WO2000008005A3 - Piperazinonderivate - Google Patents

Piperazinonderivate Download PDF

Info

Publication number
WO2000008005A3
WO2000008005A3 PCT/EP1999/005070 EP9905070W WO0008005A3 WO 2000008005 A3 WO2000008005 A3 WO 2000008005A3 EP 9905070 W EP9905070 W EP 9905070W WO 0008005 A3 WO0008005 A3 WO 0008005A3
Authority
WO
WIPO (PCT)
Prior art keywords
derivatives
piperazinone derivatives
piperazinone
solvates
inhibitors
Prior art date
Application number
PCT/EP1999/005070
Other languages
English (en)
French (fr)
Other versions
WO2000008005A2 (de
Inventor
Joachim Di Gante
Dieter Dorsch
Horst Juraszyk
Werner Mederski
Hanns Wurziger
Hans-Peter Buchstaller
Sabine Bernotat-Danielowski
Guido Melzer
Original Assignee
Merck Patent Gmbh
Gante Helga Hf
Dieter Dorsch
Horst Juraszyk
Werner Mederski
Hanns Wurziger
Buchstaller Hans Peter
Bernotat Danielowski Sabine
Guido Melzer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh, Gante Helga Hf, Dieter Dorsch, Horst Juraszyk, Werner Mederski, Hanns Wurziger, Buchstaller Hans Peter, Bernotat Danielowski Sabine, Guido Melzer filed Critical Merck Patent Gmbh
Priority to AU54114/99A priority Critical patent/AU5411499A/en
Publication of WO2000008005A2 publication Critical patent/WO2000008005A2/de
Publication of WO2000008005A3 publication Critical patent/WO2000008005A3/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Neue Piperazinonderivate der Formel (I), worin R?1, R2, R3, R4, R5, R6, R7, R8¿, W und X die in Patentanspruch (1) angegebene Bedeutung haben, sowie deren Salze und Solvate sind Inhibitoren des Koagulationsfaktors Xa und können zur Prophylaxe und/oder Therapie von thromboembolischen Erkrankungen eingesetzt werden.
PCT/EP1999/005070 1998-08-08 1999-07-16 Piperazinonderivate WO2000008005A2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU54114/99A AU5411499A (en) 1998-08-08 1999-07-16 Piperazinone derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19835950.0 1998-08-08
DE19835950A DE19835950A1 (de) 1998-08-08 1998-08-08 Piperazinonderivate

Publications (2)

Publication Number Publication Date
WO2000008005A2 WO2000008005A2 (de) 2000-02-17
WO2000008005A3 true WO2000008005A3 (de) 2000-05-18

Family

ID=7876912

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/005070 WO2000008005A2 (de) 1998-08-08 1999-07-16 Piperazinonderivate

Country Status (4)

Country Link
AR (1) AR020124A1 (de)
AU (1) AU5411499A (de)
DE (1) DE19835950A1 (de)
WO (1) WO2000008005A2 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010034442A (ko) * 1998-01-27 2001-04-25 아벤티스 파마슈티칼즈 프로덕츠 인코포레이티드 치환된 옥소아자헤테로사이클릴 인자 Ｘａ 억제제
AU2002211280A1 (en) * 2000-09-29 2002-04-08 Cor Therapeutics, Inc. Piperazin-2-one amides as inhibitors of factor Xa
WO2004032871A2 (en) * 2002-10-09 2004-04-22 Millennium Pharmaceuticals, Inc. Piperazine and piperazinone inhibitors of factor xa
US7479502B2 (en) 2002-12-03 2009-01-20 Pharmacyclics, Inc. 2-(2-hydroxybiphenyl-3-yl)-1H-benzoimidazole-5-carboxamidine derivatives as factor VIIA inhibitors

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0608759A2 (de) * 1993-01-29 1994-08-03 MERCK PATENT GmbH Piperazinderivate
EP0623615A1 (de) * 1993-05-01 1994-11-09 MERCK PATENT GmbH Adhäsionsrezeptor -Antagonisten
WO1996010022A1 (en) * 1994-09-26 1996-04-04 Zeneca Limited Aminoheterocyclic derivatives as antithrombotic or anticoagulant agents
WO1997008165A1 (de) * 1995-08-23 1997-03-06 Boehringer Mannheim Gmbh Neue cyclische guanidine, verfahren zu ihrer herstellung und arzneimittel
EP0765660A2 (de) * 1995-09-28 1997-04-02 Takeda Chemical Industries, Ltd. Mikrokapseln enthaltend 2-Piperazinon-1-essigsäure Verbindungen
WO1998009987A1 (en) * 1996-09-06 1998-03-12 Biochem Pharma, Inc. Lactam inhibitors of thrombin

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0608759A2 (de) * 1993-01-29 1994-08-03 MERCK PATENT GmbH Piperazinderivate
EP0623615A1 (de) * 1993-05-01 1994-11-09 MERCK PATENT GmbH Adhäsionsrezeptor -Antagonisten
WO1996010022A1 (en) * 1994-09-26 1996-04-04 Zeneca Limited Aminoheterocyclic derivatives as antithrombotic or anticoagulant agents
WO1997008165A1 (de) * 1995-08-23 1997-03-06 Boehringer Mannheim Gmbh Neue cyclische guanidine, verfahren zu ihrer herstellung und arzneimittel
EP0765660A2 (de) * 1995-09-28 1997-04-02 Takeda Chemical Industries, Ltd. Mikrokapseln enthaltend 2-Piperazinon-1-essigsäure Verbindungen
WO1998009987A1 (en) * 1996-09-06 1998-03-12 Biochem Pharma, Inc. Lactam inhibitors of thrombin

Also Published As

Publication number Publication date
AU5411499A (en) 2000-02-28
AR020124A1 (es) 2002-04-10
WO2000008005A2 (de) 2000-02-17
DE19835950A1 (de) 2000-02-10

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