DE69628597D1 - Verfahren zur herstellung biologisch aktiver derivate des 1,2,4-triazols und in diesem verfahren nuetzliche zwischenprodukte - Google Patents

Verfahren zur herstellung biologisch aktiver derivate des 1,2,4-triazols und in diesem verfahren nuetzliche zwischenprodukte

Info

Publication number
DE69628597D1
DE69628597D1 DE69628597T DE69628597T DE69628597D1 DE 69628597 D1 DE69628597 D1 DE 69628597D1 DE 69628597 T DE69628597 T DE 69628597T DE 69628597 T DE69628597 T DE 69628597T DE 69628597 D1 DE69628597 D1 DE 69628597D1
Authority
DE
Germany
Prior art keywords
triazole
biologically active
difluorophenyl
intermediate products
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69628597T
Other languages
English (en)
Other versions
DE69628597T2 (de
Inventor
Coll Alberto Palomo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KRKA dd
Original Assignee
KRKA Tovarna Zdravil dd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by KRKA Tovarna Zdravil dd filed Critical KRKA Tovarna Zdravil dd
Publication of DE69628597D1 publication Critical patent/DE69628597D1/de
Application granted granted Critical
Publication of DE69628597T2 publication Critical patent/DE69628597T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C241/00—Preparation of compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C241/02—Preparation of hydrazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/10—Hydrazines
    • C07C243/12—Hydrazines having nitrogen atoms of hydrazine groups bound to acyclic carbon atoms
    • C07C243/16—Hydrazines having nitrogen atoms of hydrazine groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C243/18—Hydrazines having nitrogen atoms of hydrazine groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69628597T 1996-05-21 1996-12-20 Verfahren zur herstellung biologisch aktiver derivate des 1,2,4-triazols und in diesem verfahren nuetzliche zwischenprodukte Expired - Fee Related DE69628597T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SI9600165A SI9600165A (en) 1996-05-21 1996-05-21 Process for preparation of biological active derivative of 1,2,4- triazole and intermediates useful in this process
SI9600165 1996-05-21
PCT/ES1996/000245 WO1997044330A1 (es) 1996-05-21 1996-12-20 Procedimiento para la preparacion de derivados biologicamente activos de 1,2,4-triazol e intermedios utiles en este procedimiento

Publications (2)

Publication Number Publication Date
DE69628597D1 true DE69628597D1 (de) 2003-07-10
DE69628597T2 DE69628597T2 (de) 2004-04-22

Family

ID=20431850

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69628597T Expired - Fee Related DE69628597T2 (de) 1996-05-21 1996-12-20 Verfahren zur herstellung biologisch aktiver derivate des 1,2,4-triazols und in diesem verfahren nuetzliche zwischenprodukte

Country Status (13)

Country Link
EP (1) EP0967210B1 (de)
KR (1) KR20000015811A (de)
AT (1) ATE242221T1 (de)
AU (1) AU1098297A (de)
DE (1) DE69628597T2 (de)
HR (1) HRP970271A2 (de)
HU (1) HU223570B1 (de)
NO (1) NO985408L (de)
RU (1) RU2170736C2 (de)
SI (1) SI9600165A (de)
UA (1) UA64712C2 (de)
WO (1) WO1997044330A1 (de)
YU (1) YU19097A (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100327818B1 (ko) * 1999-04-16 2002-03-09 윤재승 플루코나졸의 제조방법
KR100341688B1 (ko) * 1999-04-16 2002-06-24 윤재승 플루코나졸의 제조방법
AU2002328176A1 (en) * 2002-08-26 2004-03-11 Ranbaxy Laboratories Limited Azole derivatives as antifungal agents
EP2984080B1 (de) 2013-04-12 2017-08-30 Bayer CropScience Aktiengesellschaft Neuartige triazolderivate
BR102013027313B1 (pt) * 2013-10-23 2019-06-18 Iharabras S.A. Indústrias Químicas Processo para a preparação seletiva de (1h-1,2,4-triazol-1-il) alcanóis, composto hidrazinil alcanol obtido por tal processo e seu uso

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2099818A (en) * 1981-06-06 1982-12-15 Pfizer Ltd Triazoles
IT1249211B (it) * 1990-06-08 1995-02-20 Ind Chimica Srl Processo per la preparazione di triazolil isopropanoli in particolare fluconazolo
CA2106032C (en) * 1993-09-13 1995-11-07 Gamini Weeratunga Methods for the manufacture of fluconazole and forms thereof, intermediates useful in the manufacture thereof, and combinations comprising fluconazole
HU212424B (en) * 1993-09-23 1996-06-28 Richter Gedeon Vegyeszet New propan-2-ol derivatives substituted with triazole or imidazole and process for producing them
GB9415544D0 (en) * 1994-08-02 1994-09-21 Zeneca Ltd Chemical process and intermediates
GB9415617D0 (en) * 1994-08-02 1994-09-21 Zeneca Ltd Pharmaceutical compound

Also Published As

Publication number Publication date
SI9600165A (en) 1997-12-31
EP0967210A1 (de) 1999-12-29
ATE242221T1 (de) 2003-06-15
KR20000015811A (ko) 2000-03-15
HUP9903524A2 (hu) 2000-02-28
YU19097A (sh) 1999-09-27
HRP970271A2 (en) 1998-04-30
HUP9903524A3 (en) 2001-12-28
NO985408L (no) 1999-01-20
EP0967210B1 (de) 2003-06-04
HU223570B1 (hu) 2004-09-28
NO985408D0 (no) 1998-11-20
UA64712C2 (en) 2004-03-15
AU1098297A (en) 1997-12-09
DE69628597T2 (de) 2004-04-22
RU2170736C2 (ru) 2001-07-20
WO1997044330A1 (es) 1997-11-27

Similar Documents

Publication Publication Date Title
FI97381C (fi) Menetelmä korkeaa verenpainetta alentavien substituoitujen pyrroli-, pyratsoli- ja triatsoliyhdisteiden valmistamiseksi
KR890014500A (ko) 트리아졸 유도체, 그의 제법 및 살균제로서의 그의 용도
KR890006593A (ko) 아르마타제 억제4(5)- 이미다졸
DE3684431D1 (de) Derivate des ((4-(4-(4-phenyl-1-piperazinyl)phenoxymethyl)-1,3-dioxolan-2yl)methyl)-1h-imidazol und 1h-1,2,4-triazol.
AU4215593A (en) 4-substituted 1,2,4-triazole derivatives
DE69628597D1 (de) Verfahren zur herstellung biologisch aktiver derivate des 1,2,4-triazols und in diesem verfahren nuetzliche zwischenprodukte
RU97106099A (ru) Ингибиторы 5-липоксигеназы
ATE192440T1 (de) Verfahren zur herstellung von 1-(1,2,4-triazol-1- yl)-propan-2-ol-derivaten
YU101291A (sh) Postupak za dobijanje triazolil-izopropanola
DE60209708D1 (de) Azol- oder triazol-derivate, verfahren zu deren herstellung und ihre verwendung als fungizide
KR860004033A (ko) 광학적으로 활성인 아졸릴카르비놀 유도체, 즉 광학적으로 활성인 2-(4-클로로페녹시메틸)-3,3-디메틸-1-(1,2,4-트리아졸-1-일)-2-부탄올의 제조방법
DE60205239D1 (de) Azol- oder triazol-derivate, verfahren zu deren herstellung und ihre verwendung als antifungale arzneimittel
KR940000456A (ko) 트리아졸 유도체
BR8202823A (pt) Processo para a preparacao de 1-azolil-3-metil-1-fenoxibutan-2-onas e-ois-3 substituidos composicoes fungicidas processo para o combate de fungos e para a preparacao de composicoes
WO1991017978A3 (en) Selective monoacylation of substituted hydrazines
PT93707A (pt) Processo para a preparacao de derivados de imidazol dicloro-substituidos com accao antifungica
HUP9903490A2 (hu) Allergiás betegségek kezelésére használható helyettesített 4-(1H-benzimidazol-2-il)[1,4]diazepan-származékok, előállításuk és alkalmazásuk

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee