DE69624789T2 - Verfahren zur herstellung von makrophagen und ausrüstungen zur durchführung dieses verfahrens - Google Patents

Verfahren zur herstellung von makrophagen und ausrüstungen zur durchführung dieses verfahrens

Info

Publication number
DE69624789T2
DE69624789T2 DE69624789T DE69624789T DE69624789T2 DE 69624789 T2 DE69624789 T2 DE 69624789T2 DE 69624789 T DE69624789 T DE 69624789T DE 69624789 T DE69624789 T DE 69624789T DE 69624789 T2 DE69624789 T2 DE 69624789T2
Authority
DE
Germany
Prior art keywords
stage
carrying
equipment
monocytes
constituents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69624789T
Other languages
English (en)
Other versions
DE69624789D1 (de
Inventor
Jean-Loup Romet-Lemonne
Mohamed Chokri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IDM Immuno Designed Molecules
Original Assignee
IDM Immuno Designed Molecules
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IDM Immuno Designed Molecules filed Critical IDM Immuno Designed Molecules
Application granted granted Critical
Publication of DE69624789D1 publication Critical patent/DE69624789D1/de
Publication of DE69624789T2 publication Critical patent/DE69624789T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0645—Macrophages, e.g. Kuepfer cells in the liver; Monocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/38—Vitamins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/22—Colony stimulating factors (G-CSF, GM-CSF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/24—Interferons [IFN]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/25—Tumour necrosing factors [TNF]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE69624789T 1995-01-24 1996-01-24 Verfahren zur herstellung von makrophagen und ausrüstungen zur durchführung dieses verfahrens Expired - Fee Related DE69624789T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9500785A FR2729570A1 (fr) 1995-01-24 1995-01-24 Procede de preparation de macrophages actives, trousses et compositions pour la mise en oeuvre de ce procede
PCT/FR1996/000121 WO1996022781A1 (fr) 1995-01-24 1996-01-24 Procede de preparation de macrophages, trousses et compositions pour la mise en ×uvre de ce procede

Publications (2)

Publication Number Publication Date
DE69624789D1 DE69624789D1 (de) 2002-12-19
DE69624789T2 true DE69624789T2 (de) 2003-07-03

Family

ID=9475438

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69624789T Expired - Fee Related DE69624789T2 (de) 1995-01-24 1996-01-24 Verfahren zur herstellung von makrophagen und ausrüstungen zur durchführung dieses verfahrens

Country Status (10)

Country Link
US (3) US5804442A (de)
EP (1) EP0806959B1 (de)
JP (1) JP3537443B2 (de)
AT (1) ATE227579T1 (de)
AU (1) AU720285B2 (de)
CA (1) CA2210449C (de)
DE (1) DE69624789T2 (de)
ES (1) ES2185759T3 (de)
FR (1) FR2729570A1 (de)
WO (1) WO1996022781A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL110195A (en) * 1994-07-03 2003-10-31 David Danon Method and system for cultivating macrophages
FR2729570A1 (fr) * 1995-01-24 1996-07-26 Idm Immuno Designed Molecules Procede de preparation de macrophages actives, trousses et compositions pour la mise en oeuvre de ce procede
EP0808897A1 (de) * 1996-05-21 1997-11-26 I.D.M. Immuno-Designed Molecules Antigenpräsentierende Zellen, ein Verfahren zur deren Herstellung und deren Verwendung als zelluläre Impfstoffen
US20020068048A1 (en) * 1997-09-05 2002-06-06 Patrick A. Dreyfus Method for the treatment or diagnosis of human pathologies with disseminated or difficult to access cells or tissues
AU768813B2 (en) * 1998-03-30 2004-01-08 I.D.M. Immuno-Designed Molecules Suppressive monocyte derived cells, process for their preparation and their uses in pharmaceutical compositions
JP2002509715A (ja) 1998-03-30 2002-04-02 イ・デ・エム・イミュノ−デジネ・モレキュル 刺激された単球に由来する細胞、その調製及び用途
US6616925B1 (en) * 1998-04-02 2003-09-09 I.D.M. Immuno-Designed Molecules Combined preparation for the treatment of neoplasic diseases or of infectious diseases
US20020168347A1 (en) * 1998-04-09 2002-11-14 Jacques Bartholeyns Use of monocytes derived cells, antigens and antibodies for optimal induction of immunotherapeutic efficiency
WO1999053027A1 (en) * 1998-04-09 1999-10-21 I.D.M. Immuno-Designed Molecules Use of monocytes derived cells and antibodies in a synergic way for optimal induction of immunotherapeutic efficiency
US6649746B1 (en) 1999-05-07 2003-11-18 University Of Virginia Patent Foundation Biological production of stable glutamine, poly-glutamine derivatives in transgenic organisms and their use for therapeutic purposes
US7541184B2 (en) 2000-02-24 2009-06-02 Invitrogen Corporation Activation and expansion of cells
US6797514B2 (en) * 2000-02-24 2004-09-28 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
US20030235908A1 (en) * 2000-02-24 2003-12-25 Xcyte Therapies, Inc. Activation and expansion of cells
US7572631B2 (en) * 2000-02-24 2009-08-11 Invitrogen Corporation Activation and expansion of T cells
US6867041B2 (en) * 2000-02-24 2005-03-15 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
US20030119185A1 (en) * 2000-02-24 2003-06-26 Xcyte Therapies, Inc. Activation and expansion of cells
CA2377874A1 (en) * 2000-05-25 2001-11-29 Xcyte Therapies, Inc. Methods for restoring or enhancing t-cell immune surveillance following naturally or artifically induced immunosuppression
AU2002353022A1 (en) * 2001-12-05 2003-06-23 Gambro, Inc. Methods and apparatus for separation of blood components
US20050084967A1 (en) 2002-06-28 2005-04-21 Xcyte Therapies, Inc. Compositions and methods for eliminating undesired subpopulations of T cells in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation
US20040151704A1 (en) * 2002-06-28 2004-08-05 Xcyte Therapies, Inc. Compositions and methods for restoring immune repertoire in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation
US20040175373A1 (en) * 2002-06-28 2004-09-09 Xcyte Therapies, Inc. Compositions and methods for eliminating undesired subpopulations of T cells in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation
US6914120B2 (en) * 2002-11-13 2005-07-05 Eastman Chemical Company Method for making isosorbide containing polyesters
JP2006524991A (ja) * 2003-05-08 2006-11-09 エクサイト セラピーズ インコーポレーティッド 抗原特異的ｔ細胞の作製および単離の方法
DE10339762B4 (de) * 2003-08-27 2007-08-02 Infineon Technologies Ag Chipstapel von Halbleiterchips und Verfahren zur Herstellung desselben
CA2539716A1 (en) * 2003-09-22 2005-04-07 Xcyte Therapies, Inc. Compositions and methods to accelerate hematologic recovery
DE10358590A1 (de) * 2003-12-12 2005-07-07 Newfrey Llc, Newark Verfahren zur Vorbehandlung von Oberflächen von Schweissteilen aus Aluminium oder seinen Legierungen und entsprechende Schweissteile
FR2915398B1 (fr) * 2007-04-25 2012-12-28 Lab Francais Du Fractionnement "ensemble de moyens pour le traitement d'une pathologie maligne, d'une maladie auto-immune ou d'une maladie infectieuse"
EP2495567A1 (de) * 2011-03-04 2012-09-05 Erasmus University Medical Center Rotterdam Verfahren und Vorrichtungen zur Überwachung von Störungen der Gewebehomöostase im gesamten Körper
US9517584B2 (en) 2013-12-18 2016-12-13 Eastman Chemical Company Articles comprising isosorbide and processes for their manufacture
EP3250623B1 (de) 2015-01-30 2022-07-27 Zephyros Inc. Haftendes material und verfahren zur verwendung davon
US10882971B2 (en) 2015-02-03 2021-01-05 Zephyros, Inc. One part epoxy-based composition

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2742086A1 (de) * 1977-09-19 1979-03-29 Siemens Ag Vorrichtung zum trocknen der schlichte von glasseidefaeden o.dgl.
US4912045A (en) 1980-01-08 1990-03-27 Ortho Pharmaceutical Corporation Hybrid cell line for producing monoclonal antibody to a human monocyte, antigen, antibody and methods
US4434237A (en) 1982-03-31 1984-02-28 Dinarello Charles A Human leukocytic pyrogen test for the detection of exogenous fever-producing substances
US5112948A (en) 1986-10-10 1992-05-12 Jones C Michael Methods and compositions for inducing monocyte cytotoxicity
US5374549A (en) 1991-01-31 1994-12-20 Terumo Corporation Process of enriching adherent CD4+ T cells from monocyte depleted peripheral blood mononuclear cells with interleukin 2 and interleukin 4
CA2163218C (en) * 1993-05-18 2002-09-10 Mohamed Chokri New macrophages, process for preparing the same and their use as active substances of pharmaceutical compositions
FR2729570A1 (fr) * 1995-01-24 1996-07-26 Idm Immuno Designed Molecules Procede de preparation de macrophages actives, trousses et compositions pour la mise en oeuvre de ce procede

Also Published As

Publication number Publication date
JPH11505512A (ja) 1999-05-21
US5804442A (en) 1998-09-08
DE69624789D1 (de) 2002-12-19
CA2210449C (fr) 2003-03-18
US6221576B1 (en) 2001-04-24
EP0806959B1 (de) 2002-11-13
CA2210449A1 (fr) 1996-08-01
JP3537443B2 (ja) 2004-06-14
EP0806959A1 (de) 1997-11-19
WO1996022781A1 (fr) 1996-08-01
US6140122A (en) 2000-10-31
FR2729570B1 (de) 1997-02-28
FR2729570A1 (fr) 1996-07-26
ES2185759T3 (es) 2003-05-01
AU720285B2 (en) 2000-05-25
ATE227579T1 (de) 2002-11-15
AU4626596A (en) 1996-08-14

Similar Documents

Publication Publication Date Title
DE69624789T2 (de) Verfahren zur herstellung von makrophagen und ausrüstungen zur durchführung dieses verfahrens
ATE513905T1 (de) Verfahren für die replikation von influenza in zellkultur, und die bei diesem verfahren hergestellten influenza viren
ATE447009T1 (de) Verfahren zur herstellung angereicherter hämatopoietischer zusammensetzungen, dadurch hergestellte zusammensetzungen sowie deren verwendungen
DE69837041D1 (de) Verfahren und mikroorganism zur herstellung von purin-nukleosiden durch fermentation
ATE187176T1 (de) Verfahren zur herstellung von heterologen bispezifischen antikörpern
ATE414162T1 (de) Verfahren und materialien zur herstellung von glucosamin
ATE553125T1 (de) Herstellung eines multimeren proteins durch zellfusionsverfahren
DE69535120D1 (de) L-Isoleucin produzierendes Bacterium und Verfahren zur Herstellung von L-Isoleucin durch Fermentation
DE60236016D1 (de) Zelluläre zusammensetzungen und verfahren zur deren bereitung und verwendung
ATE125157T1 (de) Methoden und zusammensetzungen zur impfung gegen hiv.
ZA975851B (en) Hepatocyte grown factor receptor agonists and uses thereof
ATE316570T1 (de) Verfahren zur verminderung der schaumbildung während der kultivierung eines mikroorganismus
ATE430807T1 (de) Verfahren zur kultivierung von circovirus
ATE317912T1 (de) Verfahren zur herstellung von beta-lactamen
DE69125331D1 (de) Zelluloseesterzusammensetzungen und verfahren zu deren herstellung
ATE330003T1 (de) Rekombinanter stabiler zellklon, seine herstellung und verwendung
ATE443756T1 (de) Chondroitin synthasegen und verfahren zur dessen herstellung und anwendung
ATE366120T1 (de) Hocheffizientes gewebespezifisches system zur bereitstellung von verbindungen unter verwendung eines streptavidin-protein a fusionsproteins
DE69415345D1 (de) Verfahren zur herstellung von bisnoraldehyden aus bisnoralkohol
ATE266719T1 (de) Verfahren und zusammensetzung zur herstellung von austrocknungstoleranten sporen von paecitomyces fumosoroseus
AU5326198A (en) Synthetic biepitope compounds which can be used as standards in the biological assays of troponin I
WO2002012535B1 (en) Use of anti-ceacam antibodies for stimulating b cells in the production of monoclonal antibodies or in immunotherapy
DE69625933D1 (de) Verfahren zur herstellung eines alkoholisches getränk durch fermentation und fermentationstestsatz zur durchführung des verfahrens
DE3485399D1 (de) Verfahren zur herstellung von 21-hydroxy-20-keto-delta-16-steroiden und in diesem verfahren erhaltene zwischenprodukte.
ATE522604T1 (de) Verfahren zur herstellung von proteinen durch elektropulsierung

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee