DE69632401T2 - Neue zielgerichtete mittel zur diagnostischen und therapeutischen verwendung - Google Patents

Neue zielgerichtete mittel zur diagnostischen und therapeutischen verwendung Download PDF

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Publication number
DE69632401T2
DE69632401T2 DE69632401T DE69632401T DE69632401T2 DE 69632401 T2 DE69632401 T2 DE 69632401T2 DE 69632401 T DE69632401 T DE 69632401T DE 69632401 T DE69632401 T DE 69632401T DE 69632401 T2 DE69632401 T2 DE 69632401T2
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DE
Germany
Prior art keywords
vesicles
composition according
targeted composition
lipid
gas
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69632401T
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German (de)
English (en)
Other versions
DE69632401D1 (de
Inventor
C. Evan UNGER
Dekang Shen
Guanli Wu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ImaRx Pharmaceutical Corp
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ImaRx Pharmaceutical Corp
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Publication date
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Application filed by ImaRx Pharmaceutical Corp filed Critical ImaRx Pharmaceutical Corp
Publication of DE69632401D1 publication Critical patent/DE69632401D1/de
Application granted granted Critical
Publication of DE69632401T2 publication Critical patent/DE69632401T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/227—Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/228—Host-guest complexes, clathrates, chelates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Acoustics & Sound (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nanotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Diabetes (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE69632401T 1995-06-07 1996-06-06 Neue zielgerichtete mittel zur diagnostischen und therapeutischen verwendung Expired - Fee Related DE69632401T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US49768495A 1995-06-07 1995-06-07
US497684 1995-06-07
US64046496A 1996-05-01 1996-05-01
US640464 1996-05-01
PCT/US1996/009938 WO1996040285A1 (en) 1995-06-07 1996-06-06 Novel targeted compositions for diagnostic and therapeutic use

Publications (2)

Publication Number Publication Date
DE69632401D1 DE69632401D1 (de) 2004-06-09
DE69632401T2 true DE69632401T2 (de) 2005-05-19

Family

ID=27052585

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69632401T Expired - Fee Related DE69632401T2 (de) 1995-06-07 1996-06-06 Neue zielgerichtete mittel zur diagnostischen und therapeutischen verwendung

Country Status (8)

Country Link
EP (2) EP1444991A1 (enExample)
JP (1) JP4215820B2 (enExample)
CN (2) CN1083280C (enExample)
AT (1) ATE265863T1 (enExample)
AU (1) AU709562B2 (enExample)
CA (1) CA2218541A1 (enExample)
DE (1) DE69632401T2 (enExample)
WO (1) WO1996040285A1 (enExample)

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020150539A1 (en) 1989-12-22 2002-10-17 Unger Evan C. Ultrasound imaging and treatment
US5776429A (en) * 1989-12-22 1998-07-07 Imarx Pharmaceutical Corp. Method of preparing gas-filled microspheres using a lyophilized lipids
US5205290A (en) 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
US7083572B2 (en) 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
US5830430A (en) * 1995-02-21 1998-11-03 Imarx Pharmaceutical Corp. Cationic lipids and the use thereof
US6521211B1 (en) 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
US6139819A (en) * 1995-06-07 2000-10-31 Imarx Pharmaceutical Corp. Targeted contrast agents for diagnostic and therapeutic use
US6548046B1 (en) 1995-06-08 2003-04-15 Barnes-Jewish Hospital Site specific binding system, imaging compositions and methods
US5780010A (en) * 1995-06-08 1998-07-14 Barnes-Jewish Hospital Method of MRI using avidin-biotin conjugated emulsions as a site specific binding system
US6821506B2 (en) 1995-06-08 2004-11-23 Barnes-Jewish Hospital Site specific binding system, imaging compositions and methods
AU736301B2 (en) 1996-05-01 2001-07-26 Imarx Therapeutics, Inc. Methods for delivering compounds into a cell
US5846517A (en) 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
US6261537B1 (en) 1996-10-28 2001-07-17 Nycomed Imaging As Diagnostic/therapeutic agents having microbubbles coupled to one or more vectors
US6331289B1 (en) 1996-10-28 2001-12-18 Nycomed Imaging As Targeted diagnostic/therapeutic agents having more than one different vectors
BR9712683A (pt) 1996-10-28 1999-10-19 Nyomed Imaging A S Agente de diagnóstico e/ou terapeuticamente ativo alvejável, formulação combinada, processo para preparação e uso do mesmo, formulação combinada, e processos para gerar imagens intensificadas de um corpo animal humano ou não-humano e para investigação in vitro de alvejamento por um agente.
US6493570B1 (en) * 1998-11-02 2002-12-10 Photogen, Inc. Method for improved imaging and photodynamic therapy
US6537246B1 (en) 1997-06-18 2003-03-25 Imarx Therapeutics, Inc. Oxygen delivery agents and uses for the same
US7452551B1 (en) * 2000-10-30 2008-11-18 Imarx Therapeutics, Inc. Targeted compositions for diagnostic and therapeutic use
US6416740B1 (en) * 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
US6245318B1 (en) 1997-05-27 2001-06-12 Mallinckrodt Inc. Selectively binding ultrasound contrast agents
AU9400798A (en) * 1997-09-18 1999-04-05 University Of Pittsburgh Icam-1 selective echogenic microbubbles
ATE248583T1 (de) † 1997-09-29 2003-09-15 Nektar Therapeutics In dosierinhalatoren verwendbare, stabilisierte zubereitungen
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
WO1999020312A1 (en) * 1997-10-21 1999-04-29 Nycomed Imaging As Ultrasound imaging with contrast agent targeted to microvasculature and a vasodilator drug
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
NZ511677A (en) * 1998-12-18 2003-10-31 Du Pont Pharm Co Vitronectin receptor antagonist pharmaceuticals
WO2000062813A2 (en) * 1999-04-20 2000-10-26 The University Of British Columbia Cationic peg-lipids and methods of use
US6254852B1 (en) * 1999-07-16 2001-07-03 Dupont Pharmaceuticals Company Porous inorganic targeted ultrasound contrast agents
AU6522400A (en) * 1999-08-10 2001-03-05 Imarx Therapeutics, Inc. Targeted thrombolytic agents
US7220401B2 (en) 1999-09-24 2007-05-22 Barnes-Jewish Hospital Blood clot-targeted nanoparticles
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
US8263739B2 (en) 2000-06-02 2012-09-11 Bracco Suisse Sa Compounds for targeting endothelial cells, compositions containing the same and methods for their use
JP5078212B2 (ja) 2000-06-02 2012-11-21 ブラッコ・スイス・ソシエテ・アノニム 内皮細胞を標的とするための化合物、それを含む組成物およびその使用方法
WO2002030466A2 (en) * 2000-10-11 2002-04-18 Purdue Research Foundation Pharmaceutical applications of hydrotropic agents, polymers thereof, and hydrogels thereof
US7829074B2 (en) 2001-10-18 2010-11-09 Nektar Therapeutics Hydroxypatite-targeting poly(ethylene glycol) and related polymers
US7087212B2 (en) * 2001-08-17 2006-08-08 Mallinckrodt, Inc Multicomponent assemblies having enhanced binding properties for diagnosis and therapy
TWI324518B (en) 2001-12-19 2010-05-11 Nektar Therapeutics Pulmonary delivery of aminoglycosides
CN100356984C (zh) * 2002-01-24 2007-12-26 巴内斯－朱威胥医院 整联蛋白靶向的影像剂
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
WO2004065621A1 (en) 2002-03-01 2004-08-05 Dyax Corp. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
US7211240B2 (en) 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
US7666979B2 (en) 2002-03-01 2010-02-23 Bracco International B.V. Methods for preparing multivalent constructs for therapeutic and diagnostic applications and methods of preparing the same
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
WO2003092647A2 (de) * 2002-04-29 2003-11-13 Biotesys Gmbh Peptid-modifizierte lipide als biologische transportsysteme für mikronutrients
ATE444984T1 (de) 2002-12-31 2009-10-15 Nektar Therapeutics Al Corp Hydrolysestabile maleimidendgruppen-enthaltende polymere
US7432331B2 (en) 2002-12-31 2008-10-07 Nektar Therapeutics Al, Corporation Hydrolytically stable maleimide-terminated polymers
US20070128117A1 (en) * 2003-02-04 2007-06-07 Bracco International B.V. Ultrasound contrast agents and process for the preparation thereof
ES2557286T3 (es) 2003-03-03 2016-01-25 Dyax Corp. Usos de péptidos que se unen específicamente al receptor del HGF (cMet)
US20040265393A1 (en) * 2003-06-13 2004-12-30 Unger Evan C. Non-invasive intravascular thrombolysis using modified ultrasound techniques
US7358226B2 (en) 2003-08-27 2008-04-15 The Regents Of The University Of California Ultrasonic concentration of drug delivery capsules
WO2005027808A1 (en) 2003-09-12 2005-03-31 Z-Medica Corporation Calcium zeolite hemostatic agent
CN1321697C (zh) * 2003-12-23 2007-06-20 中国人民解放军军事医学科学院毒物药物研究所 一种以磷脂类成分为成膜材料的超声造影剂组合物及其制备方法
US8012457B2 (en) * 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
EP1853326B1 (en) 2005-02-15 2016-06-15 Virginia Commonwealth University Mineral technologies (mt) for acute hemostasis and for the treatment of acute wounds and chronic ulcers
US9326995B2 (en) 2005-04-04 2016-05-03 The Regents Of The University Of California Oxides for wound healing and body repair
CN100402092C (zh) * 2005-06-07 2008-07-16 西安交通大学 血栓诊断和/或治疗用含气干粉活性剂及其制备工艺
JP2007001923A (ja) * 2005-06-23 2007-01-11 Shinshu Univ Ｎ−アセチルグルコサミン糖鎖認識タンパク質
ES2428964T3 (es) * 2005-12-09 2013-11-12 Bracco Suisse Sa Conjugados de vectores específicos de una diana-fosfolípidos
US8938898B2 (en) 2006-04-27 2015-01-27 Z-Medica, Llc Devices for the identification of medical products
US7604819B2 (en) 2006-05-26 2009-10-20 Z-Medica Corporation Clay-based hemostatic agents and devices for the delivery thereof
US12685799B2 (en) 2006-05-26 2026-07-21 Teleflex Life Sciences Ii Llc Hemostatic devices
EP2117603A2 (en) 2006-12-19 2009-11-18 Bracco International B.V. Targeting and therapeutic compounds and gas-filled microvesicles comprising said compounds
WO2008123478A1 (en) * 2007-03-29 2008-10-16 Canon Kabushiki Kaisha Active energy ray curable liquid composition and liquid cartridge
DE102007041832A1 (de) * 2007-09-03 2009-03-05 Siemens Ag Arzneimittel und Verfahren zur Behandlung von Prostatakrebs
JP2011525180A (ja) * 2008-06-16 2011-09-15 バインド バイオサイエンシズ インコーポレイテッド 治療的標的化ナノ粒子の製作に用いるためのジブロックコポリマーで官能化された標的薬の製造方法
CN101721719B (zh) * 2008-10-28 2011-09-28 温州医学院 超声造影剂及其制备方法
CN101549161B (zh) * 2009-05-13 2010-12-01 中南大学 一种肝、脾脏特异性阳性核磁共振对比剂及其制备方法
WO2010139003A1 (en) * 2009-06-01 2010-12-09 Commonwealth Scientific And Industrial Research Organisation Chelating amphiphiles
US8858969B2 (en) 2010-09-22 2014-10-14 Z-Medica, Llc Hemostatic compositions, devices, and methods
EP3412320A1 (en) 2012-06-22 2018-12-12 Z-Medica, LLC Hemostatic devices
US10035009B2 (en) 2013-04-15 2018-07-31 The Board Of Trustees Of The Leland Stanford Junior University Systems and methods for treating pancreatic cancer
US20160193366A1 (en) * 2013-08-16 2016-07-07 The Regents Of The University Of California Silicone-based enteric ct contrast material
KR102031571B1 (ko) * 2014-03-07 2019-10-14 주식회사 퍼시픽시스템 약물 전달을 위해 기포를 포함하는 미셀 및 이를 제조하는 방법
US10105454B2 (en) * 2014-07-08 2018-10-23 Agency For Science, Technology And Research Ultrashort peptides as exogenous second harmonic probes for bioimaging applications
CN107205691B (zh) * 2014-10-20 2022-02-08 博迪维仁医疗有限公司 手术装置及其使用方法
IL296875A (en) 2014-12-31 2022-12-01 Lantheus Medical Imaging Inc Fat-wrapped gas microsphere preparations and related methods
CA3022698A1 (en) 2016-05-04 2017-11-09 Lantheus Medical Imaging, Inc. Methods and devices for preparation of ultrasound contrast agents
US9789210B1 (en) 2016-07-06 2017-10-17 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents
JP7500536B2 (ja) * 2018-03-23 2024-06-17 アデノサイト リミテッド 強化された細胞病理学的細胞採取のための細胞および／または組織片の剥離を誘導する方法
CN110591054B (zh) * 2019-09-17 2021-05-18 江苏泰特尔新材料科技股份有限公司 一种总氯含量低、无重金属残留的环氧化物及其合成工艺
CN112266930B (zh) * 2020-10-14 2023-03-14 中国科学院苏州生物医学工程技术研究所 超声穿孔转染细胞的方法
WO2022139583A1 (en) * 2020-12-27 2022-06-30 Solstice Pharmaceuticals B.V. A cartridge for mixing a phospholipid composition intended for intracorporeal use
CN113694215B (zh) * 2021-09-09 2023-12-29 南京超维景生物科技有限公司 磁性纳米滴液的组合物，磁性造影剂及其制备方法
WO2026027682A1 (en) * 2024-07-31 2026-02-05 Schrader Juergen Combination comprising a cd63-binding molecule and a drug and/or a tracer and uses thereof
CN121343147A (zh) * 2025-12-18 2026-01-16 广州方中化工有限公司 一种基于蓖麻油衍生物的可降解农药增效剂
CN122145690B (zh) * 2026-05-09 2026-07-21 中国石油大学(华东) 一种海洋油气钻井液用柔性封堵剂及其制备方法与应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2060184T3 (es) * 1989-06-22 1994-11-16 Atta Moleculas anfifilicas conteniendo fluor y fosforo con propiedades tensoactivas.
US5209720A (en) * 1989-12-22 1993-05-11 Unger Evan C Methods for providing localized therapeutic heat to biological tissues and fluids using gas filled liposomes
IN172208B (enExample) * 1990-04-02 1993-05-01 Sint Sa
US5874062A (en) * 1991-04-05 1999-02-23 Imarx Pharmaceutical Corp. Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents
DE4232755A1 (de) * 1992-09-26 1994-03-31 Schering Ag Mikropartikelpräparationen aus biologisch abbaubaren Mischpolymeren
NZ262237A (en) * 1993-01-25 1997-06-24 Sonus Pharma Inc Ultrasound contrast agents comprising phase shift colloids having a boiling point below the body temperature of the animal it is used in
US5362478A (en) * 1993-03-26 1994-11-08 Vivorx Pharmaceuticals, Inc. Magnetic resonance imaging with fluorocarbons encapsulated in a cross-linked polymeric shell
EP0727225A3 (en) * 1995-02-14 1997-01-15 Sonus Pharma Inc Compositions and methods for directed ultrasonic imaging
US5695760A (en) * 1995-04-24 1997-12-09 Boehringer Inglehiem Pharmaceuticals, Inc. Modified anti-ICAM-1 antibodies and their use in the treatment of inflammation

Also Published As

Publication number Publication date
DE69632401D1 (de) 2004-06-09
WO1996040285A1 (en) 1996-12-19
EP0831932A4 (en) 2000-01-12
CA2218541A1 (en) 1996-12-19
JP4215820B2 (ja) 2009-01-28
CN1187137A (zh) 1998-07-08
EP0831932B1 (en) 2004-05-06
AU6270396A (en) 1996-12-30
EP1444991A1 (en) 2004-08-11
AU709562B2 (en) 1999-09-02
CN1397348A (zh) 2003-02-19
EP0831932A1 (en) 1998-04-01
ATE265863T1 (de) 2004-05-15
JPH11507638A (ja) 1999-07-06
CN1083280C (zh) 2002-04-24

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