DE69630699D1 - Heterocyclische verbindungen als bradykinin antagonisten - Google Patents

Heterocyclische verbindungen als bradykinin antagonisten

Info

Publication number
DE69630699D1
DE69630699D1 DE69630699T DE69630699T DE69630699D1 DE 69630699 D1 DE69630699 D1 DE 69630699D1 DE 69630699 T DE69630699 T DE 69630699T DE 69630699 T DE69630699 T DE 69630699T DE 69630699 D1 DE69630699 D1 DE 69630699D1
Authority
DE
Germany
Prior art keywords
pct
formula
date mar
sec
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69630699T
Other languages
English (en)
Other versions
DE69630699T2 (de
Inventor
Teruo Oku
Hiroshi Kayakiri
Yoshito Abe
Yuki Sawada
Tsuyoshi Mizutani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Pharma Inc
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of DE69630699D1 publication Critical patent/DE69630699D1/de
Application granted granted Critical
Publication of DE69630699T2 publication Critical patent/DE69630699T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE69630699T 1995-09-18 1996-09-18 Heterocyclische verbindungen als bradykinin antagonisten Expired - Lifetime DE69630699T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9519077 1995-09-18
GBGB9519077.3A GB9519077D0 (en) 1995-09-18 1995-09-18 New heterocyclic compounds
PCT/JP1996/002669 WO1997011069A1 (en) 1995-09-18 1996-09-18 Heterocyclic compounds as bradykinin antagonists

Publications (2)

Publication Number Publication Date
DE69630699D1 true DE69630699D1 (de) 2003-12-18
DE69630699T2 DE69630699T2 (de) 2004-09-30

Family

ID=10780895

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69630699T Expired - Lifetime DE69630699T2 (de) 1995-09-18 1996-09-18 Heterocyclische verbindungen als bradykinin antagonisten

Country Status (9)

Country Link
US (3) US6008229A (de)
EP (1) EP0861243B1 (de)
JP (1) JP2000515848A (de)
AT (1) ATE254121T1 (de)
AU (1) AU6999796A (de)
DE (1) DE69630699T2 (de)
ES (1) ES2205058T3 (de)
GB (1) GB9519077D0 (de)
WO (1) WO1997011069A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPN952696A0 (en) * 1996-04-29 1996-05-23 Fujisawa Pharmaceutical Co., Ltd. New heterocyclic compounds
JP2001501202A (ja) 1996-09-26 2001-01-30 ノバルティス アクチエンゲゼルシャフト ロイコトリエンｂ４（ｌｔｂ―４）レセプターアンタゴニスト活性によるアリル置換アクリルアミド
DE19712960A1 (de) * 1997-03-27 1998-10-01 Hoechst Ag Benzyloxy-substituierte, anellierte N-Heterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Bradykininrezeptorantagonisten
US6444849B1 (en) 1997-06-25 2002-09-03 Mitsubishi Chemical Corporation Amide derivatives
ATE396187T1 (de) * 1997-08-27 2008-06-15 Solvay Pharm Gmbh Indolmethyl-n,n'-bisacylpiperazine als neurokininrezeptorantagonisten
DE19824865A1 (de) * 1997-08-27 1999-03-04 Solvay Pharm Gmbh Neue Harnstoffderivate
EP1142868A4 (de) * 1998-12-22 2004-09-29 Mitsubishi Chem Corp Amidderivate
AUPP818099A0 (en) * 1999-01-14 1999-02-11 Fujisawa Pharmaceutical Co., Ltd. New n-containing heterocyclic compounds
FR2790260B1 (fr) 1999-02-26 2001-05-04 Fournier Ind & Sante Nouveaux composes de n-(benzenesulfonamide), procede de preparation et utilisation en therapeutique
US6281237B1 (en) 1999-04-02 2001-08-28 Neurogen Corporation N-phenyl benzimidazolecarboxamide and N-phenyl indolecarboxamide derivatives
AU4055300A (en) * 1999-04-02 2000-10-23 Neurogen Corporation Aryl and heteroaryl fused aminoalkyl-imidazole derivatives: selective modulators of Bradykinin B2 receptors
US6699486B1 (en) 1999-11-18 2004-03-02 Bolla Corporation Treatment or prevention of photoaging and skin cancer
US7105172B1 (en) 1999-11-18 2006-09-12 Bolla John D Treatment of rosacea
CA2408913A1 (en) 2000-05-16 2001-11-22 Takeda Chemical Industries, Ltd. Melanin-concentrating hormone antagonist
EP1914236A1 (de) 2002-04-10 2008-04-23 Ortho-McNeil Pharmaceutical, Inc. Neue Heteroaryl-Alkylamid-Derivate als Bradykininrezeptormodulatoren
CA2481855A1 (en) * 2002-04-10 2003-10-23 Ortho-Mcneil Pharmaceutical, Inc. Novel heteroaryl alkylamide derivatives useful as bradykinin receptor modulators
WO2007129745A1 (ja) 2006-05-09 2007-11-15 Daiichi Sankyo Company, Limited ヘテロアリールアミド低級カルボン酸誘導体
TWI407960B (zh) * 2007-03-23 2013-09-11 Jerini Ag 小分子緩激肽ｂ２受體調節劑
WO2009058216A1 (en) 2007-11-01 2009-05-07 Acucela, Inc. Amine derivative compounds for treating ophthalmic diseases and disorders
CN106986862A (zh) 2010-12-22 2017-07-28 Abbvie 公司 丙型肝炎抑制剂及其用途
US8883857B2 (en) 2012-12-07 2014-11-11 Baylor College Of Medicine Small molecule xanthine oxidase inhibitors and methods of use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5574042A (en) * 1992-11-02 1996-11-12 Fujisawa Pharmaceutical Co., Ltd Imidazo [1,2-a] pyridines and their pharmaceutical use
AU686115B2 (en) * 1992-11-02 1998-02-05 Fujisawa Pharmaceutical Co., Ltd. Imidazo (I,2-a) pyridine derivatives as bradykinin antagonists, pharmaceuticals and processes for their preparation
AU680870B2 (en) * 1993-04-28 1997-08-14 Astellas Pharma Inc. New heterocyclic compounds
WO1996004251A1 (fr) * 1994-08-03 1996-02-15 Fujisawa Pharmaceutical Co., Ltd. Compose heterocyclique
ES2218554T3 (es) * 1994-10-27 2004-11-16 Fujisawa Pharmaceutical Co., Ltd. Piridopirimidonas, quinolinas y n-heterociclos condensados que son antagonistas de bradiquinina.

Also Published As

Publication number Publication date
ES2205058T3 (es) 2004-05-01
AU6999796A (en) 1997-04-09
EP0861243A1 (de) 1998-09-02
GB9519077D0 (en) 1995-11-15
US6008229A (en) 1999-12-28
WO1997011069A1 (en) 1997-03-27
US6100284A (en) 2000-08-08
US6344462B1 (en) 2002-02-05
ATE254121T1 (de) 2003-11-15
JP2000515848A (ja) 2000-11-28
DE69630699T2 (de) 2004-09-30
EP0861243B1 (de) 2003-11-12

Similar Documents

Publication Publication Date Title
ATE254121T1 (de) Heterocyclische verbindungen als bradykinin antagonisten
DE69533174D1 (de) Pyridopyrimidinone, chinoline und anellierte n-heterozyklen als bradykinin-antagonisten
WO1996016981A3 (en) Peptide compounds for prevention and/or treatment of no-mediated diseases
ATE273958T1 (de) Heterocyclische verbindungen als h+-atpasen
ES2141174T3 (es) 4-arilmetiloximetil piperidinas como antagonistas de taquiquinina.
AR003005A1 (es) Compuestos derivados de benzamida, procedimientos para prepararlos, las composiciones farmaceuticas que los contienen, el metodo de tratamientoterapeutico y/o de prevencion con dichos compuestos, y las aplicaciones de dichos compuestos como medicamentos, y para la obtencion de medicamentos.
MX9801716A (es) Derivados de meta-guanidina, urea, tiourea o acido aminobenzoico azaciclico, como antagonistas de integrina.
LU91145I2 (fr) FIROCOXIB facultativement sous forme d'un sel pharmaceutiquement acceptable (PREVICOX).
ATE260658T1 (de) Pharmazeutische zubereitungen zur verminderung von atmungsdepressionen
DE69724098D1 (de) Chinolin- und benzimidazolderivate als bradykinin agonisten
IL137266A0 (en) Heterocyclic chemokine receptor antagonists and pharmaceutical compositions containing the same
SE9703414D0 (sv) New compounds
NO924929L (no) Farmasoeytisk aktive benzoquinazolinforbindelser
TR199801218T2 (xx) Takikinin antagonistleri olarak N-asil-2-ikameli-4-(Benzimidazolil-ya da imidazopiridinil-ikameli art�klar)-piperidinler.
DE69611728D1 (de) N-(4-substituerte benzyl)-2-aminolactamderivate
ATE277893T1 (de) N-(2-phenyl-4-amino-butyl)-1-naphthamide als neurokinin-1 rezeptorantagonisten
EP0774462A4 (de) Heterocyclische verbindungen
DK0823909T3 (da) Hidtil ukendte heterocykliske forbindelser
PT986393E (pt) Utilizacao de um nitroxido ou de um seu pro-farmaco no tratamento profilactico e terapeutico do cancro
WO1998031704A3 (en) Tachykinin antagonists
SE0004462D0 (sv) Novel method and use
UA74421C2 (uk) Похідні індолону, які є антагоністами gal3 рецептора для лікування депресії і/або тривоги та композиції, придатні для такого лікування
DE60137451D1 (de) N-substituierte Amide als NK1 Rezeptor Antagonisten
BR9306870A (pt) Derivados farmacologicamente ativos de (aminometila terciária) - benzenometanol
MX9603343A (es) Antagonistas del receptor endotelial, procedimiento para preparar dichos compuestos y preparaciones farmaceuticas que los contienen.

Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: ASTELLAS PHARMA INC., TOKIO/TOKYO, JP

8364 No opposition during term of opposition