AR012443A1 - NEW CARBOXAMIDS AS INHIBITORS OF THE PLATELET AGGREGATION, PROCEDURE FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND USE OF THE SAME IN THE MANUFACTURE OF MEDICINES - Google Patents
NEW CARBOXAMIDS AS INHIBITORS OF THE PLATELET AGGREGATION, PROCEDURE FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND USE OF THE SAME IN THE MANUFACTURE OF MEDICINESInfo
- Publication number
- AR012443A1 AR012443A1 ARP980101743A AR012443A1 AR 012443 A1 AR012443 A1 AR 012443A1 AR P980101743 A ARP980101743 A AR P980101743A AR 012443 A1 AR012443 A1 AR 012443A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- 4alkyl
- formula
- group
- carboxamids
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compuestos de formula I donde: uno de Y1 o Y2 representa N y el otro representa NR5, O o S, o bien uno de Y1 o Y2 representa S y el otro representaCR5, donde R5 representa hidrogeno o C1-4 alquilo; m representa 0, 1 o 2; R1 y R3 representa hidrogeno, C1-6 alquilo, C2-6 alquenilo, C2-6 alquinilo, C1-6alcoxi, C1-6 haloalquilo, C3-7 cicloalquilo, C3-7 cicloalquilC1-4 alquilo, arilo, arilC1-4 alquilo, arilC1-4 alcoxi, arilC3-7 cicloalquilo, heteroarilo,heteroarilC1-4 alquilo, R6SO2NR2-,R6CONR2-, R6OCONR2-, R2R7NCONR2-, R2R7N-, R6SO2NR2C1-4 alquilo, R6CONR2C1-4 alquilo, R6OCONR2C1-4 alquilo-R2R7NCONR2C1-4 alquilo, R6SO2C1-4 alquilo, R2R7NSO2C1-4 alquilo, R2R7NCOC1-4 alquilo, R6COC1-4 alquilo, R7OOCC1-4 alquilo, R6OC1-4 alquilo, o R2R7NC1-4alquilo; A representa CO-2 alquileno opcionalmente sustituido; R2 representa hidrogeno n C1-4 alquilo; B representa carboxi o un éster o amidametabolicamente lábil del mismos; y R4 representa un grupo de formula (i) o (ii). R6 representa C1-6 alquilo, C2-6 alquenilo, C2-6 alquinilo, C1-6haloalquilo, C1-4 alcoxiC1-4 alquilo, C1-7 cicloalquilo, C3-7 cicloalquilC1-4 alquilo, arilo, arilC1-4, alquilo, arilcarboniloC1-4, alquilo, heteroarilo, oheteroalrilC1-4, alquilo, R7 representa halogeno o cualquiera de los significados descitos para R6, R8 representa halogeno o C1-4 alquilo; prepresenta 1 o 2. X1 representa un grupo de formula: N,CH>N-CH2-, o >CH-CH2-; X2 representa un grupo de formula: N,CH-CH2-N<, -CH2-<CH,-NH-<CH o -O-<CH;X3 representa N o CH, con la condicion de que cuando X3 sea N no puede ser un grupo: N, -CH2-<N, -NH-<CH o -O-<CH; uno de Z1 o Z2 representa Z y el otrorepresenta CH2, con la condicion de que cuando X3 representa N, entonces Z2ha de ser CH2; Z representa un grupo de formula: HN<, C1-6 alquilo <N.Compounds of formula I where: one of Y1 or Y2 represents N and the other represents NR5, O or S, or one of Y1 or Y2 represents S and the other represents CR5, where R5 represents hydrogen or C1-4 alkyl; m represents 0, 1 or 2; R1 and R3 represent hydrogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6alkoxy, C1-6haloalkyl, C3-7cycloalkyl, C3-7cycloalkylC1-4alkyl, aryl, arylC1-4alkyl, arylC1-4alkoxy, arylC3-7 cycloalkyl, heteroaryl, heteroarylC1-4alkyl, R6SO2NR2-, R6CONR2-, R6OCONR2-, R2R7NCONR2-, R2R7N-, R6SO2NR2C1-4R2C2R2C1R2C1R2C1R2C2 alkyl, R6SO2C1-4 alkyl, R2R7NSO2C1-4 alkyl, R2R7NCOC1-4 alkyl, R6COC1-4 alkyl, R7OOCC1-4 alkyl, R6OC1-4 alkyl, or R2R7NC1-4alkyl; A represents CO-2 optionally substituted alkylene; R2 represents hydrogen n C1-4 alkyl; B represents carboxy or an ester or amidametabolically labile thereof; and R4 represents a group of formula (i) or (ii). R6 represents C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6haloalkyl, C1-4alkoxyC1-4alkyl, C1-7cycloalkyl, C3-7cycloalkylC1-4alkyl, aryl, arylC1-4alkyl, C 1-4 arylcarbonyl, alkyl, heteroaryl, C 1-4 heteroaryl, alkyl, R7 represents halogen or any of the meanings for R6, R8 represents halogen or C1-4 alkyl; it represents 1 or 2. X1 represents a group of formula: N, CH> N-CH2-, or> CH-CH2-; X2 represents a group of the formula: N, CH-CH2-N <, -CH2- <CH, -NH- <CH or -O- <CH; X3 represents N or CH, with the proviso that when X3 is N there is no it can be a group: N, -CH2- <N, -NH- <CH or -O- <CH; one of Z1 or Z2 represents Z and the other represents CH2, with the proviso that when X3 represents N, then Z2 must be CH2; Z represents a group of the formula: HN <, C1-6 alkyl <N.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9700807 | 1997-04-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR012443A1 true AR012443A1 (en) | 2000-10-18 |
Family
ID=8298973
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP980101743 AR012443A1 (en) | 1997-04-16 | 1998-04-15 | NEW CARBOXAMIDS AS INHIBITORS OF THE PLATELET AGGREGATION, PROCEDURE FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND USE OF THE SAME IN THE MANUFACTURE OF MEDICINES |
Country Status (3)
Country | Link |
---|---|
AR (1) | AR012443A1 (en) |
AU (1) | AU7526398A (en) |
WO (1) | WO1998046599A1 (en) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI288745B (en) * | 2000-04-05 | 2007-10-21 | Daiichi Seiyaku Co | Ethylenediamine derivatives |
DE10029077A1 (en) * | 2000-06-13 | 2001-12-20 | Bayer Ag | New heterocyclic-substituted thiazole derivatives, useful as total or selective herbicides, insecticides, acaricides, nematocides, ectoparasiticides or antifouling agents |
US7115652B2 (en) | 2002-06-17 | 2006-10-03 | Sunesis Pharmaceuticals, Inc. | Aspartyl protease inhibitors |
AU2003276047A1 (en) | 2002-06-17 | 2003-12-31 | Sunesis Pharmaceuticals, Inc. | Aspartyl protease inhibitors |
GB0230162D0 (en) * | 2002-12-24 | 2003-02-05 | Metris Therapeutics Ltd | Compounds useful in inhibiting angiogenesis |
ES2383525T3 (en) | 2003-11-05 | 2012-06-21 | Sarcode Bioscience Inc. | Cell adhesion modulators |
JP2007531773A (en) | 2004-03-31 | 2007-11-08 | レキシコン・ジェネティクス・インコーポレーテッド | 2-Aminomethylthiazole-5-carboxamide as a protein kinase modulator |
WO2006125119A1 (en) | 2005-05-17 | 2006-11-23 | Sarcode Corporation | Compositions and methods for treatment of eye disorders |
GB0518494D0 (en) * | 2005-09-09 | 2005-10-19 | Argenta Discovery Ltd | Thiazole compounds |
EP2112880A4 (en) * | 2006-12-14 | 2011-12-21 | Merck Sharp & Dohme | Acyl bipiperidinyl compounds, compositions containing such compounds and methods of treatment |
CA3105972A1 (en) | 2007-10-19 | 2009-04-30 | Novartis Ag | Compositions and methods for treatment of diabetic retinopathy |
WO2009139817A2 (en) | 2008-04-15 | 2009-11-19 | Sarcode Corporation | Crystalline pharmaceutical and methods of preparation and use thereof |
WO2011050175A1 (en) | 2009-10-21 | 2011-04-28 | Sarcode Corporation | Crystalline pharmaceutical and methods of preparation and use thereof |
AU2011276539A1 (en) * | 2010-06-28 | 2013-02-07 | President And Fellows Of Harvard College | Compounds for the inhibition of cellular proliferation |
KR102157608B1 (en) | 2012-07-25 | 2020-09-18 | 에스에이알코드 바이오사이언스 인코포레이티드 | Lfa-1 inhibitor and polymorph thereof |
WO2014122474A1 (en) | 2013-02-07 | 2014-08-14 | Takeda Pharmaceutical Company Limited | Piperidin-1 -yl and azepin-1 -yl carboxylates as muscarinic m4 receptor agonists |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4124942A1 (en) * | 1991-07-27 | 1993-01-28 | Thomae Gmbh Dr K | 5-LOW HETEROCYCLES, METHOD FOR THE PRODUCTION THEREOF AND MEDICAMENTS CONTAINING SUCH COMPOUNDS |
WO1994002472A1 (en) * | 1992-07-15 | 1994-02-03 | Taisho Pharmaceutical Co., Ltd. | Thiazoline derivative |
GB9406144D0 (en) * | 1993-03-29 | 1994-05-18 | Zeneca Ltd | Heterocyclic compounds |
DE19524765A1 (en) * | 1995-07-07 | 1997-01-09 | Boehringer Mannheim Gmbh | New oxazolidinone derivatives, processes for their preparation and medicaments containing these compounds |
-
1998
- 1998-04-15 AR ARP980101743 patent/AR012443A1/en unknown
- 1998-04-16 WO PCT/EP1998/002226 patent/WO1998046599A1/en active Application Filing
- 1998-04-16 AU AU75263/98A patent/AU7526398A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU7526398A (en) | 1998-11-11 |
WO1998046599A1 (en) | 1998-10-22 |
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