DE69628015T2 - Verfahren zur herstellung von ioversol - Google Patents

Verfahren zur herstellung von ioversol

Info

Publication number
DE69628015T2
DE69628015T2 DE69628015T DE69628015T DE69628015T2 DE 69628015 T2 DE69628015 T2 DE 69628015T2 DE 69628015 T DE69628015 T DE 69628015T DE 69628015 T DE69628015 T DE 69628015T DE 69628015 T2 DE69628015 T2 DE 69628015T2
Authority
DE
Germany
Prior art keywords
bis
reacting
produce
product
triiodoisopthalamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69628015T
Other languages
English (en)
Other versions
DE69628015D1 (de
Inventor
Jeffrey Dunn
H White
Thomas Kneller
M Jones
Ocampo Doran
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Inc
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Publication of DE69628015D1 publication Critical patent/DE69628015D1/de
Application granted granted Critical
Publication of DE69628015T2 publication Critical patent/DE69628015T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69628015T 1995-06-07 1996-06-06 Verfahren zur herstellung von ioversol Expired - Lifetime DE69628015T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/482,380 US5648536A (en) 1995-06-07 1995-06-07 Process for producing ioversol
PCT/US1996/010097 WO1996040286A1 (en) 1995-06-07 1996-06-06 Process for producing ioversol

Publications (2)

Publication Number Publication Date
DE69628015D1 DE69628015D1 (de) 2003-06-12
DE69628015T2 true DE69628015T2 (de) 2003-12-04

Family

ID=23915832

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69628015T Expired - Lifetime DE69628015T2 (de) 1995-06-07 1996-06-06 Verfahren zur herstellung von ioversol

Country Status (9)

Country Link
US (1) US5648536A (de)
EP (1) EP0839056B1 (de)
AT (1) ATE239510T1 (de)
DE (1) DE69628015T2 (de)
DK (1) DK0839056T3 (de)
ES (1) ES2198492T3 (de)
NO (1) NO323216B1 (de)
PT (1) PT839056E (de)
WO (1) WO1996040286A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6596904B1 (en) * 1996-01-29 2003-07-22 Mallinc Krodt Inc Process for producing ioversol
GB9725010D0 (en) * 1997-11-26 1998-01-28 Nycomed Imaging As Process
ITMI20011706A1 (it) * 2001-08-03 2003-02-03 Bracco Imaging Spa Agenti di contrasto radiografici ionici e non ionici, utilizzabili per l'indagine diagnostica combinata tramite raggi-x e risonanza magnetic
US8518373B2 (en) * 2001-08-03 2013-08-27 Bracco Imaging Spa Ionic and non-ionic radiographic contrast agents for use in combined X-ray and nuclear magnetic resonance diagnostics
CN100344606C (zh) * 2005-12-28 2007-10-24 江苏省原子医学研究所 一种碘昔兰的制备方法
WO2008104853A1 (en) * 2007-02-26 2008-09-04 Wockhardt Research Centre Processes for the preparation of pure ioversol
US20120184773A1 (en) 2009-09-30 2012-07-19 Mallinckrodt Llc Reduction of fused bicyclic impurities in triiodinated x-ray contrast media
EP2483235A1 (de) 2009-09-30 2012-08-08 Mallinckrodt LLC Alkylierung triiod-substituierter arylamide in einem system für wässrige mischlösungen
CN105669488A (zh) * 2016-01-11 2016-06-15 浙江海洲制药有限公司 X-ct造影剂含碘中间体母液的预处理及中间体回收方法
CN106336362B (zh) * 2016-08-24 2018-01-26 江苏恒瑞医药股份有限公司 一种碘佛醇的制备方法
CN106496058B (zh) * 2016-10-12 2018-11-16 浙江海洲制药有限公司 非离子型造影剂碘佛醇中间体的制备方法
CN106749323B (zh) * 2016-10-19 2018-10-09 江苏恒瑞医药股份有限公司 一种碘佛醇杂质的制备方法
CN107698456A (zh) * 2017-05-22 2018-02-16 成都丽璟科技有限公司 一种碘佛醇及其合成方法
KR102079983B1 (ko) * 2018-04-12 2020-02-21 (주)유케이케미팜 X선 조영제 이오버솔의 제조방법
CN110028418A (zh) * 2019-03-26 2019-07-19 大道隆达（北京）医药科技发展有限公司 一种碘佛醇的制备方法
CN110156623B (zh) * 2019-05-17 2022-05-27 浙江海洲制药有限公司 一种制备碘佛醇的方法
CN114213273A (zh) * 2021-12-15 2022-03-22 兄弟科技股份有限公司 一种碘美普尔的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4396598A (en) * 1982-01-11 1983-08-02 Mallinckrodt, Inc. Triiodoisophthalamide X-ray contrast agent
US5256393A (en) * 1991-04-16 1993-10-26 Mallinckrodt Medical, Inc. Use of azeotropic distillation in process to dry 5-amino-N,N'bis (2,3-dihydroxypropyl)-2,4,6-triiodoisphthalamide
US5177261A (en) * 1991-07-22 1993-01-05 Mallinckrodt Medical, Inc. Synthesis of ioversol using chloroacetyl chloride
US5371278A (en) * 1994-03-25 1994-12-06 Mallinckrodt Medical Pmc Synthesis of ioversol using a minimal excess of acetoxyacetylchloride

Also Published As

Publication number Publication date
NO975743L (no) 1998-02-06
ATE239510T1 (de) 2003-05-15
EP0839056B1 (de) 2003-05-07
NO975743D0 (no) 1997-12-05
EP0839056A1 (de) 1998-05-06
EP0839056A4 (de) 2000-09-13
DE69628015D1 (de) 2003-06-12
NO323216B1 (no) 2007-01-29
WO1996040286A1 (en) 1996-12-19
US5648536A (en) 1997-07-15
DK0839056T3 (da) 2003-09-01
ES2198492T3 (es) 2004-02-01
PT839056E (pt) 2003-09-30

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