WO1999020606A3 - Piperidines and piperazines as platelet aggregation inhibitors - Google Patents
Piperidines and piperazines as platelet aggregation inhibitors Download PDFInfo
- Publication number
- WO1999020606A3 WO1999020606A3 PCT/EP1998/006751 EP9806751W WO9920606A3 WO 1999020606 A3 WO1999020606 A3 WO 1999020606A3 EP 9806751 W EP9806751 W EP 9806751W WO 9920606 A3 WO9920606 A3 WO 9920606A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- platelet aggregation
- piperazines
- piperidines
- aggregation inhibitors
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU21513/99A AU2151399A (en) | 1997-10-23 | 1998-10-23 | Novel piperidines and piperazines as platelet aggregation inhibitors |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ESP9702188 | 1997-10-23 | ||
ES9702188 | 1997-10-23 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1999020606A2 WO1999020606A2 (en) | 1999-04-29 |
WO1999020606A3 true WO1999020606A3 (en) | 1999-07-29 |
Family
ID=8300941
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1998/006751 WO1999020606A2 (en) | 1997-10-23 | 1998-10-23 | Piperidines and piperazines as platelet aggregation inhibitors |
Country Status (3)
Country | Link |
---|---|
AR (1) | AR013693A1 (en) |
AU (1) | AU2151399A (en) |
WO (1) | WO1999020606A2 (en) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2380817A1 (en) * | 1999-08-13 | 2001-02-22 | Biogen, Inc. | Cell adhesion inhibitors |
GB0001930D0 (en) | 2000-01-27 | 2000-03-22 | Novartis Ag | Organic compounds |
TWI290136B (en) | 2000-04-05 | 2007-11-21 | Daiichi Seiyaku Co | Ethylenediamine derivatives |
US20030105144A1 (en) | 2001-04-17 | 2003-06-05 | Ping Gao | Stabilized oral pharmaceutical composition |
WO2003000657A1 (en) | 2001-06-20 | 2003-01-03 | Daiichi Pharmaceutical Co., Ltd. | Diamine derivatives |
EP1830837B1 (en) | 2004-09-20 | 2013-09-04 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes |
AU2005286648A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
AR051090A1 (en) | 2004-09-20 | 2006-12-20 | Xenon Pharmaceuticals Inc | HETEROCICLIC DERIVATIVES AND THEIR USE AS INHIBITORS OF ESTEAROIL-COA DESATURASA |
AU2005286728A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase |
MX2007003325A (en) | 2004-09-20 | 2007-06-05 | Xenon Pharmaceuticals Inc | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors. |
BRPI0515482A (en) | 2004-09-20 | 2008-07-22 | Xenon Pharmaceuticals Inc | heterocyclic derivatives and their uses as therapeutic agents |
AR051094A1 (en) | 2004-09-20 | 2006-12-20 | Xenon Pharmaceuticals Inc | HETEROCICLIC DERIVATIVES AND THEIR USE AS INHIBITORS OF ESTEAROIL-COA DESATURASA |
KR20070107040A (en) | 2005-02-16 | 2007-11-06 | 쉐링 코포레이션 | Heteroaryl substituted pyrazinyl-piperazine-piperidlnes with cxcr3 antagonist activity |
KR20070107075A (en) | 2005-02-16 | 2007-11-06 | 쉐링 코포레이션 | Novel heterocyclic substituted pyridine or phenyl compounds with cxcr3 antagonist activity |
US7868005B2 (en) | 2005-02-16 | 2011-01-11 | Schering Corporation | Pyrazinyl substituted piperazine-piperidines with CXCR3 antagonist activity |
CA2598456A1 (en) | 2005-02-16 | 2006-08-24 | Schering Corporation | Heterocyclic substituted piperazines with cxcr3 antagonist activity |
CN101189238A (en) | 2005-02-16 | 2008-05-28 | 先灵公司 | Piperazine-piperidines with CXCR3 antagonist activity |
CN101213185A (en) | 2005-02-16 | 2008-07-02 | 先灵公司 | Pyridyl and phenyl substituted piperazine-piperidines with CXCR3 antagonist activity |
JP2009513563A (en) | 2005-06-03 | 2009-04-02 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | Aminothiazole derivatives as human stearoyl-CoA desaturase inhibitors |
US7671221B2 (en) | 2005-12-28 | 2010-03-02 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-Binding Cassette transporters |
WO2007087066A2 (en) | 2005-12-28 | 2007-08-02 | Vertex Pharmaceuticals Incorporated | 1-(benzo [d] [1,3] di0x0l-5-yl) -n- (phenyl) cyclopropane- carboxamide derivatives and related compounds as modulators of atp-binding cassette transporters for the treatment of cystic fibrosis |
AR059224A1 (en) * | 2006-01-31 | 2008-03-19 | Jerini Ag | COMPOUNDS FOR THE INHIBITION OF INTEGRINS AND USE OF THESE |
WO2007109238A1 (en) | 2006-03-21 | 2007-09-27 | Schering Corporation | Heterocyclic substituted pyridine compounds with cxcr3 antagonist activity |
KR20090043512A (en) | 2006-07-14 | 2009-05-06 | 쉐링 코포레이션 | Heterocyclic substituted piperazine compounds with cxcr3 antagonist activity |
WO2008076243A2 (en) | 2006-12-14 | 2008-06-26 | Merck & Co., Inc. | Acyl bipiperidinyl compounds, compositions containing such compounds and methods of treatment |
US9181226B2 (en) * | 2011-07-18 | 2015-11-10 | Merck Patent Gmbh | Benzamides |
CN106543089A (en) * | 2016-11-04 | 2017-03-29 | 山东铂源药业有限公司 | A kind of synthetic method of Dasatinib intermediate |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0441226A1 (en) * | 1990-01-29 | 1991-08-14 | J. URIACH & CIA. S.A. | (cyanomethyl)pyridines useful as PAF antagonists |
EP0528172A1 (en) * | 1991-08-08 | 1993-02-24 | J. URIACH & CIA. S.A. | (2-Alkyl-3-pyridyl)methylpiperazine derivatives as PAF antagonists |
EP0542363A2 (en) * | 1991-11-14 | 1993-05-19 | Glaxo Group Limited | Piperidineacetic acid derivatives as inhibitors of fibrinogen-dependent blood platelet aggregation |
WO1993014077A1 (en) * | 1992-01-21 | 1993-07-22 | Glaxo Group Limited | Piperidineacetic acid derivatives as inhibitors of fibrinogen-dependent blood platelet aggregation |
EP0560669A1 (en) * | 1992-03-11 | 1993-09-15 | Bristol-Myers Squibb Company | Piperazinyl-and piperidinyl-cyclohexenes and cyclohexanes |
US5563141A (en) * | 1993-03-29 | 1996-10-08 | Zeneca Limited | Heterocyclic compounds |
DE19524765A1 (en) * | 1995-07-07 | 1997-01-09 | Boehringer Mannheim Gmbh | New oxazolidinone derivatives, processes for their preparation and medicaments containing these compounds |
WO1997002245A1 (en) * | 1995-07-06 | 1997-01-23 | Japan Tobacco Inc. | Benzamidoxime derivatives and medicinal use thereof |
WO1997026258A1 (en) * | 1996-01-15 | 1997-07-24 | Janssen Pharmaceutica N.V. | Angiogenesis inhibiting pyridazinamines |
-
1998
- 1998-10-15 AR ARP980105142 patent/AR013693A1/en unknown
- 1998-10-23 AU AU21513/99A patent/AU2151399A/en not_active Abandoned
- 1998-10-23 WO PCT/EP1998/006751 patent/WO1999020606A2/en active Application Filing
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0441226A1 (en) * | 1990-01-29 | 1991-08-14 | J. URIACH & CIA. S.A. | (cyanomethyl)pyridines useful as PAF antagonists |
EP0528172A1 (en) * | 1991-08-08 | 1993-02-24 | J. URIACH & CIA. S.A. | (2-Alkyl-3-pyridyl)methylpiperazine derivatives as PAF antagonists |
EP0542363A2 (en) * | 1991-11-14 | 1993-05-19 | Glaxo Group Limited | Piperidineacetic acid derivatives as inhibitors of fibrinogen-dependent blood platelet aggregation |
WO1993014077A1 (en) * | 1992-01-21 | 1993-07-22 | Glaxo Group Limited | Piperidineacetic acid derivatives as inhibitors of fibrinogen-dependent blood platelet aggregation |
EP0560669A1 (en) * | 1992-03-11 | 1993-09-15 | Bristol-Myers Squibb Company | Piperazinyl-and piperidinyl-cyclohexenes and cyclohexanes |
US5352678A (en) * | 1992-03-11 | 1994-10-04 | Bristol-Myers Squibb Co. | Antiischemic piperazinyl- and piperidinyl-cyclohexanes |
US5563141A (en) * | 1993-03-29 | 1996-10-08 | Zeneca Limited | Heterocyclic compounds |
WO1997002245A1 (en) * | 1995-07-06 | 1997-01-23 | Japan Tobacco Inc. | Benzamidoxime derivatives and medicinal use thereof |
DE19524765A1 (en) * | 1995-07-07 | 1997-01-09 | Boehringer Mannheim Gmbh | New oxazolidinone derivatives, processes for their preparation and medicaments containing these compounds |
WO1997026258A1 (en) * | 1996-01-15 | 1997-07-24 | Janssen Pharmaceutica N.V. | Angiogenesis inhibiting pyridazinamines |
Non-Patent Citations (1)
Title |
---|
L. ALIG ET AL.: "Low Molecular Weight, Non-peptide Fibrinogen Receptor Antagonists", J. MED. CHEM., vol. 35, no. 23, 1992, pages 4393 - 4407, XP000561169 * |
Also Published As
Publication number | Publication date |
---|---|
AU2151399A (en) | 1999-05-10 |
AR013693A1 (en) | 2001-01-10 |
WO1999020606A2 (en) | 1999-04-29 |
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