myers Squibb Pharma Company Factor xa inhibitors
WO2002002519A2 (en) * 2000-06-29 2002-01-10 Bristol-Myers Squibb Pharma Company THROMBIN OR FACTOR Xa INHIBITORS
DE10129725A1 (de) 2001-06-20 2003-01-02 Bayer Ag Kombinationstherapie substituierter Oxazolidinone
US7022705B2 (en) 2001-10-25 2006-04-04 Astrazeneca Ab Isoxazoline derivatives useful as antimicrobials
WO2003042190A1 (en) 2001-11-12 2003-05-22 Pfizer Products Inc. N-alkyl-adamantyl derivatives as p2x7-receptor antagonists
PA8557501A1 (es) 2001-11-12 2003-06-30 Pfizer Prod Inc Benzamida, heteroarilamida y amidas inversas
HUE025683T2 (hu) 2002-12-03 2016-04-28 Pharmacyclics Llc VIIA faktor inhibitor 2-(2-hidroxi-bifenil-3-il)-1H-benzoimidazol-5-karboxamidin-származékok
PA8591801A1 (es) 2002-12-31 2004-07-26 Pfizer Prod Inc Inhibidores benzamidicos del receptor p2x7.
EA011764B1 (ru) 2004-03-05 2009-06-30 Ниссан Кемикал Индастриз, Лтд. Изоксазолинзамещённое производное бензамида и пестицид
TWI441819B (zh) 2005-01-07 2014-06-21 Synta Pharmaceuticals Corp 用於炎症及免疫相關用途之化合物
BRPI0617076B1 (pt) 2005-09-02 2021-07-06 Nissan Chemical Corporation Composto benzamida substituída por isoxazolina da fórmula (1) ou sal do mesmo; composto benzamida substituido por 4-hidroxiiminametila da fórmula (2) ou sal do mesmo; pesticida; agente agroquímico; parasiticida interno ou externo para mamíferos ou aves; inseticida ou acaricida
DE602007006288D1 (de) 2006-03-10 2010-06-17 Nissan Chemical Ind Ltd Substituierte isoxazolin-verbindung und schädlingsbekämpfungsmittel
WO2008059335A1 (en) 2006-11-13 2008-05-22 Pfizer Products Inc. Diaryl, dipyridinyl and aryl-pyridinyl derivatives and uses thereof
JP6415983B2 (ja) 2011-12-23 2018-10-31 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ 無脊椎有害生物を駆除するためのイソチアゾリン化合物
EP2900644B1 (de) * 2012-09-25 2016-09-21 Bayer CropScience AG Herbizid und fungizid wirksame 5-oxy-substituierte 3-phenylisoxazolin-5-carboxamide und 5-oxy-substituierte 3-phenylisoxazolin-5-thioamide
WO2014202751A1 (en) 2013-06-21 2014-12-24 Basf Se Methods for controlling pests in soybean
MX2015018013A (es) * 2013-06-24 2016-04-13 Merial Inc Compuestos de isotiazolina sustituidos con tiofeno o furano como plaguicidas.
JP7113810B2 (ja) 2016-07-07 2022-08-05 ブリストル－マイヤーズ スクイブ カンパニー Ｒｏｃｋ阻害剤としてのスピロラクタム
CN110869362A (zh) * 2017-05-12 2020-03-06 国立研究开发法人理化学研究所 A类gpcr结合性化合物改性体
RU2704967C1 (ru) * 2018-06-19 2019-11-01 Федеральное государственное бюджетное образовательное учреждение высшего образования "Ярославский государственный педагогический университет им. К.Д. Ушинского (ЯГПУ им. К.Д. Ушинского) Карбоксамидные производные изоксазолина, способ их получения и применения для лечения воспалительных заболеваний

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9110858D0 (en) * 1991-05-20 1991-07-10 Shell Int Research Herbicidal compounds
NZ276631A (en) * 1993-11-24 1997-06-24 Du Pont Merck Pharma Isoxazoline derivatives and medicaments
EP0730590B1 (de) * 1993-11-24 2001-01-17 Dupont Pharmaceuticals Company Isoxazoline und isoxazole derivate als fibrinogen rezeptor antagonisten

Also Published As

Publication number Publication date
DE69632548T2 (de) 2005-06-02
HRP960597A2 (en) 1998-04-30
EP0874629A4 (de) 1999-08-04
JP2001502655A (ja) 2001-02-27
AU1335897A (en) 1997-07-17
EP0874629B1 (de) 2004-05-19
CA2240946A1 (en) 1997-07-03
ES2219706T3 (es) 2004-12-01
ATE267011T1 (de) 2004-06-15
WO1997023212A1 (en) 1997-07-03
EP0874629A1 (de) 1998-11-04
CA2240946C (en) 2002-09-10

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Legal Events

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