AR012443A1 - NEW CARBOXAMIDS AS INHIBITORS OF THE PLATELET AGGREGATION, PROCEDURE FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND USE OF THE SAME IN THE MANUFACTURE OF MEDICINES - Google Patents

NEW CARBOXAMIDS AS INHIBITORS OF THE PLATELET AGGREGATION, PROCEDURE FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND USE OF THE SAME IN THE MANUFACTURE OF MEDICINES

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Publication number
AR012443A1
AR012443A1 ARP980101743A AR012443A1 AR 012443 A1 AR012443 A1 AR 012443A1 AR P980101743 A ARP980101743 A AR P980101743A AR 012443 A1 AR012443 A1 AR 012443A1
Authority
AR
Argentina
Prior art keywords
alkyl
4alkyl
formula
group
carboxamids
Prior art date
Application number
Other languages
Spanish (es)
Original Assignee
Uriach & Cia Sa J
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uriach & Cia Sa J filed Critical Uriach & Cia Sa J
Publication of AR012443A1 publication Critical patent/AR012443A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compuestos de formula I donde: uno de Y1 o Y2 representa N y el otro representa NR5, O o S, o bien uno de Y1 o Y2 representa S y el otro representaCR5, donde R5 representa hidrogeno o C1-4 alquilo; m representa 0, 1 o 2; R1 y R3 representa hidrogeno, C1-6 alquilo, C2-6 alquenilo, C2-6 alquinilo, C1-6alcoxi, C1-6 haloalquilo, C3-7 cicloalquilo, C3-7 cicloalquilC1-4 alquilo, arilo, arilC1-4 alquilo, arilC1-4 alcoxi, arilC3-7 cicloalquilo, heteroarilo,heteroarilC1-4 alquilo, R6SO2NR2-,R6CONR2-, R6OCONR2-, R2R7NCONR2-, R2R7N-, R6SO2NR2C1-4 alquilo, R6CONR2C1-4 alquilo, R6OCONR2C1-4 alquilo-R2R7NCONR2C1-4 alquilo, R6SO2C1-4 alquilo, R2R7NSO2C1-4 alquilo, R2R7NCOC1-4 alquilo, R6COC1-4 alquilo, R7OOCC1-4 alquilo, R6OC1-4 alquilo, o R2R7NC1-4alquilo; A representa CO-2 alquileno opcionalmente sustituido; R2 representa hidrogeno n C1-4 alquilo; B representa carboxi o un éster o amidametabolicamente lábil del mismos; y R4 representa un grupo de formula (i) o (ii). R6 representa C1-6 alquilo, C2-6 alquenilo, C2-6 alquinilo, C1-6haloalquilo, C1-4 alcoxiC1-4 alquilo, C1-7 cicloalquilo, C3-7 cicloalquilC1-4 alquilo, arilo, arilC1-4, alquilo, arilcarboniloC1-4, alquilo, heteroarilo, oheteroalrilC1-4, alquilo, R7 representa halogeno o cualquiera de los significados descitos para R6, R8 representa halogeno o C1-4 alquilo; prepresenta 1 o 2. X1 representa un grupo de formula: N,CH>N-CH2-, o >CH-CH2-; X2 representa un grupo de formula: N,CH-CH2-N<, -CH2-<CH,-NH-<CH o -O-<CH;X3 representa N o CH, con la condicion de que cuando X3 sea N no puede ser un grupo: N, -CH2-<N, -NH-<CH o -O-<CH; uno de Z1 o Z2 representa Z y el otrorepresenta CH2, con la condicion de que cuando X3 representa N, entonces Z2ha de ser CH2; Z representa un grupo de formula: HN<, C1-6 alquilo <N.Compounds of formula I where: one of Y1 or Y2 represents N and the other represents NR5, O or S, or one of Y1 or Y2 represents S and the other represents CR5, where R5 represents hydrogen or C1-4 alkyl; m represents 0, 1 or 2; R1 and R3 represent hydrogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6alkoxy, C1-6haloalkyl, C3-7cycloalkyl, C3-7cycloalkylC1-4alkyl, aryl, arylC1-4alkyl, arylC1-4alkoxy, arylC3-7 cycloalkyl, heteroaryl, heteroarylC1-4alkyl, R6SO2NR2-, R6CONR2-, R6OCONR2-, R2R7NCONR2-, R2R7N-, R6SO2NR2C1-4R2C2R2C1R2C1R2C1R2C2 alkyl, R6SO2C1-4 alkyl, R2R7NSO2C1-4 alkyl, R2R7NCOC1-4 alkyl, R6COC1-4 alkyl, R7OOCC1-4 alkyl, R6OC1-4 alkyl, or R2R7NC1-4alkyl; A represents CO-2 optionally substituted alkylene; R2 represents hydrogen n C1-4 alkyl; B represents carboxy or an ester or amidametabolically labile thereof; and R4 represents a group of formula (i) or (ii). R6 represents C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6haloalkyl, C1-4alkoxyC1-4alkyl, C1-7cycloalkyl, C3-7cycloalkylC1-4alkyl, aryl, arylC1-4alkyl, C 1-4 arylcarbonyl, alkyl, heteroaryl, C 1-4 heteroaryl, alkyl, R7 represents halogen or any of the meanings for R6, R8 represents halogen or C1-4 alkyl; it represents 1 or 2. X1 represents a group of formula: N, CH> N-CH2-, or> CH-CH2-; X2 represents a group of the formula: N, CH-CH2-N <, -CH2- <CH, -NH- <CH or -O- <CH; X3 represents N or CH, with the proviso that when X3 is N there is no it can be a group: N, -CH2- <N, -NH- <CH or -O- <CH; one of Z1 or Z2 represents Z and the other represents CH2, with the proviso that when X3 represents N, then Z2 must be CH2; Z represents a group of the formula: HN <, C1-6 alkyl <N.

ARP980101743 1997-04-16 1998-04-15 NEW CARBOXAMIDS AS INHIBITORS OF THE PLATELET AGGREGATION, PROCEDURE FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND USE OF THE SAME IN THE MANUFACTURE OF MEDICINES AR012443A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9700807 1997-04-16

Publications (1)

Publication Number Publication Date
AR012443A1 true AR012443A1 (en) 2000-10-18

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
ARP980101743 AR012443A1 (en) 1997-04-16 1998-04-15 NEW CARBOXAMIDS AS INHIBITORS OF THE PLATELET AGGREGATION, PROCEDURE FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND USE OF THE SAME IN THE MANUFACTURE OF MEDICINES

Country Status (3)

Country Link
AR (1) AR012443A1 (en)
AU (1) AU7526398A (en)
WO (1) WO1998046599A1 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI288745B (en) * 2000-04-05 2007-10-21 Daiichi Seiyaku Co Ethylenediamine derivatives
DE10029077A1 (en) * 2000-06-13 2001-12-20 Bayer Ag New heterocyclic-substituted thiazole derivatives, useful as total or selective herbicides, insecticides, acaricides, nematocides, ectoparasiticides or antifouling agents
US7115652B2 (en) 2002-06-17 2006-10-03 Sunesis Pharmaceuticals, Inc. Aspartyl protease inhibitors
AU2003276047A1 (en) 2002-06-17 2003-12-31 Sunesis Pharmaceuticals, Inc. Aspartyl protease inhibitors
GB0230162D0 (en) * 2002-12-24 2003-02-05 Metris Therapeutics Ltd Compounds useful in inhibiting angiogenesis
ES2383525T3 (en) 2003-11-05 2012-06-21 Sarcode Bioscience Inc. Cell adhesion modulators
JP2007531773A (en) 2004-03-31 2007-11-08 レキシコン・ジェネティクス・インコーポレーテッド 2-Aminomethylthiazole-5-carboxamide as a protein kinase modulator
WO2006125119A1 (en) 2005-05-17 2006-11-23 Sarcode Corporation Compositions and methods for treatment of eye disorders
GB0518494D0 (en) * 2005-09-09 2005-10-19 Argenta Discovery Ltd Thiazole compounds
EP2112880A4 (en) * 2006-12-14 2011-12-21 Merck Sharp & Dohme Acyl bipiperidinyl compounds, compositions containing such compounds and methods of treatment
CA3105972A1 (en) 2007-10-19 2009-04-30 Novartis Ag Compositions and methods for treatment of diabetic retinopathy
WO2009139817A2 (en) 2008-04-15 2009-11-19 Sarcode Corporation Crystalline pharmaceutical and methods of preparation and use thereof
WO2011050175A1 (en) 2009-10-21 2011-04-28 Sarcode Corporation Crystalline pharmaceutical and methods of preparation and use thereof
AU2011276539A1 (en) * 2010-06-28 2013-02-07 President And Fellows Of Harvard College Compounds for the inhibition of cellular proliferation
KR102157608B1 (en) 2012-07-25 2020-09-18 에스에이알코드 바이오사이언스 인코포레이티드 Lfa-1 inhibitor and polymorph thereof
WO2014122474A1 (en) 2013-02-07 2014-08-14 Takeda Pharmaceutical Company Limited Piperidin-1 -yl and azepin-1 -yl carboxylates as muscarinic m4 receptor agonists

Family Cites Families (4)

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DE4124942A1 (en) * 1991-07-27 1993-01-28 Thomae Gmbh Dr K 5-LOW HETEROCYCLES, METHOD FOR THE PRODUCTION THEREOF AND MEDICAMENTS CONTAINING SUCH COMPOUNDS
WO1994002472A1 (en) * 1992-07-15 1994-02-03 Taisho Pharmaceutical Co., Ltd. Thiazoline derivative
GB9406144D0 (en) * 1993-03-29 1994-05-18 Zeneca Ltd Heterocyclic compounds
DE19524765A1 (en) * 1995-07-07 1997-01-09 Boehringer Mannheim Gmbh New oxazolidinone derivatives, processes for their preparation and medicaments containing these compounds

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WO1998046599A1 (en) 1998-10-22

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