AR013693A1 - NEW PIPERIDINES AND PIPERAZINAS AS INHIBITORS OF THE PLAQUETARY AGREGATION - Google Patents

NEW PIPERIDINES AND PIPERAZINAS AS INHIBITORS OF THE PLAQUETARY AGREGATION

Info

Publication number
AR013693A1
AR013693A1 ARP980105142A AR013693A1 AR 013693 A1 AR013693 A1 AR 013693A1 AR P980105142 A ARP980105142 A AR P980105142A AR 013693 A1 AR013693 A1 AR 013693A1
Authority
AR
Argentina
Prior art keywords
alkyl
plaquetary
piperazinas
agregation
inhibitors
Prior art date
Application number
Other languages
Spanish (es)
Original Assignee
Uriach & Cia Sa J
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uriach & Cia Sa J filed Critical Uriach & Cia Sa J
Publication of AR013693A1 publication Critical patent/AR013693A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

Compuestos de formula (I) donde: uno de X1 o X2 representa C sustituido por R1 y el otro representa CR2 o N, y los restantes grupos X3, X4 y X5representan CR2 o N, con la condicion de que el anillo puede contener como máximo 2 átomos de N; R1 representa un grupo de formula (i); R2 representahidrogeno, halogeno, C1-6 alquilo, C2-6 alquenilo, C2-6 alquinilo, C1-6 alcoxi, C1-6 haloalquilo, C3-7 cicloalquilo C0-4 alquilo, aril C0-4 alquilo,heteroaril C0-4 alquilo, ciano, nitro, R3R4N C0-4 alquilo, R5SO2NR3 C0-4 alquilo, R5CONR3 C0-4 alquilo, R5OCONR3 C0-4 alquilo, R3R4NCONR3 C0-4 alquilo,R5SOq C0-4 alquilo, R3R4NSO2 C0-4 alquilo, R3R4NCO C0-4 alquilo, R5CO C0-4 alquilo, HOOC C0-4 alquilo, R5OOC C0-4 alquilo, hidroxi C0-4 alquilo o R5OC0-4 alquilo; m representa 0 o 1; A representa un grupo -CONR3-, -CSNR3-, -SO2NR3-, -NR3CO-, -NR3CS-, -NR3SO2-, -NR3COO-, -OCONR3- o -NR3CONR3-; Brepresenta C1-5 alquileno que puede estar opcionalmente sustituido; y D representa carboxi o un éster o amida metabolicamente lábil del mismo. Estoscompuestos son utiles como antiagregantes plaquetarios.Compounds of formula (I) where: one of X1 or X2 represents C substituted by R1 and the other represents CR2 or N, and the remaining groups X3, X4 and X5 represent CR2 or N, with the proviso that the ring may contain at most 2 atoms of N; R1 represents a group of formula (i); R2 represents hydrogen, halogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, C1-6 haloalkyl, C3-7 cycloalkyl C0-4 alkyl, aryl C0-4 alkyl, heteroaryl C0-4 alkyl , cyano, nitro, R3R4N C0-4 alkyl, R5SO2NR3 C0-4 alkyl, R5CONR3 C0-4 alkyl, R5OCONR3 C0-4 alkyl, R3R4NCONR3 C0-4 alkyl, R5SOq C0-4 alkyl, R3R4NSO2 C0-4 alkyl, R3R4NCO C0- 4 alkyl, R5CO C0-4 alkyl, HOOC C0-4 alkyl, R5OOC C0-4 alkyl, hydroxy C0-4 alkyl or R5OC0-4 alkyl; m represents 0 or 1; A represents a group -CONR3-, -CSNR3-, -SO2NR3-, -NR3CO-, -NR3CS-, -NR3SO2-, -NR3COO-, -OCONR3- or -NR3CONR3-; Brepresenta C1-5 alkylene which may be optionally substituted; and D represents carboxy or a metabolically labile ester or amide thereof. These compounds are useful as platelet antiaggregants.

ARP980105142 1997-10-23 1998-10-15 NEW PIPERIDINES AND PIPERAZINAS AS INHIBITORS OF THE PLAQUETARY AGREGATION AR013693A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9702188 1997-10-23

Publications (1)

Publication Number Publication Date
AR013693A1 true AR013693A1 (en) 2001-01-10

Family

ID=8300941

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP980105142 AR013693A1 (en) 1997-10-23 1998-10-15 NEW PIPERIDINES AND PIPERAZINAS AS INHIBITORS OF THE PLAQUETARY AGREGATION

Country Status (3)

Country Link
AR (1) AR013693A1 (en)
AU (1) AU2151399A (en)
WO (1) WO1999020606A2 (en)

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SK287075B6 (en) * 1999-08-13 2009-11-05 Biogen Idec Ma Inc. Cell adhesion inhibitors and pharmaceutical compositions comprising them
GB0001930D0 (en) 2000-01-27 2000-03-22 Novartis Ag Organic compounds
TWI288745B (en) 2000-04-05 2007-10-21 Daiichi Seiyaku Co Ethylenediamine derivatives
US20030105144A1 (en) 2001-04-17 2003-06-05 Ping Gao Stabilized oral pharmaceutical composition
WO2003000657A1 (en) 2001-06-20 2003-01-03 Daiichi Pharmaceutical Co., Ltd. Diamine derivatives
TW200626155A (en) 2004-09-20 2006-08-01 Xenon Pharmaceuticals Inc Heterocyclic derivatives and their use as therapeutic agents
BRPI0515482A (en) 2004-09-20 2008-07-22 Xenon Pharmaceuticals Inc heterocyclic derivatives and their uses as therapeutic agents
TW200626138A (en) 2004-09-20 2006-08-01 Xenon Pharmaceuticals Inc Heterocyclic derivatives and their use as therapeutic agents
AU2005286647A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
CA2580856A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
AU2005286793A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-CoA desaturase enzymes
EP1799668A1 (en) 2004-09-20 2007-06-27 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as mediators of stearoyl-coa desaturase
AU2006214480A1 (en) 2005-02-16 2006-08-24 Pharmacopeia, Inc. Novel heterocyclic substituted pyridine or phenyl compounds with CXCR3 antagonist activity
JP2008530220A (en) 2005-02-16 2008-08-07 シェーリング コーポレイション Pyrazinyl-substituted piperazine-piperidine having CXCR3 antagonist activity
MX2007009945A (en) 2005-02-16 2007-09-26 Schering Corp Heterocyclic substituted piperazines with cxcr3 antagonist activity.
WO2006088836A2 (en) 2005-02-16 2006-08-24 Schering Corporation Piperazine-piperidines with cxcr3 antagonist activity
MX2007009946A (en) 2005-02-16 2007-09-26 Schering Corp Pyridyl and phenyl substituted piperazine-piperidines with cxcr3 antagonist activity.
KR20070107040A (en) 2005-02-16 2007-11-06 쉐링 코포레이션 Heteroaryl substituted pyrazinyl-piperazine-piperidlnes with cxcr3 antagonist activity
CA2618646A1 (en) 2005-06-03 2007-11-15 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
EP2016065B1 (en) 2005-12-28 2012-09-19 Vertex Pharmaceuticals Incorporated 1-(benzo[d][1,3]dioxol-5-yl)-n-(phenyl)cyclopropane-carboxamide derivatives and related compounds as modulators of atp-binding cassette transporters for the treatment of cystic fibrosis
US7671221B2 (en) 2005-12-28 2010-03-02 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
AR059224A1 (en) * 2006-01-31 2008-03-19 Jerini Ag COMPOUNDS FOR THE INHIBITION OF INTEGRINS AND USE OF THESE
PE20071144A1 (en) 2006-03-21 2008-01-10 Schering Corp HETEROCYCLIC COMPOUNDS OF PYRIDINE SUBSTITUTED AS ANTAGONISTS OF α-CHEMOKIN RECEPTOR 3 (CXCR3)
WO2008008453A1 (en) 2006-07-14 2008-01-17 Schering Corporation Heterocyclic substituted piperazine compounds with cxcr3 antagonist activity
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EP2734517B1 (en) 2011-07-18 2017-08-30 Merck Patent GmbH Benzamides
CN106543089A (en) * 2016-11-04 2017-03-29 山东铂源药业有限公司 A kind of synthetic method of Dasatinib intermediate

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Also Published As

Publication number Publication date
WO1999020606A2 (en) 1999-04-29
AU2151399A (en) 1999-05-10
WO1999020606A3 (en) 1999-07-29

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